Polymer Materials Synthesized in Living Cells for Regulating Biological Functions

Cheng-Fei Liu; Yi-Fan Jin; Jia-Hui Ma; Wei Tian; Hua-Ping Xu

doi:10.1007/s10118-025-3341-7

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Polymer Materials Synthesized in Living Cells for Regulating Biological Functions

REVIEW | Updated：2025-07-26

- Polymer Materials Synthesized in Living Cells for Regulating Biological Functions
- Polymer Materials Synthesized in Living Cells for Regulating Biological Functions
- 高分子科学（英文） 2025年43卷第8期页码：1293-1310
- Affiliations：
  
  a.Shaanxi Key Laboratory of Macromolecular Science and Technology, Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic Device, MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an 710072, China
  b.Key Lab of Organic Optoelectronics & Molecular Engineering and Laboratory of Flexible Electronics Technology, Department of Chemistry, Tsinghua University, Beijing 100084, China
- Author bio：
  
  happytw_3000@nwpu.edu.cn (W.T.)
  xuhuaping@mail.tsinghua.edu.cn (H.P.X.)
- Funds：
  
  This work was financially supported by the National Key R&D Program of China (No. 2023YFA0915300), the National Natural Science Foundation of China (Nos. 52233012, 22405212 and 22471219), and the Funds for Creative Research Groups of China of the National Natural Science Foundation of China (No. 21821001). The authors would like to thank Xplorer Prize.;Wei Tian completed his Ph.D. from the Northwestern Polytechnical University in 2009 under the supervision of Professor Xiaodong Fan. He pursued his research in polymer chemistry as a postdoctoral researcher at the same university until 2010. Following academic appointments at Northwestern Polytechnical University, he joined the Department of Industrial and Systems Engineering at Hong Kong Polytechnic University as a research associate. He returned to Northwestern Polytechnical University in 2011 and became a full-time professor in 2014. His scientific interests have focused on supramolecular hyperbranched polymers and macromolecular self-assemblies.Hua-Ping Xu received his bachelor’s and Ph.D. degrees from Jilin University under the supervision of Prof. Xi Zhang. He worked as a postdoc at the University of Twente, under the supervision of Prof. David N. Reinhoudt and Prof. Jurriaan Huskens. He is currently a full professor at the Tsinghua University. In 2014, he received the Natural Science Fund for Outstanding Young Scholars from the National Natural Science Foundation of China (NSFC). In 2023, he received the Xplore Prize. He has served as an associate editor for ACS Biomaterials Science & Engineering from to 2017−2024. Since 2024, he has served as the executive editor for ACS Applied Materials and Interfaces. His scientific interests include the preparation of selenium/tellurium-containing polymers, their unique stimuli-responsive and dynamic properties, and their diverse applications in adaptive and biomedical materials.
- DOI：10.1007/s10118-025-3341-7
  中图分类号：
- 收稿日期：2025-02-17，
  
  修回日期：2025-03-14，
  
  录用日期：2025-03-18，
  
  网络出版日期：2025-05-23，
  
  纸质出版日期：2025-08-01
- Accepted：
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Liu, C. F.; Jin, Y. F.; Ma, J. H.; Tian, W.; Xu, H. P. Polymer materials synthesized in living cells for regulating biological functions. Chinese J. Polym. Sci. 2025, 43, 1293–1310

Cheng-Fei Liu, Yi-Fan Jin, Jia-Hui Ma, et al. Polymer Materials Synthesized in Living Cells for Regulating Biological Functions[J]. Chinese journal of polymer science, 2025, 43(8): 1293-1310.
Liu, C. F.; Jin, Y. F.; Ma, J. H.; Tian, W.; Xu, H. P. Polymer materials synthesized in living cells for regulating biological functions. Chinese J. Polym. Sci. 2025, 43, 1293–1310 DOI： 10.1007/s10118-025-3341-7.

Cheng-Fei Liu, Yi-Fan Jin, Jia-Hui Ma, et al. Polymer Materials Synthesized in Living Cells for Regulating Biological Functions[J]. Chinese journal of polymer science, 2025, 43(8): 1293-1310. DOI： 10.1007/s10118-025-3341-7.

摘要

We summarized recent advances and future trends in the field of intracellular polymerization

specifically focusing on covalent and supramolecular polymerization. This discussion comprehensively covers the diverse chemical designs

reaction mechanisms

responsive features

and functional applications.

Abstract

Intracellular polymerization is an emerging field

showcasing high diversity and efficiency of chemistry. Motivated by the principles of natural biomolecular synthesis

polymerization within living cells is believed to be a powerful and versatile tool to modulate cell behavior. In this review

we summarized recent advances and future trends in the field of intracellular polymerization

specifically focusing on covalent and supramolecular polymerization. This discussion comprehensively covers the diverse chemical designs

reaction mechanisms

responsive features

and functional applications. Furthermore

we also clarified the connection between preliminary design of polymer synthesis and their subsequent biological applications. We hope this review will serve as an innovative platform for chemists and biologists to regulate biological functions in practical applications and clinical trials.

关键词

Keywords

references

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