Backbone Degradable Polymers <italic style="font-style: italic">via</italic> Chain-growth Radical Polymerization

Hai-Wang Lai; Makoto Ouchi

doi:10.1007/s10118-025-3278-x

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Backbone Degradable Polymers via Chain-growth Radical Polymerization

REVIEW | Updated：2025-05-30

- Backbone Degradable Polymers via Chain-growth Radical Polymerization
- Backbone Degradable Polymers via Chain-growth Radical Polymerization
- 高分子科学（英文） 2025年43卷第6期页码：887-907
- Affiliations：
  
  a.Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems, Great Bay University, Dongguan 523000, China
  b.Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
- Author bio：
  
  laihaiwang@gbu.edu.cn (H.W.L.)
  makoto.2v@kyoto-u.ac.jp (M.O.)
- Funds：
  
  H.L. acknowledges funding from the National Natural Science Foundation of China (No. 22401037). M.O. acknowledges funding from JST CREST (No. JPMJCR23L1).;Hai-Wang Lai obtained his Ph.D. in 2018 under the guidance of Prof. Martina H. Stenzel and Dr. Pu Xiao. Following his Ph.D., he worked as a Research Associate at the Australian National University. From 2019 to 2021, he was a postdoctoral researcher at Jinan University, after which he joined Prof. Makoto Ouchi's group at Kyoto University as a JSPS International Fellow. He later returned to China in 2022 and joined Great Bay University as an assistant professor. Additionally, he was a visiting scholar in Prof. Hua Lu’s group at Peking University. His research interests include degradable sequence-controlled polymers, light-regulated polymerization and biomass-derived polymers.Makoto Ouchi received his Ph.D. degree at Kyoto University in 2001. He then worked at Toyota Central R&D Labs on the development of polylactic acid-based automotive resins. In 2004, he moved to Kyoto University to start his academic carrier as Assistant Professor. He was promoted to Associate Professor (2010) and Professor (2017) at the Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University. From 2013 to 2017, he was concurrently appointed as a PRESTO researcher of Japan Science and Technology Agency (JST) for a project of molecular technology. His current research interest is precision polymerization for seeking inherent features of polymers, particularly sequence-controlled polymerization, stereospecific polymerization, ring-expansion polymerization, and polymerization for stimulus-responsive degradation, etc.
- DOI：10.1007/s10118-025-3278-x
  中图分类号：
- 收稿日期：2024-10-31，
  
  修回日期：2024-11-23，
  
  录用日期：2024-11-27，
  
  网络出版日期：2025-02-24，
  
  纸质出版日期：2025-05-20
- Accepted：
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Lai, H. W.; Ouchi, M. Backbone degradable polymers via chain-growth radical polymerization. Chinese J. Polym. Sci. 2025, 43, 887–907

Hai-Wang Lai, Makoto Ouchi. Backbone Degradable Polymers via Chain-growth Radical Polymerization[J]. Chinese journal of polymer science, 2025, 43(6): 887-907.
Lai, H. W.; Ouchi, M. Backbone degradable polymers via chain-growth radical polymerization. Chinese J. Polym. Sci. 2025, 43, 887–907 DOI： 10.1007/s10118-025-3278-x.

Hai-Wang Lai, Makoto Ouchi. Backbone Degradable Polymers via Chain-growth Radical Polymerization[J]. Chinese journal of polymer science, 2025, 43(6): 887-907. DOI： 10.1007/s10118-025-3278-x.

摘要

This review summarizes recent advances in endowing vinyl polymers with degradability

aiming to reduce their environmental impact and enhance their application in bio-relevant areas.

Abstract

Chain-growth radical polymerization of vinyl monomers is essential for producing a wide range of materials with properties tailored to specific applications. However

the inherent resistance of the polymer's C―C backbone to degradation raises significant concerns regarding long-term environmental persistence

which also limits their potential in biomedical applications. To address these challenges

researchers have developed strategies to either degrade preexisting vinyl polymers or incorporate cleavable units into the backbone to modify them with enhanced degradability. This review explores the various approaches aimed at achieving backbone degradability in chain-growth radical polymerization of vinyl monomers

while also highlighting future research directions for the development of application-driven degradable vinyl polymers.

关键词

Keywords

references

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DOI：10.1007/s10118-025-3278-x

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