Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment

Xin-Rao Zhang; Fu-Shan Wang; Xin Wang; Yan Gao; Hong-Xing Zhang; Zhi-Qin Liu; Jia-Chun Feng

doi:10.1007/s10118-024-3213-6

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Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment

RESEARCH ARTICLE | Updated：2024-12-31

- Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment
- Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment
- 高分子科学（英文） 2025年43卷第1期页码：90-100
- Affiliations：
  
  a.State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China
  b.Lanzhou Petrochemical Corporation of PetroChina, Lanzhou 730060, China
- Author bio：
  
  jcfeng@fudan.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (No. 52173056) and the Science and Technology Program of Gansu Province, China (No. 23ZDGA001).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3213-6.
- DOI：10.1007/s10118-024-3213-6
  中图分类号： M
- 纸质出版日期：2025-01-01，
  
  网络出版日期：2024-10-21，
  
  收稿日期：2024-01-24，
  
  修回日期：2024-07-18，
  
  录用日期：2024-07-31
- Accepted：
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Zhang, X. R.; Wang, F. S.; Wang, X.; Gao, Y.; Zhang, H. X.; Liu, Z. Q.; Feng, J. C. Comparative investigation of the migration behavior of two stearate acid scavengers from Ziegler-Natta polypropylene into water during autoclaving treatment. Chinese J. Polym. Sci. 2025, 43, 90–100

XIN-RAO ZHANG, FU-SHAN WANG, XIN WANG, et al. Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment. [J]. Chinese journal of polymer science, 2025, 43(1): 90-100.
Zhang, X. R.; Wang, F. S.; Wang, X.; Gao, Y.; Zhang, H. X.; Liu, Z. Q.; Feng, J. C. Comparative investigation of the migration behavior of two stearate acid scavengers from Ziegler-Natta polypropylene into water during autoclaving treatment. Chinese J. Polym. Sci. 2025, 43, 90–100 DOI： 10.1007/s10118-024-3213-6.

XIN-RAO ZHANG, FU-SHAN WANG, XIN WANG, et al. Comparative Investigation of the Migration Behavior of Two Stearate Acid Scavengers from Ziegler-Natta Polypropylene into Water during Autoclaving Treatment. [J]. Chinese journal of polymer science, 2025, 43(1): 90-100. DOI： 10.1007/s10118-024-3213-6.

摘要

The migration of the two commonly used acid scavengers

calcium stearate and zinc stearate

from the plates of a Z-N polypropylene into water during autoclaving were comparatively investigated. It was found that these two acid scavengers exhibited significantly different migration behaviors.

Abstract

Although Ziegler-Natta (Z-N) polyolefins have been widely used as raw materials to produce pharmaceutical or food packaging

the migration of acid scavengers

an additive usually introduced in Z-N polyolefins

from the packaging to its contents has not been reported. In this work

the migration of the two most used acid scavengers

calcium stearate (CaSt

) and zinc stearate (ZnSt

)

from a Z-N polypropylene random copolymer (PPR) into water during autoclaving at 121 °C were comparatively investigated. It was found that

for PPR plates containing 0.1 wt% CaSt

or ZnSt

(PPR-0.1CaSt

PPR-0.1ZnSt

respectively)

the concentration of migrated calcium ion into water increased with autoclaving time

while that of zinc ion was much lower at same treatment durations and did not show a significant increase with treatment time. Interestingly

after removing all plates and acidification treatment

a considerable amount of stearic acid was detected in sterilized water for PPR-0.1ZnSt

but no such significant stearic acid was detected in sterilized water for PPR-0.1CaSt

. Based on the structural evolution of the two soaps upon heating

possible mechanisms for the different migration behavior of CaSt

and ZnSt

from PPR into water during autoclaving treatment were proposed. Our results suggest that the migration issue of acid scavengers is worthy of attention in pharmaceutical packaging materials produced from Z-N polyolefins.

关键词

Keywords

Zinc stearateCalcium stearateZiegler-Natta polyolefinAutoclaving treatmentMigration

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