Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

Mei-Yu Jiang; Jia-Sheng Wu; Wei-Min Liu; Hao-Hui Ren; Xin Wang; Peng-Fei Wang

doi:10.1007/s10118-022-2795-0

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Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

RESEARCH ARTICLE | Updated：2022-08-19

- Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma
- Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma
- 高分子科学（英文版） 2022年40卷第9期页码：1120-1128
- Affiliations：
  
  a.Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
- Author bio：
  
  wujs@mail.ipc.ac.cn (J.S.W.)
  wangpf@mail.ipc.ac.cn (P.F.W.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 21873110 and 61720106014) and the Instrument Developing Project of the Chinese Academy of Sciences (No. YJKYYQ20170015).
- DOI：10.1007/s10118-022-2795-0
  中图分类号：
- 纸质出版日期：2022-09-01，
  
  网络出版日期：2022-07-12，
  
  收稿日期：2022-04-06，
  
  修回日期：2022-04-29，
  
  录用日期：2022-05-07
- Accepted：
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Jiang, M. Y.; Wu, J. S.; Liu, W. M.; Ren, H. H.; Wang, X.; Wang, P. F. Porphyrin-based nanosonosensitizers combined with targeting peptides for sonodynamic therapy of glioma. Chinese J. Polym. Sci. 2022, 40, 1120–1128

Mei-Yu Jiang, Jia-Sheng Wu, Wei-Min Liu, et al. Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma[J]. Chinese Journal of Polymer Science, 2022,40(9):1120-1128.
Jiang, M. Y.; Wu, J. S.; Liu, W. M.; Ren, H. H.; Wang, X.; Wang, P. F. Porphyrin-based nanosonosensitizers combined with targeting peptides for sonodynamic therapy of glioma. Chinese J. Polym. Sci. 2022, 40, 1120–1128 DOI： 10.1007/s10118-022-2795-0.

Mei-Yu Jiang, Jia-Sheng Wu, Wei-Min Liu, et al. Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma[J]. Chinese Journal of Polymer Science, 2022,40(9):1120-1128. DOI： 10.1007/s10118-022-2795-0.

摘要

In this work

T-cRGD NPs

was obtained by the self-assembly of DSPE-PEG-cRGD and TPP-PPh3-4PEG for targeting sonodynamic therapy. Peptide targeting endows

T-cRGD NPs

with superior ultrasound therapeutic efficacy and tumor enrichment ability.

Abstract

Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer cells. Peptide-targeted sonodynamic therapy (SDT) can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven therapy. Herein

we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting

which constituted a nano sonosensitizer (

T-cRGD NPs

) for fluorescence imaging-guided sonodynamic therapy. A comparable sonosensitizer (

T-PEG NPs

) without the targeting unit was also prepared for illustration of therapeutic performance. Attribute to the role of peptide targeting

T-cRGD NPs

can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than

T-PEG NPs

in vitro

. The imaging

in vivo

reveals that

T-cRGD NPs

can enrich in tumor tissues within 14 h with a good biocompatibility.

关键词

Keywords

Sonodynamic therapyGliomaCyclic peptideTarget enrichmentDeep penetration

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