NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT

Zhao-qiang Wu; Shu Yang; Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences; Wuhan University; Wuhan 430072; China

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NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT

Updated：2021-06-21

- NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT
- NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT
- 高分子科学（英文版） 2006年第3期页码：315-321
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  This work was supported by the National Natural Science Foundation of China （No. 20474044）.()
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Zhao-qiang Wu, Shu Yang, Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences, 等. NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J]. 高分子科学（英文版）, 2006,(3):315-321.

Zhao-qiang Wu, Shu Yang, Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences, et al. NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J]. 2006,(3):315-321.
Zhao-qiang Wu, Shu Yang, Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences, 等. NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J]. 高分子科学（英文版）, 2006,(3):315-321. DOI：

Zhao-qiang Wu, Shu Yang, Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences, et al. NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J]. 2006,(3):315-321. DOI：

摘要

<正>Novel amphiphilic fluorescent graft copolymer （PVP-PyAHy） was successfully synthesized by the free radical copolymerization of hydrophobic monomer N-（1-pyrenebutyryl）-N’-acryloyl hydrazide （PyAHy） with hydrophilic precursor polymers of vinyl-functionaiized poly（N-vinylpyrrolidone）（PVP） in DMF. The copolymer is amphiphilic and has intrinsic fluorescence. FT-IR, 1H-NMR, TEM, gel permeation chromatography-multi-angle laser light scattering, UV-Vis spectroscopy and fluorescence spectroscopy were used to characterize this copolymer. The TEM observation shows that the copolymer PVP-PyAHy forms micelles in aqueous solution. Results of fluorometric measurements illustrate that the critical micelle concentration （CMC） value of PVP-PyAHy in aqueous solution is about 0.90 mg/mL. To examine the encapsulation ability of the copolymer in aqueous media, methyl yellow was employed as a model hydrophobic agent. The loading level of the polymer to methyl yellow is 8.8 mg/g. The cytotoxicity assays for Madin Darby Canine Kidney （MDCK） cells shows good biocompatibility of PVP-PyAHy in vitro. These results suggest the potential of this copolymer PVP-PyAHy as drugs delivery carrier and fluorescent tracer.

Abstract

Novel amphiphilic fluorescent graft copolymer （PVP-PyAHy） was successfully synthesized by the free radical copolymerization of hydrophobic monomer N-（1-pyrenebutyryl）-N’-acryloyl hydrazide （PyAHy） with hydrophilic precursor polymers of vinyl-functionaiized poly（N-vinylpyrrolidone）（PVP） in DMF. The copolymer is amphiphilic and has intrinsic fluorescence. FT-IR, 1H-NMR, TEM, gel permeation chromatography-multi-angle laser light scattering, UV-Vis spectroscopy and fluorescence spectroscopy were used to characterize this copolymer. The TEM observation shows that the copolymer PVP-PyAHy forms micelles in aqueous solution. Results of fluorometric measurements illustrate that the critical micelle concentration （CMC） value of PVP-PyAHy in aqueous solution is about 0.90 mg/mL. To examine the encapsulation ability of the copolymer in aqueous media, methyl yellow was employed as a model hydrophobic agent. The loading level of the polymer to methyl yellow is 8.8 mg/g. The cytotoxicity assays for Madin Darby Canine Kidney （MDCK） cells shows good biocompatibility of PVP-PyAHy in vitro. These results suggest the potential of this copolymer PVP-PyAHy as drugs delivery carrier and fluorescent tracer.

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