NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES

You-xiang Wang a; Ying Zhu c; Jia-cong Shen a

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NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES

Note | Updated：2021-06-21

- NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES
- NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES
- 高分子科学（英文版） 2008年26卷第4期页码：507-512
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You-xiang Wang a, Ying Zhu c, Jia-cong Shen a. NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES[J]. 高分子科学（英文版）, 2008,26(4):507-512.

You-xiang Wang a, b, Ying Zhu c. NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES[J]. 2008,26(4):507-512.
You-xiang Wang a, Ying Zhu c, Jia-cong Shen a. NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES[J]. 高分子科学（英文版）, 2008,26(4):507-512. DOI：

You-xiang Wang a, b, Ying Zhu c. NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES[J]. 2008,26(4):507-512. DOI：

摘要

Enhanced stability of polyplexes in physiological condition was an important prerequisite for successful systemic gene delivery. Herein novel method was reported to develop stable gene vector by nanotechnology. Thiolated polyplexes were constructed and then cross-linked with gold nanoparticles (AuNPs) by gold-thiol interactions. TEM pictures showed that AuNPs were attached to the shell of spherical polyplexes. The hybrid gene vector was stable enough in physiological condition and maintained efficient transfection, which showed great potential in gene delivery research and application.

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