Polysaccharide-based Hydrogel Formed <italic style="font-style: italic">via In situ</italic> Schiff Base Reaction with Contact Lens-like Ocular Surface Coverage for Sustained Ophthalmic Drug Delivery

Xin Yang; Hai-Hua Wang; Chao-Jun Yue; De-Hua Tan; Ge Sun; Shuai-Jun Guo; Hai-Liang Pei; Yu-Lin Hu; Shan-Hao Feng; Yang Qiao; Yi-Ming Hua; Li-Juan Zhang; Shi-Lei Zhu; Ya-Nan Ye; Qiang Zheng

doi:10.1007/s10118-026-3614-9

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Polysaccharide-based Hydrogel Formed via In situ Schiff Base Reaction with Contact Lens-like Ocular Surface Coverage for Sustained Ophthalmic Drug Delivery

Special Topic: Functional Gels | Updated：2026-05-30

- Polysaccharide-based Hydrogel Formed via In situ Schiff Base Reaction with Contact Lens-like Ocular Surface Coverage for Sustained Ophthalmic Drug Delivery
- Chinese Journal of Polymer Science Vol. 44, Issue 6, Pages: 1804-1819(2026)
- Affiliations：
  
  a.Shaanxi Key Laboratory of Chemical Additives for Industry, Xi’an Key Laboratory of Advanced Performance Materials and Polymers, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China
  b.College of Materials Science & Engineering, Taiyuan University of Technology, Taiyuan 030024, China
  c.China Institute for Radiation Protection, Taiyuan 030006, China
  d.Shanxi Eye Hospital, Shanxi Medical University, Taiyuan 030002, China
  e.Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  whh@sust.edu.cn (H.H.W.)
  zhanglj2004@163.com (L.J.Z.)
  zhushilei@tyut.edu.cn (S.L.Z.)
  yeyanan@tyut.edu.cn (Y.N.Y.)
- Funds：
- DOI：10.1007/s10118-026-3614-9
  CLC：
- Received：13 December 2025，
  
  Revised：2026-02-17，
  
  Accepted：28 February 2026，
  
  Online First：26 May 2026，
  
  Published：05 June 2026
- Accepted：
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Yang, X.; Wang, H. H.; Yue, C. J.; Tan, D. H.; Sun, G.; Guo, S. J.; Pei, H. L.; Hu, Y. L.; Feng, S. H.; Qiao, Y.; Hua, Y. M.; Zhang, L. J.; Zhu, S. L.; Ye, Y. N.; Zheng, Q. Polysaccharide-based hydrogel formed via in situ schiff base reaction with contact lens-like ocular surface coverage for sustained ophthalmic drug delivery. Chinese J. Polym. Sci. 2026, 44, 1804–1819

Xin Yang, Hai-Hua Wang, Chao-Jun Yue, et al. Polysaccharide-based Hydrogel Formed via In situ Schiff Base Reaction with Contact Lens-like Ocular Surface Coverage for Sustained Ophthalmic Drug Delivery[J]. Chinese Journal of Polymer Science, 2026, 44(6): 1804-1819. DOI: 10.1007/s10118-026-3614-9.
Yang, X.; Wang, H. H.; Yue, C. J.; Tan, D. H.; Sun, G.; Guo, S. J.; Pei, H. L.; Hu, Y. L.; Feng, S. H.; Qiao, Y.; Hua, Y. M.; Zhang, L. J.; Zhu, S. L.; Ye, Y. N.; Zheng, Q. Polysaccharide-based hydrogel formed via in situ schiff base reaction with contact lens-like ocular surface coverage for sustained ophthalmic drug delivery. Chinese J. Polym. Sci. 2026, 44, 1804–1819 DOI： 10.1007/s10118-026-3614-9.

Xin Yang, Hai-Hua Wang, Chao-Jun Yue, et al. Polysaccharide-based Hydrogel Formed via In situ Schiff Base Reaction with Contact Lens-like Ocular Surface Coverage for Sustained Ophthalmic Drug Delivery[J]. Chinese Journal of Polymer Science, 2026, 44(6): 1804-1819. DOI: 10.1007/s10118-026-3614-9. DOI：

摘要

A dual dynamic

in situ

gel rapidly forms within the ocular clearance window and conforms during blinking

reducing drug loss while improving ocular retention and bioavailability.

Abstract

The unique physiological barriers and rapid clearance of the ocular surface result in less than 5% bioavailability of topical drugs

forcing frequent high-dose administration

reducing compliance

and risking toxicity. Existing ophthalmic semi-solid formulations can delay clearance but often cause blurred vision and foreign body sensation due to high viscosity

limiting clinical use. In this stud

a polysaccharide-based dual-dynamic crosslinked hydrogel (HC gels) was prepared

via

in situ

Schiff base reaction between aldehyde-functionalized hyaluronic acid and aminated carboxymethylcellulose under physiological conditions for sustained ocular drug delivery. By modulating the gelation kinetics

a controllable transition from a low-viscosity solution to a gel (15−384 s) was achieved. The

in situ

-formed gel dynamically adapts to the ocular surface during blinking

forming a thin

uniform

transparent layer that ensures conformal coverage

resists blinking and tear clearance

and significantly extends drug retention. In a rat model of uveitis

HC gels effectively alleviated inflammation

via

sustained dexamethasone release. Overall

HC gels provide a novel strategy for safe

effective

and sustained ocular drug delivery.

关键词

Keywords

references

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⁰

Polysaccharide-based Hydrogel Formed via In situ Schiff Base Reaction with Contact Lens-like Ocular Surface Coverage for Sustained Ophthalmic Drug Delivery

DOI：10.1007/s10118-026-3614-9

摘要

Abstract

关键词

Keywords

references