Lignin-derived High-performance Near-infrared Light-responsive Shape Memory Polyurethanes for Biomedical Applications

Su-Yang Dai; Jia-Yue Li; Ling-Chen Mao; Dan-Hua Zhou; Yu Zhang; Zhi-Hua Gan; Zhen-Bo Ning; Yun-Feng Lu

doi:10.1007/s10118-026-3574-0

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Lignin-derived High-performance Near-infrared Light-responsive Shape Memory Polyurethanes for Biomedical Applications

RESEARCH ARTICLE | Updated：2026-03-26

- Lignin-derived High-performance Near-infrared Light-responsive Shape Memory Polyurethanes for Biomedical Applications
- Chinese Journal of Polymer Science Vol. 44, Issue 4, Pages: 1090-1101(2026)
- Affiliations：
  
  a.State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  b.Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen 361102, China
  c.Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
  d.Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  zhoudh@xmu.edu.cn (D.H.Z.)
  zhangyu@ipe.ac.cn (Y.Z.)
  zbning@mail.buct.edu.cn (Z.B.N.)
- Funds：
- DOI：10.1007/s10118-026-3574-0
  CLC：
- Received：10 December 2025，
  
  Accepted：14 January 2026，
  
  Online First：05 March 2026，
  
  Published：05 April 2026
- Accepted：
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Dai, S. Y.; Li, J. Y.; Mao, L. C.; Zhou, D. H.; Zhang, Y.; Gan, Z. H.; Ning, Z. B.; Lu, Y. F. Lignin-derived high-performance near-infrared light-responsive shape memory polyurethanes for biomedical applications. Chinese J. Polym. Sci. 2026, 44, 1090–1101

Su-Yang Dai, Jia-Yue Li, Ling-Chen Mao, et al. Lignin-derived High-performance Near-infrared Light-responsive Shape Memory Polyurethanes for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2026, 44(4): 1090-1101.
Dai, S. Y.; Li, J. Y.; Mao, L. C.; Zhou, D. H.; Zhang, Y.; Gan, Z. H.; Ning, Z. B.; Lu, Y. F. Lignin-derived high-performance near-infrared light-responsive shape memory polyurethanes for biomedical applications. Chinese J. Polym. Sci. 2026, 44, 1090–1101 DOI： 10.1007/s10118-026-3574-0.

Su-Yang Dai, Jia-Yue Li, Ling-Chen Mao, et al. Lignin-derived High-performance Near-infrared Light-responsive Shape Memory Polyurethanes for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2026, 44(4): 1090-1101. DOI： 10.1007/s10118-026-3574-0.

摘要

Demethylated dealkaline lignin (DDL) was used to prepare polyurethane followed by Fe

complexation to form DDL-Fe

complexes. This strategy significantly enhanced the photothermal performance of natural lignin. The resulting PU-DDL+Fe

polyurethane exhibits excellent NIR light-responsive shape memory performance with good mechanical properties and biocompatibility.

Abstract

Near-infrared (NIR) light-responsive shape memory polymers (SMPs) show great promise for biomedical applications

but conventional photothermal agents suffer from high cost

complex preparation

or poor biocompatibility

while lignin-based alternatives exhibit insufficient photothermal conversion efficiency. Herein

we developed a novel strategy to enhance photothermal performance of lignin through sequential demethylation modification and Fe

complexation for constructing NIR light responsive SMPs. Dealkaline lignin (DL) was first demethylated using iodocyclohexane to produce demethylated lignin (DDL) with increased catechol content

which was then incorporated into polycaprolactone-based polyurethane synthesis followed by Fe

complexation. Results showed that DDL-Fe

complexes have signific

antly enhanced photothermal conversion performance

and the resulting PU-DDL+Fe

polyurethane with 0.5 wt% DDL content demonstrated a temperature increases of 39.8 °C under 0.33 W·cm

–2

808 nm NIR irradiation. This excellent photothermal performance enables the shape-fixed PU-DDL+Fe

polyurethane to rapidly recover to its initial shape under NIR light irradiation. Additionally

PU-DDL+Fe

polyurethane exhibits good mechanical properties and biocompatibility

demonstrating significant biomedical application potential.

关键词

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references

Cui, J.; Xu, J.; Li, J.; Qiu, H.; Zheng, S.; Yang, J. A crosslinkable graphene oxide in waterborne polyurethane anticorrosive coatings: experiments and simulation. Compos. B Eng. 2020 , 188 , 107889..

Petrović, Z. S.; Ferguson, J. Polyurethane elastomers. Prog. Polym. Sci. 1991 , 16 , 695−836..

Zhao, X.; Dong, R.; Guo, B.; Ma, P. X. Dopamine-incorporated dual bioactive electroactive shape memory polyurethane elastomers with physiological shape recovery temperature, high stretchability, and enhanced C2C12 myogenic differentiation. ACS Appl. Mater. Interfaces 2017 , 9 , 29595−29611..

Qiu, J.; Zhao, H.; Luan, S.; Wang, L.; Shi, H. Recent advances in functional polyurethane elastomers: from structural design to biomedical applications. Biomater. Sci. 2025 , 13 , 2526−2540.

Delaey, J.; Dubruel, P.; Van Vlierberghe, S. Shape-memory polymers for biomedical applications. Adv. Funct. Mater. 2020 , 30 , 1909047..

Xia, Y.; He, Y.; Zhang, F.; Liu, Y.; Leng, J. A Review of shape memory polymers and composites: mechanisms, materials, and applications. Adv. Mater. 2021 , 33 , 2000713..

Ramaraju, H.; Akman, R. E.; Safranski, D. L.; Hollister, S. J. Designing biodegradable shape memory polymers for tissue repair. Adv. Funct. Mater. 2020 , 30 , 2002014..

Zhao, W.; Liu, L.; Zhang, F.; Leng, J.; Liu, Y. Shape memory polymers and their composites in biomedical applications. Mater. Sci. Eng. C 2019 , 97 , 864−883..

Zhu, Y.; Deng, K.; Zhou, J.; Lai, C.; Ma, Z.; Zhang, H.; Pan, J.; Shen, L.; Bucknor, M. D.; Ozhinsky, E.; Kim, S.; Chen, G.; Ye, S.-h.; Zhang, Y.; Liu, D.; Gao, C.; Xu, Y.; Wang, H.; Wagner, W. R. Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating. Nat. Commun. 2024 , 15 , 1123..

Liu, X.; Wu, J.; Tang, Z.; Wu, J.; Huang, Z.; Yin, X.; Du, J.; Lin, X.; Lin, W.; Yi, G. Photoreversible bond-based shape memory polyurethanes with light-induced self-healing, recyclability, and 3D fluorescence encryption. ACS Appl. Mater. Interfaces 2022 , 14 , 33829−33841..

Lu, L.; Tian, T.; Wu, S.; Xiang, T.; Zhou, S. A pH-induced self-healable shape memory hydrogel with metal-coordination cross-links. Polym. Chem. 2019 , 10 , 1920−1929..

Xue, J.; Ge, Y.; Liu, Z.; Liu, Z.; Jiang, J.; Li, G. Photoprogrammable moisture-responsive actuation of a shape memory polymer film. ACS Appl. Mater. Interfaces 2022 , 14 , 10836−10843..

Dai, S.; Yue, S.; Ning, Z.; Jiang, N.; Gan, Z. Polydopamine nanoparticle-reinforced near-Infrared light-triggered shape memory polycaprolactone–polydopamine polyurethane for biomedical implant applications. ACS Appl. Mater. Interfaces 2022 , 14 , 14668−14676..

Chen, G.; Sun, J.; Peng, Q.; Sun, Q.; Wang, G.; Cai, Y.; Gu, X.; Shuai, Z.; Tang, B. Z. Biradical-featured stable organic-small-molecule photothermal materials for highly efficient solar-driven water evaporation. Adv. Mater. 2020 , 32 , 1908537..

Xie, W.; Yan, F.; Pakdel, E.; Sharp, J.; Liu, D.; Wang, X.; Zhan, S.; Sun, L. Natural melanin/polyurethane composites as highly efficient near-infrared-photoresponsive shape memory implants. ACS Biomater. Sci. Eng. 2020 , 6 , 5305−5314..

Bai, Y.; Zhang, J.; Chen, X. A thermal-, water-, and near-infrared light-induced shape memory composite based on polyvinyl alcohol and polyaniline fibers. ACS Appl. Mater. Interfaces 2018 , 10 , 14017−14025..

Lizundia, E .; Sipponen, M. H.; Greca, L. G.; Balakshin, M.; Tardy, B. L.; Rojas, O. J.; Puglia, D. Multifunctional lignin-based nanocomposites and nanohybrids. Green Chem. 2021 , 23 , 6698−6760..

Zhuang, Z.; Li, T.; Ning, Z.; Jiang, N.; Gan, Z. Melt and nucleation reinforcement for stereocomplex crystallites in poly(ʟ-lactide) / lignin-grafted-poly(ᴅ-lactide) blend. Eur. Polym. J. 2022 , 167 , 111072..

Li, J.; Liu, W.; Qiu, X.; Zhao, X.; Chen, Z.; Yan, M.; Fang, Z.; Li, Z.; Tu, Z.; Huang, J. Lignin: a sustainable photothermal block for smart elastomers. Green Chem. 2022 , 24 , 823−836..

Wang, J.; Zhang, D.; Chu, F. Wood-derived functional polymeric materials. Adv. Mater. 2020 , 33 , 2001135..

Xu, J.; Xu, J. J.; Lin, Q.; Jiang, L.; Zhang, D.; Li, Z.; Ma, B.; Zhang, C.; Li, L.; Kai, D.; Yu, H. D.; Loh, X. J. Lignin-incorporated nanogel serving as an antioxidant biomaterial for wound healing. ACS Appl. Bio Mater. 2021 , 4 , 3−13..

Peng, J.; Wang, H.; Chen, S.; Liu, W.; Qiu, X. Mechanically Ro bust, Reprocessable, and light-controlled healable solvent-free lignin-containing polyurethane elastomers based on dynamic phenol-carbamate network. Macromolecules 2025 , 58 , 836−854..

Wang, H.; Huang, J.; Liu, W.; Huang, J.; Yang, D.; Qiu, X.; Zhang, J. Tough and fast light-controlled healable lignin-containing polyurethane elastomers. Macromolecules 2022 , 55 , 8629−8641..

Li, H.; Sun, J.-T.; Wang, C.; Liu, S.; Yuan, D.; Zhou, X.; Tan, J.; Stubbs, L.; He, C. High modulus, strength, and toughness polyurethane elastomer based on unmodified lignin. ACS Sustain. Chem. Eng. 2017 , 5 , 7942−7949..

Liu, W.; Fang, C.; Wang, S.; Huang, J.; Qiu, X. High-performance lignin-containing polyurethane elastomers with dynamic covalent polymer networks. Macromolecules 2019 , 52 , 6474−6484..

Zhang, G.; Tian, C.; Shi, J.; Zhang, X.; Liu, J.; Tan, T.; Zhang, L. Mechanically robust, self-repairable, shape memory and recyclable ionomeric elastomer composites with renewable lignin via interfacial metal–ligand interactions. ACS Appl. Mater. Interfaces 2022 , 14 , 38216−38227..

Dai, S.; Mao, L.; Chen, X.; Zhang, J.; Li, X.; Zhang, M.; Jiang, N.; Yang, K.; Duan, S.; Gan, Z.; Ning, Z. A heterogeneous hydrogel patch with mechanical activity and bioactivity for chronic diabetic wound healing. Biomaterials 2026 , 324 , 123531..

Sawamura, K.; Tobimatsu, Y.; Kamitakahara, H.; Takano, T. Lignin Functionalization through chemical demethylation: preparation and tannin-like properties of demethylated guaiacyl-type synthetic lignins. ACS Sustain. Chem. Eng. 2017 , 5 , 5424−5431..

Qian, Y.; Zhou, Y.; Lu, M.; Guo, X.; Yang, D.; Lou, H.; Qiu, X.; Guo, C. F. Direct construction of catechol lignin for engineering long-acting conductive, adhesive, and UV-blocking hydrogel bioelectronics. Small Methods 2021 , 5 , 2001311..

Wang, S.; Yao, S.; Hu, Q.; Wang, Z.; Zhao, Y.; Li, L. A metal-quercetin-histidine co-coordinated nanoparticle enhances cancer photothermal therapy via reshaping immunosuppressive tumor microenvironment. Chem. Eng. J. 2024 , 499 , 156027..

Zhen, X.; Li, H.; Xu, Z.; Wang, Q.; Xu, J.; Zhu, S.; Wang, Z.; Yuan, Z. Demethylation, phenolation, and depolymerization of lignin for the synth esis of lignin-based epoxy resin via a one-pot strategy. Ind. Crop. Prod. 2021 , 173 , 114135..

Zhao, W.; Wei, C.; Cui, Y.; Ye, J.; He, B.; Liu, X.; Sun, J. Efficient demethylation of lignin for polyphenol production enabled by low-cost bifunctional protic ionic liquid under mild and halogen-free conditions. Chem. Eng. J. 2022 , 443 , 136486..

Reeve, R., Histological and histochemical changes in developing and ripening peaches. I. The catechol tannins. Am. J. Bot. 1959 , 46 , 210−217..

Yuan, J.; Liu, Y.; Li, Y.; Chang, Q.; Deng, X.; Xie, Y. Metal-loaded synthetic melanin via oxidative polymerization of neurotransmitter norepinephrine exhibiting high photothermal conversion. Nano Lett. 2024 , 24 , 6353−6361..

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