Multicomponent Polymerization of Alkynes, Amines, and Benzaldehyde toward Main-chain Charged Aggregation-induced Emission Polyelectrolytes

Qiu-Shuo Zhang; Bo Song; An-Jun Qin; Ben-Zhong Tang

doi:10.1007/s10118-026-3559-z

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Multicomponent Polymerization of Alkynes, Amines, and Benzaldehyde toward Main-chain Charged Aggregation-induced Emission Polyelectrolytes

RESEARCH ARTICLE | Updated：2026-03-26

- Multicomponent Polymerization of Alkynes, Amines, and Benzaldehyde toward Main-chain Charged Aggregation-induced Emission Polyelectrolytes
- Chinese Journal of Polymer Science Vol. 44, Issue 4, Pages: 988-995(2026)
- Affiliations：
  
  a.State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China
  b.Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen 518172, China
- Author bio：
  
  songbo@scut.edu.cn (B.S.)
  msqinaj@scut.edu.cn (A.J.Q.)
- Funds：
- DOI：10.1007/s10118-026-3559-z
  CLC：
- Received：09 November 2025，
  
  Accepted：03 January 2026，
  
  Online First：02 March 2026，
  
  Published：05 April 2026
- Accepted：
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Zhang, Q. S.; Song, B.; Qin, A. J.; Tang, B. Z. Multicomponent polymerization of alkynes, amines, and benzaldehyde toward main-chain charged aggregation-induced emission polyelectrolytes. Chinese J. Polym. Sci. 2026, 44, 988–995

Qiu-Shuo Zhang, Bo Song, An-Jun Qin, et al. Multicomponent Polymerization of Alkynes, Amines, and Benzaldehyde toward Main-chain Charged Aggregation-induced Emission Polyelectrolytes[J]. Chinese Journal of Polymer Science, 2026, 44(4): 988-995.
Zhang, Q. S.; Song, B.; Qin, A. J.; Tang, B. Z. Multicomponent polymerization of alkynes, amines, and benzaldehyde toward main-chain charged aggregation-induced emission polyelectrolytes. Chinese J. Polym. Sci. 2026, 44, 988–995 DOI： 10.1007/s10118-026-3559-z.

Qiu-Shuo Zhang, Bo Song, An-Jun Qin, et al. Multicomponent Polymerization of Alkynes, Amines, and Benzaldehyde toward Main-chain Charged Aggregation-induced Emission Polyelectrolytes[J]. Chinese Journal of Polymer Science, 2026, 44(4): 988-995. DOI： 10.1007/s10118-026-3559-z.

摘要

One-pot multicomponent polymerization enables the direct preparation of main-chain aggregation-induced emission (AIE) ionic polyelectrolytes with intrinsic AIE features from non-emissive monomers

which exhibit potent antimicrobial activity against bacteria and fungi.

Abstract

Aggregation-induced emission (AIE) polymers have been extensively studied; however

the integration of AIE units into polyelectrolytes remains largely limited by the laborious multistep synthesis of pre-designed emissive monomers. Herein

we report a one-pot multicomponent polymerization method that directly produces main-chain charged polyelectrolytes with intrinsic AIE characteristics from non-emissive building blocks. By optimizing the monomer structures and reaction conditions

a series of soluble high-molecular-weight polymers with well-defined backbones were obtained in high yields. The resulting polyelectrolytes displayed robust AIE behavior

exhibiting fluorescence enhancement up to about 60-fold in an aqueous environment

and maintained excellent thermal stability. Owing to their cationic backbones

these polymers interact strongly with microbial surfaces and exhibit remarkable antimicrobial activities. This study establishes a synthetically efficient route to AIE polyelectrolytes and highlights their potential applications as multifunctional materials for bioimaging

antimicrobial therapy

and other applications.

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references

[Mei, J.; Leung, N. L.; Kwok, R. T.; Lam, J. W.; Tang, B. Z. Aggregation-induced emission: together we shine, united we soar! Chem. Rev . 2015 , 115 , 11718−11940..

Wu, W.; Liu, B. Aggregation-induced emission: challenges and opportunities. Nat. Sci. Rev. 2021 , 8 , nwaa222..

Li, B.; Liu, Y.Y.; Luo, P.; Liu, Y.R.; Chen, Y. J.; Li, K.; Zang, S. Q. Multi-stimuli-responsive aggregation-induced emission copper iodide cluster. Sci. China Chem. 2024 , 67 , 1193−1197..

Guan, J.; Wei, R.; Prlj, A.; Peng, J.; Lin, K. H.; Liu, J.; Han, H.; Corminboeuf, C.; Zhao, D.; Yu, Z. Direct observation of aggregation-induced emission mechanism. Angew. Chem. Int. Ed. 2020 , 59 , 14903−14909..

Zhu, J.; Jiang, X. How does aggregation-induced emission aggregate interdisciplinary research. Aggregate 2024 , 5 , e451..

Qu, R.; Zhen, X.; Jiang, X. Emerging designs of aggregation-induced emission agents for enhanced phototherapy applications. CCS Chem. 2022 , 4 , 401−419..

Peng, Z.; Jia, P. P.; Wang, X. Q.; Zhao, X. L.; Yang, H. B.; Wang, W. Sequence engineering in tuning the circularly polarized luminescence of aggregation-induced emission-active hetero [3 ] rotaxanes. CCS Chem. 2024 , 6 , 2489−2501..

Liu, Y.; Chen, X.; Liu, X.; Guan, W.; Lu, C. Aggregation-induced emission-active micelles: synthesis, characterization, and applications. Chem. Soc. Rev. 2023 , 52 , 1456−1490..

Tang, S.; Ye, S.; Zhang, X. When aggregation-induced emission meets protein aggregates. Nat. Sci. Rev. 2021 , 8 , nwab013..

Zhou, Y.; Hua, J.; Ding, D.; Tang, Y. Interrogating amyloid aggregation with aggregation-induced emission fluorescence probes. Biomaterials 2022 , 286 , 121605..

Cen, P.; Huang, J.; Jin, C.; Wang, J.; Wei, Y.; Zhang, H.; Tian, M. Aggregation-induced emission luminogens for in vivo molecular imaging and theranostics in cancer. Aggregate 2023 , 4 , e352..

Zhang, X.; Liu, H.; Zhuang, G.; Yang, S.; Du, P. An unexpected dual-emissive luminogen with tunable aggregation-induced emission and enhanced chiroptical property. Nat. Commun. 2022 , 13 , 3543..

Xu, L.; Gao, H.; Zhan, W.; Deng, Y.; Liu, X.; Jiang, Q.; Sun, X.; Xu, J.-J.; Liang, G. Dual aggregations of a near-infrared aggregation-induced emission luminogen for enhanced imaging of Alzheimer’s disease. J. Am. Chem. Soc. 2023 , 145 , 27748−27756..

Zhou, B.; Ling, X.; Senthil, T.; Liu, B.; Goodson III, T. Enhanced sensitivity of nonlinear optical signatures of aggregation-induced emission. J. Am. Chem. Soc. 2025 , 147 , 34601−34609..

Sanz-Velasco, A.; Amargós-Reyes, O.; Kähäri, A.; Lipinski, S.; Cavinato, L. M.; Costa, R. D.; Kostiainen, M. A.; Anaya-Plaza, E. Controlling aggregation-induced emission by supramolecular interactions and colloidal stability in ionic emitters for light-emitting electrochemical cells. Chem. Sci. 2024 , 15 , 2755−2762..

Huang, D.; Qin, A.; Tang, B. Z. Water in triple-bond-based polymerizations: roles as a solvent or monomer. Polym. Sci. Technol. 2025 , 1 , 221−232..

Wang, B.; Liu, Y.; Chen, X.; Liu, X. T.; Liu, Z.; Lu, C. Aggregation-induced emission-active supramolecular polymers: from controlled preparation to applications. Chem. Soc. Rev. 2024 , 53 , 10189−10215..

Li, R.; Ma, Y.; Yang, T.; Yang, X.; Tao, R.; Jin, Y.; Zhang, W.; Qiu, L. Rehealable and recyclable aggregation-induced emission (AIE)-active luminescent vitrimers. ACS Mater. Lett. 2023 , 5 , 2348−2354..

Chen, S.; Han, T.; Tang, B. Z. Functional polymeric micromaterials based on aggregation-induced emission luminogens. Adv. Funct. Mater. 2023 , 33 , 2307267..

Teo, N. K. S.; Fan, B.; Ardana, A.; Thang, S. H. Aggregation-induced emission polymers via reversible-deactivation radical polymerization. Aggregate 2024 , 5 , e414..

[Wu, G.; Liu, Y.; Yang, Z.; Ma, L.; Tang, Y.; Zhao, X.; Rouh, H.; Zheng, Q.; Zhou, P.; Wang, J.-Y. Triple-columned and multiple-layered 3D polymers: design, synthesis, aggregation-induced emission (AIE), and computational study. Research 2021 , 2021 , 3565791..

Aniés, F.; Hamilton, I.; De Castro, C. S.; Furlan, F.; Marsh, A. V.; Xu, W.; Pirela, V.; Patel, A.; Pompilio, M.; Cacialli, F. A conjugated carboranyl main chain polymer with aggregation-induced emission in the near-infrared. J. Am. Chem. Soc. 2024 , 146 , 13607−13616..

Zhao, Y.; He, M.; Xu, L.; Zhang, C.; Guo, L.; Feng, W.; Yan, H. Tuning the emission of a nonconventional aggregation-induced emission polymer via silicon-bridged twisted intramolecular charge transfer for targeted delivery and visualized drug release. Biomacromolecules 2023 , 24 , 1888−1900..

He, Y.; Cheng, Y.; Yang, C.; Guo, C. F. Creep-free polyelectrolyte elastomer for drift-free iontronic sensing. Nat. Mater. 2024 , 23 , 1107−1114..

Xiong, T.; Li, C.; He, X.; Xie, B.; Zong, J.; Jiang, Y.; Ma, W.; Wu, F.; Fei, J.; Yu, P. Neuromorphic functions with a polyelectrolyte-confined fluidic memristor. Science 2023 , 379 , 156−161..

Wang, H.; Sun, Y.; He, T.; Huang, Y.; Cheng, H.; Li, C.; Xie, D.; Yang, P.; Zhang, Y.; Qu, L. Bilayer of polyelectrolyte films for spontaneous power generation in air up to an integrated 1,000 V output. Nat. Nanotechnol. 2021 , 16 , 811−819..

Yuan, Y. m.; Liu, B.; Adibeig, M. R.; Xue, Q.; Qin, C.; Sun, Q. y.; Jin, Y.; Wang, M.; Yang, C. Microstructured polyelectrolyte elastomer-based ionotronic sensors with high sensitivities and excellent stability for artificial skins. Adv. Mater. 2024 , 36 , 2310429..

Liu, X.; Zhu, C.; Tang, B. Z. Bringing inherent charges into aggregation-induced emission research. Acc. Chem. Res. 2022 , 55 , 197−208..

Mei, L. J.; Li, C.; Zhao, P. J.; Chen, T.; Tian, R.; Guo, J.; Zhu, M. Q. Cationic conjugated polyelectrolytes with aggregation-induced ratiometric fluorescence. Macromol. Rapid Commun. 2022 , 43 , 2100899..

Yao, Y.; Ding, P.; Yan, C.; Tao, Y.; Peng, B.; Liu, W.; Wang, J.; Cohen Stuart, M. A.; Guo, Z. Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed. 2023 , 62 , e202218983..

Xie, H.; Hu, W.; Zhang, F.; Zhao, C.; Peng, T.; Zhu, C.; Xu, J. AIE-active polyelectrolyte based photosensitizers: the effects of structure on antibiotic-resistant bacterial sensing and killing and pollutant decomposition. J. Mater. Chem. B 2021 , 9 , 5309−5317..

Fan, D.; Wang, D.; Han, T.; Tang, B. Z. Fused heterocyclic polymers with aggregation-induced emission: synthesis and applications. ACS Appl. Polym. Mater. 2022 , 4 , 3120−3130..

Duan, Q.; Li, X.; Wu, Z.; Lin, S.; Zeng, R.; Xiao, T. Enhanced emission in polyelectrolyte assemblies for the development of artificial light-harvesting systems and color-tunable LED device. Macromol. Rapid Commun. 2025 , 46 , 2400752..

Huang, B.; Wang, K.; Zhang, J.; Yan, H.; Zhao, H.; Han, L.; Han, T.; Tang, B. Z. Targeted and long-term fluorescence imaging of plant cytomembranes using main-chain charged polyelectrolytes with aggregation-induced emission. ACS Appl. Mater. Interfaces 2024 , 16 , 20011−20022..

Hu, R.; Yang, X.; Qin, A.; Tang, B. Z. AIE polymers in sensing, imaging and theranostic applications. Mater. Chem. Front. 2021 , 5 , 4073−4088..

Zhou, T.; Hu, R.; Wang, L.; Qiu, Y.; Zhang, G.; Deng, Q.; Zhang, H.; Yin, P.; Situ, B.; Zhan, C. An AIE-active conjugated polymer with high ROS-generation ability and biocompatibility for efficient photodynamic therapy of bacterial infections. Angew. Chem. Int. Ed. 2020 , 59 , 9952−9956..

Wang, K.; Liu, J.; Liu, P.; Wang, D.; Han, T.; Tang, B. Z. Multifunctional fluorescent main-chain charged polyelectrolytes synthesized by cascade C-H activation/annulation polymerizations. J. Am. Chem. Soc. 2023 , 145 , 4208−4220..

Fan, D.; Wang, D.; Zhang, J.; Fu, X.; Yan, X.; Wang, D.; Qin, A.; Han, T.; Tang, B. Z. Cobalt-catalyzed cascade C-H activation/annulation polymerizations toward diversified and multifunctional sulfur-containing fused heterocyclic polymers. J. Am. Chem. Soc. 2024 , 146 , 17270−17284..

Wang, K.; Yan, S.; Han, T.; Wu, Q.; Yan, N.; Kang, M.; Ge, J.; Wang, D.; Tang, B. Z. Cascade C-H-activated polyannulations toward ring-fused heteroaromatic polymers for intracellular pH mapping and cancer cell killing. J. Am. Chem. Soc. 2022 , 144 , 11788−11801..

Liao, J.; Fan, D.; Yang, C.; Li, J.; Wang, D.; Han, T.; Tang, B. Z. Facile synthesis of diversified biisoquinoline-containing polymers by multicomponent C-H activation/annulation polymerizations. Angew. Chem. Int. Ed. 2025 , 64 , e202513695..

Song, B.; Hu, K.; Qin, A.; Tang, B. Z. Oxygen as a crucial comonomer in alkyne-based polymerization toward functional poly(tetrasubstituted furan)s. Macromolecules 2018 , 51 , 7013−7018..

Jayakumar, J.; Parthasarathy, K.; Cheng, C. H. One-pot synthesis of isoquinolinium salts by rhodium-Catalyzed C-H bond activation: application to the total synthesis of oxychelerythrine. Angew. Chem. Int. Ed. 2012 , 51 , 197−200..

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