Water-soluble Polymer Ligand Mediated Synthesis of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Ping-Ting Gong; Jiao-Jiao Guo; Chang Gao; Wei-Tao Yang; Chun-Sheng Xiao; Yi Xu; Yue Yao; Irshad Hussain; Wen Fan; Wei Yan

doi:10.1007/s10118-025-3522-4

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Water-soluble Polymer Ligand Mediated Synthesis of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging

RESEARCH ARTICLE | Updated：2026-01-30

- Water-soluble Polymer Ligand Mediated Synthesis of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging
- Chinese Journal of Polymer Science Vol. 44, Issue 2, Pages: 407-415(2026)
- Affiliations：
  
  a.Key Laboratory of Green Preparation and Application for Functional Materials of Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Material Science and Engineering, Hubei University, Wuhan 430062, China
  b.Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen 518038, China
  c.Manchester Metropolitan Joint Institute, Hubei University, Wuhan 430062, China
  d.Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai 200065, China
  e.State Key Laboratory of Polymer Science and Technology, Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  f.Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China
  g.Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS). DHA, Lahore 54792, Pakistan
- Author bio：
  
  weitaoyang@tongji.edu.cn (W.T.Y.)
  xiaocs@ciac.ac.cn (C.S.X.)
  willieyan2003@hubu.edu.cn (W.Y.)
- Funds：
- DOI：10.1007/s10118-025-3522-4
  CLC：
- Received：25 October 2025，
  
  Accepted：30 November 2025，
  
  Published Online：23 January 2026，
  
  Published：05 February 2026
- Accepted：
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Gong, P. T.; Guo, J. J.; Gao, C.; Yang, W. T.; Xiao, C. S.; Xu, Y.; Yao, Y.; Hussain, I.; Fan, W.; Yan, W. Water-soluble polymer ligand mediated synthesis of superparamagnetic iron oxide nanoparticles for magnetic resonance imaging. Chinese J. Polym. Sci. 2026, 44, 407–415

Ping-Ting Gong, Jiao-Jiao Guo, Chang Gao, et al. Water-soluble Polymer Ligand Mediated Synthesis of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging[J]. Chinese Journal of Polymer Science, 2026, 44(2): 407-415.
Gong, P. T.; Guo, J. J.; Gao, C.; Yang, W. T.; Xiao, C. S.; Xu, Y.; Yao, Y.; Hussain, I.; Fan, W.; Yan, W. Water-soluble polymer ligand mediated synthesis of superparamagnetic iron oxide nanoparticles for magnetic resonance imaging. Chinese J. Polym. Sci. 2026, 44, 407–415 DOI： 10.1007/s10118-025-3522-4.

Ping-Ting Gong, Jiao-Jiao Guo, Chang Gao, et al. Water-soluble Polymer Ligand Mediated Synthesis of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging[J]. Chinese Journal of Polymer Science, 2026, 44(2): 407-415. DOI： 10.1007/s10118-025-3522-4.

摘要

Using high-temperature co-precipitation method

super paramagnetic iron oxide nanoparticles (MIONs) were synthesized in the presenc

e of polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(

-vinyl-2-pyrrolidone) (PTMP-PVP). These nanoparticles were demonstrated by

in vivo

magnetic resonance imaging (MRI) studies to be promising

-weighted contrast agent.

Abstract

Magnetic resonance imaging (MRI) is one of the most widely used diagnostic techniques. Iron oxide nanoparticles

as a promising kind of contrast agents

have attracted intense research interest due to their low toxicity and superparamagnetism. However

it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity

excellent water solubility and biocompatibility. In this paper

a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(

-vinyl-2-pyrrolidone) (PTMP-PVP) was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100 °C. The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution

and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.

In vivo

MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective

-weighted MRI contrast agent.

关键词

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references

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