Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin

Hong-Xiang Yin; Yue-Yuan Xiao; Yu-Cheng Cai; Shuai-Lin He; Yang Wang; Gang-Shen Zhang; Cheng Zhang; Bi-En Tan; Irshad Hussain; Wei Yan

doi:10.1007/s10118-025-3484-6

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Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin

RESEARCH ARTICLE | Updated：2026-01-13

- Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin
  Enhanced Publication
- Chinese Journal of Polymer Science Vol. 44, Issue 1, Pages: 154-161(2026)
- Affiliations：
  
  a.Key Laboratory of Green Preparation and Application for Functional Materials of Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Material Science and Engineering, Hubei University, Wuhan 430062, China
  b.Shenzhen Huazhong University of Science and Technology Research institute, Shenzhen 518038, China
  c.School of Life Science, Hubei University, Wuhan 430062, China
  d.School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
  e.Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS), DHA, Lahore 54792, Pakistan
- Author bio：
  
  20041222@hubu.edu.cn (G.S.Z.)
  ihussain@lums.edu.pk (I.H.)
  willieyan2003@hubu.edu.cn (W.Y.)
- Funds：
- DOI：10.1007/s10118-025-3484-6
  CLC：
- Received：30 September 2025，
  
  Accepted：27 October 2025，
  
  Published Online：25 December 2025，
  
  Published：15 January 2026
- Accepted：
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Yin, H. X.; Xiao, Y. Y.; Cai, Y. C.; He, S. L.; Wang, Y.; Zhang, G. S.; Zhang, C.; Tan, B. E.; Hussain, I.; Yan, W. Ionic hyper crosslinked polymers as high performance hemoperfusion adsorbent for efficient removal of excessive bilirubin. Chinese J. Polym. Sci. 2026, 44, 154–161

Hong-Xiang Yin, Yue-Yuan Xiao, Yu-Cheng Cai, et al. Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin[J]. Chinese Journal of Polymer Science, 2026, 44(1): 154-161.
Yin, H. X.; Xiao, Y. Y.; Cai, Y. C.; He, S. L.; Wang, Y.; Zhang, G. S.; Zhang, C.; Tan, B. E.; Hussain, I.; Yan, W. Ionic hyper crosslinked polymers as high performance hemoperfusion adsorbent for efficient removal of excessive bilirubin. Chinese J. Polym. Sci. 2026, 44, 154–161 DOI： 10.1007/s10118-025-3484-6.

Hong-Xiang Yin, Yue-Yuan Xiao, Yu-Cheng Cai, et al. Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin[J]. Chinese Journal of Polymer Science, 2026, 44(1): 154-161. DOI： 10.1007/s10118-025-3484-6.

摘要

By incorporating a cationic monomer into the cross-linked polymer framework

we introduced electrostatic interactions that enhance the polymer’s affinity for bilirubin

resulting in outstanding adsorption performance and demonstrating its potential as an effective hemoperfusion adsorbent.

Abstract

Liver is a vital organ in the human body and plays a central role in the metabolism and detoxification of endotoxins and exotoxins. Bilirubin is an endotoxin derived from hemoglobin (Hb). Removing excess bilirubin in the blood is crucial for the treatment of liver diseases. Hemoperfusion

which relies on adsorbents to efficiently adsorb toxins

is a widely applied procedure for the removal of blood toxins. To broaden and improve the range and performance of hemoperfusion adsorbents

we synthesized cationic hyper crosslinked polymers (HCPs) with strong affinity for bilirubin. This material exhibited outstanding adsorption performance

with a maximum adsorption capacity of 934 mg/g and a removal efficiency of 96%. Further investigation confirmed their excellent selectivity

reusability

and biocompatibility. These findings expand the potential applications of HCPs and provide insight into strategies for constructing promising hemoperfusion adsorbent materials.

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references

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