pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

Jing-Yuan Xiang; Wen-Long Zhang; He-Ting Li; Ya-Ning He

doi:10.1007/s10118-023-3000-9

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pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

RESEARCH ARTICLE | Updated：2023-12-26

- pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging
- Chinese Journal of Polymer Science Vol. 42, Issue 1, Pages: 7-13(2024)
- Affiliations：
  
  Department of Chemical Engineering, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing 100084, China
- Author bio：
  
  heyaning@mail.tsinghua.edu.cn
- Funds：
- DOI：10.1007/s10118-023-3000-9
  CLC：
- Received：07 April 2023，
  
  Revised：2023-5-5，
  
  Accepted：08 May 2023，
  
  Online First：15 June 2023，
  
  Published：01 January 2024
- Accepted：
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Xiang, J. Y.; Zhang, W. L.; Li, H. T.; He, Y. N. pH induced self-assembly of AIE fluorescent probe for tumor imaging. Chinese J. Polym. Sci. 2024, 42, 7–13

Jing-Yuan Xiang, Wen-Long Zhang, He-Ting Li, et al. pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging[J]. Chinese Journal of Polymer Science, 2024, 42(1): 7-13.
Xiang, J. Y.; Zhang, W. L.; Li, H. T.; He, Y. N. pH induced self-assembly of AIE fluorescent probe for tumor imaging. Chinese J. Polym. Sci. 2024, 42, 7–13 DOI： 10.1007/s10118-023-3000-9.

Jing-Yuan Xiang, Wen-Long Zhang, He-Ting Li, et al. pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging[J]. Chinese Journal of Polymer Science, 2024, 42(1): 7-13. DOI： 10.1007/s10118-023-3000-9.

摘要

This work reported an AIE fluorescent probe for tumor imaging based on the pH induced self-assembly strategy. Under acidic tumor microenvironment

the transition of AIE molecules from dispersed state to aggregated state will lead to an obvious increase in fluorescence intensity.

Abstract

This work reported an AIE fluorescent probe for tumor imaging based on the pH induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-

-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen (AIEgen) TPE-2SO

−

. The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment

which would be further self-assembled with TPE-2SO

−

to form aggregated nanoparticles. The transition of TPE-2SO

−

from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

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references

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