Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media

Qiang-Qiang Shi; Xin Zhou; Jie Xu; Ning Wang; Jia-Lin Zhang; Xiang-Long Hu; Shi-Yong Liu

doi:10.1007/s10118-023-2946-y

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Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media

RESEARCH ARTICLE | Updated：2023-04-21

- Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media
- Chinese Journal of Polymer Science Vol. 41, Issue 5, Pages: 768-777(2023)
- Affiliations：
  
  a.CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China
  b.School of Biomedical Engineering and Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou 215123, China
- Author bio：
  
  huxlong@ustc.edu.cn(X.L.H.)
  sliu@ustc.edu.cn(S.Y.L.)
- Funds：
- DOI：10.1007/s10118-023-2946-y
  CLC：
- Received：11 December 2022，
  
  Revised：2022-12-29，
  
  Accepted：04 January 2023，
  
  Online First：03 March 2023，
  
  Published：01 May 2023
- Accepted：
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Shi, Q. Q.; Zhou, X.; Xu, J.; Wang, N.; Zhang, J. L.; Hu, X. L.; Liu, S. Y. Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media.Chinese J. Polym. Sci.2023,41, 768–777

Qiang-Qiang Shi, Xin Zhou, Jie Xu, et al. Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media[J]. Chinese Journal of Polymer Science, 2023, 41(5): 768-777.
Shi, Q. Q.; Zhou, X.; Xu, J.; Wang, N.; Zhang, J. L.; Hu, X. L.; Liu, S. Y. Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media.Chinese J. Polym. Sci.2023,41, 768–777 DOI： 10.1007/s10118-023-2946-y.

Qiang-Qiang Shi, Xin Zhou, Jie Xu, et al. Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media[J]. Chinese Journal of Polymer Science, 2023, 41(5): 768-777. DOI： 10.1007/s10118-023-2946-y.

摘要

Controlled fabrication of uniform nanorods have remained a considerable challenge. We report the formation of helical nanorods with controlled handedness and uniform lengths in aqueous media

via

self-assembly of digital amphiphiles and subsequent thermal annealing. We also explored the precise synthesis and controlled self-assembly of digital dendrimers with discrete molecular weights.

Abstract

Compared with spherical micelles

rod/worm-like micelles not only have extended blood circulation duration

but also exhibit favorable cellular uptake behavior

which is promising for next-generation nanomedicine and biomaterials. However

the controllable fabrication of narrowly dispersed nanorods in aqueous media is still challenging. Herein

the methodology of thermal annealing was developed for the fabrication of helical nanorods as well as a series of nanorods with different lengths. The thermal annealing process generally consisted of adding a percentage of organic solvent (10%(

) or 20%(

)) to the digital micellar aqueous dispersion

followed by heating at 90 °C for 1 h

then cooling naturally to room temperature

and dialyzing against water to remove the organic solvent. Right-handed helical nanorods were afforded by the treatment of 45 nm digital micelles in the presence of 10%(

) dioxane

while left-handed helical nanorods were obtained in the presence of 20%(

) dioxane. Meanwhile

the controlled growth of rod-like digital micelles was achieved after thermal annealing in the presence of different types of organic solvents

and the length of the annealed nanorods was correlated with the types of organic solvent. Furthermore

no matter the size of initial digital micelles

they all exhibited similar trend of rod growth in the presence of a certain amount of organic solvent

allowing for controllable formulation of narrowly dispersed nanorods. In addition

supramolecular self-assembly by amphiphilic dendritic oligourethane readily fabricated diverse uniform nanorods in aqueous media. Overall

this work provided an attractive methodology to fabricate uniform digital nanorods.

关键词

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references

Lehn, J. M . Perspectives in supramolecular chemistry—from molecular recognition towards molecular information processing and self-organization . Angew. Chem. Int. Ed. , 1990 , 29 1304 - 1319 . DOI: 10.1002/anie.199013041 http://doi.org/10.1002/anie.199013041 .

Mai, Y.; Eisenberg, A . Self-assembly of block copolymers . Chem. Soc. Rev. , 2012 , 41 5969 - 5985 . DOI: 10.1039/c2cs35115c http://doi.org/10.1039/c2cs35115c .

Yang, G.; Ding, H. M.; Kochovski, Z.; Hu, R.; Lu, Y.; Ma, Y. Q.; Chen, G.; Jiang, M . Highly ordered self-assembly of native proteins into 1D, 2D, and 3D structures modulated by the tether length of assembly-inducing ligands . Angew. Chem. Int. Ed. , 2017 , 56 10691 - 10695 . DOI: 10.1002/anie.201703052 http://doi.org/10.1002/anie.201703052 .

Zhang, L.; Qin, L.; Wang, X.; Cao, H.; Liu, M . Supramolecular chirality in self-assembled soft materials: regulation of chiral nanostructures and chiral functions . Adv. Mater. , 2014 , 26 6959 - 6964 . DOI: 10.1002/adma.201305422 http://doi.org/10.1002/adma.201305422 .

Zhang, X . Supramolecular polymer chemistry: past, present, and future . Chinese J. Polym. Sci. , 2022 , 40 541 - 542 . DOI: 10.1007/s10118-022-2748-7 http://doi.org/10.1007/s10118-022-2748-7 .

Ye, J.; Cao, Y.; Lu, X.; Wu, F.; Liu, N.; Dong, Y.; Shi, Q . Self-assembly of DNA-organic hybrid amphiphiles by frame-guided assembly strategies . Giant , 2022 , 11 100113 DOI: 10.1016/j.giant.2022.100113 http://doi.org/10.1016/j.giant.2022.100113 .

Luo, D.; Wu, L. X.; Zhang, Y.; Huang, Y. L.; Chen, X. L.; Zhou, X. P.; Li, D . Self-assembly of a photoluminescent metal-organic cage and its spontaneous aggregation in dilute solutions enabling time-dependent emission enhancement . Sci. China Chem. , 2022 , 65 1105 - 1111 . DOI: 10.1007/s11426-022-1245-1 http://doi.org/10.1007/s11426-022-1245-1 .

Wang, H.; Li, A.; Yang, M.; Zhao, Y.; Shi, L.; Ma, R . Self-assembled nanochaperones enable the disaggregation of amyloid insulin fibrils . Sci. China Chem. , 2022 , 65 353 - 362 . DOI: 10.1007/s11426-021-1155-9 http://doi.org/10.1007/s11426-021-1155-9 .

Geng, Z.; Wang, H.; Jin, S.-M.; Yan, X.; Ren, M.; Xiong, B.; Wang, K.; Deng, R.; Chen, S.; Lee, E.; Zhang, L.; Zhu, J.; Yang, Z . Hierarchical microphase behaviors of chiral block copolymers under kinetic and thermodynamic control . CCS Chem. , 2022 , 4 2460 - 2468 . DOI: 10.31635/ccschem.021.202101067 http://doi.org/10.31635/ccschem.021.202101067 .

Zhu, Y.; Lu, Z . Dynamics simulations of supramolecular and polymeric self-assemblies . Acta Polymerica Sinica (in Chinese) , 2021 , 52 884 - 897 . DOI: 10.11777/j.issn1000-3304.2021.21090 http://doi.org/10.11777/j.issn1000-3304.2021.21090 .

Wang, X.; Gao, P.; Wang, J.; Yang, Y.; You, Y.; Wu, D . A robust strategy for precise fabrication of rigid-flexible coupling dendrimers toward self-coordinated hierarchical assembly . CCS Chem. , 2021 , 3 1093 - 1104 . DOI: 10.31635/ccschem.020.202000238 http://doi.org/10.31635/ccschem.020.202000238 .

Zhao, L.; Li, S.; Liu, Y.; Xing, R.; Yan, X . Kinetically controlled self-assembly of phthalocyanine-peptide conjugate nanofibrils enabling superlarge redshifted absorption . CCS Chem. , 2019 , 1 173 - 180 . DOI: 10.31635/ccschem.019.20180017 http://doi.org/10.31635/ccschem.019.20180017 .

Zhang, L.; Eisenberg, A . Multiple morphologies of "crew-cut" aggregates of polystyrene- b -poly(acrylic acid) block copolymers . Science , 1995 , 268 1728 - 1731 . DOI: 10.1126/science.268.5218.1728 http://doi.org/10.1126/science.268.5218.1728 .

Schacher, F. H.; Rupar, P. A.; Manners, I . Functional block copolymers: nanostructured materials with emerging applications . Angew. Chem. Int. Ed. , 2012 , 51 7898 - 7921 . DOI: 10.1002/anie.201200310 http://doi.org/10.1002/anie.201200310 .

Groschel, A. H.; Walther, A.; Lobling, T. I.; Schacher, F. H.; Schmalz, H.; Muller, A. H . Guided hierarchical co-assembly of soft patchy nanoparticles . Nature , 2013 , 503 247 - 251 . DOI: 10.1038/nature12610 http://doi.org/10.1038/nature12610 .

Cornel, E. J.; Jiang, J.; Chen, S.; Du, J . Principles and characteristics of polymerization-induced self-assembly with various polymerization techniques . CCS Chem. , 2021 , 3 2104 - 2125 . DOI: 10.31635/ccschem.020.202000470 http://doi.org/10.31635/ccschem.020.202000470 .

Cao, S.; Shao, J.; Abdelmohsen, L. K. E. A.; Hest, J. C. M . Amphiphilic AIEgen-polymer aggregates: design, self-assembly and biomedical applications . Aggregate , 2021 , 3 e128 DOI: 10.1002/agt2.128 http://doi.org/10.1002/agt2.128 .

Cheng, X.; Miao, T.; Yin, L.; Zhang, W.; Zhu, X . Construction of supramolecular chirality in polymer systems: chiral induction, transfer and application . Chinese J. Polym. Sci. , 2021 , 39 1357 - 1375 . DOI: 10.1007/s10118-021-2561-8 http://doi.org/10.1007/s10118-021-2561-8 .

Liu, Z.; Yao, Y.; Tao, X.; Wei, J.; Lin, S . Helical supramolecular nanorods via sequential meticulous tailoring of noncovalent interaction and light irradiation . Sci. China Chem. , 2022 , 65 1749 - 1757 . DOI: 10.1007/s11426-022-1286-7 http://doi.org/10.1007/s11426-022-1286-7 .

Li, H.; Xiong, B.; Xu, J.; Zhu, J . Chiral transfer-dictated self-assembly of chiral block copolymers . Aggregate , 2021 , 2 e122 DOI: 10.1002/agt2.122 http://doi.org/10.1002/agt2.122 .

Fang, B.; Walther, A.; Wolf, A.; Xu, Y.; Yuan, J.; Muller, A. H . Undulated multicompartment cylinders by the controlled and directed stacking of polymer micelles with a compartmentalized corona . Angew. Chem. Int. Ed. , 2009 , 48 2877 - 2880 . DOI: 10.1002/anie.200806051 http://doi.org/10.1002/anie.200806051 .

Ge, Z.; Liu, S . Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance . Chem. Soc. Rev. , 2013 , 42 7289 - 7325 . DOI: 10.1039/c3cs60048c http://doi.org/10.1039/c3cs60048c .

Ladmiral, V.; Semsarilar, M.; Canton, I.; Armes, S. P . Polymerization-induced self-assembly of galactose-functionalized biocompatible diblock copolymers for intracellular delivery . J. Am. Chem. Soc. , 2013 , 135 13574 - 13581 . DOI: 10.1021/ja407033x http://doi.org/10.1021/ja407033x .

Tan, J.; Deng, Z.; Song, C.; Xu, J.; Zhang, Y.; Yu, Y.; Hu, J.; Liu, S . Coordinating external and built-in triggers for tunable degradation of polymeric nanoparticles via cycle amplification . J. Am. Chem. Soc. , 2021 , 143 13738 - 13748 . DOI: 10.1021/jacs.1c05617 http://doi.org/10.1021/jacs.1c05617 .

Liu, G.; Tan, J.; Cen, J.; Zhang, G.; Hu, J.; Liu, S . Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning . Nat. Commun. , 2022 , 13 585 DOI: 10.1038/s41467-022-28227-6 http://doi.org/10.1038/s41467-022-28227-6 .

Zheng, C.; Zhao, Y.; Liu, Y . Recent advances in self-assembled nano-therapeutics . Chinese J. Polym. Sci. , 2018 , 36 322 - 346 . DOI: 10.1007/s10118-018-2078-y http://doi.org/10.1007/s10118-018-2078-y .

Yang, Y. H.; Qin, Y.; Zhang, Y.; Zhang, L . Rotor orientation direction controls geometric curvature and chirality for assemblies of motor amphiphiles in water . Aggregate , 2022 : e268 DOI: 10.1002/agt2.268 http://doi.org/10.1002/agt2.268 .

Zhao, Z.; Dong, Y.; Duan, Z.; Jin, D.; Yuan, W.; Liu, D . DNA-organic molecular amphiphiles: Synthesis, self-assembly, and hierarchical aggregates . Aggregate , 2021 , 2 e95 DOI: 10.1002/agt2.95 http://doi.org/10.1002/agt2.95 .

Ding, Z.; Cen, J.; Wu, Y.; Zhong, K.; Liu, G.; Hu, J.; Liu, S . Self-Immolative nanoparticles for stimuli-triggered activation, covalent trapping and accumulation of in situ generated small molecule theranostic fragments . Giant , 2020 , 1 100012 DOI: 10.1016/j.giant.2020.100012 http://doi.org/10.1016/j.giant.2020.100012 .

Zhou, J.; Zhang, Y.; Wang, R . Controllable loading and release of nanodrugs in polymeric vesicles . Giant , 2022 , 12 100126 DOI: 10.1016/j.giant.2022.100126 http://doi.org/10.1016/j.giant.2022.100126 .

Geng, Y.; Dalhaimer, P.; Cai, S.; Tsai, R.; Tewari, M.; Minko, T.; Discher, D. E . Shape effects of filaments versus spherical particles in flow and drug delivery . Nat. Nanotechnol. , 2007 , 2 249 - 255 . DOI: 10.1038/nnano.2007.70 http://doi.org/10.1038/nnano.2007.70 .

Gratton, S. E.; Ropp, P. A.; Pohlhaus, P. D.; Luft, J. C.; Madden, V. J.; Napier, M. E.; DeSimone, J. M . The effect of particle design on cellular internalization pathways . Proc. Natl. Acad. Sci. U.S.A. , 2008 , 105 11613 - 11618 . DOI: 10.1073/pnas.0801763105 http://doi.org/10.1073/pnas.0801763105 .

Zhang, K.; Rossin, R.; Hagooly, A.; Chen, Z.; Welch, M. J.; Wooley, K. L . Folate-mediated cell uptake of shell-crosslinked spheres and cylinders . J. Polym. Sci., Part A: Polym. Chem. , 2008 , 46 7578 - 7583 . DOI: 10.1002/pola.23020 http://doi.org/10.1002/pola.23020 .

Albanese, A.; Tang, P. S.; Chan, W. C . The effect of nanoparticle size, shape, and surface chemistry on biological systems . Annu. Rev. Biomed. Eng. , 2012 , 14 1 - 16 . DOI: 10.1146/annurev-bioeng-071811-150124 http://doi.org/10.1146/annurev-bioeng-071811-150124 .

Won, Y. Y.; Davis, H. T.; Bates, F. S . Giant wormlike rubber micelles . Science , 1999 , 283 960 - 963 . DOI: 10.1126/science.283.5404.960 http://doi.org/10.1126/science.283.5404.960 .

Dreiss, C. C. A . Wormlike micelles: where do we stand? Recent developments, linear rheology and scattering techniques. . Soft Matter , 2007 , 3 956 - 970 . DOI: 10.1039/b705775j http://doi.org/10.1039/b705775j .

Tritschler, U.; Pearce, S.; Gwyther, J.; Whittell, G. R.; Manners, I. . 50 th Anniversary perspective: functional nanoparticles from the solution self-assembly of block copolymers . Macromolecules , 2017 , 50 3439 - 3463 . DOI: 10.1021/acs.macromol.6b02767 http://doi.org/10.1021/acs.macromol.6b02767 .

Foster, J. C.; Varlas, S.; Couturaud, B.; Coe, Z.; O'Reilly, R. K . Getting into shape: reflections on a new generation of cylindrical nanostructures' self-assembly using polymer building blocks . J. Am. Chem. Soc. , 2019 , 141 2742 - 2753 . DOI: 10.1021/jacs.8b08648 http://doi.org/10.1021/jacs.8b08648 .

Chen, Y.; Jin, B.; Li, Q.; Luo, Y.; Chi, S.; Li, X . Precise supramolecular polymerization of liquid crystalline block copolymer initiated by heavy metallic salts . Chinese J. Polym. Sci. , 2022 , 40 624 - 630 . DOI: 10.1007/s10118-022-2715-3 http://doi.org/10.1007/s10118-022-2715-3 .

Liu, X.; Gao, L.; Wang, L.; Zhang, C.; Lin, J . Polymerization-like assembly behavior of the nanorods . Acta Polymerica Sinica (in Chinese) , 2018 : 1279 - 1286 . DOI: 10.11777/j.issn1000-3304.2018.18082 http://doi.org/10.11777/j.issn1000-3304.2018.18082 .

Shi, B.; Wang, G . Application of polymerization-induced self-assembly (PISA) technology . Acta Polymerica Sinica (in Chinese) , 2022 , 53 15 - 29 . DOI: 10.11777/j.issn1000-3304.2021.21156 http://doi.org/10.11777/j.issn1000-3304.2021.21156 .

Ou, H.; Zhang, B.; Liu, C. . Bimodal polymer-grafted nanoparticles with precisely controlled structures . Acta Polymerica Sinica (in Chinese) , 2022 , 53 1388 - 1398 . DOI: 10.11777/j.issn1000-3304.2022.22110 http://doi.org/10.11777/j.issn1000-3304.2022.22110 .

Gadt, T.; Ieong, N. S.; Cambridge, G.; Winnik, M. A.; Manners, I . Complex and hierarchical micelle architectures from diblock copolymers using living, crystallization-driven polymerizations . Nat. Mater. , 2009 , 8 144 - 150 . DOI: 10.1038/nmat2356 http://doi.org/10.1038/nmat2356 .

Gilroy, J. B.; Gadt, T.; Whittell, G. R.; Chabanne, L.; Mitchels, J. M.; Richardson, R. M.; Winnik, M. A.; Manners, I . Monodisperse cylindrical micelles by crystallization-driven living self-assembly . Nat. Chem. , 2010 , 2 566 - 570 . DOI: 10.1038/nchem.664 http://doi.org/10.1038/nchem.664 .

Hudson, Z. M.; Boott, C. E.; Robinson, M. E.; Rupar, P. A.; Winnik, M. A.; Manners, I . Tailored hierarchical micelle architectures using living crystallization-driven self-assembly in two dimensions . Nat. Chem. , 2014 , 6 893 - 898 . DOI: 10.1038/nchem.2038 http://doi.org/10.1038/nchem.2038 .

Boott, C. E.; Gwyther, J.; Harniman, R. L.; Hayward, D. W.; Manners, I . Scalable and uniform 1D nanoparticles by synchronous polymerization, crystallization and self-assembly . Nat. Chem. , 2017 , 9 785 - 792 . DOI: 10.1038/nchem.2721 http://doi.org/10.1038/nchem.2721 .

Dankers, P. Y.; Hermans, T. M.; Baughman, T. W.; Kamikawa, Y.; Kieltyka, R. E.; Bastings, M. M.; Janssen, H. M.; Sommerdijk, N. A.; Larsen, A.; van Luyn, M. J.; Bosman, A. W.; Popa, E. R.; Fytas, G.; Meijer, E. W . Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system . Adv. Mater. , 2012 , 24 2703 - 2709 . DOI: 10.1002/adma.201104072 http://doi.org/10.1002/adma.201104072 .

Krieg, E.; Bastings, M. M.; Besenius, P.; Rybtchinski, B . Supramolecular polymers in aqueous media . Chem. Rev. , 2016 , 116 2414 - 2477 . DOI: 10.1021/acs.chemrev.5b00369 http://doi.org/10.1021/acs.chemrev.5b00369 .

Nazemi, A.; Boott, C. E.; Lunn, D. J.; Gwyther, J.; Hayward, D. W.; Richardson, R. M.; Winnik, M. A.; Manners, I . Monodisperse cylindrical micelles and block comicelles of controlled length in aqueous media . J. Am. Chem. Soc. , 2016 , 138 4484 - 4493 . DOI: 10.1021/jacs.5b13416 http://doi.org/10.1021/jacs.5b13416 .

Arno, M. C.; Inam, M.; Coe, Z.; Cambridge, G.; Macdougall, L. J.; Keogh, R.; Dove, A. P.; O'Reilly, R. K . Precision epitaxy for aqueous 1D and 2D poly( ε -caprolactone) assemblies . J. Am. Chem. Soc. , 2017 , 139 16980 - 16985 . DOI: 10.1021/jacs.7b10199 http://doi.org/10.1021/jacs.7b10199 .

Alvarez, Z.; Kolberg-Edelbrock, A. N.; Sasselli, I. R.; Ortega, J. A.; Qiu, R.; Syrgiannis, Z.; Mirau, P. A.; Chen, F.; Chin, S. M.; Weigand, S.; Kiskinis, E.; Stupp, S. I . Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury . Science , 2021 , 374 848 - 856 . DOI: 10.1126/science.abh3602 http://doi.org/10.1126/science.abh3602 .

Shi, Q.; Yin, H.; Song, R.; Xu, J.; Tan, J.; Zhou, X.; Cen, J.; Deng, Z.; Tong, H.; Cui, C.; Zhang, Y.; Li, X.; Zhang, Z.; Liu, S . Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification . Nat. Chem. , 2023 , 15 257 - 270 . DOI: 10.1038/s41557-022-01076-y http://doi.org/10.1038/s41557-022-01076-y .

Chen, W. H.; Chen, Q. W.; Chen, Q.; Cui, C.; Duan, S.; Kang, Y.; Liu, Y.; Liu, Y.; Muhammad, W.; Shao, S.; Tang, C.; Wang, J.; Wang, L.; Xiong, M. H.; Yin, L.; Zhang, K.; Zhang, Z.; Zhen, X.; Feng, J.; Gao, C.; Gu, Z.; He, C.; Ji, J.; Jiang, X.; Liu, W.; Liu, Z.; Peng, H.; Shen, Y.; Shi, L.; Sun, X.; Wang, H.; Wang, J.; Xiao, H.; Xu, F. J.; Zhong, Z.; Zhang, X. Z.; Chen, X . Biomedical polymers: synthesis, properties, and applications . Sci. China Chem. , 2022 , 65 1010 - 1075 . DOI: 10.1007/s11426-022-1243-5 http://doi.org/10.1007/s11426-022-1243-5 .

Aksakal, R.; Mertens, C.; Soete, M.; Badi, N.; Du Prez, F . Applications of discrete synthetic macromolecules in life and materials science: recent and future trends . Adv. Sci. , 2021 , 8 2004038 DOI: 10.1002/advs.202004038 http://doi.org/10.1002/advs.202004038 .

Genabeek, B.; Lamers, B. A. G.; Hawker, C. J.; Meijer, E. W.; Gutekunst, W. R.; Schmidt, B. V. K. J . Properties and applications of precision oligomer materials; where organic and polymer chemistry join forces . J. Polym. Sci. , 2021 , 59 373 - 403 . DOI: 10.1002/pol.20200862 http://doi.org/10.1002/pol.20200862 .

Lutz, J. F.; Ouchi, M.; Liu, D. R.; Sawamoto, M . Sequence-controlled polymers . Science , 2013 , 341 1238149 DOI: 10.1126/science.1238149 http://doi.org/10.1126/science.1238149 .

Solleder, S. C.; Schneider, R. V.; Wetzel, K. S.; Boukis, A. C.; Meier, M. A. R . Recent progress in the design of monodisperse, sequence-defined macromolecules . Macromol. Rapid Commun. , 2017 , 38 1600711 DOI: 10.1002/marc.201600711 http://doi.org/10.1002/marc.201600711 .

Babi, J.; Zhu, L.; Lin, A.; Uva, A.; El-Haddad, H.; Peloewetse, A.; Tran, H . Self-assembled free-floating nanomaterials from sequence-defined polymers . J. Polym. Sci. , 2021 , 59 2378 - 2404 . DOI: 10.1002/pol.20210366 http://doi.org/10.1002/pol.20210366 .

Li, Z.; Cai, B.; Yang, W.; Chen, C. L . Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers . Chem. Rev. , 2021 , 121 14031 - 14087 . DOI: 10.1021/acs.chemrev.1c00024 http://doi.org/10.1021/acs.chemrev.1c00024 .

Huang, Z.; Zhao, J.; Wang, Z.; Meng, F.; Ding, K.; Pan, X.; Zhou, N.; Li, X.; Zhang, Z.; Zhu, X . Combining orthogonal chain-end deprotections and thiol-maleimide michael coupling: engineering discrete oligomers by an iterative growth strategy . Angew. Chem. Int. Ed. , 2017 , 56 13612 - 13617 . DOI: 10.1002/anie.201706522 http://doi.org/10.1002/anie.201706522 .

Huang, Z.; Shi, Q.; Guo, J.; Meng, F.; Zhang, Y.; Lu, Y.; Qian, Z.; Li, X.; Zhou, N.; Zhang, Z.; Zhu, X . Binary tree-inspired digital dendrimer . Nat. Commun. , 2019 , 10 1918 DOI: 10.1038/s41467-019-09957-6 http://doi.org/10.1038/s41467-019-09957-6 .

Bousmail, D.; Chidchob, P.; Sleiman, H. F . Cyanine-mediated DNA nanofiber growth with controlled dimensionality . J. Am. Chem. Soc. , 2018 , 140 9518 - 9530 . DOI: 10.1021/jacs.8b04157 http://doi.org/10.1021/jacs.8b04157 .

Sternhagen, G. L.; Gupta, S.; Zhang, Y.; John, V.; Schneider, G. J.; Zhang, D . Solution self-assemblies of sequence-defined ionic peptoid block copolymers . J. Am. Chem. Soc. , 2018 , 140 4100 - 4109 . DOI: 10.1021/jacs.8b00461 http://doi.org/10.1021/jacs.8b00461 .

Yan, X. Y.; Lin, Z.; Zhang, W.; Xu, H.; Guo, Q. Y.; Liu, Y.; Luo, J.; Liu, X. Y.; Zhang, R.; Huang, J.; Liu, T.; Su, Z.; Zhang, R.; Zhang, S.; Liu, T.; Cheng, S. Z. D . Magnifying the structural components of biomembranes: a prototype for the study of the self-assembly of giant lipids . Angew. Chem. Int. Ed. , 2020 , 59 5226 - 5234 . DOI: 10.1002/anie.201916149 http://doi.org/10.1002/anie.201916149 .

Rizzuto, F. J.; Dore, M. D.; Rafique, M. G.; Luo, X.; Sleiman, H. F . DNA sequence and length dictate the assembly of nucleic acid block copolymers . J. Am. Chem. Soc. , 2022 , 144 12272 - 12279 . DOI: 10.1021/jacs.2c03506 http://doi.org/10.1021/jacs.2c03506 .

Shi, Q.; Zhou, X.; Xu, J.; Zhang, J.; Wang, N.; Zhang, G.; Hu, J.; Liu, S . Dendritic quaternary-encoded oligourethanes for data encryption . Angew. Chem. Int. Ed. , 2023 , 62 e202214695 DOI: 10.1002/anie.202214695 http://doi.org/10.1002/anie.202214695 .

Su, H.; Zhang, W.; Wang, H.; Wang, F.; Cui, H . Paclitaxel-promoted supramolecular polymerization of peptide conjugates . J. Am. Chem. Soc. , 2019 , 141 11997 - 12004 . DOI: 10.1021/jacs.9b04730 http://doi.org/10.1021/jacs.9b04730 .

Usov, I.; Mezzenga, R . FiberApp: an open-source software for tracking and analyzing polymers, filaments, biomacromolecules, and fibrous objects . Macromolecules , 2015 , 48 1269 - 1280 . DOI: 10.1021/ma502264c http://doi.org/10.1021/ma502264c .

Yang, B. K. C.; Puneet, P.; Ho, R. M . Reaction: amplification of macromolecular helicity through self-assembly . Giant , 2020 , 2 100015 DOI: 10.1016/j.giant.2020.100015 http://doi.org/10.1016/j.giant.2020.100015 .

Cai, C.; Lin, J.; Zhu, X.; Gong, S.; Wang, X. S.; Wang, L . Superhelices with designed helical structures and temperature-stimulated chirality transitions . Macromolecules , 2016 , 49 15 - 22 . DOI: 10.1021/acs.macromol.5b02254 http://doi.org/10.1021/acs.macromol.5b02254 .

Hifsudheen, M.; Mishra, R. K.; Vedhanarayanan, B.; Praveen, V. K.; Ajayaghosh, A . The helix to super-helix transition in the self-assembly of π -systems: superseding of molecular chirality at hierarchical level . Angew. Chem. Int. Ed. , 2017 , 56 12634 - 12638 . DOI: 10.1002/anie.201707392 http://doi.org/10.1002/anie.201707392 .

Garcia, F.; Aparicio, F.; Marenchino, M.; Campos-Olivas, R.; Sanchez, L . Helical and flat structures from chiral dendronized rectangular oligo(phenylene ethynylene)s . Org. Lett. , 2010 , 12 4264 - 4267 . DOI: 10.1021/ol101673z http://doi.org/10.1021/ol101673z .

Ouyang, G.; Liu, M . Self-assembly of chiral supra-amphiphiles . Mat. Chem. Front. , 2020 , 4 155 - 167 . DOI: 10.1039/C9QM00571D http://doi.org/10.1039/C9QM00571D .

Petit, B. E.; Lotz, B.; Lutz, J. F . About the crystallization of abiotic coded matter . ACS Macro Lett. , 2019 , 8 779 - 782 . DOI: 10.1021/acsmacrolett.9b00307 http://doi.org/10.1021/acsmacrolett.9b00307 .

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