Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive Curcumin Release for Synergistic Antibacterial Activity

Xing Wang; Ya-Qiang Wang; De-Cheng Wu

doi:10.1007/s10118-022-2884-0

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Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive Curcumin Release for Synergistic Antibacterial Activity

RESEARCH ARTICLE | Updated：2023-03-07

- Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive Curcumin Release for Synergistic Antibacterial Activity
- Chinese Journal of Polymer Science Vol. 41, Issue 4, Pages: 564-573(2023)
- Affiliations：
  
  a.Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.University of Chinese Academy of Sciences, Beijing 100049, China
  c.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
- Author bio：
  
  wangxing@iccas.ac.cn (X.W.)
  wudc@sustech.edu.cn (D.C.W.)
- Funds：
- DOI：10.1007/s10118-022-2884-0
  CLC：
- Received：14 September 2022，
  
  Revised：2022-10-8，
  
  Accepted：10 October 2022，
  
  Online First：12 December 2022，
  
  Published：01 April 2023
- Accepted：
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Wang, X.; Wang, Y. Q.; Wu, D. C. Facile Fabrication of hyperbranched polyacetal quaternary ammonium with pH-responsive curcumin release for synergistic antibacterial activity. Chinese J. Polym. Sci. 2023, 41, 564–573

Xing Wang, Ya-Qiang Wang, De-Cheng Wu. Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive Curcumin Release for Synergistic Antibacterial Activity[J]. Chinese Journal of Polymer Science, 2023, 41(4): 564-573.
Wang, X.; Wang, Y. Q.; Wu, D. C. Facile Fabrication of hyperbranched polyacetal quaternary ammonium with pH-responsive curcumin release for synergistic antibacterial activity. Chinese J. Polym. Sci. 2023, 41, 564–573 DOI： 10.1007/s10118-022-2884-0.

Xing Wang, Ya-Qiang Wang, De-Cheng Wu. Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive Curcumin Release for Synergistic Antibacterial Activity[J]. Chinese Journal of Polymer Science, 2023, 41(4): 564-573. DOI： 10.1007/s10118-022-2884-0.

摘要

A type of hyperbranched polyacetal quaternary ammonium was fabricated by a succession of efficient click strategies

exhibiting inherent antibacterial speciality and bacterial-responsive curcumin release to facilitate the antibacterial activity.

Abstract

In the current global crisis of antibiotic resistance

persuit of an effective multi-pathway collaborative approach to enhance antibacterial activity is urgently needed. Here

a kind of hyperbranched polyacetal quaternary ammonium (Hyper-ace-QA) with efficiently antibacterial function were synthesized by a succession of efficient click strategies. The high molecular weights can be obtained just after UV irradiation for 3 h

and the grafting ratio can be easily adjusted through controlling solvent system

molar ratio

and temperature. Cytotoxicity studies indicated that Hyper-ace-QA had good biocompatibility and can be used as a potential antibacterial dressing. More importantly

after

in situ

encapsulation of bioactive curcumin drugs into the hyperbranched intramolecular cavities

the acid-liable acetal linkers within the hyperbranched backbone made the loading antibacterial drugs rapidly release with pH- or bacterial-responsive behaviors since many bacteria can produce acids at the infection site by the combined actions of immune response and bacterial metabolism. Therefore

the integration of quaternary ammonium characteristics and pH-triggered curcumin release could facilitate the antibacterial activity against gram-positive

Staphylococcus aureus

. This work represents a synergistic strategy on offering important guidance to rational design of multifunctional antimicrobial vehicles

which would be promising therapeutic alternatives for first aid treatment of wound infection in critical situations.

关键词

Keywords

references

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