A ROS-Sensitive Diselenide-Crosslinked Polymeric Nanogel for NIR Controlled Release

Ji-Chao Hu; Qi-Hua Zhang; Qiu-Qin Mu; Yi-Yuan Tang; Zhen Wu; Guo-Jie Wang

doi:10.1007/s10118-022-2867-1

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A ROS-Sensitive Diselenide-Crosslinked Polymeric Nanogel for NIR Controlled Release

RESEARCH ARTICLE | Updated：2023-01-18

- A ROS-Sensitive Diselenide-Crosslinked Polymeric Nanogel for NIR Controlled Release
- Chinese Journal of Polymer Science Vol. 41, Issue 3, Pages: 386-393(2023)
- Affiliations：
  
  a.School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China
  b.Keiraku Display Technology Co., LTD., Suzhou 215614, China
- Author bio：
  
  guojie.wang@mater.ustb.edu.cn
- Funds：
- DOI：10.1007/s10118-022-2867-1
  CLC：
- Received：14 June 2022，
  
  Revised：2022-7-15，
  
  Accepted：30 July 2022，
  
  Online First：10 October 2022，
  
  Published：01 March 2023
- Accepted：
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Hu, J. C.; Zhang, Q. H.; Mu, Q. Q.; Tang, Y. Y.; Wu, Z.; Wang, G. J. A ros-sensitive diselenide-crosslinked polymeric nanogel for NIR controlled release. Chinese J. Polym. Sci. 2023, 41, 386–393

Ji-Chao Hu, Qi-Hua Zhang, Qiu-Qin Mu, et al. A ROS-Sensitive Diselenide-Crosslinked Polymeric Nanogel for NIR Controlled Release[J]. Chinese Journal of Polymer Science, 2023, 41(3): 386-393.
Hu, J. C.; Zhang, Q. H.; Mu, Q. Q.; Tang, Y. Y.; Wu, Z.; Wang, G. J. A ros-sensitive diselenide-crosslinked polymeric nanogel for NIR controlled release. Chinese J. Polym. Sci. 2023, 41, 386–393 DOI： 10.1007/s10118-022-2867-1.

Ji-Chao Hu, Qi-Hua Zhang, Qiu-Qin Mu, et al. A ROS-Sensitive Diselenide-Crosslinked Polymeric Nanogel for NIR Controlled Release[J]. Chinese Journal of Polymer Science, 2023, 41(3): 386-393. DOI： 10.1007/s10118-022-2867-1.

摘要

In this work

a diselenium-bonded cross-linked polymeric nanogel with redox and NIR light responsiveness was designed and synthesized

which could release the loaded guest molecules under oxidative environment and NIR light stimulation. The polymeric nanogel has great potential applications in the field of controlled release.

Abstract

Here we report a novel polymeric nanogel with stable loading cargo and near-infrared (NIR) controlled release properties. The nanogels are crosslinked by quaternization reactions of biocompatible poly(

-amino esters) and diselenide-bonded crosslinker (DSeDCl) in microemulsions. The hydrophobic cavities of the nanogels have the property of stably encapsulating the hydrophobic guest molecules

resulted from the crosslinked network structure. Due to the redox responsiveness of the diselenide bonds on the DSeDCl crosslinker

the nanogels can respond to oxidant H

causing the disintegration of the crosslinked network structure

thus the encapsulated guest cargo molecules will be released. It is noted that

upon loading the photosensitizer IR780

the nanogels can generate reactive oxygen species (ROS) under NIR irradiation to release the cargo. The advantages of encapsulated cargo stability enhanced by chemical cross-linking and remote stimulation response performance

via

NIR offer great potential of nanogels for applications of cargo controlled release.

关键词

Keywords

references

Mao, J.; Li, Y.; Wu, T.; Yuan, C.; Zeng, B.; Xu, Y.; Dai, L . A simple dual-pH responsive prodrug-based polymeric micelles for drug delivery . ACS Appl. Mater. Interfaces , 2016 . 8 17109 - 17117 . DOI: 10.1021/acsami.6b04247 http://doi.org/10.1021/acsami.6b04247 .

Chen, S.; Gao, Y.; Cao, Z.; Wu, B.; Wang, L.; Wang, H.; Dang, Z.; Wang, G . Nanocomposites of spiropyran-functionalized polymers and upconversion nanoparticles for controlled release stimulated by near-infrared light and pH . Macromolecules , 2016 . 49 7490 - 7496 . DOI: 10.1021/acs.macromol.6b01760 http://doi.org/10.1021/acs.macromol.6b01760 .

Pan, G. Y.; Jia, H. R.; Zhu, Y. X.; Wu, F. G . Turning double hydrophilic into amphiphilic: IR825-conjugated polymeric nanomicelles for near-infrared fluorescence imaging-guided photothermal cancer therapy . Nanoscale , 2018 . 10 2115 - 2127 . DOI: 10.1039/C7NR07495F http://doi.org/10.1039/C7NR07495F .

Sun, F.; Zhang, P.; Liu, Y.; Lu, C.; Qiu, Y.; Mu, H . A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy . Carbohydr. Polym. , 2019 . 206 309 - 318 . DOI: 10.1016/j.carbpol.2018.11.005 http://doi.org/10.1016/j.carbpol.2018.11.005 .

Peng, C. L.; Chen, Y. I.; Liu, H. J.; Lee, P. C.; Luo, T. Y.; Shieh, M. J . A novel temperature-responsive micelle for enhancing combination therapy . Int. J. Nanomedicine , 2016 . 11 3357 - 3369 . DOI: 10.2147/IJN.S100469 http://doi.org/10.2147/IJN.S100469 .

Wang, H.; Li, Y.; Zhang, M.; Wu, D.; Shen, Y.; Tang, G.; Ping, Y . Redox-activatable ATP-depleting micelles with dual modulation characteristics for multidrug-resistant cancer therapy . Adv. Healthc. Mater. , 2017 . 6 1601293 DOI: 10.1002/adhm.201601293 http://doi.org/10.1002/adhm.201601293 .

Ren, H.; Wu, Y.; Ma, N.; Xu, H.; Zhang, X . Side-chain selenium-containing amphiphilic block copolymers: redox-controlled self-assembly and disassembly . Soft Matter , 2012 . 8 1460 - 1466 . DOI: 10.1039/C1SM06673K http://doi.org/10.1039/C1SM06673K .

Shi, L.; Jin, Y.; Du, W.; Lai, S.; Shen, Y.; Zhou, R . Diselenide-containing nonionic gemini polymeric micelles as a smart redox-responsive carrier for potential programmable drug release . Polymer , 2020 . 198 122551 DOI: 10.1016/j.polymer.2020.122551 http://doi.org/10.1016/j.polymer.2020.122551 .

Wang, Y.; Deng, Y.; Luo, H.; Zhu, A.; Ke, H.; Yang, H.; Chen, H . Light-responsive nanoparticles for highly efficient cytoplasmic delivery of anticancer agents . ACS Nano , 2017 . 11 12134 - 12144 . DOI: 10.1021/acsnano.7b05214 http://doi.org/10.1021/acsnano.7b05214 .

Cao, W.; Li, Y.; Yi, Y.; Ji, S.; Zeng, L.; Sun, Z.; Xu, H . Coordination-responsive selenium-containing polymer micelles for controlled drug release . Chem. Sci. , 2012 . 3 3403 - 3408 . DOI: 10.1039/c2sc21315j http://doi.org/10.1039/c2sc21315j .

Gao, S.; Li, T.; Guo, Y.; Sun, C.; Xianyu, B.; Xu, H . Selenium-containing nanoparticles combine the NK cells mediated immunotherapy with radiotherapy and chemotherapy . Adv. Mater. , 2020 . 32 1907568 DOI: 10.1002/adma.201907568 http://doi.org/10.1002/adma.201907568 .

Hailemeskel, B. Z.; Addisu, K. D.; Prasannan, A.; Mekuria, S. L.; Kao, C. Y.; Tsai, H. C . Synthesis and characterization of diselenide linked poly(ethylene glycol) nanogel as multi-responsive drug carrier . Appl. Surf. Sci. , 2018 . 449 15 - 22 . DOI: 10.1016/j.apsusc.2017.12.058 http://doi.org/10.1016/j.apsusc.2017.12.058 .

Li, T.; Xu, H . Selenium-containing nanomaterials for cancer treatment . Cell Rep. Phys. Sci. , 2020 . 1 100111 DOI: 10.1016/j.xcrp.2020.100111 http://doi.org/10.1016/j.xcrp.2020.100111 .

Ma, N.; Li, Y.; Xu, H.; Wang, Z.; Zhang, X . Dual redox responsive assemblies formed from diselenide block copolymers . J. Am. Chem. Soc. , 2010 . 132 442 - 443 . DOI: 10.1021/ja908124g http://doi.org/10.1021/ja908124g .

Ma, N.; Xu, H.; An, L.; Li, J.; Sun, Z.; Zhang, X . Radiation-sensitive diselenide block co-polymer micellar aggregates: toward the combination of radiotherapy and chemotherapy . Langmuir , 2011 . 27 5874 - 5878 . DOI: 10.1021/la2009682 http://doi.org/10.1021/la2009682 .

Li, T.; Pan, S.; Zhuang, H.; Gao, S.; Xu, H . Selenium-containing carrier-free assemblies with aggregation-induced emission property combine cancer radiotherapy with chemotherapy . ACS Appl. Bio Mater. , 2020 . 3 1283 - 1292 . DOI: 10.1021/acsabm.9b01172 http://doi.org/10.1021/acsabm.9b01172 .

Sun, C.; Ji, S.; Li, F.; Xu, H . Diselenide-containing hyperbranched polymer with light-induced cytotoxicity . ACS Appl. Mater. Interfaces , 2017 . 9 12924 - 12929 . DOI: 10.1021/acsami.7b02367 http://doi.org/10.1021/acsami.7b02367 .

Fu, C.; Wei, R.; Xu, P.; Luo, S.; Zhang, C.; Kankala, R . K.; Wang, S.; Jiang, X.; Wei, X.; Zhang, L.; Chen, A.; Yang, R. Supercritical fluid-assisted fabrication of diselenide-bridged polymeric composites for improved indocyanine green-guided photodynamic therapy . Chem. Eng. J. , 2021 . 407 127108 DOI: 10.1016/j.cej.2020.127108 http://doi.org/10.1016/j.cej.2020.127108 .

Du, W.; Jin, Y.; Lai, S.; Shi, L.; Fan, W.; Pan, J . Near-infrared light triggered shape memory and self-healable polyurethane/functionalized graphene oxide composites containing diselenide bonds . Polymer , 2018 . 158 120 - 129 . DOI: 10.1016/j.polymer.2018.10.059 http://doi.org/10.1016/j.polymer.2018.10.059 .

Tang Y, Wang G . NIR light-responsive nanocarriers for controlled release . J. Photochem. Photobiol. C , 2021 . 47 100420 DOI: 10.1016/j.jphotochemrev.2021.100420 http://doi.org/10.1016/j.jphotochemrev.2021.100420 .

Kaur, J.; Mishra, V.; Singh, S. K.; Gulati, M.; Kapoor, B.; Chellappan, D. K.; Gupta, G.; Dureja, H.; Anand, K.; Dua, K.; Khatik, G. L.; Gowthamarajan, K . Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: breakthroughs and bottlenecks . J. Control. Rel. , 2021 . 334 64 - 95 . DOI: 10.1016/j.jconrel.2021.04.014 http://doi.org/10.1016/j.jconrel.2021.04.014 .

Li, W.; Fan, X.; Lv, X.; Du, J.; Liu, Q.; Lin, J.; Hu, Z.; Li, Z . Reduction-responsive shell cross-linked micelles derived from amphiphilic triblock copolymer as anticancer drug delivery carrier . Mater. Sci. Eng., C , 2019 . 96 383 - 390 . DOI: 10.1016/j.msec.2018.11.015 http://doi.org/10.1016/j.msec.2018.11.015 .

Han, X.; Gong, F.; Sun, J.; Li, Y.; Liu, X.; Chen, D.; Liu, J.; Shen, Y . Glutathione-responsive core cross-linked micelles for controlled cabazitaxel delivery . J. Nanopart. Res. , 2018 . 20 1 - 15 . DOI: 10.1007/s11051-017-4105-2 http://doi.org/10.1007/s11051-017-4105-2 .

Li, X. M.; Wu, Z. Z.; Zhang, B.; Pan, Y.; Meng, R.; Chen, H. Q . Fabrication of chitosan hydrochloride and carboxymethyl starch complex nanogels as potential delivery vehicles for curcumin . Food Chem. , 2019 . 293 197 - 203 . DOI: 10.1016/j.foodchem.2019.04.096 http://doi.org/10.1016/j.foodchem.2019.04.096 .

Qu, Y.; Chu, B.; Wei, X.; Lei, M.; Hu, D.; Zha, R.; Zhong, L.; Wang, M.; Wang, F.; Qian, Z . Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for "on-demand" drug delivery . J. Control. Rel. , 2019 . 296 93 - 106 . DOI: 10.1016/j.jconrel.2019.01.016 http://doi.org/10.1016/j.jconrel.2019.01.016 .

Cao, Z.; Zhou, X.; Wang, G . Selective release of hydrophobic and hydrophilic cargos from multi-stimuli-responsive nanogels . ACS Appl. Mater. Interfaces , 2016 . 8 28888 - 28896 . DOI: 10.1021/acsami.6b10360 http://doi.org/10.1021/acsami.6b10360 .

Chen, S.; Bian, Q.; Wang, P.; Zheng, X.; Lv, L.; Dang, Z.; Wang, G . Photo, pH and redox multi-responsive nanogels for drug delivery and fluorescence cell imaging . Polym. Chem. , 2017 . 8 6150 - 6157 . DOI: 10.1039/C7PY01424D http://doi.org/10.1039/C7PY01424D .

Lu, F.; Li, Z.; Sheng, Y.; Ma, Y.; Yang, Y.; Ren, Y.; Su, Z.; Yu, R.; Zhang, S . Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy . Biomaterials , 2021 . 276 121035 DOI: 10.1016/j.biomaterials.2021.121035 http://doi.org/10.1016/j.biomaterials.2021.121035 .

Nagy-Simon, T.; Potara, M.; Craciun, A . M.; Licarete, E.; Astilean, S. IR780-dye loaded gold nanoparticles as new near infrared activatable nanotheranostic agents for simultaneous photodynamic and photothermal therapy and intracellular tracking by surface enhanced resonant Raman scattering imaging . J. Colloid Interface Sci. , 2018 . 517 239 - 250 . DOI: 10.1016/j.jcis.2018.02.007 http://doi.org/10.1016/j.jcis.2018.02.007 .

Ruttala, H. B.; Ramasamy, T.; Ruttala, R. R. T.; Tran, T. H.; Jeong, J. H.; Choi, H. G.; Ku, S. K.; Yong, C. S.; Kim, J. O . Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments . J. Colloid Interface Sci. , 2021 . 86 139 - 150 . .

Wang, K.; Zhang, Y.; Wang, J.; Yuan, A.; Sun, M.; Wu, J.; Hu, Y . Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and Pdt/Ptt agent for cancer therapy . Sci. Rep. , 2016 . 6 27421 DOI: 10.1038/srep27421 http://doi.org/10.1038/srep27421 .

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