Facile and One-step Direct Synthesis of Poly(valine) as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

Ya-Bin Meng; Jun Wu

doi:10.1007/s10118-022-2701-9

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Facile and One-step Direct Synthesis of Poly(valine) as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

RESEARCH ARTICLE | Updated：2022-08-19

- Facile and One-step Direct Synthesis of Poly(valine) as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy
- Chinese Journal of Polymer Science Vol. 40, Issue 9, Pages: 1016-1027(2022)
- Affiliations：
  
  School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
- Author bio：
  
  wujun29@mail.sysu.edu.cn
- Funds：
- DOI：10.1007/s10118-022-2701-9
  CLC：
- Received：24 December 2021，
  
  Revised：2022-01-20，
  
  Accepted：24 January 2022，
  
  Online First：05 May 2022，
  
  Published：01 September 2022
- Accepted：
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Meng, Y. B.; Wu, J. Facile and one-step direct synthesis of poly(valine) as a robust drug nanocarrier for enhanced breast cancer therapy. Chinese J. Polym. Sci. 2022, 40, 1016–1027

Ya-Bin Meng, Jun Wu. Facile and One-step Direct Synthesis of Poly(valine) as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy[J]. Chinese Journal of Polymer Science, 2022, 40(9): 1016-1027.
Meng, Y. B.; Wu, J. Facile and one-step direct synthesis of poly(valine) as a robust drug nanocarrier for enhanced breast cancer therapy. Chinese J. Polym. Sci. 2022, 40, 1016–1027 DOI： 10.1007/s10118-022-2701-9.

Ya-Bin Meng, Jun Wu. Facile and One-step Direct Synthesis of Poly(valine) as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy[J]. Chinese Journal of Polymer Science, 2022, 40(9): 1016-1027. DOI： 10.1007/s10118-022-2701-9.

摘要

In this study an easy-operating but effective strategy is used to prepare PVal which can self-assemble into nanoparticles (PVal-NPs

~104 nm) by nanoprecipitation and have a higher drug payload for tumor chemotherapy. This nanoplatform is stable under physiological conditions and could induce the apoptosis of 4T1 cells like free DOX while alleviating its toxicity. The in vivo evaluation indicated that DOX@PVal-NPs have a high tumor accumulation

penetration and therapeutic performance after intravenous injection without causing toxicity to main organs. Overall

this study provides a new strategy for synthesis of poly(amino acid)s as drug carrier to deliver antitumor drugs.

Abstract

Synthetic poly(amino acid)s with good biodegradable and biocompatible properties have attracted increased attention as carriers in biomedical applications in recent years

their synthesis and purification procedures are usually complicated and some by-products would occur yet. Given this

polypeptide with good biodegradable and biocompatible properties is prepared and optimized by one-step and direct synthesis strategy and poly(valine) (PVal) is selected here as a model polypeptide in this study. This newly generated PVal can self-assemble into poly(valine) nanoparticles (PVal-NPs) with a high drug-loading capacity (

20 wt%) of doxorubicin (DOX) and shows strong cytotoxicity against 4T1 cells. Upon cellular internalization

the release of DOX could be accelerated by the endosomal acidic environment which leads to enhanced anticancer effects. The results

in vivo

show that DOX@PVal-NPs have a long blood circulation time

high cancer accumulation and penetration

and good therapeutic performance in 4T1 tumor-bearing mice without causing obvious adverse effect on main organs. With these combined advantages

these PVal-based nanoplatform would provide an effective drug delivery tool for clinical breast cancer therapy.

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