Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

Wei Hu; Ya-Wei Su; Yi-Kun Jiang; Wen-Di Fan; Song-Yue Cheng; Zai-Zai Tong; Chao Cen; Guo-Hua Jiang

doi:10.1007/s10118-021-2640-x

Your Location：

Home >

Browse articles >

Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

Papers | Updated：2021-11-04

- Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats
- Chinese Journal of Polymer Science Vol. 40, Issue 2, Pages: 157-165(2022)
- Affiliations：
  
  a.College of Materials Science and Engineering and Institute of Smart Biomedical Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China
  b.Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
- Author bio：
  
  tongzz@zstu.edu.cn (Z.Z.T.)
  cenchao@zju.edu.cn (C.C.)
- Funds：
  
  This work was financially supported by the Natural Science Foundation of Zhejiang Province (No. LY20E030005) and the Opening Project of Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices (No. PMND201905).
- DOI：10.1007/s10118-021-2640-x
  CLC：
- Received：08 July 2021，
  
  Revised：2021-8-11，
  
  Accepted：19 August 2021，
  
  Online First：04 November 2021，
  
  Published：01 February 2022
- Accepted：
Scan QR Code
Hu, W.; Su, Y. W.; Jiang, Y. K.; Fan, W. D.; Cheng, S. Y.; Tong, Z. Z.; Cen, C.; Jiang, G. H. Polymer vesicles with upper critical solution temperature for near-infrared light-triggered transdermal delivery of metformin in diabetic rats. Chinese J. Polym. Sci. 2022, 40, 157–165

Wei Hu, Ya-Wei Su, Yi-Kun Jiang, et al. Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats[J]. Chinese Journal of Polymer Science, 2022, 40(2): 157-165.
Hu, W.; Su, Y. W.; Jiang, Y. K.; Fan, W. D.; Cheng, S. Y.; Tong, Z. Z.; Cen, C.; Jiang, G. H. Polymer vesicles with upper critical solution temperature for near-infrared light-triggered transdermal delivery of metformin in diabetic rats. Chinese J. Polym. Sci. 2022, 40, 157–165 DOI： 10.1007/s10118-021-2640-x.

Wei Hu, Ya-Wei Su, Yi-Kun Jiang, et al. Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats[J]. Chinese Journal of Polymer Science, 2022, 40(2): 157-165. DOI： 10.1007/s10118-021-2640-x.

摘要

Abstract

Near-infrared light (NIR) triggered transdermal drug delivery systems are of great interest due to their on-demand drug release

which enable to enhance drug treatment efficiency as well as reduce side effect. Herein

a NIR-triggered microneedle (MN) patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature (UCST) into dissolvable polymer matrix. The UCST-type polymer has a clearing point temperature of 41 °C and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior

in vitro

due to the disassociation of polymer vesicles upon NIR irradiation. After applying MNs to diabetic rats

significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours

which enables to achieve the goal of on-demand drug release. This work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes

especially for those requiring an active drug release manner.

关键词

Keywords

references

Davoodi, P.; Lee, L. Y.; Xu, Q.; Sunil, V.; Sun, Y.; Soh, S.; Wang, C. H . Drug delivery systems for programmed and on-demand release . Adv. Drug Deliv. Rev. , 2018 . 132 104 - 138 . DOI: 10.1016/j.addr.2018.07.002 http://doi.org/10.1016/j.addr.2018.07.002 .

Karimi, M.; Ghasemi, A.; Sahandi Zangabad, P.; Rahighi, R.; Moosavi Basri, S. M.; Mirshekari, H.; Amiri, M.; Shafaei Pishabad, Z.; Aslani, A.; Bozorgomid, M.; Ghosh, D.; Beyzavi, A.; Vaseghi, A.; Aref, A. R.; Haghani, L.; Bahrami, S.; Hamblin, M. R . Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems . Chem. Soc. Rev. , 2016 . 45 1457 - 1501 . DOI: 10.1039/C5CS00798D http://doi.org/10.1039/C5CS00798D .

Drews, J . Drug discovery: a historical perspective . Science , 2000 . 287 1960 - 1964 . DOI: 10.1126/science.287.5460.1960 http://doi.org/10.1126/science.287.5460.1960 .

Tibbitt, M. W.; Dahlman, J. E.; Langer, R . Emerging frontiers in drug delivery . J. Am. Chem. Soc. , 2016 . 138 704 - 717 . DOI: 10.1021/jacs.5b09974 http://doi.org/10.1021/jacs.5b09974 .

Fenton, O. S.; Olafson, K. N.; Pillai, P. S.; Mitchell, M. J.; Langer, R . Advances in biomaterials for drug delivery . Adv. Mater. , 2018 . 30 1705328 DOI: 10.1002/adma.201705328 http://doi.org/10.1002/adma.201705328 .

Gu, X.; Liu, Y.; Chen, G.; Wang, H.; Shao, C.; Chen, Z.; Lu, P.; Zhao, Y . Mesoporous colloidal photonic crystal particles for intelligent drug delivery . ACS Appl. Mater. Interfaces , 2018 . 10 33936 - 33944 . DOI: 10.1021/acsami.8b11175 http://doi.org/10.1021/acsami.8b11175 .

Zhang, H.; Ba, S.; Lee, J. Y.; Xie, J.; Loh, T. P.; Li, T . Cancer biomarker-triggered disintegrable DNA nanogels for intelligent drug delivery . Nano Lett. , 2020 . 20 8399 - 8407 . DOI: 10.1021/acs.nanolett.0c03671 http://doi.org/10.1021/acs.nanolett.0c03671 .

Meng, X.; Gui, B.; Yuan, D.; Zeller, M.; Wang, C . Mechanized azobenzene-functionalized zirconium metal-organic framework for on-command cargo release . Sci. Adv. , 2016 . 2 e1600480 DOI: 10.1126/sciadv.1600480 http://doi.org/10.1126/sciadv.1600480 .

Lu, Y.; Aimetti, A. A.; Langer, R.; Gu, Z . Bioresponsive materials . Nat. Rev. Mater. , 2017 . 2 16075 DOI: 10.1038/natrevmats.2016.75 http://doi.org/10.1038/natrevmats.2016.75 .

Lavrador, P.; Esteves, M. R.; Gaspar, V. M.; Mano, J. F . Stimuli-responsive nanocomposite hydrogels for biomedical applications . Adv. Funct. Mater. , 2021 . 31 2005941 DOI: 10.1002/adfm.202005941 http://doi.org/10.1002/adfm.202005941 .

Liu, G.; Zhao, X.; Zhang, Y.; Xu, J.; Xu, J.; Li, Y.; Min, H.; Shi, J.; Zhao, Y.; Wei, J.; Wang, J.; Nie, G . Engineering biomimetic platesomes for pH-responsive drug delivery and enhanced antitumor activity . Adv. Mater. , 2019 . 31 1900795 DOI: 10.1002/adma.201900795 http://doi.org/10.1002/adma.201900795 .

Xu, C.; Yan, Y.; Tan, J.; Yang, D.; Jia, X.; Wang, L.; Xu, Y.; Cao, S.; Sun, S . Biodegradable nanoparticles of polyacrylic acid-stabilized amorphous CaCO 3 for tunable pH-responsive drug delivery and enhanced tumor inhibition . Adv. Funct. Mater. , 2019 . 29 1808146 DOI: 10.1002/adfm.201808146 http://doi.org/10.1002/adfm.201808146 .

Lei, Z.; Ju, Y.; Lin, Y.; Bai, X.; Hu, W.; Wang, Y.; Luo, H.; Tong, Z . Reactive oxygen species synergistic pH/H 2 O 2 -responsive of poly(L-lactic acid)-block-poly(sodium 4-styrenesulfonate)/citrate-Fe(III)@ZIF-8 hybrid nanocomposites for controlled drug release . ACS Appl. Bio Mater. , 2019 . 2 3648 - 3658 . DOI: 10.1021/acsabm.9b00497 http://doi.org/10.1021/acsabm.9b00497 .

Lei, Z.; Tang, Q.; Ju, Y.; Lin, Y.; Bai, X.; Luo, H.; Tong, Z . Block copolymer@ZIF-8 nanocomposites as a pH-responsive multi-steps release system for controlled drug delivery . J. Biomater. Sci. Polym. Ed. , 2020 . 31 695 - 711 . DOI: 10.1080/09205063.2020.1713451 http://doi.org/10.1080/09205063.2020.1713451 .

Zhou, J.; Tang, Q.; Zhong, J.; Lei, Z.; Luo, H.; Tong, Z.; G. H. Jiang; Liu, X. D . Construction of glucose and H 2 O 2 dual stimuli-responsive polymeric vesicles and their application in controlled drug delivery . J. Mater. Sci. , 2018 . 53 14063 - 14074 . DOI: 10.1007/s10853-018-2622-8 http://doi.org/10.1007/s10853-018-2622-8 .

Lin, Y.; Hu, W.; Bai, X.; Ju, Y.; Cao, C.; Zou, S.; Tong, Z.; Cen, C.; Jiang, G.; Kong, X . Glucose- and pH-responsive supramolecular polymer vesicles based on host-guest interaction for transcutaneous delivery of insulin . ACS Appl. Bio Mater. , 2020 . 3 6376 - 6383 . DOI: 10.1021/acsabm.0c00813 http://doi.org/10.1021/acsabm.0c00813 .

Scott, E. A.; Stano, A.; Gillard, M.; Maio-Liu, A. C.; Swartz, M. A.; Hubbell, J. A . Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes . Biomaterials , 2012 . 33 6211 - 6219 . DOI: 10.1016/j.biomaterials.2012.04.060 http://doi.org/10.1016/j.biomaterials.2012.04.060 .

Guo, D. S.; Wang, K.; Wang, Y. X.; Liu, Y . Cholinesterase-responsive supramolecular vesicle . J. Am. Chem. Soc. , 2012 . 134 10244 - 10250 . DOI: 10.1021/ja303280r http://doi.org/10.1021/ja303280r .

Wang, H.; Zhang, C.; Zhang, Y.; Tian, R.; Cheng, G.; Pan, H.; Cui, M.; Chang, J . An efficient delivery of photosensitizers and hypoxic prodrugs for a tumor combination therapy by membrane camouflage nanoparticles . J. Mat. Chem. B , 2020 . 8 2876 - 2886 . DOI: 10.1039/D0TB00235F http://doi.org/10.1039/D0TB00235F .

Yao, C.; Wang, W.; Wang, P.; Zhao, M.; Li, X.; Zhang, F . Near-infrared upconversion mesoporous cerium oxide hollow biophotocatalyst for concurrent pH-/H 2 O 2 -responsive O 2 -evolving synergetic cancer therapy . Adv. Mater. , 2018 . 30 1704833 DOI: 10.1002/adma.201704833 http://doi.org/10.1002/adma.201704833 .

Moughton, A. O.; O’Reilly, R. K . Thermally induced micelle to vesicle morphology transition for a charged chain end diblock copolymer . Chem. Commun. , 2010 . 46 1091 - 1093 . DOI: 10.1039/B922289H http://doi.org/10.1039/B922289H .

López-Noriega, A.; Hastings, C. L.; Ozbakir, B.; O'Donnell, K. E.; O'Brien, F. J.; Storm, G.; Hennink, W. E.; Duffy, G. P.; Ruiz-Hernández, E . Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy . Adv. Healthc. Mater. , 2014 . 3 854 - 859 . DOI: 10.1002/adhm.201300649 http://doi.org/10.1002/adhm.201300649 .

Chen, S.; Weitemier, A. Z.; Zeng, X.; He, L.; Wang, X.; Tao, Y.; Huang, A. J. Y.; Hashimotodani, Y.; Kano, M.; Iwasaki, H.; Parajuli, L. K.; Okabe, S.; Teh, D. B. L.; All, A. H.; Tsutsui-Kimura, I.; Tanaka, K. F.; Liu, X.; McHugh, T. J . Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics . Science , 2018 . 359 679 DOI: 10.1126/science.aaq1144 http://doi.org/10.1126/science.aaq1144 .

Hu, W.; Bai, X.; Wang, Y.; Lei, Z.; Luo, H; Tong, Z . Upper critical solution temperature polymer-grafted hollow mesoporous silica nanoparticles for near-infrared-irradiated drug release . J. Mat. Chem. B , 2019 . 7 5789 - 5796 . DOI: 10.1039/C9TB01071H http://doi.org/10.1039/C9TB01071H .

Wang, J.; Liu, Y.; Ma, Y.; Sun, C.; Tao, W . NIR-activated supersensitive drug release using nanoparticles with a flow core . Adv. Funct. Mater. , 2016 . 26 7516 - 7525 . DOI: 10.1002/adfm.201603195 http://doi.org/10.1002/adfm.201603195 .

Qin, J.; Asempah, I.; Laurent, S.; Fornara, A.; Muller, R. N.; Muhammed, M . Injectable superparamagnetic ferrogels for controlled release of hydrophobic drugs . Adv. Mater. , 2009 . 21 1354 - 1357 . DOI: 10.1002/adma.200800764 http://doi.org/10.1002/adma.200800764 .

Serrà, A.; Gimeno, N.; Gómez, E.; Mora, M.; Lluïsa Sagristá, M.; Vallés, E . Magnetic mesoporous nanocarriers for drug delivery with improved therapeutic efficacy . Adv. Funct. Mater. , 2016 . 26 6601 - 6611 . DOI: 10.1002/adfm.201601473 http://doi.org/10.1002/adfm.201601473 .

Mehrali, M.; Thakur, A.; Pennisi, C. P.; Talebian, S.; Arpanaei, A.; Nikkhah, M.; Dolatshahi-Pirouz, A . Nanoreinforced hydrogels for tissue engineering: biomaterials that are compatible with load-bearing and electroactive tissues . Adv. Mater. , 2017 . 29 1603612 DOI: 10.1002/adma.201603612 http://doi.org/10.1002/adma.201603612 .

Kennedy, S.; Hu, J.; Kearney, C.; Skaat, H.; Gu, L.; Gentili, M.; Vandenburgh, H.; Mooney, D . Sequential release of nanoparticle payloads from ultrasonically burstable capsules . Biomaterials , 2016 . 75 91 - 101 . DOI: 10.1016/j.biomaterials.2015.10.008 http://doi.org/10.1016/j.biomaterials.2015.10.008 .

Di, J.; Yu, J.; Wang, Q.; Yao, S.; Suo, D.; Ye, Y.; Pless, M.; Zhu, Y.; Jing, Y.; Gu, Z . Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules . Nano Res. , 2017 . 10 1393 - 1402 . DOI: 10.1007/s12274-017-1500-z http://doi.org/10.1007/s12274-017-1500-z .

Wu, Z.; Lin, X.; Zou, X.; Sun, J.; He, Q. Biodegradable protein-based rockets for drug transportation and light-triggered release. ACS Appl. Mater. Interfaces 2015 , 7 , 250−255.

Tao, Y.; Chan, H. F.; Shi, B.; Li, M.; Leong, K. W . Light: a magical tool for controlled drug delivery . Adv. Funct. Mater. , 2020 . 30 2005029 DOI: 10.1002/adfm.202005029 http://doi.org/10.1002/adfm.202005029 .

Rapp, T. L.; DeForest, C. A . Targeting drug delivery with light: a highly focused approach . Adv. Drug Deliv. Rev. , 2021 . 171 94 - 107 . DOI: 10.1016/j.addr.2021.01.009 http://doi.org/10.1016/j.addr.2021.01.009 .

Alvarez-Lorenzo, C.; Bromberg, L.; Concheiro, A . Light-sensitive intelligent drug delivery systems . Photochem. Photobiol. , 2009 . 85 848 - 860 . DOI: 10.1111/j.1751-1097.2008.00530.x http://doi.org/10.1111/j.1751-1097.2008.00530.x .

Kimura, H.; Lee, C.; Hayashi, K.; Yamauchi, K.; Yamamoto, N.; Tsuchiya, H.; Tomita, K.; Bouvet, M.; Hoffman, R. M . UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo . J. Cell. Biochem. , 2010 . 110 1439 - 1446 . DOI: 10.1002/jcb.22693 http://doi.org/10.1002/jcb.22693 .

Fomina, N.; McFearin, C.; Sermsakdi, M.; Edigin, O.; Almutairi, A . UV and near-IR triggered release from polymeric nanoparticles . J. Am. Chem. Soc. , 2010 . 132 9540 - 9542 . DOI: 10.1021/ja102595j http://doi.org/10.1021/ja102595j .

Sponchioni, M.; Bassam, P. R.; Moscatelli, D.; Arosio, P.; Palmiero, U. C . Biodegradable zwitterionic nanoparticles with tunable UCST-type phase separation under physiological conditions . Nanoscale , 2019 . 11 16582 - 16591 . DOI: 10.1039/C9NR04311J http://doi.org/10.1039/C9NR04311J .

Zou, Y.; Brooks, D. E.; Kizhakkedathu, J. N . A novel functional polymer with tunable LCST . Macromolecules , 2008 . 41 5393 - 5405 . DOI: 10.1021/ma8006703 http://doi.org/10.1021/ma8006703 .

Berndt, I.; Richtering, W . Doubly temperature sensitive core-shell microgels . Macromolecules , 2003 . 36 8780 - 8785 . DOI: 10.1021/ma034771+ http://doi.org/10.1021/ma034771+ .

Seuring, J.; Agarwal, S . First example of a universal and cost-effective approach: polymers with tunable upper critical solution temperature in water and electrolyte solution . Macromolecules , 2012 . 45 3910 - 3918 . DOI: 10.1021/ma300355k http://doi.org/10.1021/ma300355k .

Dong, Z.; Mao, J.; Wang, D.; Yang, M.; Wang, W.; Bo, S.; Ji, X . Tunable dual-thermoresponsive phase behavior of zwitterionic polysulfobetaine copolymers containing poly( N , N -dimethylaminoethyl methacrylate)-grafted silica nanoparticles in aqueous solution . Macromol. Chem. Phys. , 2014 . 215 111 - 120 . DOI: 10.1002/macp.201300552 http://doi.org/10.1002/macp.201300552 .

Xue, X.; Thiagarajan, L.; Braim, S.; Saunders, B. R.; Shakesheff, K.; Alexander, C . Upper critical solution temperature thermo-responsive polymer brushes and a mechanism for controlled cell attachment . J. Mat. Chem. B , 2017 . 5 4926 - 4933 . DOI: 10.1039/C7TB00052A http://doi.org/10.1039/C7TB00052A .

Maaden, K.; Jiskoot, W.; Bouwstra, J . Microneedle technologies for (trans)dermal drug and vaccine delivery . J. Control. Release , 2012 . 161 645 - 655 . DOI: 10.1016/j.jconrel.2012.01.042 http://doi.org/10.1016/j.jconrel.2012.01.042 .

Kim, Y. C.; Park, J. H.; Prausnitz, M. R . Microneedles for drug and vaccine delivery . Adv. Drug Deliv. Rev. , 2012 . 64 1547 - 1568 . DOI: 10.1016/j.addr.2012.04.005 http://doi.org/10.1016/j.addr.2012.04.005 .

Jeong, W. L.; Park, J. H.; Mark, R. P . Dissolving microneedles for transdermal drug delivery . Biomaterials , 2008 . 29 2113 - 2124 . DOI: 10.1016/j.biomaterials.2007.12.048 http://doi.org/10.1016/j.biomaterials.2007.12.048 .

Yu, W.; Jiang, G.; Zhang, Y.; Liu, D.; Xu, B.; Zhou, J . Near-infrared light triggered and separable microneedles for transdermal delivery of metformin in diabetic rats . J. Mat. Chem. B , 2017 . 5 9507 - 9513 . DOI: 10.1039/C7TB02236K http://doi.org/10.1039/C7TB02236K .

Liu; D.; Yu, B.; Jiang, G.; Yu, W.; Zhang, Y.; Xu, B . Fabrication of composite microneedles integrated with insulin-loaded CaCO 3 microparticles and PVP for transdermal delivery in diabetic rats . Mater. Sci. Eng. C , 2018 . 90 180 - 188 . DOI: 10.1016/j.msec.2018.04.055 http://doi.org/10.1016/j.msec.2018.04.055 .

Tong, Z.; Zhou, J.; Zhong, J.; Tang, Q.; Lei, Z.; Luo, H.; Ma, P.; Liu, X . Glucose- and H 2 O 2 -responsive polymeric vesicles integrated with microneedle patches for glucose-sensitive transcutaneous delivery of insulin in diabetic rats . ACS Appl. Mater. Interfaces , 2018 . 10 20014 - 20024 . DOI: 10.1021/acsami.8b04484 http://doi.org/10.1021/acsami.8b04484 .

Ye, Y.; Yu, J.; Wang, C.; Nguyen, N. Y.; Walker, G. M.; Buse, J. B.; Gu, Z . Microneedles integrated with pancreatic cells and synthetic glucose-signal amplifiers for smart insulin delivery . Adv. Mater. , 2016 . 28 3115 - 3121 . DOI: 10.1002/adma.201506025 http://doi.org/10.1002/adma.201506025 .

Xu, B.; Cao, Q.; Zhang, Y.; Yu, W.; Jiang, G . Microneedles integrated with ZnO quantum dots capped mesoporous bioactive glasses for glucose-mediated insulin delivery . ACS Biomater. Sci. Eng. , 2018 . 4 2473 - 2483 . DOI: 10.1021/acsbiomaterials.8b00626 http://doi.org/10.1021/acsbiomaterials.8b00626 .

Niskanen, J.; Tenhu, H . How to manipulate the upper critical solution temperature (UCST)? . Polym. Chem. , 2017 . 8 220 - 232 . DOI: 10.1039/C6PY01612J http://doi.org/10.1039/C6PY01612J .

Xu, Z.; Liu, W . Poly( N -acryloyl glycinamide): a fascinating polymer that exhibits a range of properties from UCST to high-strength hydrogels . Chem. Commun. , 2018 . 54 10540 - 10553 . DOI: 10.1039/C8CC04614J http://doi.org/10.1039/C8CC04614J .

Views

158

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

CO2-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

Two-way Shape Memory Effect of Polycaprolactone-based Polyurethane via Synergistic Role of Hydrogen Bonding and Crystallization Tuned by Malic Acid

Special Topic: Chirality in Polymers

Molecular Segregation and Melt Memory in Dilute Polycaprolactone with Reduced Entanglements

Advances in Polymer-based Circularly Polarized Luminescent Materials

Related Author

Zhi-Yu Huang

Bao-Gang Wang

Hong-Sheng Lu

Xian-Wu Jing

Related Institution

College of Chemistry and Chemical Engineering, Southwest Petroleum University

Engineering Research Center of Oilfield Chemistry, Ministry of Education

⁰