Self-healing Hydrogels and Underlying Reversible Intermolecular Interactions

Meng Wu; Qiong-Yao Peng; Lin-Bo Han; Hong-Bo Zeng

doi:10.1007/s10118-021-2631-y

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Self-healing Hydrogels and Underlying Reversible Intermolecular Interactions

FEATURE ARTICLE | Updated：2021-08-18

- Self-healing Hydrogels and Underlying Reversible Intermolecular Interactions
- Chinese Journal of Polymer Science Vol. 39, Issue 10, Pages: 1246-1261(2021)
- Affiliations：
  
  a.Department of Chemical & Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada
  b.College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China
- Author bio：
  
  hongbo.zeng@ualberta.ca
- Funds：
- DOI：10.1007/s10118-021-2631-y
  CLC：
- Received：16 June 2021，
  
  Revised：2021-7-3，
  
  Accepted：06 July 2021，
  
  Online First：18 August 2021，
  
  Published：20 August 2021
- Accepted：
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Wu, M.; Peng, Q. Y.; Han, L. B.; Zeng, H. B. Self-healing hydrogels and underlying reversible intermolecular interactions. Chinese J. Polym. Sci. 2021, 39, 1246–1261

Meng Wu, Qiong-Yao Peng, Lin-Bo Han, et al. Self-healing Hydrogels and Underlying Reversible Intermolecular Interactions[J]. Chinese Journal of Polymer Science, 2021, 39(10): 1246-1261.
Wu, M.; Peng, Q. Y.; Han, L. B.; Zeng, H. B. Self-healing hydrogels and underlying reversible intermolecular interactions. Chinese J. Polym. Sci. 2021, 39, 1246–1261 DOI： 10.1007/s10118-021-2631-y.

Meng Wu, Qiong-Yao Peng, Lin-Bo Han, et al. Self-healing Hydrogels and Underlying Reversible Intermolecular Interactions[J]. Chinese Journal of Polymer Science, 2021, 39(10): 1246-1261. DOI： 10.1007/s10118-021-2631-y.

摘要

Abstract

Self-healing hydrogels have attracted growing attention over the past decade due to their biomimetic structure

biocompatibility

as well as enhanced lifespan and reliability

thereby have been widely used in various biomedical

electrical and environmental engineering applications. This feature article has reviewed our recent progress in self-healing hydrogels derived from mussel-inspired interactions

multiple hydrogen-bonding functional groups such as 2-ureido-4[1

]-pyrimidinone (UPy)

dynamic covalent bonds (

e.g.

Schiff base reactions and boronic ester bonds). The underlying molecular basics of these interactions

hydrogel preparation principles

and corresponding performances and applications are introduced. The underlying reversible intermolecular interaction mechanisms in these hydrogels were investigated using nanomechanical techniques such as surface forces apparatus (SFA) and atomic force microscopy (AFM)

providing fundamental insights into the self-healing mechanisms of the hydrogels. The remaining challenging issues and perspectives in this rapidly developing research area are also discussed.

关键词

Keywords

references

Ahmed, E. M. . Hydrogel: Preparation, characterization, and applications: a review . J. Adv. Res. , 2015 . 6 105 - 121 . DOI: 10.1016/j.jare.2013.07.006 http://doi.org/10.1016/j.jare.2013.07.006 .

Ganji, F.; Vasheghani, F. S.; Vasheghani, F. E. . Theoretical description of hydrogel swelling: a review . Iran. Polym. J. , 2010 . 19 375 - 398 . .

Kopeček, J. . Hydrogel biomaterials: a smart future? . Biomaterials , 2007 . 28 5185 - 5192 . DOI: 10.1016/j.biomaterials.2007.07.044 http://doi.org/10.1016/j.biomaterials.2007.07.044 .

Billiet, T.; Vandenhaute, M.; Schelfhout, J.; Van Vlierberghe, S.; Dubruel, P. . A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering . Biomaterials , 2012 . 33 6020 - 6041 . DOI: 10.1016/j.biomaterials.2012.04.050 http://doi.org/10.1016/j.biomaterials.2012.04.050 .

Vashist, A.; Vashist, A.; Gupta, Y.; Ahmad, S. . Recent advances in hydrogel based drug delivery systems for the human body . J. Mater. Chem. B , 2014 . 2 147 - 166 . DOI: 10.1039/C3TB21016B http://doi.org/10.1039/C3TB21016B .

Kamoun, E. A.; Kenawy, E.-R. S.; Chen, X. . A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings . J. Adv. Res. , 2017 . 8 217 - 233 . DOI: 10.1016/j.jare.2017.01.005 http://doi.org/10.1016/j.jare.2017.01.005 .

Gupta, P.; Vermani, K.; Garg, S. . Hydrogels: from controlled release to pH-responsive drug delivery . Drug Discov. Today , 2002 . 7 569 - 579 . .

Peppas, N. A.; Hilt, J. Z.; Khademhosseini, A.; Langer, R. . Hydrogels in biology and medicine: from molecular principles to bionanotechnology . Adv. Mater. , 2006 . 18 1345 - 1360 . DOI: 10.1002/adma.200501612 http://doi.org/10.1002/adma.200501612 .

Hoffman, A. S. . Hydrogels for biomedical applications . Adv. Drug Deliv. Rev. , 2012 . 64 18 - 23 . DOI: 10.1016/j.addr.2012.09.010 http://doi.org/10.1016/j.addr.2012.09.010 .

Van Vlierberghe, S.; Dubruel, P.; Schacht, E. . Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review . Biomacromolecules , 2011 . 12 1387 - 1408 . DOI: 10.1021/bm200083n http://doi.org/10.1021/bm200083n .

Zhu, J.; Marchant, R. E. . Design properties of hydrogel tissue-engineering scaffolds . Expert Rev. Med. Devices , 2011 . 8 607 - 626 . DOI: 10.1586/erd.11.27 http://doi.org/10.1586/erd.11.27 .

Dhivya, S.; Padma, V. V.; Santhini, E. . Wound dressings - a review . BioMedicine , 2015 . 5 22 - 22 . DOI: 10.7603/s40681-015-0022-9 http://doi.org/10.7603/s40681-015-0022-9 .

Sirousazar, M.; Yari, M. . Dehydration kinetics of polyvinyl alcohol hydrogel wound dressings during wound healing process . Chinese J. Polym. Sci. , 2010 . 28 573 - 580 . DOI: 10.1007/s10118-010-9099-5 http://doi.org/10.1007/s10118-010-9099-5 .

Yang, X.; Li, P.; Tang, W.; Du, S.; Yu, M.; Lu, H.; Tan, H.; Xing, X. . A facile injectable carbon dot/oxidative polysaccharide hydrogel with potent self-healing and high antibacterial activity . Carbohydr. Polym. , 2021 . 251 117040 DOI: 10.1016/j.carbpol.2020.117040 http://doi.org/10.1016/j.carbpol.2020.117040 .

Chen, L.; Li, X. Q.; Cao, L. P.; Li, X. L.; Meng, J. R.; Dong, J.; Yu, L.; Ding, J. D. . An injectable hydrogel with or without drugs for prevention of epidural scar adhesion after laminectomy in rats . Chinese J. Polym. Sci. , 2016 . 34 147 - 163 . DOI: 10.1007/s10118-016-1740-5 http://doi.org/10.1007/s10118-016-1740-5 .

Zhu, F. B.; Yu, H. C.; Lei, W. X.; Ren, K. F.; Qian, J.; Wu, Z. L.; Zheng, Q. . Tough polyion complex hydrogel films of natural polysaccharides . Chinese J. Polym. Sci. , 2017 . 35 1276 - 1285 . DOI: 10.1007/s10118-017-1977-7 http://doi.org/10.1007/s10118-017-1977-7 .

Yuk, H.; Lu, B.; Zhao, X. . Hydrogel bioelectronics . Chem. Soc. Rev. , 2019 . 48 1642 - 1667 . DOI: 10.1039/C8CS00595H http://doi.org/10.1039/C8CS00595H .

Liu, Y.; Liu, J.; Chen, S.; Lei, T.; Kim, Y.; Niu, S.; Wang, H.; Wang, X.; Foudeh, A. M.; Tok, J. B. H. . Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation . Nat. Biomed. Eng. , 2019 . 3 58 - 68 . DOI: 10.1038/s41551-018-0335-6 http://doi.org/10.1038/s41551-018-0335-6 .

Wang, C.; Wang, C.; Huang, Z.; Xu, S. . Materials and structures toward soft electronics . Adv. Mater. , 2018 . 30 1801368 DOI: 10.1002/adma.201801368 http://doi.org/10.1002/adma.201801368 .

Lai, Y. C.; Wu, H. M.; Lin, H. C.; Chang, C. L.; Chou, H. H.; Hsiao, Y. C.; Wu, Y. C. . Entirely, intrinsically, and autonomously self-healable, highly transparent, and superstretchable triboelectric nanogenerator for personal power sources and self-powered electronic skins . Adv. Funct. Mater. , 2019 . 29 1904626 DOI: 10.1002/adfm.201904626 http://doi.org/10.1002/adfm.201904626 .

Kim, C. C.; Lee, H. H.; Oh, K. H.; Sun, J. Y. . Y. Highly stretchable, transparent ionic touch panel . Science , 2016 . 353 682 - 687 . DOI: 10.1126/science.aaf8810 http://doi.org/10.1126/science.aaf8810 .

Peng, Q.; Chen, J.; Wang, T.; Peng, X.; Liu, J.; Wang, X.; Wang, J.; Zeng, H. . Recent advances in designing conductive hydrogels for flexible electronics . InfoMat , 2020 . 2 843 - 865 . DOI: 10.1002/inf2.12113 http://doi.org/10.1002/inf2.12113 .

Sun, X.; Yao, F.; Li, J. . Nanocomposite hydrogel-based strain and pressure sensors: a review . J. Mater. Chem. A , 2020 . 8 18605 - 18623 . DOI: 10.1039/D0TA06965E http://doi.org/10.1039/D0TA06965E .

Wang, Z.; Cong, Y.; Fu, J. . Stretchable and tough conductive hydrogels for flexible pressure and strain sensors . J. Mater. Chem. B , 2020 . 8 3437 - 3459 . DOI: 10.1039/C9TB02570G http://doi.org/10.1039/C9TB02570G .

Ionov, L. . Hydrogel-based actuators: possibilities and limitations . Mater. Today , 2014 . 17 494 - 503 . DOI: 10.1016/j.mattod.2014.07.002 http://doi.org/10.1016/j.mattod.2014.07.002 .

Wang, J. J.; Zhang, Q.; Ji, X. X.; Liu, L. B. . Highly stretchable, compressible, adhesive, conductive self-healing composite hydrogels with sensor capacity . Chinese J. Polym. Sci. , 2020 . 38 1221 - 1229 . DOI: 10.1007/s10118-020-2472-0 http://doi.org/10.1007/s10118-020-2472-0 .

van Tran, V.; Park, D.; Lee, Y. C. . Hydrogel applications for adsorption of contaminants in water and wastewater treatment . Environ. Sci. Pollut. Res. , 2018 . 25 24569 - 24599 . DOI: 10.1007/s11356-018-2605-y http://doi.org/10.1007/s11356-018-2605-y .

Guo, H.; Jiao, T.; Zhang, Q.; Guo, W.; Peng, Q.; Yan, X. . Preparation of graphene oxide-based hydrogels as efficient dye adsorbents for wastewater treatment . Nanoscale Res. Lett. , 2015 . 10 1 - 10 . DOI: 10.1186/1556-276X-10-1 http://doi.org/10.1186/1556-276X-10-1 .

Pakdel, P. M.; Peighambardoust, S. J. . M.; Peighambardoust, S. J. Review on recent progress in chitosan-based hydrogels for wastewater treatment application . Carbohydr. Polym. , 2018 . 201 264 - 279 . DOI: 10.1016/j.carbpol.2018.08.070 http://doi.org/10.1016/j.carbpol.2018.08.070 .

Pakdel, P. M.; Peighambardoust, S. J. . M.; Peighambardoust, S. J. A review on acrylic based hydrogels and their applications in wastewater treatment . J. Environ. Manage. , 2018 . 217 123 - 143 . DOI: 10.1016/j.jenvman.2018.03.076 http://doi.org/10.1016/j.jenvman.2018.03.076 .

Zhang, P. B.; Tang, A. Q.; Wang, Z. H.; Lu, J. Y.; Zhu, B. K.; Zhu, L. P. . Tough poly(L-DOPA)-containing double network hydrogel beads with high capacity of dye adsorption . Chinese J. Polym. Sci. , 2018 . 36 1251 - 1261 . DOI: 10.1007/s10118-018-2163-2 http://doi.org/10.1007/s10118-018-2163-2 .

Hager, M. D. Self-healing materials. in Handbook of Solid State Chemistry. Wiley-VCH VerlagGmbH & amp;Co. KGaA 2017 , 201−225.

Taylor, D. L.; in het Panhuis, M. . Self-healing hydrogels . Adv. Mater. , 2016 . 28 9060 - 9093 . DOI: 10.1002/adma.201601613 http://doi.org/10.1002/adma.201601613 .

Wang, W.; Narain, R.; Zeng, H. . Rational design of self-healing tough hydrogels: a mini review . Front. Chem. , 2018 . 6 497 DOI: 10.3389/fchem.2018.00497 http://doi.org/10.3389/fchem.2018.00497 .

Wang, W.; Narain, R.; Zeng, H. Chapter 10 - Hydrogels. In Polymer Science and Nanotechnology , Narain, R., Ed. Elsevier: 2020 ; pp 203−244.

Kilic, R.; Sanyal, A. Self-healing hydrogels based on reversible covalent linkages: a survey of dynamic chemical bonds in network formation. In Self-healing and self-recovering hydrogels , Creton, C.; Okay, O., Eds. Springer International Publishing: Cham, 2020 ; pp 243−294.

Corbett, P. T.; Leclaire, J.; Vial, L.; West, K. R.; Wietor, J. L.; Sanders, J. K.; Otto, S. . Dynamic combinatorial chemistry . Chem. Rev. , 2006 . 106 3652 - 3711 . DOI: 10.1021/cr020452p http://doi.org/10.1021/cr020452p .

Wang, P.; Huang, C.; Xing, Y.; Fang, W.; Ren, J.; Yu, H.; Wang, G. . NIR-light- and pH-responsive graphene oxide hybrid cyclodextrin-based supramolecular hydrogels . Langmuir , 2019 . 35 1021 - 1031 . DOI: 10.1021/acs.langmuir.8b03689 http://doi.org/10.1021/acs.langmuir.8b03689 .

Israelachvili, J. N.; Adams, G. E. . Direct measurement of long range forces between two mica surfaces in aqueous KNO 3 solutions . Nature , 1976 . 262 774 - 776 . DOI: 10.1038/262774a0 http://doi.org/10.1038/262774a0 .

Tabor, D.; Winterton, R. . The direct measurement of normal and retarded van der Waals forces . Proc. Math. Phys. Eng. Sci. , 1969 . 312 435 - 450 . .

Lin, Q.; Gourdon, D.; Sun, C.; Holten-Andersen, N.; Anderson, T. H.; Waite, J. H.; Israelachvili, J. N. . Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3 . Proc. Natl. Acad. Sci. , 2007 . 104 3782 - 3786 . DOI: 10.1073/pnas.0607852104 http://doi.org/10.1073/pnas.0607852104 .

Israelachvili, J. N.; McGuiggan, P. M. . Adhesion and short-range forces between surfaces. Part I: New apparatus for surface force measurements . J. Mater. Res. , 1990 . 5 2223 - 2231 . DOI: 10.1557/JMR.1990.2223 http://doi.org/10.1557/JMR.1990.2223 .

Helm, C. A.; Knoll, W.; Israelachvili, J. N. . Measurement of ligand-receptor interactions . Proc. Natl. Acad. Sci. , 1991 . 88 8169 - 8173 . DOI: 10.1073/pnas.88.18.8169 http://doi.org/10.1073/pnas.88.18.8169 .

Li, L.; Zeng, H. . Marine mussel adhesion and bio-inspired wet adhesives . Biotribology , 2016 . 5 44 - 51 . DOI: 10.1016/j.biotri.2015.09.004 http://doi.org/10.1016/j.biotri.2015.09.004 .

Israelachvili, J.; Min, Y.; Akbulut, M.; Alig, A.; Carver, G.; Greene, W.; Kristiansen, K.; Meyer, E.; Pesika, N.; Rosenberg, K. . Recent advances in the surface forces apparatus (SFA) technique . Rep. Prog. Phys. , 2010 . 73 036601 DOI: 10.1088/0034-4885/73/3/036601 http://doi.org/10.1088/0034-4885/73/3/036601 .

Zeng, H.; Hwang, D. S.; Israelachvili, J. N.; Waite, J. H. . Strong reversible Fe 3+ -mediated bridging between dopa-containing protein films in water . Proc. Natl. Acad. Sci. , 2010 . 107 12850 - 12853 . DOI: 10.1073/pnas.1007416107 http://doi.org/10.1073/pnas.1007416107 .

Zeng, H.; Tian, Y.; Anderson, T. H.; Tirrell, M.; Israelachvili, J. N. . New SFA techniques for studying surface forces and thin film patterns induced by electric fields . Langmuir , 2008 . 24 1173 - 1182 . DOI: 10.1021/la7017242 http://doi.org/10.1021/la7017242 .

Meyer, E.; Heinzelmann, H.; Grütter, P.; Jung, T.; Hidber, H. R.; Rudin, H.; Güntherodt, H. J. . Atomic force microscopy for the study of tribology and adhesion . Thin Solid Films , 1989 . 181 527 - 544 . DOI: 10.1016/0040-6090(89)90522-1 http://doi.org/10.1016/0040-6090(89)90522-1 .

Cappella, B.; Dietler, G. . Force-distance curves by atomic force microscopy . Surf. Sci. Rep. , 1999 . 34 1 - 104 . DOI: 10.1016/S0167-5729(99)00003-5 http://doi.org/10.1016/S0167-5729(99)00003-5 .

Butt, H. J.; Jaschke, M.; Ducker, W. . Measuring surface forces in aqueous electrolyte solution with the atomic force microscope . Bioelectrochem. Bioenerg. , 1995 . 38 191 - 201 . DOI: 10.1016/0302-4598(95)01800-T http://doi.org/10.1016/0302-4598(95)01800-T .

Weisenhorn, A.; Hansma, P.; Albrecht, T.; Quate, C. . Forces in atomic force microscopy in air and water . Appl. Phys. Lett. , 1989 . 54 2651 - 2653 . DOI: 10.1063/1.101024 http://doi.org/10.1063/1.101024 .

Kappl, M.; Butt, H. J. . The colloidal probe technique and its application to adhesion force measurements . Part. Part. Syst. Char. , 2002 . 19 129 - 143 . DOI: 10.1002/1521-4117(200207)19:3<129::AID-PPSC129>3.0.CO;2-G http://doi.org/10.1002/1521-4117(200207)19:3<129::AID-PPSC129>3.0.CO;2-G .

Xie, L.; Gong, L.; Zhang, J.; Han, L.; Xiang, L.; Chen, J.; Liu, J.; Yan, B.; Zeng, H. . A wet adhesion strategy via synergistic cation– π and hydrogen bonding interactions of antifouling zwitterions and mussel-inspired binding moieties . J. Mater. Chem. A , 2019 . 7 21944 - 21952 . DOI: 10.1039/C9TA08152F http://doi.org/10.1039/C9TA08152F .

Cui, X.; Liu, J.; Xie, L.; Huang, J.; Liu, Q.; Israelachvili, J. N.; Zeng, H. . Modulation of hydrophobic interaction by mediating surface nanoscale structure and chemistry, not monotonically by hydrophobicity . Angew. Chem. Int. Ed. , 2018 . 57 11903 - 11908 . DOI: 10.1002/anie.201805137 http://doi.org/10.1002/anie.201805137 .

Shi, C.; Cui, X.; Xie, L.; Liu, Q.; Chan, D. Y. C.; Israelachvili, J. N.; Zeng, H. . Measuring forces and spatiotemporal evolution of thin water films between an air bubble and solid surfaces of different hydrophobicity . ACS Nano , 2015 . 9 95 - 104 . DOI: 10.1021/nn506601j http://doi.org/10.1021/nn506601j .

Xie, L.; Shi, C.; Cui, X.; Zeng, H. . Surface forces and interaction mechanisms of emulsion drops and gas bubbles in complex fluids . Langmuir , 2017 . 33 3911 - 3925 . DOI: 10.1021/acs.langmuir.6b04669 http://doi.org/10.1021/acs.langmuir.6b04669 .

Zeng, H. Polymer adhesion, friction, and lubrication . John Wiley & amp; Sons: 2013 .

Waite, J. H. . Nature's underwater adhesive specialist . Int. J. Adhes. Adhes. , 1987 . 7 9 - 14 . DOI: 10.1016/0143-7496(87)90048-0 http://doi.org/10.1016/0143-7496(87)90048-0 .

Waite, J. H. . Adhesion in byssally attached bivalves . Biol. Rev. , 1983 . 58 209 - 231 . .

Lee, B. P.; Messersmith, P. B.; Israelachvili, J. N.; Waite, J. H. . Mussel-inspired adhesives and coatings . Annu. Rev. Mater. Res. , 2011 . 41 99 - 132 . DOI: 10.1146/annurev-matsci-062910-100429 http://doi.org/10.1146/annurev-matsci-062910-100429 .

Waite, J. H. The formation of mussel byssus: anatomy of a natural manufacturing process. In Structure, cellular synthesis and assembly of biopolymers , Case, S. T., Ed. Springer Berlin Heidelberg: Berlin, Heidelberg, 1992 ; pp 27−54.

Harrington, M. J.; Waite, J. H. . Holdfast heroics: comparing the molecular and mechanical properties of Mytilus californianus byssal threads . J. Exp. Biol. , 2007 . 210 4307 - 4318 . DOI: 10.1242/jeb.009753 http://doi.org/10.1242/jeb.009753 .

Li, L.; Smitthipong, W.; Zeng, H. . Mussel-inspired hydrogels for biomedical and environmental applications . Polym. Chem. , 2015 . 6 353 - 358 . DOI: 10.1039/C4PY01415D http://doi.org/10.1039/C4PY01415D .

Yu, M.; Hwang, J.; Deming, T. J. . J. Role of l -3,4-dihydroxyphenylalanine in mussel adhesive proteins . J. Am. Chem. Soc. , 1999 . 121 5825 - 5826 . DOI: 10.1021/ja990469y http://doi.org/10.1021/ja990469y .

Waite, J. H.; Tanzer, M. L. . The bioadhesive of Mytilus byssus: a protein containing L-DOPA . Biochem. Biophys. Res. Commun. , 1980 . 96 1554 - 1561 . DOI: 10.1016/0006-291X(80)91351-0 http://doi.org/10.1016/0006-291X(80)91351-0 .

WAITE, J. H.; TANZER, M. L. . Polyphenolic substance of Mytilus edulis : novel adhesive containing L-Dopa and hydroxyproline . Science , 1981 . 212 1038 - 1040 . DOI: 10.1126/science.212.4498.1038 http://doi.org/10.1126/science.212.4498.1038 .

Lu, Q.; Hwang, D. S.; Liu, Y.; Zeng, H. . Molecular interactions of mussel protective coating protein, mcfp-1, from Mytilus californianus . Biomaterials , 2012 . 33 1903 - 1911 . DOI: 10.1016/j.biomaterials.2011.11.021 http://doi.org/10.1016/j.biomaterials.2011.11.021 .

Lu, Q.; Oh, D. X.; Lee, Y.; Jho, Y.; Hwang, D. S.; Zeng, H. . Nanomechanics of cation– π interactions in aqueous solution . Angew. Chem. Int. Ed. , 2013 . 52 3944 - 3948 . DOI: 10.1002/anie.201210365 http://doi.org/10.1002/anie.201210365 .

Zhang, C.; Wu, B.; Zhou, Y.; Zhou, F.; Liu, W.; Wang, Z. . Mussel-inspired hydrogels: from design principles to promising applications . Chem. Soc. Rev. , 2020 . 49 3605 - 3637 . DOI: 10.1039/C9CS00849G http://doi.org/10.1039/C9CS00849G .

Bandara, N.; Zeng, H.; Wu, J. . Marine mussel adhesion: biochemistry, mechanisms, and biomimetics . J. Adhes. Sci. Technol. , 2013 . 27 2139 - 2162 . DOI: 10.1080/01694243.2012.697703 http://doi.org/10.1080/01694243.2012.697703 .

Zhang, J.; Xiang, L.; Yan, B.; Zeng, H. . Nanomechanics of anion− π interaction in aqueous solution . J. Am. Chem. Soc. , 2020 . 142 1710 - 1714 . DOI: 10.1021/jacs.9b11552 http://doi.org/10.1021/jacs.9b11552 .

Xiang, L.; Zhang, J.; Wang, W.; Gong, L.; Zhang, L.; Yan, B.; Zeng, H. . Nanomechanics of π -cation- π interaction with implications for bio-inspired wet adhesion . Acta Biomater. , 2020 . 117 294 - 301 . DOI: 10.1016/j.actbio.2020.09.043 http://doi.org/10.1016/j.actbio.2020.09.043 .

Han, L.; Liu, K.; Wang, M.; Wang, K.; Fang, L.; Chen, H.; Zhou, J.; Lu, X. . Mussel-inspired adhesive and conductive hydrogel with long-lasting moisture and extreme temperature tolerance . Adv. Funct. Mater. , 2018 . 28 1704195 DOI: 10.1002/adfm.201704195 http://doi.org/10.1002/adfm.201704195 .

Brubaker, C. E.; Messersmith, P. B. . Enzymatically degradable mussel-inspired adhesive hydrogel . Biomacromolecules , 2011 . 12 4326 - 4334 . DOI: 10.1021/bm201261d http://doi.org/10.1021/bm201261d .

Han, L.; Lu, X.; Liu, K.; Wang, K.; Fang, L.; Weng, L. T.; Zhang, H.; Tang, Y.; Ren, F.; Zhao, C.; Sun, G.; Liang, R.; Li, Z. . Mussel-inspired adhesive and tough hydrogel based on nanoclay confined dopamine polymerization . ACS Nano , 2017 . 11 2561 - 2574 . DOI: 10.1021/acsnano.6b05318 http://doi.org/10.1021/acsnano.6b05318 .

Li, L.; Yan, B.; Yang, J.; Chen, L.; Zeng, H. . Novel mussel-inspired injectable self-healing hydrogel with anti-biofouling property . Adv. Mater. , 2015 . 27 1294 - 1299 . DOI: 10.1002/adma.201405166 http://doi.org/10.1002/adma.201405166 .

Holten-Andersen, N.; Harrington, M. J.; Birkedal, H.; Lee, B. P.; Messersmith, P. B.; Lee, K. Y. C.; Waite, J. H. . pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli . Proc. Natl. Acad. Sci. , 2011 . 108 2651 - 2655 . DOI: 10.1073/pnas.1015862108 http://doi.org/10.1073/pnas.1015862108 .

Li, L.; Yan, B.; Yang, J.; Huang, W.; Chen, L.; Zeng, H. . Injectable self-healing hydrogel with antimicrobial and antifouling properties . ACS Appl. Mater. Interfaces , 2017 . 9 9221 - 9225 . DOI: 10.1021/acsami.6b16192 http://doi.org/10.1021/acsami.6b16192 .

Fullenkamp, D. E.; Rivera, J. G.; Gong, Y. K.; Lau, K. H. A.; He, L.; Varshney, R.; Messersmith, P. B. . Mussel-inspired silver-releasing antibacterial hydrogels . Biomaterials , 2012 . 33 3783 - 3791 . DOI: 10.1016/j.biomaterials.2012.02.027 http://doi.org/10.1016/j.biomaterials.2012.02.027 .

Liu, S. Q.; Yang, C.; Huang, Y.; Ding, X.; Li, Y.; Fan, W. M.; Hedrick, J. L.; Yang, Y. Y. . Antimicrobial and antifouling hydrogels formed in situ from polycarbonate and poly(ethylene glycol) via Michael addition . Adv. Mater. , 2012 . 24 6484 - 6489 . DOI: 10.1002/adma.201202225 http://doi.org/10.1002/adma.201202225 .

Cheng, H.; Yue, K.; Kazemzadeh-Narbat, M.; Liu, Y.; Khalilpour, A.; Li, B.; Zhang, Y. S.; Annabi, N.; Khademhosseini, A. . Mussel-inspired multifunctional hydrogel coating for prevention of infections and enhanced osteogenesis . ACS Appl. Mater. Interfaces , 2017 . 9 11428 - 11439 . DOI: 10.1021/acsami.6b16779 http://doi.org/10.1021/acsami.6b16779 .

Li, Q.; Barrett, D. G.; Messersmith, P. B.; Holten-Andersen, N. . B.; Holten-Andersen, N. Controlling hydrogel mechanics via bio-inspired polymer–nanoparticle bond dynamics . ACS Nano , 2016 . 10 1317 - 1324 . DOI: 10.1021/acsnano.5b06692 http://doi.org/10.1021/acsnano.5b06692 .

Israelachvili, J. N. . Thin film studies using multiple-beam interferometry . J. Colloid Interface Sci. , 1973 . 44 259 - 272 . DOI: 10.1016/0021-9797(73)90218-X http://doi.org/10.1016/0021-9797(73)90218-X .

Hwang, D. S.; Zeng, H.; Lu, Q.; Israelachvili, J.; Waite, J. H. . Adhesion mechanism in a DOPA-deficient foot protein from green mussels . Soft Matter , 2012 . 8 5640 - 5648 . DOI: 10.1039/c2sm25173f http://doi.org/10.1039/c2sm25173f .

Kim, S.; Huang, J.; Lee, Y.; Dutta, S.; Yoo, H. Y.; Jung, Y. M.; Jho, Y.; Zeng, H.; Hwang, D. S. . Complexation and coacervation of like-charged polyelectrolytes inspired by mussels . Proc. Natl. Acad. Sci. , 2016 . 113 E847 - E853 . DOI: 10.1073/pnas.1521521113 http://doi.org/10.1073/pnas.1521521113 .

Kim, S.; Yoo, H. Y.; Huang, J.; Lee, Y.; Park, S.; Park, Y.; Jin, S.; Jung, Y. M.; Zeng, H.; Hwang, D. S.; Jho, Y. . Salt triggers the simple coacervation of an underwater adhesive when cations meet aromatic π electrons in seawater . ACS Nano , 2017 . 11 6764 - 6772 . DOI: 10.1021/acsnano.7b01370 http://doi.org/10.1021/acsnano.7b01370 .

Fan, H.; Wang, J.; Tao, Z.; Huang, J.; Rao, P.; Kurokawa, T.; Gong, J. P. . Adjacent cationic–aromatic sequences yield strong electrostatic adhesion of hydrogels in seawater . Nat. Commun. , 2019 . 10 1 - 8 . DOI: 10.1038/s41467-018-07882-8 http://doi.org/10.1038/s41467-018-07882-8 .

Ahn, B. K.; Lee, D. W.; Israelachvili, J. N.; Waite, J. H. . Surface-initiated self-healing of polymers in aqueous media . Nat. Mater. , 2014 . 13 867 - 872 . DOI: 10.1038/nmat4037 http://doi.org/10.1038/nmat4037 .

Han, L.; Gong, L.; Chen, J.; Zhang, J.; Xiang, L.; Zhang, L.; Wang, Q.; Yan, B.; Zeng, H. . Universal mussel-inspired ultrastable surface-anchoring strategy via adaptive synergy of catechol and cations . ACS Appl. Mater. Interfaces , 2018 . 10 2166 - 2173 . DOI: 10.1021/acsami.7b15756 http://doi.org/10.1021/acsami.7b15756 .

Sherrington, D. C.; Taskinen, K. A. . Self-assembly in synthetic macromolecular systems multiple hydrogen bonding interactions . Chem. Soc. Rev. , 2001 . 30 83 - 93 . DOI: 10.1039/b008033k http://doi.org/10.1039/b008033k .

Chen, J.; Yan, B.; Wang, X.; Huang, Q.; Thundat, T.; Zeng, H. . Core cross-linked double hydrophilic block copolymer micelles based on multiple hydrogen-bonding interactions . Polym. Chem. , 2017 . 8 3066 - 3073 . DOI: 10.1039/C7PY00210F http://doi.org/10.1039/C7PY00210F .

Brunsveld, L.; Folmer, B. J. B.; Meijer, E. W.; Sijbesma, R. P. . Supramolecular polymers . Chem. Rev. , 2001 . 101 4071 - 4098 . DOI: 10.1021/cr990125q http://doi.org/10.1021/cr990125q .

Beijer, F. H.; Sijbesma, R. P.; Kooijman, H.; Spek, A. L.; Meijer, E. . Strong dimerization of ureidopyrimidones via quadruple hydrogen bonding . J. Am. Chem. Soc. , 1998 . 120 6761 - 6769 . DOI: 10.1021/ja974112a http://doi.org/10.1021/ja974112a .

Sijbesma, R. P.; Beijer, F. H.; Brunsveld, L.; Folmer, B. J.; Hirschberg, J. K.; Lange, R. F.; Lowe, J. K.; Meijer, E. . Reversible polymers formed from self-complementary monomers using quadruple hydrogen bonding . Science , 1997 . 278 1601 - 1604 . DOI: 10.1126/science.278.5343.1601 http://doi.org/10.1126/science.278.5343.1601 .

Faghihnejad, A.; Feldman, K. E.; Yu, J.; Tirrell, M. V.; Israelachvili, J. N.; Hawker, C. J.; Kramer, E. J.; Zeng, H. . Adhesion and surface interactions of a self-healing polymer with multiple hydrogen-bonding groups . Adv. Funct. Mater. , 2014 . 24 2322 - 2333 . DOI: 10.1002/adfm.201303013 http://doi.org/10.1002/adfm.201303013 .

Chen, J.; Liu, J.; Thundat, T.; Zeng, H. . Polypyrrole-doped conductive supramolecular elastomer with stretchability, rapid self-healing, and adhesive property for flexible electronic sensors . ACS Appl. Mater. Interfaces , 2019 . 11 18720 - 18729 . DOI: 10.1021/acsami.9b03346 http://doi.org/10.1021/acsami.9b03346 .

Zhu, B.; Jasinski, N.; Benitez, A.; Noack, M.; Park, D.; Goldmann, A. S.; Barner-Kowollik, C.; Walther, A. . Hierarchical nacre mimetics with synergistic mechanical properties by control of molecular interactions in self-healing polymers . Angew. Chem. Int. Ed. , 2015 . 54 8653 - 8657 . DOI: 10.1002/anie.201502323 http://doi.org/10.1002/anie.201502323 .

Zhou, B.; He, D.; Hu, J.; Ye, Y.; Peng, H.; Zhou, X.; Xie, X.; Xue, Z. . A flexible, self-healing and highly stretchable polymer electrolyte via quadruple hydrogen bonding for lithium-ion batteries . J. Mater. Chem. A , 2018 . 6 11725 - 11733 . DOI: 10.1039/C8TA01907J http://doi.org/10.1039/C8TA01907J .

Cui, J.; del Campo, A. . Multivalent H-bonds for self-healing hydrogels . Chem. Commun. , 2012 . 48 9302 - 9304 . DOI: 10.1039/c2cc34701f http://doi.org/10.1039/c2cc34701f .

Hou, S.; Wang, X.; Park, S.; Jin, X.; Ma, P. X. . Rapid self-integrating, injectable hydrogel for tissue complex regeneration . Adv. Healthc. Mater. , 2015 . 4 1491 - 1495 . DOI: 10.1002/adhm.201500093 http://doi.org/10.1002/adhm.201500093 .

Jeon, I.; Cui, J.; Illeperuma, W. R.; Aizenberg, J.; Vlassak, J. J. . Extremely stretchable and fast self-healing hydrogels . Adv. Mater. , 2016 . 28 4678 - 4683 . DOI: 10.1002/adma.201600480 http://doi.org/10.1002/adma.201600480 .

Chen, J.; Peng, Q.; Thundat, T.; Zeng, H. . Stretchable, injectable, and self-healing conductive hydrogel enabled by multiple hydrogen bonding toward wearable electronics . Chem. Mater. , 2019 . 31 4553 - 4563 . DOI: 10.1021/acs.chemmater.9b01239 http://doi.org/10.1021/acs.chemmater.9b01239 .

Chen, J.; Wu, M.; Gong, L.; Zhang, J.; Yan, B.; Liu, J.; Zhang, H.; Thundat, T.; Zeng, H. . Mechanistic understanding and nanomechanics of multiple hydrogen-bonding interactions in aqueous environment . J. Phys. Chem. C , 2019 . 123 4540 - 4548 . .

Söntjens, S. H.; Sijbesma, R. P.; van Genderen, M. H.; Meijer, E. . Stability and lifetime of quadruply hydrogen bonded 2-ureido-4 [1 H ]-pyrimidinone dimers . J. Am. Chem. Soc. , 2000 . 122 7487 - 7493 . DOI: 10.1021/ja000435m http://doi.org/10.1021/ja000435m .

Sun, H.; Lee, H. H.; Blakey, I.; Dargaville, B.; Chirila, T. V.; Whittaker, A. K.; Smith, S. C. . Multiple hydrogen-bonded complexes based on 2-ureido-4[1 H ]-pyrimidinone: a theoretical study . J. Phys. Chem. B , 2011 . 115 11053 - 11062 . DOI: 10.1021/jp2061305 http://doi.org/10.1021/jp2061305 .

Schiff, H. . Mittheilungen aus dem Universitätslaboratorium in Pisa: Eine neue Reihe organischer Basen . Justus Liebigs Annalen der Chemie , 1864 . 131 118 - 119 . DOI: 10.1002/jlac.18641310113 http://doi.org/10.1002/jlac.18641310113 .

Wang, T.; Turhan, M.; Gunasekaran, S. . Selected properties of pH-sensitive, biodegradable chitosan–poly(vinyl alcohol) hydrogel . Polym. Int. , 2004 . 53 911 - 918 . .

Godoy-Alcántar, C.; Yatsimirsky, A. K.; Lehn, J. M. . Structure-stability correlations for imine formation in aqueous solution . J. Phys. Org. Chem. , 2005 . 18 979 - 985 . DOI: 10.1002/poc.941 http://doi.org/10.1002/poc.941 .

Xin, Y.; Yuan, J. . Schiff's base as a stimuli-responsive linker in polymer chemistry . Polym. Chem. , 2012 . 3 3045 - 3055 . DOI: 10.1039/c2py20290e http://doi.org/10.1039/c2py20290e .

Wojtecki, R. J.; Meador, M. A.; Rowan, S. J. . Using the dynamic bond to access macroscopically responsive structurally dynamic polymers . Nat. Mater. , 2011 . 10 14 DOI: 10.1038/nmat2891 http://doi.org/10.1038/nmat2891 .

Zhang, Y.; Tao, L.; Li, S.; Wei, Y. . Synthesis of multiresponsive and dynamic chitosan-based hydrogels for controlled release of bioactive molecules . Biomacromolecules , 2011 . 12 2894 - 2901 . DOI: 10.1021/bm200423f http://doi.org/10.1021/bm200423f .

Tseng, T. C.; Tao, L.; Hsieh, F. Y.; Wei, Y.; Chiu, I. M.; Hsu, S. H. . An injectable, self-healing hydrogel to repair the central nervous system . Adv. Mater. , 2015 . 27 3518 - 3524 . DOI: 10.1002/adma.201500762 http://doi.org/10.1002/adma.201500762 .

Dong, R.; Zhao, X.; Guo, B.; Ma, P. X. . Self-healing conductive injectable hydrogels with antibacterial activity as cell delivery carrier for cardiac cell therapy . ACS Appl. Mater. Interfaces , 2016 . 8 17138 - 17150 . DOI: 10.1021/acsami.6b04911 http://doi.org/10.1021/acsami.6b04911 .

Wei, Z.; Yang, J. H.; Liu, Z. Q.; Xu, F.; Zhou, J. X.; Zrinyi, M.; Osada, Y.; Chen, Y. M. . Novel Biocompatible Polysaccharide-Based Self-Healing Hydrogel . Adv. Funct. Mater. , 2015 . 25 1352 - 1359 . DOI: 10.1002/adfm.201401502 http://doi.org/10.1002/adfm.201401502 .

Chen, G.; Yu, Y.; Wu, X.; Wang, G.; Ren, J.; Zhao, Y. . Bioinspired multifunctional hybrid hydrogel promotes wound healing . Adv. Funct. Mater. , 2018 . 28 .

Qu, J.; Zhao, X.; Liang, Y.; Zhang, T.; Ma, P. X.; Guo, B. . Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing . Biomaterials , 2018 . 183 185 - 199 . DOI: 10.1016/j.biomaterials.2018.08.044 http://doi.org/10.1016/j.biomaterials.2018.08.044 .

Pettignano, A.; Haering, M.; Bernardi, L.; Tanchoux, N.; Quignard, F.; Diaz Diaz, D. . Self-healing alginate-gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters . Mater. Chem. Front. , 2017 . 1 73 - 79 . DOI: 10.1039/C6QM00066E http://doi.org/10.1039/C6QM00066E .

Vahedi, M.; Barzin, J.; Shokrolahi, F.; Shokrollahi, P. . Self-healing, injectable gelatin hydrogels cross-linked by dynamic schiff base linkages support cell adhesion and sustained release of antibacterial drugs . Macromol. Mater. Eng. , 2018 . 303 .

Yan, B.; Huang, J.; Han, L.; Gong, L.; Li, L.; Israelachvili, J. N.; Zeng, H. . Duplicating dynamic strain-stiffening behavior and nanomechanics of biological tissues in a synthetic self-healing flexible network hydrogel . ACS Nano , 2017 . 11 11074 - 11081 . DOI: 10.1021/acsnano.7b05109 http://doi.org/10.1021/acsnano.7b05109 .

Yan, B.; Han, L.; Xiao, H.; Zhang, J.; Huang, J.; Hu, W.; Gu, Y.; Liu, Q.; Zeng, H. . Rapid dewatering and consolidation of concentrated colloidal suspensions: mature fine tailings via self-healing composite hydrogel . ACS Appl. Mater. Interfaces , 2019 . 11 21610 - 21618 . DOI: 10.1021/acsami.9b05692 http://doi.org/10.1021/acsami.9b05692 .

Wang, W. D.; Xiang, L.; Gong, L.; Hu, W. H.; Huang, W. J.; Chen, Y. J.; Asha, A. B.; Srinivas, S.; Chen, L. Y.; Narain, R.; Zeng, H. B. . Injectable, self-healing hydrogel with tunable optical, mechanical, and antimicrobial properties . Chem. Mater. , 2019 . 31 2366 - 1376 . DOI: 10.1021/acs.chemmater.8b04803 http://doi.org/10.1021/acs.chemmater.8b04803 .

Wu, M.; Chen, J.; Huang, W.; Yan, B.; Peng, Q.; Liu, J.; Chen, L.; Zeng, H. . Injectable and self-healing nanocomposite hydrogels with ultrasensitive pH-responsiveness and tunable mechanical properties: implications for controlled drug delivery . Biomacromolecules , 2020 . 21 2409 - 2420 . DOI: 10.1021/acs.biomac.0c00347 http://doi.org/10.1021/acs.biomac.0c00347 .

Wu, M.; Chen, J.; Ma, Y.; Yan, B.; Pan, M.; Peng, Q.; Wang, W.; Han, L.; Liu, J.; Zeng, H. . Ultra elastic, stretchable, self-healing conductive hydrogels with tunable optical properties for highly sensitive soft electronic sensors . J. Mater. Chem. A , 2020 . 8 24718 - 24733 . DOI: 10.1039/D0TA09735G http://doi.org/10.1039/D0TA09735G .

Guan, Y.; Zhang, Y. . Boronic acid-containing hydrogels: synthesis and their applications . Chem. Soc. Rev. , 2013 . 42 8106 - 8121 . DOI: 10.1039/c3cs60152h http://doi.org/10.1039/c3cs60152h .

Brooks, W. L. A.; Sumerlin, B. S. . Synthesis and applications of boronic acid-containing polymers: from materials to medicine . Chem. Rev. , 2016 . 116 1375 - 1397 . DOI: 10.1021/acs.chemrev.5b00300 http://doi.org/10.1021/acs.chemrev.5b00300 .

Yan, J.; Springsteen, G.; Deeter, S.; Wang, B. . The relationship among p K a , pH, and binding constants in the interactions between boronic acids and diols—it is not as simple as it appears . Tetrahedron , 2004 . 60 11205 - 11209 . DOI: 10.1016/j.tet.2004.08.051 http://doi.org/10.1016/j.tet.2004.08.051 .

Deng, C. C.; Brooks, W. L. A.; Abboud, K. A.; Sumerlin, B. S. . Boronic acid-based hydrogels undergo self-healing at neutral and acidic pH . ACS Macro Lett. , 2015 . 4 220 - 224 . DOI: 10.1021/acsmacrolett.5b00018 http://doi.org/10.1021/acsmacrolett.5b00018 .

Chen, Y.; Diaz-Dussan, D.; Wu, D.; Wang, W.; Peng, Y.-Y.; Asha, A. B.; Hall, D. G.; Ishihara, K.; Narain, R. . Bioinspired self-healing hydrogel based on benzoxaborole-catechol dynamic covalent chemistry for 3D cell encapsulation . ACS Macro Lett. , 2018 . 7 904 - 908 . DOI: 10.1021/acsmacrolett.8b00434 http://doi.org/10.1021/acsmacrolett.8b00434 .

Deuel, v. H.; Neukom, H. . Über die reaktion von borsäure und borax mit polysacchariden und anderen hochmolekularen polyoxy-verbindungen . Die Makromolekulare Chemie , 1949 . 3 13 - 30 . DOI: 10.1002/macp.1949.020030102 http://doi.org/10.1002/macp.1949.020030102 .

He, L.; Szopinski, D.; Wu, Y.; Luinstra, G. A.; Theato, P. . Toward self-healing hydrogels using one-pot thiol-ene click and borax-diol chemistry . ACS Macro Lett. , 2015 . 4 673 - 678 . DOI: 10.1021/acsmacrolett.5b00336 http://doi.org/10.1021/acsmacrolett.5b00336 .

Tseng, T. C.; Hsieh, F. Y.; Theato, P.; Wei, Y.; Hsu, S. H. . Glucose-sensitive self-healing hydrogel as sacrificial materials to fabricate vascularized constructs . Biomaterials , 2017 . 133 20 - 28 . DOI: 10.1016/j.biomaterials.2017.04.008 http://doi.org/10.1016/j.biomaterials.2017.04.008 .

Roberts, M. C.; Hanson, M. C.; Massey, A. P.; Karren, E. A.; Kiser, P. F. . Dynamically restructuring hydrogel networks formed with reversible covalent crosslinks . Adv. Mater. , 2007 . 19 2503 - 2507 . DOI: 10.1002/adma.200602649 http://doi.org/10.1002/adma.200602649 .

Yesilyurt, V.; Ayoob, A. M.; Appel, E. A.; Borenstein, J. T.; Langer, R.; Anderson, D. G. . Mixed reversible covalent crosslink kinetics enable precise, hierarchical mechanical tuning of hydrogel networks . Adv. Mater. , 2017 . 29 1605947 DOI: 10.1002/adma.201605947 http://doi.org/10.1002/adma.201605947 .

Yesilyurt, V.; Webber, M. J.; Appel, E. A.; Godwin, C.; Langer, R.; Anderson, D. G. . Injectable self-healing glucose-responsive hydrogels with pH-regulated mechanical properties . Adv. Mater. , 2016 . 28 86 - 91 . DOI: 10.1002/adma.201502902 http://doi.org/10.1002/adma.201502902 .

Amaral, A. J. R.; Emamzadeh, M.; Pasparakis, G. . Transiently malleable multi-healable hydrogel nanocomposites based on responsive boronic acid copolymers . Polym. Chem. , 2018 . 9 525 - 537 . DOI: 10.1039/C7PY01202K http://doi.org/10.1039/C7PY01202K .

Chen, Y.; Wang, W.; Wu, D.; Nagao, M.; Hall, D. G.; Thundat, T.; Narain, R. . Injectable self-healing zwitterionic hydrogels based on dynamic benzoxaborole-sugar interactions with tunable mechanical properties . Biomacromolecules , 2018 . 19 596 - 605 . DOI: 10.1021/acs.biomac.7b01679 http://doi.org/10.1021/acs.biomac.7b01679 .

Wu, D.; Wang, W. D.; Diaz-Dussan, D.; Peng, Y. Y.; Chen, Y. J.; Narain, R.; Hall, D. G. . In situ forming, dual-crosslink network, self-healing hydrogel enabled by a bioorthogonal nopoldiol-benzoxaborolate click reaction with a wide pH range . Chem. Mater. , 2019 . 31 4092 - 4102 . DOI: 10.1021/acs.chemmater.9b00769 http://doi.org/10.1021/acs.chemmater.9b00769 .

He, L.; Fullenkamp, D. E.; Rivera, J. G.; Messersmith, P. B. . pH responsive self-healing hydrogels formed by boronate–catechol complexation . Chem. Commun. , 2011 . 47 7497 - 7499 . DOI: 10.1039/c1cc11928a http://doi.org/10.1039/c1cc11928a .

Kitano, S.; Hisamitsu, I.; Koyama, Y.; Kataoka, K.; Okano, T.; Sakurai, Y. . Effect of the incorporation of amino groups in a glucose-responsive polymer complex having phenylboronic acid moieties . Polym. Adv. Technol. , 1991 . 2 261 - 264 . DOI: 10.1002/pat.1991.220020508 http://doi.org/10.1002/pat.1991.220020508 .

Wang, W.; Xiang, L.; Diaz-Dussan, D.; Zhang, J.; Yang, W.; Gong, L.; Chen, J.; Narain, R.; Zeng, H. . Dynamic flexible hydrogel network with biological tissue-like self-protective functions . Chem. Mater. , 2020 . 32 10545 - 10555 . DOI: 10.1021/acs.chemmater.0c03526 http://doi.org/10.1021/acs.chemmater.0c03526 .

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