Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-<italic style="font-style: italic">g</italic>-polyisobutylene Graft Copolymers with Silver Nanoparticles

Cong-Lei Zhao; Yu-Zhuang Gao; Meng-Ying Wu; Hang-Tian Zhang; Yi-Xian Wu

doi:10.1007/s10118-021-2621-0

Your Location：

Home >

Browse articles >

Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles

ARTICLE | Updated：2021-08-26

- Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles
- Chinese Journal of Polymer Science Vol. 39, Issue 12, Pages: 1550-1561(2021)
- Affiliations：
  
  State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  wuyx@mail.buct.edu.cn
- Funds：
- DOI：10.1007/s10118-021-2621-0
  CLC：
- Received：25 March 2021，
  
  Revised：2021-5-12，
  
  Accepted：14 June 2021，
  
  Online First：26 August 2021，
  
  Published：18 October 2021
- Accepted：
Scan QR Code
Zhao, C. L.; Gao, Y. Z.; Wu, M. Y.; Zhang, H. T.; Wu, Y. X. Biocompatible, hemocompatible and antibacterial acylated dextran-g-polyisobutylene graft copolymers with silver nanoparticles. Chinese J. Polym. Sci. 2021, 39, 1550–1561

Cong-Lei Zhao, Yu-Zhuang Gao, Meng-Ying Wu, et al. Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1550-1561. DOI: 10.1007/s10118-021-2621-0.
Zhao, C. L.; Gao, Y. Z.; Wu, M. Y.; Zhang, H. T.; Wu, Y. X. Biocompatible, hemocompatible and antibacterial acylated dextran-g-polyisobutylene graft copolymers with silver nanoparticles. Chinese J. Polym. Sci. 2021, 39, 1550–1561 DOI： 10.1007/s10118-021-2621-0.

Cong-Lei Zhao, Yu-Zhuang Gao, Meng-Ying Wu, et al. Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1550-1561. DOI: 10.1007/s10118-021-2621-0. DOI：

摘要

Abstract

The novel amphiphilic acylated dextran-

-polyisobutylene (AcyDex-

-PIB) graft copolymers with different branch lengths (

PIB

2600–5800 g/mol) and grafting numbers (

5–28 per 1000 Dex monosaccharide) were successfully synthesized

via

the nucleophilic substitution of the hydroxyl (―OH) side groups along AcyDex backbone by the living PIB-THF

chains prepared through cationic polymerization. The crystallization of AcyDex backbone in AcyDex-

-PIB graft copolymers was confined due to the presence of PIB branches and the morphology changed from short rod-like crystals to fragment-like crystals with increasing

PIB

and

. The obvious microphase separation occurred due to the incompatibility between hard AcyDex backbone and soft PIB branches. AcyDex-

-PIB graft copolymers exhibit excellent biocompatibility towards HeLa cells and good hemocompatibility with red blood cells (RBCs)

both of which increase with increasing

. The increases of water contact angle and roughness on the surface of the graft copolymers with increasing

PIB

and

manifest the anti-protein adsorption performance. The amphiphilic AcyDex-

-PIB graft copolymers could self-assemble in aqueous solution into nanospheres

which can be used as pH-sensitive drug carriers and can release 100% of the loaded drug within 72 h at pH=7.4. AcyDex-

-PIB graft copolymers bearing silver nanoparticles (Ag-NPs

0.8 wt%–3.9 wt%

4.5–9.5 nm) show good antibacterial properties. This kind of amphiphilic graft copolymer would have a promising prospect in biological and medical fields.

关键词

Keywords

references

Liu, M.; Yue, X.; Dai, Z.; Ma, Y.; Xing, L.; Zha, Z.; Liu, S.; Li, Y. . Novel thrombo-resistant coating based on iron-polysaccharide complex multilayers . ACS Appl. Mater. Interfaces , 2009 . 1 113 - 123 . DOI: 10.1021/am800042v http://doi.org/10.1021/am800042v .

Pushpamalar, J.; Veeramachineni, A. K.; Owh, C.; Loh, X. J. . Biodegradable polysaccharides for controlled drug delivery . ChemPlusChem , 2016 . 81 504 - 514 . DOI: 10.1002/cplu.201600112 http://doi.org/10.1002/cplu.201600112 .

Mehvar, R. . Dextrans for targeted and sustained delivery of therapeutic and imaging agents . J. Control. Release , 2000 . 69 1 - 25 . DOI: 10.1016/S0168-3659(00)00302-3 http://doi.org/10.1016/S0168-3659(00)00302-3 .

Singh, S.; Gupta, A.; Sharma, D.; Gupta, B. . Dextran based herbal nanobiocomposite membranes for scar free wound healing . Int. J. Biol. Macromol. , 2018 . 113 227 - 239 . DOI: 10.1016/j.ijbiomac.2018.02.097 http://doi.org/10.1016/j.ijbiomac.2018.02.097 .

Liebert, T.; Wotschadlo, J.; Laudeley, P.; Heinze, T. . Meltable dextran esters as biocompatible and functional coating materials . Biomacromolecules , 2011 . 12 3107 - 3113 . DOI: 10.1021/bm200841b http://doi.org/10.1021/bm200841b .

Tang, Y.; Li, Y.; Xu, R.; Li, S.; Hu, H.; Xiao, C.; Wu, H.; Zhu, L.; Ming, J.; Chu, Z.; Xu, H.; Yang, X.; Li, Z. . Self-assembly of folic acid dextran conjugates for cancer chemotherapy . Nanoscale , 2018 . 10 17265 - 17274 . DOI: 10.1039/C8NR04657C http://doi.org/10.1039/C8NR04657C .

Liu, P.; Situ, J. Q.; Li, W. S.; Shan, C. L.; You, J.; Yuan, H.; Hu, F. Q.; Du, Y. Z. . High tolerated paclitaxel nano-formulation delivered by poly (lactic- co -glycolic acid)- g -dextran micelles to efficient cancer therapy . Nanomed. Nanotechnol. Biol. Med. , 2015 . 11 855 - 866 . DOI: 10.1016/j.nano.2015.02.002 http://doi.org/10.1016/j.nano.2015.02.002 .

Wang, L.; Li, X.; Sun, T.; Tsou, Y. H.; Chen, H.; Xu, X. . Dual-functional dextran-PEG hydrogel as an antimicrobial biomedical material . Macromol. Biosci. , 2017 . 18 1700325 DOI: 10.1002/mabi.201700325 http://doi.org/10.1002/mabi.201700325 .

Toman, P.; Lien, C. F.; Ahmad, Z.; Dietrich, S.; Smith, J. R.; An, Q; Molnára, É.; Pilkington, G. J.; Górecki, D. C.; Tsibouklis, J.; Barbu, E. . Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: preparation and in-vitro investigation . Acta Biomater. , 2015 . 23 250 - 262 . DOI: 10.1016/j.actbio.2015.05.009 http://doi.org/10.1016/j.actbio.2015.05.009 .

Sangeun, L.; Alexandra, S.; Naomi, H.; Vincent, T.; Adah, A. . Inflammation-responsive drug-conjugated dextran nanoparticles enhance anti-inflammatory drug efficacy . ACS Appl. Mater. Interfaces , 2018 . 10 40378 - 40387 . DOI: 10.1021/acsami.8b08254 http://doi.org/10.1021/acsami.8b08254 .

Bachelder, E. M.; Pino E. N.; Ainslie K. M. . Acetalated dextran: a tunable and acid-labile biopolymer with facile synthesis and a range of applications . Chem. Rev. , 2017 . 117 1915 - 1926 . DOI: 10.1021/acs.chemrev.6b00532 http://doi.org/10.1021/acs.chemrev.6b00532 .

Liu, Z.; Jiao, Y.; Wang, Y.; Zhou, C.; Zhang, Z. . Polysaccharides-based nanoparticles as drug delivery systems . Adv. Drug Delivery Rev. , 2008 . 60 1650 - 1662 . DOI: 10.1016/j.addr.2008.09.001 http://doi.org/10.1016/j.addr.2008.09.001 .

Guo, A.; Yu, R.; Yu, J.; Zhao, L.; Yang, F.; Zhang, Y.; Wu, Y. . Progress in synthesis of graft copolymer via cationic polymerization . Polym. Bull. , 2013 . 61 - 86 . DOI: 10.14028/j.cnki.1003-3726.2013.04.006 http://doi.org/10.14028/j.cnki.1003-3726.2013.04.006 .

Jianping, Z.; Jianfeng, G.; Yao, Z.; Jiao, Y. . Preparation and characterization of cross-linked microspheres C(Dex- g -PSSS) and their drug-carrying and colon-specific drug delivery properties . J. Biomater. Sci., Polym. Ed. , 2014 . 25 1828 - 1841 . DOI: 10.1080/09205063.2014.951246 http://doi.org/10.1080/09205063.2014.951246 .

Chandel, A. K. S.; Nutan, B.; Raval, I. H.; Jewrajka, S. K. . Self-assembly of partially alkylated dextran-graft-poly[(2-dimethylamino) ethyl methacrylate] copolymer facilitating hydrophobic/hydrophilic drug delivery and improving conetwork hydrogel properties . Biomacromolecules , 2018 . 19 1142 - 1153 . DOI: 10.1021/acs.biomac.8b00015 http://doi.org/10.1021/acs.biomac.8b00015 .

Kutsevol, N.; Bezuglyi, M.; Bezugla, T.; Rawiso, M. . Synthesis of silver nanoparticles in star-like dextran-graft-polyacrylamide matrices . Mol. Cryst. Liq. Cryst. , 2014 . 590 179 - 185 . DOI: 10.1080/15421406.2013.874223 http://doi.org/10.1080/15421406.2013.874223 .

Lian, H.; Du, Y.; Chen, X.; Duan, L.; Gao, G.; Xiao, C. . Core cross-linked poly(ethylene glycol)-graft-dextran nanoparticles for reduction and pH dual responsive intracellular drug delivery . J. Colloid Interface Sci. , 2017 . 496 201 - 210 . DOI: 10.1016/j.jcis.2017.02.032 http://doi.org/10.1016/j.jcis.2017.02.032 .

Ochrimenko, S.; Vollrath, A.; Tauhardt, L.; Kempe, K.; Schubert, S.; Schubert, U. S.; Fischer, D. . Dextran-graft-linear poly(ethylene imine)s for gene delivery: importance of the linking strategy . Carbohydr. Polym. , 2014 . 113 597 - 606 . DOI: 10.1016/j.carbpol.2014.07.048 http://doi.org/10.1016/j.carbpol.2014.07.048 .

Zhao, C. L.; Deng, J. R.; Gao, Y. Z.; Wu, Y. X. . Hemocompatible, biocompatible and antifouling acylated dextran- g -polytetrahydrofuran graft copolymer with silver nanoparticles: synthesis, characterization and properties . Mater. Sci. Eng. C , 2021 . 123 111998 DOI: 10.1016/j.msec.2021.111998 http://doi.org/10.1016/j.msec.2021.111998 .

Chang, T. X.; Zhang, H. T.; Lu, C. J.; Wu, Y. X. . In situ synthesis and characterization of chitosan- g -polytetrahydrofuran graft copolymer/Ag nanocomposite via living cationic polymerization . Acta Polymerica Sinica (in Chinese) , 2018 . 700 - 711 . DOI: 10.11777/j.issn1000-3304.2017.17290 http://doi.org/10.11777/j.issn1000-3304.2017.17290 .

Gao, Y. Z.; Chang, T. X.; Wu Y. X. . In-situ preparation and properties of bio-renewable acylated sodium alginate- g -polytetrahydrofuran/Ag-NPs nanocomposites . Appl. Surf. Sci. , 2019 . 483 1027 - 1036 . DOI: 10.1016/j.apsusc.2019.03.103 http://doi.org/10.1016/j.apsusc.2019.03.103 .

Deng, J., Wu, Y. . Green synthesis and biomedical properties of novel hydroxypropyl cellulose- g -polytetrahydrofuran graft copolymers with silver nanoparticles . Ind. Eng. Chem. Res. , 2020 . 59 732 - 742 . DOI: 10.1021/acs.iecr.9b04799 http://doi.org/10.1021/acs.iecr.9b04799 .

Wu, Y. X.; Zhou, Q.; Du, J.; Wang, N. . Controlled/living cationic polymerization of olefins: system, process and application . Acta Polymerica Sinica (in Chinese) , 2017 . 1047 - 1057 . DOI: 10.11777/j.issn1000-3304.2017.17045 http://doi.org/10.11777/j.issn1000-3304.2017.17045 .

Guo, A. R.; Yang, X. J.; Yan, P. F.; Wu, Y. X. . Synthesis of highly reactive polyisobutylenes with exo-olefin terminals via controlled cationic polymerization with H 2 O/FeCl 3 /iPrOH initiating system in nonpolar hydrocarbon media . J. Polym. Sci., Part A: Polym. Chem. , 2013 . 51 4200 - 4212 . DOI: 10.1002/pola.26834 http://doi.org/10.1002/pola.26834 .

Yang, S. X.; Fan, Z. Y.; Zhang, F. Y.; Li, S. H.; Wu, Y. X. . Functionalized copolymers of isobutylene with vinyl phenol: synthesis, characterization, and property . Chinese J. Polym. Sci. , 2019 . 37 919 - 929 . DOI: 10.1007/s10118-019-2329-6 http://doi.org/10.1007/s10118-019-2329-6 .

Kennedy, J. P. . Tailoring polymers for biological uses . Chemtech , 1994 . 24 24 - 31 . .

Ranade, S. V.; Richard, R. E.; Helmus, M. N. . Styrenic block copolymers for biomaterial and drug delivery applications . Acta Biomater. , 2005 . 1 137 - 144 . DOI: 10.1016/j.actbio.2004.09.004 http://doi.org/10.1016/j.actbio.2004.09.004 .

Zhang, F.; Zhang, H.; Yang, T.; Kong, B.; Guo, A. R.; Zhang, Q.; Wu, Y. X . Synthesis and property of novel functionalized polytetrahydrofuran- b -polyisobutylene- b -polytetrahydrofuran triblock copolymers . Acta Polymerica Sinica (in Chinese) , 2020 . 51 98 - 116 . DOI: 10.11777/j.issn1000-3304.2020.19151 http://doi.org/10.11777/j.issn1000-3304.2020.19151 .

Puskas, J. E.; Chen, Y. . Biomedical application of commercial polymers and novel polyisobutylene-based thermoplastic elastomers for soft tissue replacement . Biomacromolecules , 2004 . 5 1141 - 1154 . DOI: 10.1021/bm034513k http://doi.org/10.1021/bm034513k .

Wei, M. J.; Guo, A. R.; Wu, Y. X. . Microstructure and micromorphology of poly ( γ -benzyl- L -glutamate)- g -(polytetrahydrofuran- b -polyisobutylene) copolymer . Acta Polymerica Sinica (in Chinese) , 2017 . 506 - 515 . DOI: 10.11777/j.issn1000-3304.2017.16152 http://doi.org/10.11777/j.issn1000-3304.2017.16152 .

Ren, K.; Hen, J. L.; Zhang, M. Z.; Wu, Y. X.; Ni, P. H. . Synthesis and characterization of pH-sensitive copolymer mPEG-acetal-PIB and fabrication of hydrogel for wound dressing . Acta Chim. Sin. (in Chinese) , 2015 . 73 1038 - 1046 . .

Rajasekhar, T.; Haldar, U.; De, P.; Emert, J.; Faust, R. . Cationic copolymerization and multicomponent polymerization of isobutylene with C4 olefins . Macromolecules , 2017 . 50 8325 - 8333 . DOI: 10.1021/acs.macromol.7b01941 http://doi.org/10.1021/acs.macromol.7b01941 .

Ren, K.; Zhang, M.; He, J.; Wu, Y.; Ni, P. . Preparation of polymeric prodrug paclitaxel-poly(lactic acid)- b -polyisobutylene and its application in coatings of drug eluting stent . ACS Appl. Mater. Interfaces , 2015 . 7 11263 - 11271 . DOI: 10.1021/acsami.5b01410 http://doi.org/10.1021/acsami.5b01410 .

Ma, W.; Wu, Y.; Feng, L.; Xu, R. . Synthesis of poly(styrene- co -isopropenyl acetate)- g -polyisobutylene graft copolymers via combination of radical polymerization with cationic polymerization . Polymer , 2012 . 53 3185 - 3193 . DOI: 10.1016/j.polymer.2012.05.028 http://doi.org/10.1016/j.polymer.2012.05.028 .

Liu, Y.; Wu, Y.; Li, D.; Li, Q.; Wu, G. . Synthesis of graft copolymer (PVIPA- g -PIB) via cationic polymerization of isobutylene with PVIPA macroinitiator/TiCl 4 initiating system . Acta Polymerica Sinica (in Chinese) , 2007 . 1127 - 1134 . .

Li, Q. Y.; Wu, Y. X.; Ma, W. Y.; Xu, R. W.; Wu, G. Y.; Yang, W. T. . Synthesis of graft copolymers with polyisobutylene branch chains . Chinese J. Polym. Sci. , 2010 . 28 449 - 456 . DOI: 10.1007/s10118-010-9092-z http://doi.org/10.1007/s10118-010-9092-z .

Wei, M. J.; Zhang, Q.; Zhang, H. T.; Wu, Y. X. . In situ preparation and properties of poly( γ -benzyl- L -glutamate)- g -(polytetrahydrofuran- b -polyisobutylene)/Ag nanocomposites via cationic polymerization . Acta Polymerica Sinica (in Chinese) , 2018 . 464 - 474 . DOI: 10.11777/j.issn1000-3304.2017.17130 http://doi.org/10.11777/j.issn1000-3304.2017.17130 .

Chang, T. X.; Wei, Z, T.; Wu, M. Y.; Zhang, H. T.; Gao, Y. Z.; Wu, Y. X. . Amphiphilic chitosan- g -polyisobutylene graft copolymers: synthesis, characterization, and properties . ACS Appl. Polym. Mater. , 2020 . 2 234 - 247 . DOI: 10.1021/acsapm.9b00771 http://doi.org/10.1021/acsapm.9b00771 .

Gao, Y. Z.; Chang, T. X.; Wu, Y. X. . In-situ synthesis of acylated sodium alginate- g -(tetrahydrofuran 5 - b -polyisobutylene) terpolymer/Ag-NPs nanocomposites . Carbohydr. Polym. , 2019 . 219 201 - 209 . DOI: 10.1016/j.carbpol.2019.04.087 http://doi.org/10.1016/j.carbpol.2019.04.087 .

Deng, J.; Zhao, C.; Wei, Z.; Wu, Y. . Amphiphilic graft copolymers of hydroxypropyl cellulose backbone with nonpolar polyisobutylene branches . Chinese J. Polym. Sci. , 2021 . 39 1029 - 1039 . DOI: 10.1007/s10118-021-2546-7 http://doi.org/10.1007/s10118-021-2546-7 .

G, uo; A;, Yang F.; Yu, R.; Wu, Y. . Real-time monitoring of living cationic ring-opening polymerization of THF and direct prediction of equilibrium molecular weight of poly THF . Chinese J. Polym. Sci. , 2015 . 33 23 - 35 . DOI: 10.1007/s10118-015-1571-9 http://doi.org/10.1007/s10118-015-1571-9 .

Cai, L.; Qin, X.; Xu, Z.; Song, Y.; Chen, J. . Comparison of cytotoxicity evaluation of anticancer drugs between real-time cell analysis and CCK-8 method . ACS Omega , 2019 . 4 12036 - 12042 . DOI: 10.1021/acsomega.9b01142 http://doi.org/10.1021/acsomega.9b01142 .

Zhao, J.; Bai, L.; Muhammad, K.; Ren, X. K.; Feng, Y. . Construction of hemocompatible and histocompatible surface by grafting antithrombotic peptide ACH 11 and hydrophilic PEG . ACS Biomater. Sci. Eng. , 2019 . 5 2846 - 2857 . DOI: 10.1021/acsbiomaterials.9b00431 http://doi.org/10.1021/acsbiomaterials.9b00431 .

Gholamali, H.; Shafiekhani, A.; Darabi, E.; Elahi, S. M. . Synthesis of Ag and Au nanoparticles embedded in carbon film: optical, crystalline and topography analysis . Results Phys. , 2018 . 8 336 - 340 . DOI: 10.1016/j.rinp.2017.12.033 http://doi.org/10.1016/j.rinp.2017.12.033 .

Hawkins, M. L.; Schott, S. S.; Grigoryan, B.; Rufin, M. A.; Ngo, B. K. D.; Vanderwal, L.; Stafslien, S. J.; Grunlanet, M. A. . Anti-protein and anti-bacterial behavior of amphiphilic silicones . Polym. Chem. , 2017 . 8 5239 - 5251 . DOI: 10.1039/C7PY00944E http://doi.org/10.1039/C7PY00944E .

Xu, J.; Fan, X.; Yang, J.; Ma, C.; Ye, X.; Zhang, G. . Poly( l -lactide- co -2-(2-methoxyethoxy) ethyl methacrylate): a biodegradable polymer with protein resistance . Colloids Surf. B , 2014 . 116 531 - 536 . DOI: 10.1016/j.colsurfb.2014.01.047 http://doi.org/10.1016/j.colsurfb.2014.01.047 .

Soppimath, K. S.; Tan, D. W.; Yang, Y. Y. . pH-triggered thermally responsive polymer core-shell nanoparticles for drug delivery . Adv. Mater. , 2005 . 17 318 - 323 . DOI: 10.1002/adma.200401057 http://doi.org/10.1002/adma.200401057 .

Chumachenko, V.; Shyichuk, A.; Kutsevol, N.; Rawiso, M. . Green synthesis of silver nanoparticles using dextran-graft-polyacrylamide as template . Micro Nano Lett. , 2016 . 11 256 - 259 . DOI: 10.1049/mnl.2015.0547 http://doi.org/10.1049/mnl.2015.0547 .

Chandran, S.; Venkatesan, P.; Bheeman, D.; Rajamani, R.; Bellan, C. . Shape controlled synthesis of dextran sulfate stabalized silver nanoparticles: biocompatibility and anticancer activity . Mater. Res. Express , 2019 . 6 45 - 66 . DOI: 10.1088/2053-1591/aafefc http://doi.org/10.1088/2053-1591/aafefc .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Amphiphilic Graft Copolymers of Hydroxypropyl Cellulose Backbone with Nonpolar Polyisobutylene Branches

Phenols/Al(C6F5)3Initiation Systems for Cationic Polymerizations of Isobutylene

SYNTHESIS OF HIGH MOLECULAR WEIGHT POLYISOBUTYLENE VIA CATIONIC POLYMERIZATION AT ELEVATED TEMPERATURES

SYNTHESIS OF HIGHLY REACTIVE POLYISOBUTYLENES WITH BF3·CYCLOHEXANOL INITIATING SYSTEM

End-to-End Neuron-inspired Signal Transduction Using Organic Electrochemical Transistors

Related Author

Zhi-Tao Wei

Jin-Rui Deng

Dong-Mei Cui

Xin-Li Liu

Qi-Yuan Wang

Ling Cai

Yi-xian Wu

Jue Wang

Related Institution

Department of Polymer Science and Engineering, University of Science and Technology of China

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology

State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers (Ministry of Education), Beijing University of Chemical Technology

Center of Excellence for Advanced Materials Research (CEAMR) and Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah21589, Saudi Arabia

⁰

Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles

DOI：10.1007/s10118-021-2621-0

摘要

Abstract

关键词

Keywords

references