Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery

M. Kurdtabar; S. Saif Heris; M. Dezfulian

doi:10.1007/s10118-021-2613-0

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Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery

ARTICLE | Updated：2021-07-30

- Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery
- Chinese Journal of Polymer Science Vol. 39, Issue 12, Pages: 1597-1608(2021)
- Affiliations：
  
  a.Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj 31485-313, Iran
  b.Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj 31485-313, Iran
- Author bio：
  
  m.kurdtabar@kiau.ac.ir
- Funds：
- DOI：10.1007/s10118-021-2613-0
  CLC：
- Received：11 April 2021，
  
  Accepted：25 May 2021，
  
  Online First：30 July 2021，
  
  Published：18 October 2021
- Accepted：
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Kurdtabar, M.; Saif Heris, S.; Dezfulian, M. Characterization of a multi-responsive magnetic graphene oxide nanocomposite hydrogel and its application for DOX delivery. Chinese J. Polym. Sci. 2021, 39, 1597–1608

M. Kurdtabar, S. Saif Heris, M. Dezfulian. Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1597-1608.
Kurdtabar, M.; Saif Heris, S.; Dezfulian, M. Characterization of a multi-responsive magnetic graphene oxide nanocomposite hydrogel and its application for DOX delivery. Chinese J. Polym. Sci. 2021, 39, 1597–1608 DOI： 10.1007/s10118-021-2613-0.

M. Kurdtabar, S. Saif Heris, M. Dezfulian. Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1597-1608. DOI： 10.1007/s10118-021-2613-0.

摘要

Abstract

Nanocomposite hydrogels are one of the most important types of biomaterials which can be used in many different applications such as drug delivery and tissue engineering. Incorporation of nanoparticles within a hydrogel matrix can provide unique characteristics like remote stimulate and improved mechanical strength. In this study

the synthesis of graphene oxide and graphene oxide nanocomposite hydrogel has been studied. Nanocomposite hydrogel was synthesized using carboxymethyl cellulose as a natural base

acrylic acid as a comonomer

graphene oxide as a filler

ammonium persulfate as an initiator

and iron nanoparticles as a crosslinking agent. The effect of reaction variables such as the iron nanoparticles

graphene oxide

ammonium persulfate

and acrylic acid were examined to achieve a hydrogel with maximum absorbency. Doxorubicin

an anti-cancer chemotherapy drug

was loaded into this hydrogel and its release behaviors were examined in the phosphate buffer solutions with different pH values. The structure of the graphene oxide and the optimized hydrogel were confirmed by Fourier-transform infrared spectroscopy

Raman spectroscopy

X-ray diffraction

scanning electron microscopy

and atomic force microscopy.

关键词

Keywords

references

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