Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion

Ya-Qiang Wang; Xue-Yu Dou; Hu-Fei Wang; Xing Wang; De-Cheng Wu

doi:10.1007/s10118-021-2584-1

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Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion

ARTICLE | Updated：2021-05-28

- Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion
- Chinese Journal of Polymer Science Vol. 39, Issue 11, Pages: 1421-1430(2021)
- Affiliations：
  
  a.Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.University of Chinese Academy of Sciences, Beijing 100049, China
  c.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
- Author bio：
  
  wangxing@iccas.ac.cn (X.W.)
  wudc@sustech.edu.cn (D.C.W.)
- Funds：
- DOI：10.1007/s10118-021-2584-1
  CLC：
- Received：22 March 2021，
  
  Revised：2021-3-29，
  
  Accepted：30 March 2021，
  
  Online First：28 May 2021，
  
  Published：18 September 2021
- Accepted：
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Wang, Y. Q.; Dou, X. Y.; Wang, H. F.; Wang, X.; Wu, D. C. Dendrimer-based hydrogels with controlled drug delivery property for tissue adhesion. Chinese J. Polym. Sci. 2021, 39, 1421–1430

Ya-Qiang Wang, Xue-Yu Dou, Hu-Fei Wang, et al. Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1421-1430.
Wang, Y. Q.; Dou, X. Y.; Wang, H. F.; Wang, X.; Wu, D. C. Dendrimer-based hydrogels with controlled drug delivery property for tissue adhesion. Chinese J. Polym. Sci. 2021, 39, 1421–1430 DOI： 10.1007/s10118-021-2584-1.

Ya-Qiang Wang, Xue-Yu Dou, Hu-Fei Wang, et al. Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1421-1430. DOI： 10.1007/s10118-021-2584-1.

摘要

Abstract

In recent years

the hydrogel-based tissue adhesives have been extensively investigated for their excellent biocompatibility and the ability to be administered directly within the adherent tissue. To meet the requirement for more controllable release in various physiological settings

the components of hydrogel adhesive should be more precisely tailored. In this work

the POSS-ace-PEG hydrogel adhesive was fabricated with the polyacetal dendrimer G1'-[NH

Cl]

and poly(ethylene glycol) succinimidyl carbonate (PEG-SC) due to the regular peripheral amino structure of G1'-[NH

Cl]

. Rheological and adhesion tests demonstrated that the hydrogel adhesive had good mechanical and adhesive properties

which could effectively adhere to the pigskin and severed nerves. Moreover

the tissue adhesive exhibited good stability under neutral conditions and the rapid degradation under acidic conditions

allowing for the release of doxycycline hydrochloride (DOX) drug in response to pH. Together

these results suggested that the POSS-ace-PEG adhesive had the potential to provide an alternative to tissue adhesives for applications in pathological environments (inflammation

tumors

etc

.).

关键词

Keywords

references

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