Monoclonal Antibody-conjugated Polyphosphoester-<italic style="font-style: italic">hyd</italic>-DOX Prodrug Nanoparticles for Targeted Chemotherapy of Liver Cancer Cells

Ya-Kui Huang; Hong-Rui Tian; Ming-Zu Zhang; Jin-Lin He; Jian Liu; Pei-Hong Ni

doi:10.1007/s10118-021-2582-3

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Monoclonal Antibody-conjugated Polyphosphoester-hyd-DOX Prodrug Nanoparticles for Targeted Chemotherapy of Liver Cancer Cells

ARTICLE | Updated：2021-06-25

- Monoclonal Antibody-conjugated Polyphosphoester-hyd-DOX Prodrug Nanoparticles for Targeted Chemotherapy of Liver Cancer Cells
- Chinese Journal of Polymer Science Vol. 39, Issue 11, Pages: 1392-1402(2021)
- Affiliations：
  
  a.College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis, Soochow University, Suzhou 215123, China
  b.Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China
- Author bio：
  
  phni@suda.edu.cn
- Funds：
- DOI：10.1007/s10118-021-2582-3
  CLC：
- Received：25 February 2021，
  
  Revised：2021-3-13，
  
  Accepted：19 March 2021，
  
  Online First：25 June 2021，
  
  Published：18 September 2021
- Accepted：
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Huang, Y. K.; Tian, H. R.; Zhang, M. Z.; He, J. L.; Liu, J.; Ni, P. H. Monoclonal antibody-conjugated polyphosphoester-hyd-DOX prodrug nanoparticles for targeted chemotherapy of liver cancer cells. Chinese J. Polym. Sci. 2021, 39, 1392–1402

Ya-Kui Huang, Hong-Rui Tian, Ming-Zu Zhang, et al. Monoclonal Antibody-conjugated Polyphosphoester-hyd-DOX Prodrug Nanoparticles for Targeted Chemotherapy of Liver Cancer Cells[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1392-1402. DOI: 10.1007/s10118-021-2582-3.
Huang, Y. K.; Tian, H. R.; Zhang, M. Z.; He, J. L.; Liu, J.; Ni, P. H. Monoclonal antibody-conjugated polyphosphoester-hyd-DOX prodrug nanoparticles for targeted chemotherapy of liver cancer cells. Chinese J. Polym. Sci. 2021, 39, 1392–1402 DOI： 10.1007/s10118-021-2582-3.

Ya-Kui Huang, Hong-Rui Tian, Ming-Zu Zhang, et al. Monoclonal Antibody-conjugated Polyphosphoester-hyd-DOX Prodrug Nanoparticles for Targeted Chemotherapy of Liver Cancer Cells[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1392-1402. DOI: 10.1007/s10118-021-2582-3. DOI：

摘要

Abstract

In order to overcome the limitation of traditional active nano-therapeutic drugs on tumor targeting efficiency which cannot reach the receptor/target in sufficient amount in the body

in this work

we developed a monoclonal antibody (mAb) and a polymer-

hyd

-doxorubicin prodrug conjugate

which enables the self-assembled nanoparticles to have precise targeting

tumor tissue aggregation and pH-sensitive drug release. We first prepared an amphiphilic polymer prodrug

abbreviated as H

N-PEEP-

-PBYP-

hyd

-DOX

via

a combination of ring-opening polymerization (ROP) and “click” chemistry

in which PEEP and PBYP represent two kinds of phosphoester segmemts

hyd

- is hydrazone bond. After self-assembly into prodrug nanoparticles (PDNPs) with a diameter of about 93 nm

CD147 mAb was conjugated onto the PDNPs by EDC/NHS chemistry to form mAb-PDNPs. For the PDNPs and mAb-PDNPs

we also investigated their stability

in vitro

drug release behavior and cellular uptake. The results showed that the pH-responsive PDNPs can remain relatively stable under the condition of PB 7.4 buffer solution. However

under acidic conditions or in the presence of phosphodiesterase I (PDE I)

both the amount and rate of DOX release increased at the same incubation period. Cytotoxicity assay showed that mAb-PDNPs exhibited higher cytotoxicity (IC

: 1.12 mg·L

−1

) against HepG2 cells than PDNPs (IC

: 2.62 mg·L

−1

) without monoclonal antibody. The nanoparticles with antibodies mAb-PDNPs have relatively better stability and can directly achieve the targeting drug delivery through CD147 mAb.

关键词

Keywords

references

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⁰

Monoclonal Antibody-conjugated Polyphosphoester-hyd-DOX Prodrug Nanoparticles for Targeted Chemotherapy of Liver Cancer Cells

DOI：10.1007/s10118-021-2582-3

摘要

Abstract

关键词

Keywords

references