Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

Xiao Liu; Jian-Wei Guo; Ya-Dong Liu; Ming Liu; Hui Liu; Miao-Miao Han; Sheng-Xiang Ji

doi:10.1007/s10118-021-2578-z

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Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

ARTICLE | Updated：2021-05-27

- Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films
- Chinese Journal of Polymer Science Vol. 39, Issue 8, Pages: 1020-1028(2021)
- Affiliations：
  
  a.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  b.School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
- Author bio：
  
  hanmiaomiao@ciac.ac.cn (M.M.H.)
  sji@ciac.ac.cn (S.X.J.)
- Funds：
- DOI：10.1007/s10118-021-2578-z
  CLC：
- Received：08 February 2021，
  
  Revised：2021-3-9，
  
  Accepted：10 March 2021，
  
  Online First：27 May 2021，
  
  Published：18 June 2021
- Accepted：
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Liu, X.; Guo, J. W.; Liu, Y. D.; Liu, M.; Liu, H.; Han, M. M.; Ji, S. X. Antibacterial thermoplastic polyurethane/PL-DOSS composite films. Chinese J. Polym. Sci. 2021, 39, 1020–1028

Xiao Liu, Jian-Wei Guo, Ya-Dong Liu, et al. Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films[J]. Chinese Journal of Polymer Science, 2021, 39(8): 1020-1028.
Liu, X.; Guo, J. W.; Liu, Y. D.; Liu, M.; Liu, H.; Han, M. M.; Ji, S. X. Antibacterial thermoplastic polyurethane/PL-DOSS composite films. Chinese J. Polym. Sci. 2021, 39, 1020–1028 DOI： 10.1007/s10118-021-2578-z.

Xiao Liu, Jian-Wei Guo, Ya-Dong Liu, et al. Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films[J]. Chinese Journal of Polymer Science, 2021, 39(8): 1020-1028. DOI： 10.1007/s10118-021-2578-z.

摘要

Abstract

Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein

we prepare an antibacterial composite (TPU-

) through blending medical grade thermoplastic polyurethane (TPU) and the complex (PL-DOSS) of

-polylysine (

-PL) and docusate sodium (DOSS).

99% reduction of colony forming unit (CFU) can be obtained in TPU-

composite films even at relatively low content of PL-DOSS

e.g.

0.13% for Methicillin resistant

S. aureus

(MRSA) and 0.5% for

E. coli

. The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ~100 nm. TPU-

composite films exhibit long-term stability in saline and good biocompatibility

and retain mechanical properties of TPU.

关键词

Keywords

references

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