Fabrication of Highly Anisotropic and Interconnected Porous Scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering

Ya-Hui Liu; Wei Liu; Zi-Li Zheng; Xin Wei; Nouman Ali Shah; Hao Lin; Bai-Song Zhao; Shi-Shu Huang; Jia-Zhuang Xu; Zhong-Ming Li

doi:10.1007/s10118-021-2573-4

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Fabrication of Highly Anisotropic and Interconnected Porous Scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering

ARTICLE | Updated：2021-05-25

- Fabrication of Highly Anisotropic and Interconnected Porous Scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering
- Chinese Journal of Polymer Science Vol. 39, Issue 9, Pages: 1191-1199(2021)
- Affiliations：
  
  a.College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
  b.Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China
  c.Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu 610065, China
- Author bio：
  
  zhaobaisong@gwcmc.org (B.S.Z.)
  jzxu@scu.edu.cn (J.Z.X.)
- Funds：
- DOI：10.1007/s10118-021-2573-4
  CLC：
- Received：30 January 2021，
  
  Revised：2021-2-22，
  
  Accepted：24 February 2021，
  
  Online First：25 May 2021，
  
  Published：18 July 2021
- Accepted：
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Liu, Y. H.; Liu, W.; Zheng, Z. L.; Wei, X.; Shah, N. A.; Lin, H.; Zhao, B. S.; Huang, S. S.; Xu, J. Z.; Li, Z. M. Fabrication of highly anisotropic and interconnected porous scaffolds to promote preosteoblast proliferation for bone tissue engineering. Chinese J. Polym. Sci. 2021, 39, 1191–1199

Ya-Hui Liu, Wei Liu, Zi-Li Zheng, et al. Fabrication of Highly Anisotropic and Interconnected Porous Scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1191-1199.
Liu, Y. H.; Liu, W.; Zheng, Z. L.; Wei, X.; Shah, N. A.; Lin, H.; Zhao, B. S.; Huang, S. S.; Xu, J. Z.; Li, Z. M. Fabrication of highly anisotropic and interconnected porous scaffolds to promote preosteoblast proliferation for bone tissue engineering. Chinese J. Polym. Sci. 2021, 39, 1191–1199 DOI： 10.1007/s10118-021-2573-4.

Ya-Hui Liu, Wei Liu, Zi-Li Zheng, et al. Fabrication of Highly Anisotropic and Interconnected Porous Scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1191-1199. DOI： 10.1007/s10118-021-2573-4.

摘要

Abstract

Mimicking the complex structure of natural bone remains a challenge for bone tissue scaffolds. In this study

a novel processing strategy was developed to prepare the bone-like scaffolds that are featured by highly oriented and fully interconnected pores. This type of biomimetic scaffolds was evolved from solid phase stretching of immiscible polycaprolactone (PCL)/poly(ethylene oxide) (PEO) blends with co-continuous structure and the pore morphology was inherited from selective extraction of water soluble PEO phase. The pore anisotropy was readily tuned by varying the stretching strain without loss of interconnectivity. Significant promotion in preosteoblast proliferation

alkaline phosphatase activity and osteogenic gene expression was observed in the oriented porous scaffolds compared to the isotropic porous counterpart. The oriented architecture provided a topographical cue for aligned growth of preosteoblasts

which activated the Wnt/

-catenin signaling pathway. The proposed strategy enriches the toolbox for the scaffold design and fabrication for bone tissue engineering.

关键词

Keywords

references

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