Feasible Fabrication of Hollow Micro-vesicles by Non-amphiphilic Macromolecules Based on Interfacial Cononsolvency

Jing-Hong Wang; Rui Chen; Zi-Qing Zhao; Jie Shen; He Yang; Yan Luo; Gao-Jian Chen; Hong Chen; John L. Brash

doi:10.1007/s10118-021-2541-z

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Feasible Fabrication of Hollow Micro-vesicles by Non-amphiphilic Macromolecules Based on Interfacial Cononsolvency

ARTICLE | Updated：2021-03-23

- Feasible Fabrication of Hollow Micro-vesicles by Non-amphiphilic Macromolecules Based on Interfacial Cononsolvency
- Chinese Journal of Polymer Science Vol. 39, Issue 7, Pages: 856-864(2021)
- Affiliations：
  
  a.State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
  b.Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China
  c.Department of Chemical Engineering and School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada
- Author bio：
  
  chenrui@suda.edu.cn (R.C.)
  chenh@suda.edu.cn (H.C.)
- Funds：
- DOI：10.1007/s10118-021-2541-z
  CLC：
- Received：30 November 2020，
  
  Revised：2020-12-18，
  
  Accepted：22 December 2020，
  
  Online First：23 March 2021，
  
  Published：14 May 2021
- Accepted：
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Wang, J. H.; Chen, R.; Zhao, Z. Q.; Shen, J.; Yang, H.; Luo, Y.; Chen, G. J.; Chen, H.; Brash, J. L. Feasible fabrication of hollow micro-vesicles by non-amphiphilic macromolecules based on interfacial cononsolvency. Chinese J. Polym. Sci. 2021, 39, 856–864

Jing-Hong Wang, Rui Chen, Zi-Qing Zhao, et al. Feasible Fabrication of Hollow Micro-vesicles by Non-amphiphilic Macromolecules Based on Interfacial Cononsolvency[J]. Chinese Journal of Polymer Science, 2021, 39(7): 856-864.
Wang, J. H.; Chen, R.; Zhao, Z. Q.; Shen, J.; Yang, H.; Luo, Y.; Chen, G. J.; Chen, H.; Brash, J. L. Feasible fabrication of hollow micro-vesicles by non-amphiphilic macromolecules based on interfacial cononsolvency. Chinese J. Polym. Sci. 2021, 39, 856–864 DOI： 10.1007/s10118-021-2541-z.

Jing-Hong Wang, Rui Chen, Zi-Qing Zhao, et al. Feasible Fabrication of Hollow Micro-vesicles by Non-amphiphilic Macromolecules Based on Interfacial Cononsolvency[J]. Chinese Journal of Polymer Science, 2021, 39(7): 856-864. DOI： 10.1007/s10118-021-2541-z.

摘要

Abstract

Herein we present a new perspective showing that water-soluble liquids

when added to water

undergo transient emulsification before complete dissolution. Thus

non-amphiphilic macromolecules can self-assemble at the two-miscible-phase interface when cononsolvent effect appears. A representative case shown here is that when poly(

-isopropylacrylamide) (PNIPAm)

prepared by aqueous radical polymerization

in methanol solution is added into water

the polymer chains rapidly self-assemble into hollow micro-vesicles based on the cononsolvency at water/methanol interface. This finding provides a subtle strategy to prepare hollow micro-vesicles by non-amphiphilic polymers without template participating. We proposed a new concept “interfacial cononsolvency” to describe the formation process. Due to the easy modification process

sugar-contained PNIPAm chains are synthesized by copolymerization. As an application example

it is shown that these sugar-contained PNIPAm chains can afford “sweet” micro-vesicles (containing glucose residues). And the “sweet” micro-vesicles can well mimick the protocells which are involved in the recognition of bacteria.

关键词

Keywords

references

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