A Single-wavelength NIR-triggered Polymer for <italic style="font-style: italic">in situ</italic> Generation of Peroxynitrite (ONOO<sup>–</sup>) to Enhance Phototherapeutic Efficacy

Xiang Zhang; Da-Wei Jiang; Guo-Liang Yang; Yu-Cheng Zhu; Jia Tian; Hong-Liang Cao; Yun Gao; Wei-An Zhang

doi:10.1007/s10118-021-2540-0

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A Single-wavelength NIR-triggered Polymer for in situ Generation of Peroxynitrite (ONOO^–) to Enhance Phototherapeutic Efficacy

ARTICLE | Updated：2021-12-31

- A Single-wavelength NIR-triggered Polymer for in situ Generation of Peroxynitrite (ONOO^–) to Enhance Phototherapeutic Efficacy
- Chinese Journal of Polymer Science Vol. 39, Issue 6, Pages: 692-701(2021)
- Affiliations：
  
  Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China
- Author bio：
  
  yungao127@163.com (Y.G.)
  wazhang@ecust.edu.cn (W.A.Z.)
- Funds：
- DOI：10.1007/s10118-021-2540-0
  CLC：
- Received：11 November 2020，
  
  Accepted：16 December 2020，
  
  Online First：15 January 2021，
  
  Published：15 April 2021
- Accepted：
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Zhang, X.; Jiang, D. W.; Yang, G. L.; Zhu, Y. C.; Tian. J.; Cao, H. L.; Gao, Y.; Zhang, W. A. A single-wavelength NIR-triggered polymer for , in situ, generation of peroxynitrite (ONOO^–) to enhance phototherapeutic efficacy. Chinese J. Polym. Sci. 2021, 39, 692–701 DOI: 10.1007/s10118-021-2540-0.

Xiang Zhang, Da-Wei Jiang, Guo-Liang Yang, et al. A Single-wavelength NIR-triggered Polymer for in situ Generation of Peroxynitrite (ONOO^–) to Enhance Phototherapeutic Efficacy[J]. Chinese Journal of Polymer Science, 2021, 39(6): 692-701. DOI: 10.1007/s10118-021-2540-0.
Zhang, X.; Jiang, D. W.; Yang, G. L.; Zhu, Y. C.; Tian. J.; Cao, H. L.; Gao, Y.; Zhang, W. A. A single-wavelength NIR-triggered polymer for , in situ, generation of peroxynitrite (ONOO^–) to enhance phototherapeutic efficacy. Chinese J. Polym. Sci. 2021, 39, 692–701 DOI: 10.1007/s10118-021-2540-0. DOI：

Xiang Zhang, Da-Wei Jiang, Guo-Liang Yang, et al. A Single-wavelength NIR-triggered Polymer for in situ Generation of Peroxynitrite (ONOO^–) to Enhance Phototherapeutic Efficacy[J]. Chinese Journal of Polymer Science, 2021, 39(6): 692-701. DOI: 10.1007/s10118-021-2540-0. DOI：

摘要

Abstract

Phototherapies including photodynamic therapy (PDT) and photothermal therapy (PTT) are the most promising and non-invasive cancer treatments. However

the efficacy of mono-therapy of PDT or PTT is often limited by the phototherapeutic defects such as low light penetration depth of photosensitizers and insufficiency of photothermal agents. Peroxynitrite (ONOO

−

) has been proved to be an efficient oxidizing and nitrating agent that involves in various physiological and pathological processes. Therefore

ONOO

−

produced in tumor site could be an effective treatment in cancer therapy. Herein

a novel cyanine dye-based (Cy7) polymer nanoplatform is developed for enhanced phototherapy by

in situ

producing ONOO

−

. The Cy7 units in the nanoparticles can not only be served as the photosensitizer to produce reactive oxygen species (ROS) including singlet oxygen and superoxide anion for PDT

but also be used as a heat source for PTT and the release of NO gas from

-nitrosated napthalimide (NORM) at the same time. Since NO can react quickly with superoxide anion to generate ONOO

−

the enhanced phototherapy could be achieved by

in situ

ONOO

−

produced by PCy7-NO upon exposure to the near infrared (NIR) light. Therefore

the NIR-triggered Cy7-based nanoplatform for ONOO

−

-enhanced phototherapy may provide a new perspective in cancer therapy.

关键词

Keywords

references

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A Single-wavelength NIR-triggered Polymer for in situ Generation of Peroxynitrite (ONOO–) to Enhance Phototherapeutic Efficacy

DOI：10.1007/s10118-021-2540-0

摘要

Abstract

关键词

Keywords

references

A Single-wavelength NIR-triggered Polymer for in situ Generation of Peroxynitrite (ONOO^–) to Enhance Phototherapeutic Efficacy