Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance

Wei-Bin Cai; Dong-Dong Liu; Ying Chen; Li Zhang; Jian-Bo Tan

doi:10.1007/s10118-021-2533-z

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Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance

ARTICLE | Updated：2021-02-01

- Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance
- Chinese Journal of Polymer Science Vol. 39, Issue 9, Pages: 1127-1137(2021)
- Affiliations：
  
  a.Department of Polymeric Materials and Engineering, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China
  b.Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, Guangzhou 510006, China
- Author bio：
  
  tanjianbo@gdut.edu.cn
- Funds：
- DOI：10.1007/s10118-021-2533-z
  CLC：
- Received：03 November 2020，
  
  Revised：2020-11-24，
  
  Accepted：25 November 2020，
  
  Online First：01 February 2021，
  
  Published：18 July 2021
- Accepted：
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Cai, W. B.; Liu, D. D.; Chen, Y.; Zhang, L.; Tan, J. B. Enzyme-assisted photoinitiated polymerization-induced self-assembly in continuous flow reactors with oxygen tolerance. Chinese J. Polym. Sci. 2021, 39, 1127–1137

Wei-Bin Cai, Dong-Dong Liu, Ying Chen, et al. Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1127-1137.
Cai, W. B.; Liu, D. D.; Chen, Y.; Zhang, L.; Tan, J. B. Enzyme-assisted photoinitiated polymerization-induced self-assembly in continuous flow reactors with oxygen tolerance. Chinese J. Polym. Sci. 2021, 39, 1127–1137 DOI： 10.1007/s10118-021-2533-z.

Wei-Bin Cai, Dong-Dong Liu, Ying Chen, et al. Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1127-1137. DOI： 10.1007/s10118-021-2533-z.

摘要

Abstract

Polymerization-induced self-assembly (PISA) is an emerging method for the preparation of block copolymer nano-objects at high concentrations. However

most PISA formulations have oxygen inhibition problems and inert atmospheres (

e.g

. argon

nitrogen) are usually required. Moreover

the large-scale preparation of block copolymer nano-objects at room temperature is challenging. Herein

we report an enzyme-assisted photoinitiated polymerization-induced self-assembly (photo-PISA) in continuous flow reactors with oxygen tolerance. The addition of glucose oxidase (GOx) and glucose into the reaction mixture can consume oxygen efficiently and constantly

allow the flow photo-PISA to be performed under open-air conditions. Polymerization kinetics indicated that only a small amount of GOx (0.5 μmol/L) was needed to achieve the oxygen tolerance. Block copolymer nano-objects with different morphologies can be prepared by varying reaction conditions including the degree of polymerization (DP) of core-forming block

monomer concentration

reaction temperature

and solvent composition. We expect this study will provide a facile platform for the large-scale production of block copolymer nano-objects with different morphologies at room temperature.

关键词

Keywords

references

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