Robust and Self-healable Antibiofilm Multilayer Coatings

Chao Zhou; Jun-Tao Zhou; Cheng-Ju Sheng; Dicky Pranantyo; Yan Pan; Xiao-Jia Huang

doi:10.1007/s10118-021-2513-3

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Robust and Self-healable Antibiofilm Multilayer Coatings

ARTICLE | Updated：2020-10-26

- Robust and Self-healable Antibiofilm Multilayer Coatings
- Chinese Journal of Polymer Science Vol. 39, Issue 4, Pages: 425-440(2021)
- Affiliations：
  
  a.Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China
  b.Department of Chemical and Biomolecular Engineering, National University of Singapore, 117585, Singapore
- Author bio：
  
  zhouchao@cczu.edu.cn
- Funds：
- DOI：10.1007/s10118-021-2513-3
  CLC：
- Received：28 July 2020，
  
  Revised：2020-9-16，
  
  Accepted：05 October 2020，
  
  Online First：26 October 2020，
  
  Published：01 January 2021
- Accepted：
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Zhou, C.; Zhou, J. T.; Sheng, C. J.; Pranantyo, D.; Pan, Y.; Huang, X. J. Robust and self-healable antibiofilm multilayer coatings. Chinese J. Polym. Sci. 2021, 39, 425–440

Chao Zhou, Jun-Tao Zhou, Cheng-Ju Sheng, et al. Robust and Self-healable Antibiofilm Multilayer Coatings[J]. Chinese Journal of Polymer Science, 2021, 39(4): 425-440.
Zhou, C.; Zhou, J. T.; Sheng, C. J.; Pranantyo, D.; Pan, Y.; Huang, X. J. Robust and self-healable antibiofilm multilayer coatings. Chinese J. Polym. Sci. 2021, 39, 425–440 DOI： 10.1007/s10118-021-2513-3.

Chao Zhou, Jun-Tao Zhou, Cheng-Ju Sheng, et al. Robust and Self-healable Antibiofilm Multilayer Coatings[J]. Chinese Journal of Polymer Science, 2021, 39(4): 425-440. DOI： 10.1007/s10118-021-2513-3.

摘要

Abstract

The infection induced by implantation of biomedical materials may result from the biofilm formation after bacteria attachment. Hence

the antibiofilm surface coating represents a novel technique to improve the antibacterial activity of biomedical materials. The traditional antibiofilm surface coatings exhibited some disadvantages and provided a limited service life. In this work

we used polyethyleneimine grafted 3-maleimidopropionic acid (PEIM) and poly(acrylic acid) grafted 2-furfurylamine (PAAF) to achieve robust and self-healable crosslinked multilayer coatings

employing Layer-by-Layer (LbL) self-assembly technique and Diels-Alder reaction. Then

thiol-terminated poly((3-acrylamidopropyl) trimethylammonium chloride) (PAMPTMA-SH) was grafted onto the crosslinked multilayer coating by thiol-ene click reaction to form a novel multilayer coating (PEIM/PAAF)

-PAMPTMA. We found that this coating showed robust and self-healable activity

and significantly inhibited the bacterial growth and biofilm formation after infection with

Escherichia coli

(

E. coli

) and

Staphylococcus aureus

(

S. aureus

) by

in vitro

and

in vivo

assays for 120 h. In addition

the multilayer coating did not induce significant hemolysis or affect the cell viability of red blood cells.

In vivo

studies also showed that (PEIM/PAAF)

-PAMPTMA coating efficiently blocked the infiltration of inflammatory cells and gene expression in the mouse skin challenged with

E. coli

S. aureus

. Taken together

these results showed that the prepared multilayer coating exhibited strong antibiofilm activity and provided a new strategy for the application of highly efficient antibiofilm surface coating of biomedical materials.

关键词

Keywords

references

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