A Self-assembled Nanoparticle Platform Based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy

Ying-Sa Wang; Gui-Liang Li; Shang-Bin Zhu; Fan-Chen Jing; Run-Dong Liu; Sai-Sai Li; Jing He; Jian-Du Lei

doi:10.1007/s10118-020-2401-2

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A Self-assembled Nanoparticle Platform Based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy

ARTICLE | Updated：2020-04-22

- A Self-assembled Nanoparticle Platform Based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy
- Chinese Journal of Polymer Science Vol. 38, Issue 8, Pages: 819-829(2020)
- Affiliations：
  
  Beijing Key Laboratory of Lignocellulosic Chemistry, Engineering Research Center of Forestry Biomass Materials and Bioenergy (Ministry of Education), Beijing Forestry University, Beijing 100083, China
- Author bio：
  
  hejing2008@sina.com
- Funds：
- DOI：10.1007/s10118-020-2401-2
  CLC：
- Received：18 December 2019，
  
  Revised：2020-2-7，
  
  Accepted：10 February 2020，
  
  Online First：22 April 2020，
  
  Published：2020-08
- Accepted：
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Wang, Y. S.; Li, G. L.; Zhu, S. B.; Jing, F. C.; Liu, R. D.; Li, S. S.; He, J.; Lei, J. D. A self-assembled nanoparticle platform based on amphiphilic oleanolic acid polyprodrug for cancer therapy. Chinese J. Polym. Sci. 2020, 38, 819–829

Ying-Sa Wang, Gui-Liang Li, Shang-Bin Zhu, et al. A Self-assembled Nanoparticle Platform Based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy[J]. Chinese Journal of Polymer Science, 2020, 38(8): 819-829.
Wang, Y. S.; Li, G. L.; Zhu, S. B.; Jing, F. C.; Liu, R. D.; Li, S. S.; He, J.; Lei, J. D. A self-assembled nanoparticle platform based on amphiphilic oleanolic acid polyprodrug for cancer therapy. Chinese J. Polym. Sci. 2020, 38, 819–829 DOI： 10.1007/s10118-020-2401-2.

Ying-Sa Wang, Gui-Liang Li, Shang-Bin Zhu, et al. A Self-assembled Nanoparticle Platform Based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy[J]. Chinese Journal of Polymer Science, 2020, 38(8): 819-829. DOI： 10.1007/s10118-020-2401-2.

摘要

Abstract

Oleanolic acid (OA) is a pentacyclic triterpenoid compound with extensive biological effects

such as anti-inflammatory and anticancer activities. However

the application of OA in chemotherapy is hampered by its poor solubility and severe adverse effects. To solve the problems

we developed a self-assembled nanoparticle platform based on amphiphilic oleanolic acid polyprodrug

poly[oligo(ethylene glycol) methyl ether methacrylate]-

-poly(oleanolic acid methacrylate) (POEGMA-

-POAMA)

encapsulating 10-hydroxycamptothecin (HCPT) to achieve efficient cancer therapy. The polyprodrug was prepared

via

reversible addition-fragmentation chain transfer polymerization (RAFT)

and could self-assemble to prepare POEGMA-

-POAMA/HCPT nanoparticles (NPs). The obtained nanoparticles exhibited appropriate particle size

excellent drug stability

good drug loading capacity

and high drug loading efficiency.

In vitro

drug release indicated that the drug release was prolonged to 132 h. The POEGMA-

-POAMA/HCPT NPs enhanced cell cytotoxicity in 4T1 cells and MCF-7 cells and could be efficiently uptaken by 4T1 cells. Furthermore

in vivo

antitumor efficiency showed that the POEGMA-

-POAMA/HCPT NPs had great antitumor efficiency with considerably low adverse effects in the treatment of the 4T1 mouse breast tumor xenograft tumor. Therefore

POEGMA-

-POAMA/HCPT NPs provide great potential as a platform for drug delivery applications.

关键词

Keywords

references

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