Antibacterial and pH-responsive Quaternized Hydroxypropyl Cellulose-<italic style="font-style: italic">g</italic>-Poly(THF-<italic style="font-style: italic">co</italic>-epichlorohydrin) Graft Copolymer: Synthesis, Characterization and Properties

Jin-Rui Deng; Cong-Lei Zhao; Yi-Xian Wu

doi:10.1007/s10118-020-2372-3

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Antibacterial and pH-responsive Quaternized Hydroxypropyl Cellulose-g-Poly(THF-co-epichlorohydrin) Graft Copolymer: Synthesis, Characterization and Properties

ARTICLE | Updated：2020-01-06

- Antibacterial and pH-responsive Quaternized Hydroxypropyl Cellulose-g-Poly(THF-co-epichlorohydrin) Graft Copolymer: Synthesis, Characterization and Properties
- Chinese Journal of Polymer Science Vol. 38, Issue 7, Pages: 704-714(2020)
- Affiliations：
  
  State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  wuyx@mail.buct.edu.cn
- Funds：
- DOI：10.1007/s10118-020-2372-3
  CLC：
- Received：09 October 2019，
  
  Revised：2019-11-13，
  
  Accepted：14 November 2019，
  
  Online First：06 January 2020，
  
  Published：2020-07
- Accepted：
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Deng, J. R.; Zhao, C. L.; Wu, Y. X. Antibacterial and pH-responsive quaternized hydroxypropyl cellulose-, g,-poly(THF-, co,-epichlorohydrin) graft copolymer: synthesis, characterization and properties. Chinese J. Polym. Sci. 2020, 38, 704–714

Jin-Rui Deng, Cong-Lei Zhao, Yi-Xian Wu. Antibacterial and pH-responsive Quaternized Hydroxypropyl Cellulose-g-Poly(THF-co-epichlorohydrin) Graft Copolymer: Synthesis, Characterization and Properties[J]. Chinese Journal of Polymer Science, 2020, 38(7): 704-714. DOI: 10.1007/s10118-020-2372-3.
Deng, J. R.; Zhao, C. L.; Wu, Y. X. Antibacterial and pH-responsive quaternized hydroxypropyl cellulose-, g,-poly(THF-, co,-epichlorohydrin) graft copolymer: synthesis, characterization and properties. Chinese J. Polym. Sci. 2020, 38, 704–714 DOI： 10.1007/s10118-020-2372-3.

Jin-Rui Deng, Cong-Lei Zhao, Yi-Xian Wu. Antibacterial and pH-responsive Quaternized Hydroxypropyl Cellulose-g-Poly(THF-co-epichlorohydrin) Graft Copolymer: Synthesis, Characterization and Properties[J]. Chinese Journal of Polymer Science, 2020, 38(7): 704-714. DOI: 10.1007/s10118-020-2372-3. DOI：

摘要

Abstract

The novel quaternized hydroxypropyl cellulose-

-poly(THF-

-epichlorohydrin) graft copolymers

HPC-

-QCP(THF-

-ECH)

have been successfully synthesized to combine the properties from hydrophilic hard HPC biomacromolecular backbone and hydrophobic flexible polyether branches. Firstly

the P(THF-

-ECH) living chains were synthesized by cationic ring-opening copolymerization of THF with ECH. Secondly

P(THF-

-ECH) living chains were grafted onto HPC backbone by reaction with ―OH groups along HPC to produce HPC-

-P(THF-

-ECH) graft copolymers. Thirdly

the mentioned graft copolymers were quaternized by reaction with ternary amine to generate functionalized HPC-

-QCP(THF-

-ECH). The HPC-

-QCP(THF-

-ECH) graft copolymers exhibited good antibacterial ability against

S. aureus

E. coli

bacteria. The ibuprofen (IBU)-loaded microparticles of HPC-

-(QC)P(THF-

-ECH) graft copolymers were prepared by electrospraying. The

in vitro

pH-responsive drug-release behavior of IBU reached up to 75% of drug-loaded at pH = 7.4. This quaternized graft copolymer was beneficial to solving the problems of a burst effect and fast release of HPC as drug carriers.

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⁰

Antibacterial and pH-responsive Quaternized Hydroxypropyl Cellulose-g-Poly(THF-co-epichlorohydrin) Graft Copolymer: Synthesis, Characterization and Properties

DOI：10.1007/s10118-020-2372-3

摘要

Abstract

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