Ultrasound-responsive Homopolymer Nanoparticles

Bo Yang; Jian-Zhong Du

doi:10.1007/s10118-020-2345-6

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Ultrasound-responsive Homopolymer Nanoparticles

ARTICLE | Updated：2019-09-24

- Ultrasound-responsive Homopolymer Nanoparticles
- Chinese Journal of Polymer Science Vol. 38, Issue 4, Pages: 349-356(2020)
- Affiliations：
  
  a.Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
  b.Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China
- Author bio：
  
  jzdu@tongji.edu.cn
- Funds：
- DOI：10.1007/s10118-020-2345-6
  CLC：
- Received：25 July 2019，
  
  Revised：2019-8-22，
  
  Accepted：26 August 2019，
  
  Online First：24 September 2019，
  
  Published：2020-04
- Accepted：
Scan QR Code
Yang, B.; Du, J. Z. Ultrasound-responsive homopolymer nanoparticles. Chinese J. Polym. Sci. 2020, 38, 349–356

Bo Yang, Jian-Zhong Du. Ultrasound-responsive Homopolymer Nanoparticles[J]. Chinese Journal of Polymer Science, 2020, 38(4): 349-356.
Yang, B.; Du, J. Z. Ultrasound-responsive homopolymer nanoparticles. Chinese J. Polym. Sci. 2020, 38, 349–356 DOI： 10.1007/s10118-020-2345-6.

Bo Yang, Jian-Zhong Du. Ultrasound-responsive Homopolymer Nanoparticles[J]. Chinese Journal of Polymer Science, 2020, 38(4): 349-356. DOI： 10.1007/s10118-020-2345-6.

摘要

Abstract

Noninvasive ultrasound is a more effective strategy for on-demand drug delivery of polymeric nanoparticles than many other stimuli. However

the preparation of ultrasound-responsive homopolymer nanoparticles is still very challenging. In this study

we disclose the regulating factors of ultrasound responsiveness of homopolymer nanoparticles and the disaggregation behavior of homopolymer nanoparticle aggregates. Homopolymer nanoparticles such as vesicles and large compound micelles (LCMs) are self-assembled from poly(methoxyethyl methacrylate) (PMEMA) and poly(amic acid) (PAA)

respectively. The ultrasound responsiveness of PAA vesicles at metastable state could be regulated by tuning the self-assembly temperature (

)

and was optimized when

is around the glass transition temperature (

) of PAA. However

the PMEMA LCMs did not respond to ultrasound as they are at stable state. On the other hand

poly(2-(2-ethoxyethoxy)ethyl acrylate) (PEEA) could self-assemble into vesicle aggregates or complex micelle aggregates

which were dissociated upon sonication. Overall

the above findings provide us with a fresh insight for designing ultrasound-responsive polymeric nanoparticles.

关键词

Keywords

references

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