Fluorescent Supramolecular Polymersomes Based on Pillararene/Paraquat Molecular Recognition for pH-controlled Drug Release

Run Zhao; Yu-Juan Zhou; Ke-Cheng Jie; Jie Yang; Sébastien Perrier; Fei-He Huang

doi:10.1007/s10118-019-2305-1

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Fluorescent Supramolecular Polymersomes Based on Pillararene/Paraquat Molecular Recognition for pH-controlled Drug Release

ARTICLE | Updated：2019-09-27

- Fluorescent Supramolecular Polymersomes Based on Pillararene/Paraquat Molecular Recognition for pH-controlled Drug Release
- Chinese Journal of Polymer Science Vol. 38, Issue 1, Pages: 1-8(2020)
- Affiliations：
  
  a.State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, Hangzhou 310027, China
  b.Department of Chemistry, The University of Warwick, Coventry CV4 7AL, UK
  c.Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
  d.Warwick Medical School, The University of Warwick, Coventry CV4 7AL, UK
- Author bio：
  
  J.Yang.38@warwick.ac.uk (J.Y.)
  S.Perrier@warwick.ac.uk (S.P.)
  fhuang@zju.edu.cn (F.H.H.)
- Funds：
- DOI：10.1007/s10118-019-2305-1
  CLC：
- Received：26 April 2019，
  
  Revised：2019-5-23，
  
  Accepted：25 May 2019，
  
  Online First：27 September 2019，
  
  Published：2020-01
- Accepted：
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Citation: Zhao, R.; Zhou, Y. J.; Jie, K. C.; Yang, J.; Perrier, S.; Huang, F. H. Fluorescent supramolecular polymersomes based on pillararene/paraquat molecular recognition for pH-controlled drug release. Chinese J. Polym. Sci. 2020, 38, 1–8

Run Zhao, Yu-Juan Zhou, Ke-Cheng Jie, et al. Fluorescent Supramolecular Polymersomes Based on Pillararene/Paraquat Molecular Recognition for pH-controlled Drug Release[J]. Chinese Journal of Polymer Science, 2020, 38(1): 1-8.
Citation: Zhao, R.; Zhou, Y. J.; Jie, K. C.; Yang, J.; Perrier, S.; Huang, F. H. Fluorescent supramolecular polymersomes based on pillararene/paraquat molecular recognition for pH-controlled drug release. Chinese J. Polym. Sci. 2020, 38, 1–8 DOI： 10.1007/s10118-019-2305-1.

Run Zhao, Yu-Juan Zhou, Ke-Cheng Jie, et al. Fluorescent Supramolecular Polymersomes Based on Pillararene/Paraquat Molecular Recognition for pH-controlled Drug Release[J]. Chinese Journal of Polymer Science, 2020, 38(1): 1-8. DOI： 10.1007/s10118-019-2305-1.

摘要

Abstract

Researchers have put significant efforts on developing versatile fluorescent polymeric systems due to their promising biological/biomedical labelling

tracking

monitoring

imaging

and diagnostic applications. However

complicated organic/polymeric synthesis or post-modification of these functionalized platforms is still a big obstacle for their further application and thereby provides clear motivation for exploring alternative strategies for the design and fabrication of easily available fluorescent systems. The marriage of supramolecular polymers and fluorescent imaging can provide a facile and dynamic manner instead of tedious and time-consuming synthesis due to the dynamic and reversible nature of noncovalent interactions. Herein

based on water-soluble pillararene/paraquat molecular recognition

we successfully prepare two amphiphilic polypseudorotaxanes which can self-assemble into supramolecular polymersomes in water. These polymersomes can be reversibly destroyed and reformed by tuning the solution pH. Attributed to the aggregation-induced emission of tetraphenylethylene groups

intense fluorescence can be introduced into the obtained supramolecular polymersomes. Furthermore

pH-triggered release of an encapsulated water-insoluble drug (doxorubicin) from the self-assembled fluorescent supramolecular polymersomes is also investigated.

关键词

Keywords

references

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Related Author

Xiao-fan Ji

Pi Wang

Hu Wang

Fei-he Huang

Nan-Nan Gu

Ping Wei

Jin-Hui Jiang

Jing-Hua Chen

Related Institution

State Key Laboratory of Chemical Engineering, Department of Chemistry, Zhejiang University

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University

School of Life Sciences and Health Engineering, Jiangnan University

School of Materials Science and Engineering, Wuhan Institute of Technology

Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Materials Chemistry and Service Failure, National Anti-counterfeit Engineering Research Center, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology

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