Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy

Heng-Ye Gong; Yan-Gui Chen; Xing-Su Yu; Hong Xiao; Jin-Peng Xiao; Yong Wang; Xin-Tao Shuai

doi:10.1007/s10118-019-2272-6

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Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy

ARTICLE | Updated：2021-02-18

- Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy
- Chinese Journal of Polymer Science Vol. 37, Issue 12, Pages: 1224-1233(2019)
- Affiliations：
  
  a.PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China
  b.HEC Pharma Co., Ltd., Dongguan 523871, China
  c.Reproductive Center, Guangdong Women's Health Care Center, Guangzhou 511400, China
- Author bio：
  
  shuaixt@mail.sysu.edu.cn
- Funds：
- DOI：10.1007/s10118-019-2272-6
  CLC： M
- Received：17 March 2019，
  
  Revised：2019-4-3，
  
  Accepted：08 April 2019，
  
  Online First：04 June 2019，
  
  Published：2019-12
- Accepted：
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Gong, H. Y.; Chen, Y. G.; Yu, X. S.; Xiao, H.; Xiao, J. P.; Wang, Y.; Shuai, X. T. Co-delivery of doxorubicin and afatinib with pH-responsive polymeric nanovesicle for enhanced lung cancer therapy. Chinese J. Polym. Sci. 2019, 37, 1224–1233.

Heng-Ye Gong, Yan-Gui Chen, Xing-Su Yu, et al. Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy[J]. Chinese Journal of Polymer Science, 2019, 37(12): 1224-1233.
Gong, H. Y.; Chen, Y. G.; Yu, X. S.; Xiao, H.; Xiao, J. P.; Wang, Y.; Shuai, X. T. Co-delivery of doxorubicin and afatinib with pH-responsive polymeric nanovesicle for enhanced lung cancer therapy. Chinese J. Polym. Sci. 2019, 37, 1224–1233. DOI： 10.1007/s10118-019-2272-6.

Heng-Ye Gong, Yan-Gui Chen, Xing-Su Yu, et al. Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy[J]. Chinese Journal of Polymer Science, 2019, 37(12): 1224-1233. DOI： 10.1007/s10118-019-2272-6.

摘要

Abstract

Drug-resistance and drastic side effects are two major issues of traditional chemotherapy which may result in trail failure even death. Nanoparticle-mediated multidrug combination treatment has been proven to be a feasible strategy to overcome these challenges. In the present study

amphipathic block polymer of methoxyl poly(ethylene glycol)-poly(aspartyl(dibutylethylenediamine)-

-phenylalanine) (mPEG-P(Asp(DBA)-

-Phe)) was synthesized and self-assembled into pH-responsive polymeric vesicle. The vesicle was utilized to co-deliver cancer-associated epidermal growth factor (EGFR) inhibitor of afatinib and DNA-damaging chemotherapeutic doxorubicin hydrochloride (DOX) for enhanced non-small-cell lung cancer (NSCLC) therapy. As evaluated

in vitro

the pH-responsive design of nanovesicle resulted in a rapid release of encapsulated drugs into tumor cells and caused enhanced cell apoptosis. In addition

in vivo

therapeutic studies were conducted and the results evidenced that the co-delevery of DOX and afatinib using pH-sensitive nanovector was a promising strategy for NSCLC treatment.

关键词

Keywords

references

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