An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications

Man-Zhu Zhao; Dong-Bing Cheng; Zhao-Ru Shang; Lei Wang; Zeng-Ying Qiao; Jing-Ping Zhang; Hao Wang

doi:10.1007/s10118-018-2170-3

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An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications

REVIEW | Updated：2021-02-18

- An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications
- Chinese Journal of Polymer Science Vol. 36, Issue 10, Pages: 1103-1113(2018)
- Affiliations：
  
  a.School of Chemistry, Northeast Normal University, Changchun 130024, China
  b.Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China
- Author bio：
  
  zhangjp162@nenu.edu.cn (J.P.Z.)
  wanghao@nanoctr.cn (H.W.)
- Funds：
- DOI：10.1007/s10118-018-2170-3
  CLC：
- Received：18 May 2018，
  
  Revised：2018-6-10，
  
  Accepted：12 June 2018，
  
  Online First：11 July 2018，
  
  Published：2018-10
- Accepted：
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Citation: Zhao, M. Z.; Cheng, D. B.; Shang, Z. R.; Wang, L.; Qiao, Z. Y.; Zhang, J. P.; Wang, H. An “ In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications. Chinese J. Polym. Sci. 2018, 36(10), 1103–1113.

Man-Zhu Zhao, Dong-Bing Cheng, Zhao-Ru Shang, et al. An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2018, 36(10): 1103-1113.
Citation: Zhao, M. Z.; Cheng, D. B.; Shang, Z. R.; Wang, L.; Qiao, Z. Y.; Zhang, J. P.; Wang, H. An “ In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications. Chinese J. Polym. Sci. 2018, 36(10), 1103–1113. DOI： 10.1007/s10118-018-2170-3.

Man-Zhu Zhao, Dong-Bing Cheng, Zhao-Ru Shang, et al. An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2018, 36(10): 1103-1113. DOI： 10.1007/s10118-018-2170-3.

摘要

Abstract

The interfacing study of biopolymer and supramolecular chemistry enables a better understanding of fundamental biochemical processes and the creating of new high-performance biomaterials. In this review

we introduced an "

in vivo

self-assembly” strategy which means

in situ

construction of functional self-assembled superstructures in specific physiological or pathological conditions in cell

tissue or animal levels that exhibit diverse biomedical effects. By using this strategy

unexpected phenomena and insights

e.g

assembly/aggregation induced retention (AIR) effect have been demonstrated where the self-assembled nanostructures showed extraordinary enhanced accumulation and retention of therapeutics in targeted sites.

关键词

Keywords

references

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