Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine) via Kinetic Path

Wei Pan; Dong-Xiao Yin; Hai-Rong Jing; Hao-Jing Chang; Hao Wen; De-Hai Liang

doi:10.1007/s10118-018-2166-z

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Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine) via Kinetic Path

ARTICLE | Updated：2021-02-18

- Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine) via Kinetic Path
- Chinese Journal of Polymer Science Vol. 37, Issue 1, Pages: 36-42(2019)
- Affiliations：
  
  Beijing National Laboratory for Molecular Sciences and Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
- Author bio：
  
  dliang@pku.edu.cn
- Funds：
- DOI：10.1007/s10118-018-2166-z
  CLC：
- Received：02 May 2018，
  
  Revised：2018-5-26，
  
  Accepted：28 May 2018，
  
  Online First：28 June 2018，
  
  Published：2019-01
- Accepted：
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Citation: Pan, W.; Yin, D. X.; Jing, H. R.; Chang, H. J.; Wen, H.; Liang, D. H. Core-Corona structure formed by hyaluronic acid and poly(L-lysine) , via, kinetic path. Chinese J. Polym. Sci. 2019, 37, 36–42

Wei Pan, Dong-Xiao Yin, Hai-Rong Jing, et al. Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine) via Kinetic Path[J]. Chinese Journal of Polymer Science, 2019, 37(1): 36-42.
Citation: Pan, W.; Yin, D. X.; Jing, H. R.; Chang, H. J.; Wen, H.; Liang, D. H. Core-Corona structure formed by hyaluronic acid and poly(L-lysine) , via, kinetic path. Chinese J. Polym. Sci. 2019, 37, 36–42 DOI： 10.1007/s10118-018-2166-z.

Wei Pan, Dong-Xiao Yin, Hai-Rong Jing, et al. Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine) via Kinetic Path[J]. Chinese Journal of Polymer Science, 2019, 37(1): 36-42. DOI： 10.1007/s10118-018-2166-z.

摘要

Abstract

The structure and kinetics of the complex formed by hyaluronic acid (HA) and poly(L-lysine) (PLL) were studied by time-resolved laser light scattering

TEM

and AFM. Because HA has a hydrophilic backbone

the complexes formed by HA and PLL are different from those formed by oppositely charged polyelectrolytes both having hydrophobic backbones. Instead of forming strong aggregates and even precipitates

the complex in the presence of excess HA is stable in the studied time period. More importantly

the complex spontaneously forms core-corona structure by the rearrangement of HA chains. The core is composed of complex rich of PLL and the corona is mainly HA. Further analysis shows that the hydrogen bond formed by HA creates a barrier hindering the further relaxation of HA chains. The automatic formation of core-corona structure by PLL/HA is helpful not only to understand the relaxation of polyelectrolyte in complex

but also to develop drug carriers with desirable properties.

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Keywords

references

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