Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties

Hao Tang; Jin Tang; Yi Shen; Wen-Xuan Guo; Min Zhou; Rui-Hua Wang; Ni Jiang; Zhi-Hua Gan; Qing-Song Yu

doi:10.1007/s10118-018-2159-y

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Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties

ARTICLE | Updated：2021-02-18

- Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties
- Chinese Journal of Polymer Science Vol. 36, Issue 11, Pages: 1225-1238(2018)
- Affiliations：
  
  a.The State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
  b.College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  c.Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  zhgan@mail.buct.edu.cn (Z.H.G.)
  yuqs@mail.buct.edu.cn (Q.S.Y.)
- Funds：
- DOI：10.1007/s10118-018-2159-y
  CLC：
- Received：18 April 2018，
  
  Revised：2018-5-14，
  
  Accepted：15 May 2018，
  
  Online First：30 June 2018，
  
  Published：2018-11
- Accepted：
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Citation: Tang, H.; Tang, J.; Shen, Y.; Guo, W. X.; Zhou, M.; Wang, R. H.; Jiang, N.; Gan, Z. H.; Yu, Q. S. Comb-like Poly( N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese J. Polym. Sci. 2018, 36(11), 1225–1238.

Hao Tang, Jin Tang, Yi Shen, et al. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties[J]. Chinese Journal of Polymer Science, 2018, 36(11): 1225-1238.
Citation: Tang, H.; Tang, J.; Shen, Y.; Guo, W. X.; Zhou, M.; Wang, R. H.; Jiang, N.; Gan, Z. H.; Yu, Q. S. Comb-like Poly( N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese J. Polym. Sci. 2018, 36(11), 1225–1238. DOI： 10.1007/s10118-018-2159-y.

Hao Tang, Jin Tang, Yi Shen, et al. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties[J]. Chinese Journal of Polymer Science, 2018, 36(11): 1225-1238. DOI： 10.1007/s10118-018-2159-y.

摘要

Abstract

The synthesis and structure-property correlation of poly(

-(2-hydroxypropyl) methacrylamide) (PHPMA) conjugates with various architectures including random

block

branched or star-like structures and compositions have been thoroughly explored. However

related synthesis and structure-property data are still lacking for comb-like PHPMA. In this work

we report the synthesis of comb-like PHPMA copolymer-doxorubicin (DOX) conjugates with different backbone/side-chain lengths and location of drug moieties. Well-defined comb-like PHPMA-DOX conjugates are obtained

via

the combination of controlled radical polymerization and fractional precipitation techniques. The influences of structural factors on the biological properties such as cellular uptake

blood circulation and tumor accumulation have been investigated. Long blood circulation and efficient tumor accumulation can be achieved by proper control of the comb number

length and location of drug moieties. These facile comb-like structures possess great potentials in future theranostics for brachytherapy or surgical navigation.

关键词

Keywords

references

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