<italic style="font-style: italic">ε</italic>-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities

Yi-Jie Zou; Shi-Sheng He; Jian-Zhong Du

doi:10.1007/s10118-018-2156-1

Your Location：

Home >

Browse articles >

ε-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities

ARTICLE | Updated：2021-02-18

- ε-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities
- Chinese Journal of Polymer Science Vol. 36, Issue 11, Pages: 1239-1250(2018)
- Affiliations：
  
  a.Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
  b.Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Department Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China
- Author bio：
  
  jzdu@tongji.edu.cn
- Funds：
- DOI：10.1007/s10118-018-2156-1
  CLC：
- Received：01 May 2018，
  
  Revised：2018-5-4，
  
  Accepted：08 May 2018，
  
  Online First：11 June 2018，
  
  Published：2018-11
- Accepted：
Scan QR Code
Citation: Zou, Y. J.; He, S. S.; Du, J. Z. ε-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities. Chinese J. Polym. Sci. 2018, 36(11), 1239–1250.

Yi-Jie Zou, Shi-Sheng He, Jian-Zhong Du. ε-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities[J]. Chinese Journal of Polymer Science, 2018, 36(11): 1239-1250. DOI: 10.1007/s10118-018-2156-1.
Citation: Zou, Y. J.; He, S. S.; Du, J. Z. ε-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities. Chinese J. Polym. Sci. 2018, 36(11), 1239–1250. DOI： 10.1007/s10118-018-2156-1.

Yi-Jie Zou, Shi-Sheng He, Jian-Zhong Du. ε-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities[J]. Chinese Journal of Polymer Science, 2018, 36(11): 1239-1250. DOI: 10.1007/s10118-018-2156-1. DOI：

摘要

Abstract

Bacterial infections and the associated morbidity and mortality due to bacterial pathogens in wounds and medical implants have been increasing as most of current coatings cannot fulfill all the requirements including excellent intrinsically antibacterial activity

low cytotoxicity

and favorable physical properties. Herein

we present a kind of antibacterial hydrogel based on

-poly(L-lysine) (EPL) grafted carboxymethyl chitosan (CMC-

-EPL) as the inherently antibacterial matrix and the surplus EPL as highly efficient antimicrobial agent. Such hydrogels possess tunable swelling abilities with water absorption percentages of 800%–2000% and modulus varying from 10 kPa to 100 kPa

and exhibit two-stage excellent antibacterial behavior. First

the free EPL can be released from the hydrogel network for quick and highly efficient bacteria killing with 99.99% of efficacy; second

the grafted EPL endows hydrogel matrix with prolonged intrinsically antibacterial activity

especially when most of free EPL is released from the hydrogel. Overall

we provide a new insight for preparing highly effective antibacterial hydrogels.

关键词

Keywords

references

Il Kim, S . Bacterial infection after liver transplantation . World J. Gastroenterol. , 2014 . 20 ( 20 ): 6211 - 6220 . DOI: 10.3748/wjg.v20.i20.6211 http://doi.org/10.3748/wjg.v20.i20.6211 .

Yarden-Bilavsky, H.; Ashkenazi-Hoffnung, L.; Livni, G.; Amir, J.; Bilavsky, E . Month-by-month age analysis of the risk for serious bacterial infections in febrile infants with bronchiolitis . Clin. Pediatr. , 2011 . 50 ( 11 ): 1052 - 1056 . DOI: 10.1177/0009922811412949 http://doi.org/10.1177/0009922811412949 .

Li, P.; Poon, Y. F.; Li, W. F.; Zhu, H. Y.; Yeap, S. H.; Cao, Y.; Qi, X. B.; Zhou, C. C.; Lamrani, M.; Beuerman, R. W.; Kang, E. T.; Mu, Y. G.; Li, C. M.; Chang, M. W.; Leong, S. S. J.; Chan-Park, M. B . A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability . Nat. Mater. , 2011 . 10 ( 2 ): 149 - 156 . DOI: 10.1038/nmat2915 http://doi.org/10.1038/nmat2915 .

Huang, Q. T.; Zou, Y. J.; Arno, M. C.; Chen, S.; Wang, T.; Gao, J. Y.; Dove, A. P.; Du, J. Z . Hydrogel scaffolds for differentiation of adipose-derived stem cells . Chem. Soc. Rev. , 2017 . 46 ( 20 ): 6255 - 6275 . DOI: 10.1039/C6CS00052E http://doi.org/10.1039/C6CS00052E .

Tran, N. Q.; Joung, Y. K.; Lih, E.; Park, K. D . In situ forming and Rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing . Biomacromolecules , 2011 . 12 ( 8 ): 2872 - 2880 . DOI: 10.1021/bm200326g http://doi.org/10.1021/bm200326g .

Lu, Z. T.; Zhang, J. Q.; Yu, Z. G.; Liu, Q. Z.; Liu, K.; Li, M. F.; Wang, D . Hydrogel degradation triggered by pH for the smart release of antibiotics to combat bacterial infection . New J. Chem. , 2017 . 41 ( 2 ): 432 - 436 . DOI: 10.1039/C6NJ03260E http://doi.org/10.1039/C6NJ03260E .

Ghavaminejad, A.; Park, C. H.; Kim, C. S . In situ synthesis of antimicrobial silver nanoparticles within antifouling zwitterionic hydrogels by catecholic redox chemistry for wound healing application . Biomacromolecules , 2016 . 17 ( 3 ): 1213 - 1223 . DOI: 10.1021/acs.biomac.6b00039 http://doi.org/10.1021/acs.biomac.6b00039 .

Song, T.; Xi, Y. J.; Du, J. Z . Antibacterial hydrogels incorporated with poly(glutamic acid)-based vesicles . Acta Polymerica Sininca (in Chinese) , 2018 . ( 1 ): 119 - 128 . .

Wang, R.; Zhou, B.; Xu, D. L.; Xu, H.; Liang, L.; Feng, X. H.; Ouyang, P. K.; Chi, B . Antimicrobial and biocompatible epsilon-polylysine-gamma-poly(glutamic acid)-based hydrogel system for wound healing . J. Bioact. Compat. Polym. , 2016 . 31 ( 3 ): 242 - 259 . DOI: 10.1177/0883911515610019 http://doi.org/10.1177/0883911515610019 .

Shu, Y.; Hao, T.; Yao, F. L.; Qian, Y. F.; Wang, Y.; Yang, B. G.; Li, J. J.; Wang, C. Y . RoY peptide-modified chitosan-based hydrogel to improve angiogenesis and cardiac repair under hypoxia . ACS Appl. Mater. Interfaces , 2015 . 7 ( 12 ): 6505 - 6517 . DOI: 10.1021/acsami.5b01234 http://doi.org/10.1021/acsami.5b01234 .

Xu, W. J.; Qian, J. M.; Zhang, Y. P.; Suo, A. L.; Cui, N.; Wang, J. L.; Yao, Y.; Wang, H. J . A double-network poly( N -epsilon-acryloyl L-lysine)/hyaluronic acid hydrogel as a mimic of the breast tumor microenvironment . Acta Biomater. , 2016 . 33 131 - 141 . DOI: 10.1016/j.actbio.2016.01.027 http://doi.org/10.1016/j.actbio.2016.01.027 .

Cheng, C.; Zhang, X. L.; Meng, Y. B.; Zhang, Z. H.; Chen, J. D.; Zhang, Q. Q . Multiresponsive and biocompatible self-healing hydrogel: Its facile synthesis in water, characterization and properties . Soft Matter , 2017 . 13 ( 16 ): 3003 - 3012 . DOI: 10.1039/C7SM00350A http://doi.org/10.1039/C7SM00350A .

Togo, Y.; Takahashi, K.; Saito, K.; Kiso, H.; Huang, B. Y.; Tsukamoto, H.; Hyon, S. H.; Bessho, K . Aldehyded dextran and epsilon-poly(L-lysine) hydrogel as nonviral gene carrier . Stem Cells Int. , 2013 . 634379 .

Unalan, I. U.; Ucar, K. D. A.; Arcan, I.; Korel, F.; Yemenicioglu, A . Antimicrobial potential of polylysine in edible films . Food Sci. Technol. Res. , 2011 . 17 ( 4 ): 375 - 380 . DOI: 10.3136/fstr.17.375 http://doi.org/10.3136/fstr.17.375 .

Zhou, C. C.; Yuan, Y.; Zhou, P. Y.; Wang, F. Y. K.; Hong, Y. X.; Wang, N. S.; Xu, S. G.; Du, J. Z . Highly effective antibacterial vesicles based on peptide-mimetic alternating copolymers for bone repair . Biomacromolecules , 2017 . 18 ( 12 ): 4154 - 4162 . DOI: 10.1021/acs.biomac.7b01209 http://doi.org/10.1021/acs.biomac.7b01209 .

Zhou, C. C.; Li, P.; Qi, X. B.; Sharif, A. R. M.; Poon, Y. F.; Cao, Y.; Chang, M. W.; Leong, S. S. J.; Chan-Park, M. B . A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-L-lysine . Biomaterials , 2011 . 32 ( 11 ): 2704 - 2712 . DOI: 10.1016/j.biomaterials.2010.12.040 http://doi.org/10.1016/j.biomaterials.2010.12.040 .

Gao, J. Y.; Wang, M. Z.; Wang, F. Y. K.; Du, J. Z . Synthesis and mechanism insight of a peptide-grafted hyperbranched polymer nanosheet with weak positive charges but excellent intrinsically antibacterial efficacy . Biomacromolecules , 2016 . 17 ( 6 ): 2080 - 2086 . DOI: 10.1021/acs.biomac.6b00307 http://doi.org/10.1021/acs.biomac.6b00307 .

Lam, S. J.; O'Brien-Simpson, N. M.; Pantarat, N.; Sulistio, A.; Wong, E. H. H.; Chen, Y. Y.; Lenzo, J. C.; Holden, J. A.; Blencowe, A.; Reynolds, E. C.; Qiao, G. G . Combating multidrug-resistant gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers . Nat. Microbiol. , 2016 . 1 ( 11 ): 16162 DOI: 10.1038/nmicrobiol.2016.162 http://doi.org/10.1038/nmicrobiol.2016.162 .

Papenfort, K.; Bassler, B. L . Quorum sensing signal-response systems in gram-negative bacteria . Nat. Rev. Microbiol. , 2016 . 14 ( 9 ): 576 - 588 . DOI: 10.1038/nrmicro.2016.89 http://doi.org/10.1038/nrmicro.2016.89 .

Tong, X. M.; Yang, F . Engineering interpenetrating network hydrogels as biomimetic cell niche with independently tunable biochemical and mechanical properties . Biomaterials , 2014 . 35 ( 6 ): 1807 - 1815 . DOI: 10.1016/j.biomaterials.2013.11.064 http://doi.org/10.1016/j.biomaterials.2013.11.064 .

Edwards, S. L.; Ulrich, D.; White, J. F.; Su, K.; Rosamilia, A.; Ramshaw, J. A. M.; Gargett, C. E.; Werkmeister, J. A . Temporal changes in the biomechanical properties of endometrial mesenchymal stem cell seeded scaffolds in a rat model . Acta Biomater. , 2015 . 13 286 - 294 . DOI: 10.1016/j.actbio.2014.10.043 http://doi.org/10.1016/j.actbio.2014.10.043 .

Lv, M.; Su, S.; He, Y.; Huang, Q.; Hu, W.; Li, D.; Fan, C.; Lee, S. T . Long-term antimicrobial effect of silicon nanowires decorated with silver nanoparticles . Adv. Mater. , 2010 . 22 ( 48 ): 5463 - 5467 . DOI: 10.1002/adma.v22.48 http://doi.org/10.1002/adma.v22.48 .

Wiegand, I.; Hilpert, K.; Hancock, R. E. W . Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances . Nat. Protoc. , 2008 . 3 163 - 175 . DOI: 10.1038/nprot.2007.521 http://doi.org/10.1038/nprot.2007.521 .

Dahl, T. A.; Midden, W. R.; Hartman, P. E . Comparison of killing of Gram-negative and Gram-positive bacteria by pure singlet oxygen . J. Bacteriol. , 1989 . 171 ( 4 ): 2188 - 2194 . DOI: 10.1128/jb.171.4.2188-2194.1989 http://doi.org/10.1128/jb.171.4.2188-2194.1989 .

Geng, X. D.; Yang, R. H.; Huang, J. Y.; Zhang, X.; Wang, X. Y . Evaluation antibacterial activity of quaternary-based chitin/chitosan derivatives in vitro . J. Food Sci. , 2013 . 78 ( 1 ): M90 - M97 . DOI: 10.1111/jfds.2013.78.issue-1 http://doi.org/10.1111/jfds.2013.78.issue-1 .

Sun, H.; Hong, Y. X.; Xi, Y. J.; Zou, Y. J.; Gao, J. Y.; Du, J. Z . Synthesis, self-assembly and biomedical applications of antimicrobial peptide-polymer conjugates . Biomacromolecules , 2018 . 10.1021/acs.biomac.1028b00208 DOI: 10.1021/acs.biomac.1028b00208 http://doi.org/10.1021/acs.biomac.1028b00208 .

Zheng, H.; Lu, J.; Chao, F.; Ying, Z.; Hui, B.; Zhang, X.; Xue, X.; Chen, Y.; Luo, X . Underlying mechanism of in vivo and in vitro activity of c-terminal-amidated thanatin against clinical isolates of extended-spectrum β -lactamase–producing Escherichia coli . J. Infect. Dis. , 2011 . 203 ( 2 ): 273 - 282 . DOI: 10.1093/infdis/jiq029 http://doi.org/10.1093/infdis/jiq029 .

Liu, Z. Q.; Wei, Z.; Zhu, X. L.; Huang, G. Y.; Xu, F.; Yang, J. H.; Osada, Y.; Zrinyi, M.; Li, J. H.; Chen, Y. M . Dextran-based hydrogel formed by thiol-Michael addition reaction for 3D cell encapsulation . Colloids Surf., B , 2015 . 128 140 - 148 . DOI: 10.1016/j.colsurfb.2015.02.005 http://doi.org/10.1016/j.colsurfb.2015.02.005 .

Zhou, L.; Chen, M.; Guan, Y.; Zhang, Y. J . Multiple responsive hydrogel films based on dynamic schiff base linkages . Polym. Chem. , 2014 . 5 ( 24 ): 7081 - 7089 . DOI: 10.1039/C4PY00868E http://doi.org/10.1039/C4PY00868E .

Dong, D. Y.; Li, J. J.; Cui, M.; Wang, J. M.; Zhou, Y. H.; Luo, L.; Wei, Y. F.; Ye, L.; Sun, H.; Yao, F. L . In situ "clickable" zwitterionic starch-based hydrogel for 3D cell encapsulation . ACS Appl. Mater. Interfaces , 2016 . 8 ( 7 ): 4442 - 4455 . DOI: 10.1021/acsami.5b12141 http://doi.org/10.1021/acsami.5b12141 .

Ishii-Mizuno, Y.; Umeki, Y.; Onuki, Y.; Watanabe, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M . Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan . Int. J. Pharm. , 2017 . 516 ( 1-2 ): 392 - 400 . DOI: 10.1016/j.ijpharm.2016.11.048 http://doi.org/10.1016/j.ijpharm.2016.11.048 .

Zhang, G. Z.; Ngai, T.; Deng, Y. H.; Wang, C. Y . An injectable hydrogel with excellent self-healing property based on quadruple hydrogen bonding . Macromol. Chem. Phys. , 2016 . 217 ( 19 ): 2172 - 2181 . DOI: 10.1002/macp.v217.19 http://doi.org/10.1002/macp.v217.19 .

Su, E.; Okay, O . Polyampholyte hydrogels formed via electrostatic and hydrophobic interactions . Eur. Polym. J. , 2017 . 88 191 - 204 . DOI: 10.1016/j.eurpolymj.2017.01.029 http://doi.org/10.1016/j.eurpolymj.2017.01.029 .

Sakamoto, J. M.; Gordon, T. R . Factors influencing infection of mechanical wounds by Fusarium circinatum on Monterey pines (pinus radiata) . Plant Pathol. , 2006 . 55 ( 1 ): 130 - 136 . DOI: 10.1111/ppa.2006.55.issue-1 http://doi.org/10.1111/ppa.2006.55.issue-1 .

Toda, H.; Yamamoto, M.; Uyama, H.; Tabata, Y . Fabrication of hydrogels with elasticity changed by alkaline phosphatase for stem cell culture . Acta Biomater. , 2016 . 29 215 - 227 . DOI: 10.1016/j.actbio.2015.10.036 http://doi.org/10.1016/j.actbio.2015.10.036 .

Views

836

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Thermopower Modulation of Chitosan Hydrogel via Complexation between Chitosan and Metal Ions

The Physical Chemistry for the Self-assembly of Peptide Hydrogels

Green Fabrication of High-strength Silk Fibroin Hydrogels via Thermal Oscillation in All-aqueous Media

Boosting Blood-Brain Barrier Crossing with a Mannosylated Nanocarrier

Advances in Polymer-based Circularly Polarized Luminescent Materials

Related Author

Xuan-Ran Li

Xiao-Han Sun

Hua-Feng Tian

Ang Lu

Ying Li

Yi Cao

Yu-Si Long

Mei-Yi Lu

Related Institution

Hubei Key Laboratory of Electrochemical Power Sources, College of Chemistry and Molecular Sciences, Wuhan University

School of Light Industry Science and Engineering, Beijing Technology and Business University

Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science and Engineering, Jiangsu Engineering Technology Research Centre of Environmental Cleaning Materials, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Jiangsu Joint Laboratory of Atmospheric Pollution Control, Nanjing University of Information Science & Technology

Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University

State Key Laboratory of Integrated Optoelectronics, Key Laboratory of UV Light-Emitting Materials and Technology of Ministry of Education, School of Physics, Northeast Normal University

⁰

ε-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities

DOI：10.1007/s10118-018-2156-1

摘要

Abstract

关键词

Keywords

references