Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

Silvana Alfei; Gaby Brice Taptue; Silvia Catena; Angela Bisio

doi:10.1007/s10118-018-2124-9

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Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

ARTICLE | Updated：2021-02-18

- Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids
- Chinese Journal of Polymer Science Vol. 36, Issue 9, Pages: 999-1010(2018)
- Affiliations：
  
  Dipartimento di Farmacia, Sezione di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Viale Cembrano 4, I-16148 Genova, Italy
- Author bio：
  
  alfei@difar.unige.it
- Funds：
- DOI：10.1007/s10118-018-2124-9
  CLC：
- Received：15 December 2017，
  
  Revised：2017-12-15，
  
  Accepted：07 February 2018，
  
  Online First：28 March 2018，
  
  Published：2018-09
- Accepted：
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Silvana Alfei, Gaby Brice Taptue, Silvia Catena, et al. Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids[J]. Chinese Journal of Polymer Science, 2018, 36(9): 999-1010.
DOI：

Silvana Alfei, Gaby Brice Taptue, Silvia Catena, et al. Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids[J]. Chinese Journal of Polymer Science, 2018, 36(9): 999-1010. DOI： 10.1007/s10118-018-2124-9.

摘要

Abstract

Dendrimers are macromolecules characterized by high controlled size

shape and architecture

presence of inner cavities able to accommodate small molecules and many peripheral functional groups to bind target entities. They are of eminent interest for biomedical applications

including gene transfection

tissue engineering

imaging

and drug delivery. The well-known pharmacological activities of ursolic and oleanolic acids are limited by their small water solubility

non-specific cell distribution

low bioavailability

poor pharmacokinetics

and their direct administration could result in the release of thrombi. To overcome such problems

in this paper we described their physical incorporation inside amino acids-modified polyester-based dendrimers which made them highly water-soluble. IR

NMR

zeta potential

mean size of particles

buffer capacity and drug release profiles of prepared materials were reported. The achieved water-soluble complexes harmonize a polycationic character and a buffer capacity which presuppose efficient cell penetration and increased residence time with a biodegradable cell respectful scaffold

thus appearing as a promising team of not toxic prodrugs for safe administration of ursolic and oleanolic acids.

关键词

Keywords

references

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