Recent Advances in Self-assembled Nano-therapeutics

Chun-Xiong Zheng; Yu Zhao; Yang Liu

doi:10.1007/s10118-018-2078-y

Your Location：

Home >

Browse articles >

Recent Advances in Self-assembled Nano-therapeutics

REVIEWS | Updated：2021-02-18

- Recent Advances in Self-assembled Nano-therapeutics
- Chinese Journal of Polymer Science Vol. 36, Issue 3, Pages: 322-346(2018)
- Affiliations：
  
  Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
- Author bio：
  
  Yang Liu, E-mail yliu@nankai.edu.cn
- Funds：
- DOI：10.1007/s10118-018-2078-y
  CLC：
- Received：30 September 2017，
  
  Accepted：26 October 2017，
  
  Online First：26 December 2017，
  
  Published：05 March 2018
- Accepted：
Scan QR Code
Chun-Xiong Zheng, Yu Zhao, Yang Liu. Recent Advances in Self-assembled Nano-therapeutics[J]. Chinese Journal of Polymer Science, 2018, 36(3): 322-346.
DOI：

Chun-Xiong Zheng, Yu Zhao, Yang Liu. Recent Advances in Self-assembled Nano-therapeutics[J]. Chinese Journal of Polymer Science, 2018, 36(3): 322-346. DOI： 10.1007/s10118-018-2078-y.

摘要

Abstract

The applications of nanotechnology in biomedicine have gained considerable attentions in recent years owing to the great enhancement of therapeutic efficiency. Integration of self-assembly into nanotechnology has brought tremendous convenience during the formation of nano-carriers. Based on distinctive methods of self-assembly

nano-therapeutics have been developed to an impressive stage with the ability to perform site-specific delivery with temporal and spatial control. This review focuses on the recent advances in the preparing methods for nano-therapeutics

and their applications in the treatments of diseases.

关键词

Keywords

references

J. A. Salomon , H. Wang , M. K. Freeman . Healthy life expectancy for 187 countries, ,1990-2010:a systematic analysis for the global burden of disease study . Lancet , 2013 . 381 ( 9867 ): 628 - 628 . http://europepmc.org/abstract/MED/23245606 http://europepmc.org/abstract/MED/23245606 , .

R. Porter . The nature of suffering and the goals of medicine . Hist. Phil. Life Sci. , 1997 . 19 ( 2 ): 297 - 298 . .

Y. Liu , J. Li , Y. Lu . Enzyme therapeutics for systemic detoxification . Adv. Drug Deliv. Rev. , 2015 . 90 ( 1 ): 24 - 39 . http://europepmc.org/abstract/med/25980935 http://europepmc.org/abstract/med/25980935 , .

R. Duncan . Polymer conjugates as anticancer nanomedicines . Nat. Rev. Cancer , 2006 . 6 ( 9 ): 688 - 701 . DOI: 10.1038/nrc1958 http://doi.org/10.1038/nrc1958 .

O. C. Farokhzad , R. Langer . Impact of nanotechnology on drug delivery . ACS Nano , 2009 . 3 ( 1 ): 16 - 20 . DOI: 10.1021/nn900002m http://doi.org/10.1021/nn900002m .

L. Zhang , F. X. Gu , J. M. Chan , A. Z. Wang . Nanoparticles in medicine:Therapeutic applications and developments . Clin. Pharmacol. Ther. , 2008 . 83 ( 5 ): 761 - 769 . DOI: 10.1038/sj.clpt.6100400 http://doi.org/10.1038/sj.clpt.6100400 .

M. Ferrari . Cancer nanotechnology:opportunities and challenges . Nat. Rev. Cancer , 2005 . 5 ( 3 ): 161 - 171 . DOI: 10.1038/nrc1566 http://doi.org/10.1038/nrc1566 .

K. K. Singh . Nanotechnology in cancer detection and treatment . Technol. Cancer Res. T. , 2005 . 4 ( 6 ): 583 - 583 . DOI: 10.1177/153303460500400601 http://doi.org/10.1177/153303460500400601 .

P. Couvreur , C. Vauthier . Nanotechnology:intelligent design to treat complex disease . Pharm. Res. , 2006 . 23 ( 7 ): 1417 - 1450 . DOI: 10.1007/s11095-006-0284-8 http://doi.org/10.1007/s11095-006-0284-8 .

N. Bertrand , J. Wu , X. Xu , N. Kamaly . Cancer nanotechnology:the impact of passive and active targeting in the era of modern cancer biology . Adv. Drug Deliv. Rev. , 2014 . 66 ( 1 ): 2 - 25 . https://dash.harvard.edu/bitstream/handle/1/29293165/Cancer%20Nanotechnology.pdf?sequence=1 https://dash.harvard.edu/bitstream/handle/1/29293165/Cancer%20Nanotechnology.pdf?sequence=1 , .

G. A. Ozin , K. Hou , B. V. Lotsch , L. Cademartiri . Nanofabrication by self-assembly . Mater. Today , 2009 . 12 ( 5 ): 12 - 23 . DOI: 10.1016/S1369-7021(09)70156-7 http://doi.org/10.1016/S1369-7021(09)70156-7 .

M. Mastrangeli , S. Abbasi , C. Varel , C. Van Hoof . Self-assembly from milli-to nanoscales:methods and applications . J. Micromech Microeng. , 2009 . 19 ( 8 ): DOI: 10.1088/0960-1317/19/8/083001 http://doi.org/10.1088/0960-1317/19/8/083001 .

K. J. Bishop , C. E. Wilmer , S. Soh , B. A. Grzybowski . Nanoscale forces and their uses in self-assembly . Small , 2009 . 5 ( 14 ): 1600 - 1630 . DOI: 10.1002/smll.v5:14 http://doi.org/10.1002/smll.v5:14 .

D. Peer , J. M. Karp , S. Hong , O. C. FaroKhzad . Nanocarriers as an emerging platform for cancer therapy . Nat. Nanotechnol. , 2007 . 2 ( 12 ): 751 - 760 . DOI: 10.1038/nnano.2007.387 http://doi.org/10.1038/nnano.2007.387 .

K. Letchford , H. Burt . A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures:micelles, nanospheres, nanocapsules and polymersomes . Eur. J. Pharm. Biopharm. , 2007 . 65 ( 3 ): 259 - 269 . DOI: 10.1016/j.ejpb.2006.11.009 http://doi.org/10.1016/j.ejpb.2006.11.009 .

D. Chandler . Interfaces and the driving force of hydrophobic assembly . Nature , 2005 . 437 ( 7059 ): 640 - 647 . DOI: 10.1038/nature04162 http://doi.org/10.1038/nature04162 .

C. Wang , Z. Wang , X. Zhang . Amphiphilic building blocks for self-assembly:From amphiphiles to supra-amphiphiles . Acc. Chem. Res. , 2012 . 45 ( 4 ): 608 - 618 . DOI: 10.1021/ar200226d http://doi.org/10.1021/ar200226d .

J. P. Hill , L. K. Shrestha , S. Ishihara , Q. Ji . Self-assembly:from amphiphiles to chromophores and beyond . Molecules , 2014 . 19 ( 6 ): 8589 - 8609 . http://europepmc.org/abstract/med/24959684 http://europepmc.org/abstract/med/24959684 , .

A. Rösler , G. W. M. Vandermeulen , H. A. Klok . Advanced drug delivery devices via self-assembly of amphiphilic block copolymers . Adv. Drug Deliv. Rev. , 2012 . 64 ( 1 ): 270 - 279 . https://www.sciencedirect.com/science/article/pii/S0169409X01002228 https://www.sciencedirect.com/science/article/pii/S0169409X01002228 , .

X. B. Xiong , Z. Binkhathlan , O. Molavi , A. Lavasanifar . Amphiphilic block co-polymers:Preparation and application in nanodrug and gene delivery . Acta Biomater. , 2012 . 8 ( 6 ): 2017 - 2033 . DOI: 10.1016/j.actbio.2012.03.006 http://doi.org/10.1016/j.actbio.2012.03.006 .

Z. A. B. A. Aziz , A. Ahmad , S. H. Mohd-Setapar , H. Hassan . Recent advances in drug delivery of polymeric nano-micelles . Curr. Drug Metab. , 2017 . 18 ( 1 ): 16 - 29 . DOI: 10.2174/1389200217666160921143616 http://doi.org/10.2174/1389200217666160921143616 .

V. Allain , C. Bourgaux , P. Couvreur . Self-assembled nucleolipids:From supramolecular structure to soft nucleic acid and drug delivery devices . Nucleic Acids Res. , 2012 . 40 ( 5 ): 1891 - 1903 . DOI: 10.1093/nar/gkr681 http://doi.org/10.1093/nar/gkr681 .

Y. Chen , G. Liang . Enzymatic self-assembly of nanostructures for theranostics . Theranostics , 2012 . 2 ( 2 ): 139 - 147 . DOI: 10.7150/thno.3696 http://doi.org/10.7150/thno.3696 .

Y. Mai , A. Eisenberg . Self-assembly of block copolymers . Chem. Soc. Rev. , 2012 . 41 ( 18 ): 5969 - 5985 . DOI: 10.1039/c2cs35115c http://doi.org/10.1039/c2cs35115c .

J. K. Kim , S. Y. Yang , Y. Lee , Y. Kim . Functional nanomaterials based on block copolymer self-assembly . Prog. Polym. Sci. , 2010 . 35 ( 11 ): 1325 - 1349 . DOI: 10.1016/j.progpolymsci.2010.06.002 http://doi.org/10.1016/j.progpolymsci.2010.06.002 .

Z. Zhang , R. Ma , L. Shi . Cooperative macromolecular self-assembly toward polymeric assemblies with multiple and bioactive functions . Acc. Chem. Res. , 2014 . 47 ( 4 ): 1426 - 1437 . DOI: 10.1021/ar5000264 http://doi.org/10.1021/ar5000264 .

W. Wu , D. Wu , S. Li , Z. Lin . Doxorubicin loaded ph-sensitive micelles for potential tumor therapy . J. Control. Release , 2013 . 172 ( 1 ): E72 - E73 . .

T. Cheng , R. Ma , Y. Zhang , Y. Ding . A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake . Chem. Commun. , 2015 . 51 ( 81 ): 14985 - 14988 . DOI: 10.1039/C5CC05854F http://doi.org/10.1039/C5CC05854F .

V. V. Breus , C. D. Heyes , K. Tron , G. U. Nienhaus . Zwitterionic biocompatible quantum dots for wide ph stability and weak nonspecific binding to cells . ACS Nano , 2009 . 3 ( 9 ): 2573 - 2580 . DOI: 10.1021/nn900600w http://doi.org/10.1021/nn900600w .

R. R. Arvizo , O. R. Miranda , M. A. Thompson , C. M. Pabelick . Effect of nanoparticle surface charge at the plasma membrane and beyond . Nano Lett. , 2010 . 10 ( 7 ): 2543 - 2548 . DOI: 10.1021/nl101140t http://doi.org/10.1021/nl101140t .

M. C. Deshpande , M. C. Davies , M. C. Garnett , P. M. Williams . The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes . J. Control. Release , 2004 . 97 ( 1 ): 143 - 156 . DOI: 10.1016/j.jconrel.2004.02.019 http://doi.org/10.1016/j.jconrel.2004.02.019 .

Y. Y. Yuan , C. Q. Mao , X. J. Du , J. Z. Du . Surface charge switchable nanoparticles based on zwitterionic polymer for enhanced drug delivery to tumor . Adv. Mater. , 2012 . 24 ( 40 ): 5476 - 5480 . DOI: 10.1002/adma.v24.40 http://doi.org/10.1002/adma.v24.40 .

J. Z. Du , T. M. Sun , W. J. Song , J. Wu . A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery . Angew. Chem. Int. Ed. , 2010 . 49 ( 21 ): 3621 - 3626 . DOI: 10.1002/anie.200907210 http://doi.org/10.1002/anie.200907210 .

M. H. Xiong , Y. Bao , X. Z. Yang , Y. C. Wang . Lipase-sensitive polymeric triple-layered nanogel for "on-demand" drug delivery . J. Am. Chem. Soc. , 2012 . 134 ( 9 ): 4355 - 4362 . DOI: 10.1021/ja211279u http://doi.org/10.1021/ja211279u .

J. Z. Du , X. J. Du , C. Q. Mao , J. Wang . Tailor-made dual ph-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery . J. Am. Chem. Soc. , 2011 . 133 ( 44 ): 17560 - 17563 . DOI: 10.1021/ja207150n http://doi.org/10.1021/ja207150n .

E. Pereverzeva , I. Treschalin , D. Bodyagin , O. Maksimenko . Intravenous tolerance of a nanoparticle-based formulation of doxorubicin in healthy rats . Toxicol. Lett. , 2008 . 178 ( 1 ): 9 - 19 . DOI: 10.1016/j.toxlet.2008.01.020 http://doi.org/10.1016/j.toxlet.2008.01.020 .

W. G. Harker , B. I. Sikic . Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line mes-sa . Cancer Res. , 1985 . 45 ( 9 ): 4091 - 4096 . http://www.ncbi.nlm.nih.gov/pubmed/4028002 http://www.ncbi.nlm.nih.gov/pubmed/4028002 , .

T. Cheng , J. Liu , J. Ren , F. Huang . Green tea catechin-based complex micelles combined with doxorubicin to overcome cardiotoxicity and multidrug resistance . Theranostics , 2016 . 6 ( 9 ): 1277 - 1292 . DOI: 10.7150/thno.15133 http://doi.org/10.7150/thno.15133 .

A. Sharma , U. S. Sharma . Liposomes in drug delivery:Progress and limitations . Int. J. Pharmaceut. , 1997 . 154 ( 2 ): 123 - 140 . DOI: 10.1016/S0378-5173(97)00135-X http://doi.org/10.1016/S0378-5173(97)00135-X .

Y. Wang , L. Miao , A. Satterlee , L. Huang . Delivery of oligonucleotides with lipid nanoparticles . Adv. Drug Deliv. Rev. , 2015 . 87 ( 1 ): 68 - 80 . http://www.sciencedirect.com/science/article/pii/s0169409x15000186 http://www.sciencedirect.com/science/article/pii/s0169409x15000186 , .

B. Goins , W. T. Phillips , A. Bao . Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy . Expert Opin. Drug Deliv. , 2016 . 13 ( 6 ): 873 - 889 . http://pubmedcentralcanada.ca/pmcc/articles/PMC4933501/ http://pubmedcentralcanada.ca/pmcc/articles/PMC4933501/ , .

L. Sercombe , T. Veerati , F. Moheimani , S. Y. Wu . Advances and challenges of liposome assisted drug delivery . Front Pharmacol. , 2015 . 6 DOI: 10.3389/fphar.2015.00286 http://doi.org/10.3389/fphar.2015.00286 .

Y. Barenholz . Liposome application:Problems and prospects . Curr. Opin. Colloid Interface Sci. , 2001 . 6 ( 1 ): 66 - 77 . DOI: 10.1016/S1359-0294(00)00090-X http://doi.org/10.1016/S1359-0294(00)00090-X .

J. C. Kraft , J. P. Freeling , Z. Wang , R. J. Ho . Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems . J. Pharm. Sci. , 2014 . 103 ( 1 ): 29 - 52 . http://europepmc.org/abstract/med/24338748 http://europepmc.org/abstract/med/24338748 , .

H. I. Chang , M. K. Yeh . Clinical development of liposome-based drugs:Formulation, characterization, and therapeutic efficacy . Int. J. Nanomed. , 2012 . 7 ( 1 ): 49 - 60 . http://europepmc.org/articles/PMC3260950/ http://europepmc.org/articles/PMC3260950/ , .

F. Yang , C. Jin , Y. Jiang , J. Li . Liposome based delivery systems in pancreatic cancer treatment:From bench to bedside . Cancer Treat Rev. , 2011 . 37 ( 8 ): 633 - 642 . DOI: 10.1016/j.ctrv.2011.01.006 http://doi.org/10.1016/j.ctrv.2011.01.006 .

R. Mo , T. Jiang , Z. Gu . Recent progress in multidrug delivery to cancer cells by liposomes . Nanomedicine , 2014 . 9 ( 8 ): 1117 - 1120 . DOI: 10.2217/nnm.14.62 http://doi.org/10.2217/nnm.14.62 .

M. L. Immordino , F. Dosio , L. Cattel . Stealth liposomes:Review of the basic science, rationale, and clinical applications, existing and potential . Int. J. Nanomed. , 2006 . 1 ( 3 ): 297 - 315 . DOI: 10.2217/17435889.1.3.297 http://doi.org/10.2217/17435889.1.3.297 .

H. Wang , S. Zhang , Z. Liao , C. Wang . Peglated magnetic polymeric liposome anchored with tat for delivery of drugs across the blood-spinal cord barrier . Biomaterials , 2010 . 31 ( 25 ): 6589 - 6596 . DOI: 10.1016/j.biomaterials.2010.04.057 http://doi.org/10.1016/j.biomaterials.2010.04.057 .

Z. E. Suntres . Liposomal antioxidants for protection against oxidant-induced damage . J. Toxicol. , 2011 . DOI: 10.1155/2011/152474 http://doi.org/10.1155/2011/152474 .

X. Zhang , S. Guo , R. Fan , M. Yu . Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells . Biomaterials , 2012 . 33 ( 29 ): 7103 - 7114 . DOI: 10.1016/j.biomaterials.2012.06.048 http://doi.org/10.1016/j.biomaterials.2012.06.048 .

H. Wang , P. Zhao , W. Su , S. Wang . PLGA/polymeric liposome for targeted drug and gene co-delivery . Biomaterials , 2010 . 31 ( 33 ): 8741 - 8748 . DOI: 10.1016/j.biomaterials.2010.07.082 http://doi.org/10.1016/j.biomaterials.2010.07.082 .

T. Jiang , R. Mo , A. Bellotti , J. Zhou . Gel-liposome-mediated co-delivery of anticancer membrane-associated proteins and small-molecule drugs for enhanced therapeutic efficacy . Adv. Funct. Mater. , 2014 . 24 ( 16 ): 2295 - 2304 . DOI: 10.1002/adfm.v24.16 http://doi.org/10.1002/adfm.v24.16 .

R. Mo , T. Y. Jiang , Z. Gu . Enhanced anticancer efficacy by atp-mediated liposomal drug delivery . Angew. Chem. Int Ed. , 2014 . 53 ( 23 ): 5815 - 5820 . DOI: 10.1002/anie.201400268 http://doi.org/10.1002/anie.201400268 .

J. Schafer , S. Hobel , U. Bakowsky , A. Aigner . Liposome-polyethylenimine complexes for enhanced DNA and sirna delivery . Biomaterials , 2010 . 31 ( 26 ): 6892 - 6900 . DOI: 10.1016/j.biomaterials.2010.05.043 http://doi.org/10.1016/j.biomaterials.2010.05.043 .

A. K. Rengan , A. B. Bukhari , A. Pradhan , R. Malhotra . In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer . Nano Lett. , 2015 . 15 ( 2 ): 842 - 848 . DOI: 10.1021/nl5045378 http://doi.org/10.1021/nl5045378 .

J. A. Hubbell , A. Chilkoti . Nanomaterials for drug delivery . Science , 2012 . 337 ( 6092 ): 303 - 305 . DOI: 10.1126/science.1219657 http://doi.org/10.1126/science.1219657 .

J. H. Park , S. Lee , J. H. Kim , K. Park . Polymeric nanomedicine for cancer therapy . Prog. Polym. Sci. , 2008 . 33 ( 1 ): 113 - 137 . DOI: 10.1016/j.progpolymsci.2007.09.003 http://doi.org/10.1016/j.progpolymsci.2007.09.003 .

R. Tong , J. Cheng . Anticancer polymeric nanomedicines . Polym. Rev. , 2007 . 47 ( 3 ): 345 - 381 . DOI: 10.1080/15583720701455079 http://doi.org/10.1080/15583720701455079 .

P. Huang , D. Wang , Y. Su , W. Huang . Combination of small molecule prodrug and nanodrug delivery:Amphiphilic drug-drug conjugate for cancer therapy . J. Am. Chem. Soc. , 2014 . 136 ( 33 ): 11748 - 56 . DOI: 10.1021/ja505212y http://doi.org/10.1021/ja505212y .

M. Hu , P. Huang , Y. Wang , Y. Su . Synergistic combination chemotherapy of camptothecin and floxuridine through self-assembly of amphiphilic drug-drug conjugate . Bioconjugate. Chem. , 2015 . 26 ( 12 ): 2497 - 2506 . DOI: 10.1021/acs.bioconjchem.5b00513 http://doi.org/10.1021/acs.bioconjchem.5b00513 .

T. Zhang , P. Huang , L. Shi , Y. Su . Self-assembled nanoparticles of amphiphilic twin drug from floxuridine and bendamustine for cancer therapy . Mol. Pharm. , 2015 . 12 ( 7 ): 2328 - 2336 . DOI: 10.1021/acs.molpharmaceut.5b00005 http://doi.org/10.1021/acs.molpharmaceut.5b00005 .

Y. Ma , Q. Mou , M. Sun , C. Yu . Cancer theranostic nanoparticles self-assembled from amphiphilic small molecules with equilibrium shift-induced renal clearance . Theranostics , 2016 . 6 ( 10 ): 1703 - 1716 . DOI: 10.7150/thno.15647 http://doi.org/10.7150/thno.15647 .

Q. Mou , Y. Ma , X. Zhu , D. Yan . A small molecule nanodrug consisting of amphiphilic targeting ligand-chemotherapy drug conjugate for targeted cancer therapy . J. Control. Release , 2016 . 230 ( 1 ): 34 - 44 . https://www.sciencedirect.com/science/article/pii/S0168365916301833 https://www.sciencedirect.com/science/article/pii/S0168365916301833 , .

Y. Wang , P. Huang , M. Hu , W. Huang . Self-delivery nanoparticles of amphiphilic methotrexate-gemcitabine prodrug for synergistic combination chemotherapy via effect of deoxyribonucleotide pools . Bioconjugate. Chem. , 2016 . 27 ( 11 ): 2722 - 2733 . DOI: 10.1021/acs.bioconjchem.6b00503 http://doi.org/10.1021/acs.bioconjchem.6b00503 .

D. W. Pack , A. S. Hoffman , S. Pun , P. S. Stayton . Design and development of polymers for gene delivery . Nat. Rev. Drug Discov. , 2005 . 4 ( 7 ): 581 - 93 . DOI: 10.1038/nrd1775 http://doi.org/10.1038/nrd1775 .

Z. P. Xu , Q. H. Zeng , G. Q. Lu , A. B. Yu . Inorganic nanoparticles as carriers for efficient cellular delivery . Chem Eng. Sci. , 2006 . 61 ( 3 ): 1027 - 1040 . DOI: 10.1016/j.ces.2005.06.019 http://doi.org/10.1016/j.ces.2005.06.019 .

L. Lacerda , S. Raffa , M. Prato , A. Bianco . Cell-penetrating cnts for delivery of therapeutics . Nano Today , 2007 . 2 ( 6 ): 38 - 43 . DOI: 10.1016/S1748-0132(07)70172-X http://doi.org/10.1016/S1748-0132(07)70172-X .

S. Mao , W. Sun , T. Kissel . Chitosan-based formulations for delivery of DNA and sirna . Adv. Drug Deliv. Rev. , 2010 . 62 ( 1 ): 12 - 27 . DOI: 10.1016/j.addr.2009.08.004 http://doi.org/10.1016/j.addr.2009.08.004 .

J. P. Chapel , J. F. Berret . Versatile electrostatic assembly of nanoparticles and polyelectrolytes:Coating, clustering and layer-by-layer processes . Curr. Opin. Colloid Interface Sci. , 2012 . 17 ( 2 ): 97 - 105 . DOI: 10.1016/j.cocis.2011.08.009 http://doi.org/10.1016/j.cocis.2011.08.009 .

R. B. Shmueli , D. G. Anderson , J. J. Green . Electrostatic surface modifications to improve gene delivery . Expert Opin. Drug Deliv. , 2010 . 7 ( 4 ): 535 - 550 . DOI: 10.1517/17425241003603653 http://doi.org/10.1517/17425241003603653 .

R. C. Mulligan . The basic science of gene therapy . Science , 1993 . 260 ( 5110 ): 926 - 32 . DOI: 10.1126/science.8493530 http://doi.org/10.1126/science.8493530 .

Y. Liu , J. Du , J. S. Choi , K. J. Chen . A high-throughput platform for formulating and screening multifunctional nanoparticles capable of simultaneous delivery of genes and transcription factors . Angew. Chem. Int. Ed. , 2016 . 55 ( 1 ): 169 - 173 . DOI: 10.1002/anie.201507546 http://doi.org/10.1002/anie.201507546 .

I. M. Verma , N. Somia . Gene therapy-promises, problems and prospects . Nature , 1997 . 389 ( 6648 ): 239 - 42 . DOI: 10.1038/38410 http://doi.org/10.1038/38410 .

R. Kircheis , L. Wightman , E. Wagner . Design and gene delivery activity of modified polyethylenimines . Adv. Drug Deliv. Rev. , 2001 . 53 ( 3 ): 341 - 358 . DOI: 10.1016/S0169-409X(01)00202-2 http://doi.org/10.1016/S0169-409X(01)00202-2 .

T. J. Harris , J. J. Green , P. W. Fung , R. Langer . Tissue-specific gene delivery via nanoparticle coating . Biomaterials , 2010 . 31 ( 5 ): 998 - 1006 . DOI: 10.1016/j.biomaterials.2009.10.012 http://doi.org/10.1016/j.biomaterials.2009.10.012 .

Y. Liu , H. Wang , K. I. Kamei , M. Yan . Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles . Angew. Chem. Int. Ed. , 2011 . 50 ( 13 ): 3058 - 3062 . DOI: 10.1002/anie.201005740 http://doi.org/10.1002/anie.201005740 .

Y. W. Won , P. P. Adhikary , K. S. Lim , H. J. Kim . Oligopeptide complex for targeted non-viral gene delivery to adipocytes . Nat. Mater. , 2014 . 13 ( 12 ): 1157 - 1164 . DOI: 10.1038/nmat4092 http://doi.org/10.1038/nmat4092 .

K. Ariga , Y. M. Lvov , K. Kawakami , Q. Ji . Layer-by-layer self-assembled shells for drug delivery . Adv. Drug Deliv. Rev. , 2011 . 63 ( 9 ): 762 - 771 . DOI: 10.1016/j.addr.2011.03.016 http://doi.org/10.1016/j.addr.2011.03.016 .

K. Ariga , Y. Yamauchi , G. Rydzek , Q. Ji . Layer-by-layer nanoarchitectonics:Invention, innovation, and evolution . Chem Lett. , 2014 . 43 ( 1 ): 36 - 68 . DOI: 10.1246/cl.130987 http://doi.org/10.1246/cl.130987 .

N. Fujii , K. Fujimoto , T. Michinobu , M. Akada . The simplest layer-by-layer assembly structure:Best paired polymer electrolytes with one charge per main chain carbon atom for multi layered thin films . Macromolecules , 2010 . 43 ( 8 ): 3947 - 3955 . DOI: 10.1021/ma100473j http://doi.org/10.1021/ma100473j .

Y. Lvov , M. Onda , K. Ariga , T. Kunitake . Ultrathin films of charged polysaccharides assembled alternately with linear polyions . J. Biomat. Sci. Polym. E , 1998 . 9 ( 4 ): 345 - 355 . DOI: 10.1080/09205063.1998.9753060 http://doi.org/10.1080/09205063.1998.9753060 .

K. Katagiri , R. Hamasaki , K. Ariga , J. Kikuchi . Layered paving of vesicular nanoparticles formed with cerasome as a bioinspired organic-inorganic hybrid . J. Am. Chem. Soc. , 2002 . 124 ( 27 ): 7892 - 7893 . DOI: 10.1021/ja0259281 http://doi.org/10.1021/ja0259281 .

A. Elbakry , A. Zaky , R. Liebkl , R. Rachel . Layer-by-layer assembled gold nanoparticles for sirna delivery . Nano Lett. , 2009 . 9 ( 5 ): 2059 - 2064 . DOI: 10.1021/nl9003865 http://doi.org/10.1021/nl9003865 .

E. M. Saurer , R. M. Flessner , S. P. Sullivan , M. R. Prausnitz . Layer-by-layer assembly of DNA-and protein-containing films on microneedles for drug delivery to the skin . Biomacromolecules , 2010 . 11 ( 11 ): 3136 - 3143 . DOI: 10.1021/bm1009443 http://doi.org/10.1021/bm1009443 .

S. W. Morton , N. J. Shah , M. A. Quadir , Z. J. Deng . Osteotropic therapy via targeted layer-by-layer nanoparticles . Adv. Healthc. Mater. , 2014 . 3 ( 6 ): 867 - 75 . DOI: 10.1002/adhm.201300465 http://doi.org/10.1002/adhm.201300465 .

T. G. Shutava , S. S. Balkundi , P. Vangala , J. J. Steffan . Layer-by-layer-coated gelatin nanoparticles as a vehicle for delivery of natural polyphenols . ACS Nano , 2009 . 3 ( 7 ): 1877 - 1885 . DOI: 10.1021/nn900451a http://doi.org/10.1021/nn900451a .

A. Agarwal , Y. Lvov , R. Sawant , V. Torchilin . Stable nanocolloids of poorly soluble drugs with high drug content prepared using the combination of sonication and layer-by-layer technology . J. Control. Release , 2008 . 128 ( 3 ): 255 - 260 . DOI: 10.1016/j.jconrel.2008.03.017 http://doi.org/10.1016/j.jconrel.2008.03.017 .

N. Pargaonkar , Y. M. Lvov , N. Li , J. H. Steenekamp . Controlled release of dexamethasone from microcapsules produced by polyelectrolyte layer-by-layer nanoassembly . Pharm. Res. , 2005 . 22 ( 5 ): 826 - 835 . DOI: 10.1007/s11095-005-2600-0 http://doi.org/10.1007/s11095-005-2600-0 .

Z. J. Deng , S. W. Morton , E. Ben-Akiva , E. C. Dreaden . Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and sirna for potential triple-negative breast cancer treatment . ACS Nano , 2013 . 7 ( 11 ): 9571 - 9584 . DOI: 10.1021/nn4047925 http://doi.org/10.1021/nn4047925 .

Z. Poon , D. Chang , X. Zhao , P. T. Hammond . Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia . ACS Nano , 2011 . 5 ( 6 ): 4284 - 4292 . DOI: 10.1021/nn200876f http://doi.org/10.1021/nn200876f .

B. S. Kim , S. W. Park , P. T. Hammond . Hydrogen-bonding layer-by-layer assembled biodegradable polymeric micelles as drug delivery vehicles from surfaces . ACS Nano , 2008 . 2 ( 2 ): 386 - 392 . DOI: 10.1021/nn700408z http://doi.org/10.1021/nn700408z .

X. Ma , Y. Zhao . Biomedical applications of supramolecular systems based on host-guest interactions . Chem. Rev. , 2015 . 115 ( 15 ): 7794 - 7839 . DOI: 10.1021/cr500392w http://doi.org/10.1021/cr500392w .

A. A. Karim , Q. Dou , Z. Li , X. J. Loh . Emerging supramolecular therapeutic carriers based on host-guest interactions . Chem. Asian J. , 2016 . 11 ( 9 ): 1300 - 1321 . DOI: 10.1002/asia.v11.9 http://doi.org/10.1002/asia.v11.9 .

J. Hu , S. Liu . Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications . Acc. Chem. Res. , 2014 . 47 ( 7 ): 2084 - 2095 . DOI: 10.1021/ar5001007 http://doi.org/10.1021/ar5001007 .

J. Zhang , P. X. Ma . Cyclodextrin-based supramolecular systems for drug delivery:Recent progress and future perspective . Adv. Drug Deliv. Rev. , 2013 . 65 ( 9 ): 1215 - 1233 . DOI: 10.1016/j.addr.2013.05.001 http://doi.org/10.1016/j.addr.2013.05.001 .

L. Wang , L. L. Li , Y. S. Fan , H. Wang . Host-guest supramolecular nanosystems for cancer diagnostics and therapeutics . Adv. Mater. , 2013 . 25 ( 28 ): 3888 - 3898 . DOI: 10.1002/adma.v25.28 http://doi.org/10.1002/adma.v25.28 .

R. Challa , A. Ahuja , J. Ali , R. K. Khar . Cyclodextrins in drug delivery:An updated review . AAPS PharmSciTech. , 2005 . 6 ( 2 ): E329 - E357 . DOI: 10.1208/pt060243 http://doi.org/10.1208/pt060243 .

V. J. Stella , R. A. Rajewski . Cyclodextrins:Their future in drug formulation and delivery . Pharm. Res-Dordr. , 1997 . 14 ( 5 ): 556 - 567 . DOI: 10.1023/A:1012136608249 http://doi.org/10.1023/A:1012136608249 .

R. Gref , C. Amiel , K. Molinard , S. Daoud-Mahammed . New self-assembled nanogels based on host-guest interactions:Characterization and drug loading . J. Control. Release , 2006 . 111 ( 3 ): 316 - 324 . DOI: 10.1016/j.jconrel.2005.12.025 http://doi.org/10.1016/j.jconrel.2005.12.025 .

J. Zhang , P. X. Ma . Polymeric core-shell assemblies mediated by host-guest interactions:versatile nanocarriers for drug delivery . Angew. Chem. Int. Ed. , 2009 . 48 ( 5 ): 964 - 968 . DOI: 10.1002/anie.v48:5 http://doi.org/10.1002/anie.v48:5 .

Q. D. Hu , G. P. Tang , P. K. Chu . Cyclodextrin-based host-guest supramolecular nanoparticles for delivery:from design to applications . Acc. Chem. Res. , 2014 . 47 ( 7 ): 2017 - 2025 . DOI: 10.1021/ar500055s http://doi.org/10.1021/ar500055s .

H. Wang , S. Wang , H. Su , K. J. Chen . A supramolecular approach for preparation of size-controlled nanoparticles . Angew. Chem. Int. Ed. , 2009 . 48 ( 24 ): 4344 - 4318 . DOI: 10.1002/anie.v48:24 http://doi.org/10.1002/anie.v48:24 .

C.Y. Ang , S. Y. Tan , X. Wang , Q. Zhang . Supramolecular nanoparticle carriers self-assembled from cyclodextrin-and adamantane-functionalized polyacrylates for tumor-targeted drug delivery . J. Mater. Chem. B , 2014 . 2 ( 13 ): 1879 - 1890 . DOI: 10.1039/c3tb21325k http://doi.org/10.1039/c3tb21325k .

D. H. Qu , Q. C. Wang , Q. W. Zhang , X. Ma . Photoresponsive host-guest functional systems . Chem. Rev. , 2015 . 115 ( 15 ): 7543 - 7588 . DOI: 10.1021/cr5006342 http://doi.org/10.1021/cr5006342 .

Z. Dan , H. Cao , X. He , L. Zeng . Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy . Int. J. Pharm. , 2015 . 483 ( 1-2 ): 63 - 68 . DOI: 10.1016/j.ijpharm.2015.01.035 http://doi.org/10.1016/j.ijpharm.2015.01.035 .

W. Zhang , Y. Li , J. H. Sun , C. P. Tan . Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells . Chem. Commun. , 2015 . 51 ( 10 ): 1807 - 1810 . DOI: 10.1039/C4CC08583C http://doi.org/10.1039/C4CC08583C .

Y. Wang , D. Li , Q. Jin , J. Ji . pH-responsive supramolecular prodrug micelles based on cucurbit 8 uril for intracellular drug delivery . J Control. Release , 2015 . 213 ( 1 ): E134 - E135 . .

G. Yu , K. Jie , F. Huang . Supramolecular amphiphiles based on host-guest molecular recognition motifs . Chem. Rev. , 2015 . 115 ( 15 ): 7240 - 7303 . DOI: 10.1021/cr5005315 http://doi.org/10.1021/cr5005315 .

B. Yang , X. Dong , Q. Lei , R. Zhuo . Host-guest interaction-based self-engineering of nano-sized vesicles for co-delivery of genes and anticancer drugs . ACS Appl. Mater. Interfaces , 2015 . 7 ( 39 ): 22084 - 22094 . DOI: 10.1021/acsami.5b07549 http://doi.org/10.1021/acsami.5b07549 .

Y. Liu , C. Yu , H. Jin , B. Jiang . A supramolecular janus hyperbranched polymer and its photoresponsive self-assembly of vesicles with narrow size distribution . J. Am. Chem. Soc. , 2013 . 135 ( 12 ): 4765 - 4770 . DOI: 10.1021/ja3122608 http://doi.org/10.1021/ja3122608 .

Y. Li , Y. Liu , R. Ma , Y. Xu . A g-quadruplex hydrogel via multicomponent self-assembly:Formation and zero-order controlled release . ACS Appl. Mater. Interfaces , 2017 . 9 ( 15 ): 13056 - 13067 . DOI: 10.1021/acsami.7b00957 http://doi.org/10.1021/acsami.7b00957 .

L. Zhao , R. Qu , A. Li , R. Ma . Cooperative self-assembly of porphyrins with polymers possessing bioactive functions . Chem. Commun. , 2016 . 52 ( 93 ): 13543 - 13555 . DOI: 10.1039/C6CC05449H http://doi.org/10.1039/C6CC05449H .

Z. Gu , A. Biswas , M. Zhao , Y. Tang . Tailoring nanocarriers for intracellular protein delivery . Chem. Soc. Rev. , 2011 . 40 ( 7 ): 3638 - 3655 . DOI: 10.1039/c0cs00227e http://doi.org/10.1039/c0cs00227e .

M. Yan , J. Ge , Z. Liu , P. Ouyang . Encapsulation of single enzyme in nanogel with enhanced biocatalytic activity and stability . J. Am. Chem. Soc. , 2006 . 128 ( 34 ): 11008 - 11009 . DOI: 10.1021/ja064126t http://doi.org/10.1021/ja064126t .

M. Yan , J. Du , Z. Gu , M. Liang . A novel intracellular protein delivery platform based on single-protein nanocapsules . Nat. Nanotechnol. , 2010 . 5 ( 1 ): 48 - 53 . DOI: 10.1038/nnano.2009.341 http://doi.org/10.1038/nnano.2009.341 .

Z. Gu , M. Yan , B. Hu , K. I. Joo . Protein nanocapsule weaved with enzymatically degradable polymeric network . Nano Lett. , 2009 . 9 ( 12 ): 4533 - 4538 . DOI: 10.1021/nl902935b http://doi.org/10.1021/nl902935b .

J. Wen , S. M. Anderson , J. Du , M. Yan . Controlled protein delivery based on enzyme-responsive nanocapsules . Adv. Mater. , 2011 . 23 ( 39 ): 4549 - 53 . DOI: 10.1002/adma.201101771 http://doi.org/10.1002/adma.201101771 .

S. Liang , Y. Liu , X. Jin , G. Liu . Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins . Nano Res. , 2016 . 9 ( 4 ): 1022 - 1031 . DOI: 10.1007/s12274-016-0991-3 http://doi.org/10.1007/s12274-016-0991-3 .

M. Zhao , B. Hu , Z. Gu , K. I. Joo . Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex . Nano Today , 2013 . 8 ( 1 ): 11 - 20 . DOI: 10.1016/j.nantod.2012.12.003 http://doi.org/10.1016/j.nantod.2012.12.003 .

H. Tian , J. Du , J. Wen , Y. Liu . Growth-factor nanocapsules that enable tunable controlled release for bone regeneration . ACS Nano , 2016 . 10 ( 8 ): 7362 - 7369 . DOI: 10.1021/acsnano.5b07950 http://doi.org/10.1021/acsnano.5b07950 .

C. Liu , J. Wen , Y. Meng , K. Zhang . Efficient delivery of therapeutic mirna nanocapsules for tumor suppression . Adv. Mater. , 2015 . 27 ( 2 ): 292 - 297 . DOI: 10.1002/adma.v27.2 http://doi.org/10.1002/adma.v27.2 .

D. Peer , J. M. Karp , S. Hong , O. C. FaroKHzad . Nanocarriers as an emerging platform for cancer therapy . Nat. Nanotechnol. , 2007 . 2 ( 12 ): 751 - 760 . DOI: 10.1038/nnano.2007.387 http://doi.org/10.1038/nnano.2007.387 .

M. Wang , M. Thanou . Targeting nanoparticles to cancer . Pharmacol. Res. , 2010 . 62 ( 2 ): 90 - 99 . DOI: 10.1016/j.phrs.2010.03.005 http://doi.org/10.1016/j.phrs.2010.03.005 .

C. E. DeSantis , C. C. Lin , A. B. Mariotto , R. L. Siegel . Cancer treatment and survivorship statistics, ,2014 . CA:A Cancer Journal for Clinicians , 2014 . 64 ( 4 ): 252 - 271 . DOI: 10.3322/caac.v64.4 http://doi.org/10.3322/caac.v64.4 .

T. M. Sun , Y. S. Zhang , B. Pang , D. C. Hyun . Engineered nanoparticles for drug delivery in cancer therapy . Angew. Chem. Int. Ed. , 2014 . 53 ( 46 ): 12320 - 12364 . http://europepmc.org/abstract/med/25294565 http://europepmc.org/abstract/med/25294565 , .

Y. Liu , J. Li , Y. F. Lu . Enzyme therapeutics for systemic detoxification . Adv. Drug Deliv. Rev. , 2015 . 90 24 - 39 . DOI: 10.1016/j.addr.2015.05.005 http://doi.org/10.1016/j.addr.2015.05.005 .

Y. H. Bae , K. Park . Targeted drug delivery to tumors:myths, reality and possibility . J. Control. Release , 2011 . 153 ( 3 ): 198 - 205 . DOI: 10.1016/j.jconrel.2011.06.001 http://doi.org/10.1016/j.jconrel.2011.06.001 .

D. A. LaVan , T. McGuire , R. Langer . Small-scale systems for in vivo drug delivery . Nat. Biotechnol. , 2003 . 21 ( 10 ): 1184 - 1191 . DOI: 10.1038/nbt876 http://doi.org/10.1038/nbt876 .

S. Ganta , H. Devalapally , A. Shahiwala , M. Amiji . A review of stimuli-responsive nanocarriers for drug and gene delivery . J. Control. Release , 2008 . 126 ( 3 ): 187 - 204 . DOI: 10.1016/j.jconrel.2007.12.017 http://doi.org/10.1016/j.jconrel.2007.12.017 .

G. Wang , H. Uludag . Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles . Expert Opin. Drug Deliv. , 2008 . 5 ( 5 ): 499 - 515 . DOI: 10.1517/17425247.5.5.499 http://doi.org/10.1517/17425247.5.5.499 .

H. Gao , T. Cheng , J. Liu , J. Liu . Self-regulated multifunctional collaboration of targeted nanocarriers for enhanced tumor therapy . Biomacromolecules , 2014 . 15 ( 10 ): 3634 - 3642 . DOI: 10.1021/bm5009348 http://doi.org/10.1021/bm5009348 .

A. J. Shuhendler , P. Prasad , M. Leung , A. M. Rauth . A novel solid lipid nanoparticle formulation for active targeting to tumor alpha(v)beta(3) integrin receptors reveals cyclic rgd as a double-edged sword . Adv. Healthc. Mater. , 2012 . 1 ( 5 ): 600 - 608 . DOI: 10.1002/adhm.201200006 http://doi.org/10.1002/adhm.201200006 .

T. J. Cheng , R. J. Ma , Y. M. Zhang , Y. X. Ding . A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake . Chem. Commun. , 2015 . 51 ( 81 ): 14985 - 14988 . DOI: 10.1039/C5CC05854F http://doi.org/10.1039/C5CC05854F .

A. Falamarzian , A. Lavasanifar . Optimization of the hydrophobic domain in poly(ethylene oxide)-poly(epsilon-caprolactone) based nano-carriers for the solubilization and delivery of amphotericin b . Colloids and Surfaces B-Biointerfaces , 2010 . 81 ( 1 ): 313 - 320 . DOI: 10.1016/j.colsurfb.2010.07.025 http://doi.org/10.1016/j.colsurfb.2010.07.025 .

H. J. Gao , J. Xiong , T. J. Cheng , J. J. Liu . In vivo biodistribution of mixed shell micelles with tunable hydrophilic/hydrophobic surface . Biomacromolecules , 2013 . 14 ( 2 ): 460 - 467 . DOI: 10.1021/bm301694t http://doi.org/10.1021/bm301694t .

H. X. Wang , X. Z. Yang , C. Y. Sun , C. Q. Mao . Matrix metalloproteinase 2-responsive micelle for sirna delivery . Biomaterials , 2014 . 35 ( 26 ): 7622 - 7634 . DOI: 10.1016/j.biomaterials.2014.05.050 http://doi.org/10.1016/j.biomaterials.2014.05.050 .

C. Y. Sun , S. Shen , C. F. Xu , H. J. Li . Tumor acidity-sensitive polymeric vector for active targeted sirna delivery . J. Am. Chem. Soc. , 2015 . 137 ( 48 ): 15217 - 15224 . DOI: 10.1021/jacs.5b09602 http://doi.org/10.1021/jacs.5b09602 .

X. Guan , Z. Guo , L. Lin , J. Chen . Ultrasensitive pH triggered charge/size dual-rebound gene delivery system . Nano Lett. , 2016 . 16 ( 11 ): 6823 - 6831 . DOI: 10.1021/acs.nanolett.6b02536 http://doi.org/10.1021/acs.nanolett.6b02536 .

D. Wakebayashi , N. Nishiyama , Y. Yamasaki , K. Itaka . Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system:Their preparation and gene transfecting efficiency against cultured HEPG2 cells . J. Control. Release , 2004 . 95 ( 3 ): 653 - 664 . DOI: 10.1016/j.jconrel.2004.01.003 http://doi.org/10.1016/j.jconrel.2004.01.003 .

A. Harada , K. Kataoka . Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymers . J. Control. Release , 2001 . 72 ( 1-3 ): 85 - 91 . DOI: 10.1016/S0168-3659(01)00264-4 http://doi.org/10.1016/S0168-3659(01)00264-4 .

M. H. Dufresne , J. C. Leroux . Study of the micellization behavior of different order amino block copolymers with heparin . Pharm. Res. , 2004 . 21 ( 1 ): 160 - 169 . DOI: 10.1023/B:PHAM.0000012164.60867.c6 http://doi.org/10.1023/B:PHAM.0000012164.60867.c6 .

A. Biswas , K. I. Joo , J. Liu , M. X. Zhao . Endoprotease-mediated intracellular protein delivery using nanocapsules . ACS Nano , 2011 . 5 ( 2 ): 1385 - 1394 . DOI: 10.1021/nn1031005 http://doi.org/10.1021/nn1031005 .

Y. Liu , H. Wang , K. Kamei , M. Yan . Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles . Angew. Chem. Int. Ed. , 2011 . 50 ( 13 ): 3058 - 3062 . DOI: 10.1002/anie.201005740 http://doi.org/10.1002/anie.201005740 .

T. Govender , S. Stolnik , C. Xiong , S. Zhang . Drug-polyionic block copolymer interactions for micelle formation:Physicochemical characterisation . J. Control. Release , 2001 . 75 ( 3 ): 249 - 258 . DOI: 10.1016/S0168-3659(01)00353-4 http://doi.org/10.1016/S0168-3659(01)00353-4 .

T. Safra , F. Muggia , S. Jeffers , D. D. Tsao-Wei . Pegylated liposomal doxorubicin (doxil):Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m(2) . Ann Oncol. , 2000 . 11 ( 8 ): 1029 - 1033 . DOI: 10.1023/A:1008365716693 http://doi.org/10.1023/A:1008365716693 .

K. J. Cho , X. Wang , S. M. Nie , Z. Chen . Therapeutic nanoparticles for drug delivery in cancer . Clin. Cancer Res. , 2008 . 14 ( 5 ): 1310 - 1316 . DOI: 10.1158/1078-0432.CCR-07-1441 http://doi.org/10.1158/1078-0432.CCR-07-1441 .

S. Koudelka , J. Turanek . Liposomal paclitaxel formulations . J. Control. Release , 2012 . 163 ( 3 ): 322 - 334 . DOI: 10.1016/j.jconrel.2012.09.006 http://doi.org/10.1016/j.jconrel.2012.09.006 .

W. T. Lim , S. S. Leong , C. K. Toh , C. S. Ang . A phase i pharmacokinetic study of a liposomal formulation of paclitaxel administered weekly to Asian patients with solid malignancies . J. Clin. Oncol. , 2009 . 27 ( 15 ): 2581 .

M. Markman . Pegylated liposomal doxorubicin in the treatment of cancers of the breast and ovary . Expert Opin. Pharmaco. , 2006 . 7 ( 11 ): 1469 - 1474 . DOI: 10.1517/14656566.7.11.1469 http://doi.org/10.1517/14656566.7.11.1469 .

M. M. Gaspar , R. Perez-Soler , M. E. Cruz . Biological characterization of l-asparaginase liposomal formulations . Cancer Chemother. Pharmacol. , 1996 . 38 ( 4 ): 373 - 377 . DOI: 10.1007/s002800050497 http://doi.org/10.1007/s002800050497 .

P. L. Felgner , M. Holm , H. Chan . Cationic liposome mediated transfection . Proc. West Pharmacol. Soc. , 1989 . 32 115 - 121 . .

P. L. Felgner , G. M. Ringold . Cationic liposome-mediated transfection . Nature , 1989 . 337 ( 6205 ): 387 - 388 . DOI: 10.1038/337387a0 http://doi.org/10.1038/337387a0 .

K. D. Murray , A. McQuillin , L. Stewart , C. J. Etheridge . Cationic liposome-mediated DNA transfection in organotypic explant cultures of the ventral mesencephalon . Gene Ther. , 1999 . 6 ( 2 ): 190 - 197 . DOI: 10.1038/sj.gt.3300743 http://doi.org/10.1038/sj.gt.3300743 .

J. K. Kim , S. H. Choi , C. O. Kim , J. S. Park . Enhancement of polyethylene glycol (PEG)-modified cationic liposomemediated gene deliveries:effects on serum stability and transfection efficiency . J. Pharm. Pharmacol. , 2003 . 55 ( 4 ): 453 - 460 . DOI: 10.1211/002235702928 http://doi.org/10.1211/002235702928 .

L. Zhu , P. Kate , V. P. Torchilin . Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting . ACS Nano , 2012 . 6 ( 4 ): 3491 - 3498 . DOI: 10.1021/nn300524f http://doi.org/10.1021/nn300524f .

Anonymous. Classification and diagnosis of diabetes. Diabetes Care 2015, 38(Suppl. 1), S8-S16.

S. Craft . The role of metabolic disorders in alzheimer disease and vascular dementia:Two roads converged . Arch. Neurol. , 2009 . 66 ( 3 ): 300 - 305 . http://europepmc.org/articles/PMC2717716/ http://europepmc.org/articles/PMC2717716/ , .

S. Canivell , R. Gomis . Diagnosis and classification of autoimmune diabetes mellitus . Autoimmun. Rev. , 2014 . 13 ( 4-5 ): 403 - 407 . DOI: 10.1016/j.autrev.2014.01.020 http://doi.org/10.1016/j.autrev.2014.01.020 .

H. Abdi , F. Hosseinpanah , F. Azizi , F. Hadaegh . Screening for dysglycemia:a comment on classification and diagnosis of diabetes in american diabetes association standards of medical care in diabetes-, 2016 . Arch. Iran. Med. , 2017 . 20 ( 6 ): 389 - 389 . http://europepmc.org/abstract/MED/28646849 http://europepmc.org/abstract/MED/28646849 , .

H. Yang , C. Zhang , C. Li , Y. Liu . Glucose-responsive polymer vesicles templated by alpha-CD/PEG inclusion complex . Biomacromolecules , 2015 . 16 ( 4 ): 1372 - 1381 . DOI: 10.1021/acs.biomac.5b00155 http://doi.org/10.1021/acs.biomac.5b00155 .

H. Yang , R. Ma , J. Yue , C. Li . A facile strategy to fabricate glucose-responsive vesicles via a template of thermo-sensitive micelles . Polym. Chem. , 2015 . 6 ( 20 ): 3837 - 3846 . DOI: 10.1039/C5PY00170F http://doi.org/10.1039/C5PY00170F .

L. Zhao , C. S. Xiao , L. Y. Wang , G. Q. Gai . Glucose-sensitive polymer nanoparticles for self-regulated drug delivery . Chem. Commun. , 2016 . 52 ( 49 ): 7633 - 7652 . DOI: 10.1039/C6CC02202B http://doi.org/10.1039/C6CC02202B .

B. L. Wang , R. J. Ma , G. Liu , Y. Li . Glucose-responsive micelles from self-assembly of poly(ethylene glycol)- b -poly(acrylic acid-co-acrylamidophenylboronic acid) and the controlled release of insulin . Langmuir , 2009 . 25 ( 21 ): 12522 - 12528 . DOI: 10.1021/la901776a http://doi.org/10.1021/la901776a .

J. N. Cambre , B. S. Sumerlin . Biomedical applications of boronic acid polymers . Polymer , 2011 . 52 ( 21 ): 4631 - 4643 . DOI: 10.1016/j.polymer.2011.07.057 http://doi.org/10.1016/j.polymer.2011.07.057 .

G. Liu , R. J. Ma , J. Ren , Z. Li . A glucose-responsive complex polymeric micelle enabling repeated on-off release and insulin protection . Soft Matter , 2013 . 9 ( 5 ): 1636 - 1644 . DOI: 10.1039/C2SM26690C http://doi.org/10.1039/C2SM26690C .

D. J. Selkoe , D. Schenk . Alzheimer's disease:Molecular understanding predicts amyloid-based therapeutics . Annu. Rev. Pharmacol. Toxicol , 2003 . 43 545 - 84 . DOI: 10.1146/annurev.pharmtox.43.100901.140248 http://doi.org/10.1146/annurev.pharmtox.43.100901.140248 .

D. H. Small , D. Losic , L. L. Martin , B. J. Turner . Alzheimer's disease therapeutics:new approaches to an ageing problem . IUBMB Life. , 2004 . 56 ( 4 ): 203 - 208 . DOI: 10.1080/15216540410001709211 http://doi.org/10.1080/15216540410001709211 .

R. Anand , K. D. Gill , A. A. Mahdi . Therapeutics of alzheimer's disease:Past, present and future . Neuropharmacology , 2014 . 76 27 - 50 . DOI: 10.1016/j.neuropharm.2013.07.004 http://doi.org/10.1016/j.neuropharm.2013.07.004 .

M. S. Rafii . Preclinical alzheimer's disease therapeutics . J. Alzheimers Dis. , 2014 . 42 ( Suppl. 4 ): S545 - S549 . .

J. Kelleher-Andersson . Discovery of neurogenic, alzheimer's disease therapeutics . Curr. Alzheimer Res. , 2006 . 3 ( 1 ): 55 - 62 . DOI: 10.2174/156720506775697179 http://doi.org/10.2174/156720506775697179 .

M. Boada , P. Ortiz , F. Anaya , I. Hernandez . Amyloid-targeted therapeutics in alzheimer's disease:Use of human albumin in plasma exchange as a novel approach for a beta mobilization . Drug News Perspect. , 2009 . 22 ( 6 ): 325 - 339 . DOI: 10.1358/dnp.2009.22.6.1395256 http://doi.org/10.1358/dnp.2009.22.6.1395256 .

A. Shvaloff , E. Neuman , D. Guez . Lines of therapeutics research in alzheimer's disease . Psychopharmacol. Bull. , 1996 . 32 ( 3 ): 343 - 352 . http://europepmc.org/abstract/MED/8961777 http://europepmc.org/abstract/MED/8961777 , .

J. Hardy , D. J. Selkoe . Medicine-he amyloid hypothesis of alzheimer's disease:Progress and problems on the road to therapeutics . Science , 2002 . 297 ( 5580 ): 353 - 356 . DOI: 10.1126/science.1072994 http://doi.org/10.1126/science.1072994 .

J. Dennis , M. D. Selkoe . The therapeutics of Alzheimer's disease:Where we stand and where we are heading . Ann. Neurol. , 2013 . 74 ( 3 ): 328 - 336 . DOI: 10.1002/ana.v74.3 http://doi.org/10.1002/ana.v74.3 .

A. L. Horwich . Molecular chaperones in cellular protein folding:The birth of a field . Cell , 2014 . 157 ( 2 ): 285 - 288 . DOI: 10.1016/j.cell.2014.03.029 http://doi.org/10.1016/j.cell.2014.03.029 .

F. Baneyx , J. G. Thomas . Collaboration of major and minor molecular chaperones in cellular protein folding . Abstracts of Papers of the American Chemical Society. , 2000 . 219 U179 - U180 . .

F. Huang , J. Z. Wang , A. T. Qu , L. L. Shen . Maintenance of amyloid beta peptide homeostasis by artificial chaperones based on mixed-shell polymeric micelles . Angew. Chem. Int. Ed. , 2014 . 53 ( 34 ): 8985 - 8990 . DOI: 10.1002/anie.201400735 http://doi.org/10.1002/anie.201400735 .

J. Wang , Y. Song , P. Sun , Y. An . Reversible interactions of proteins with mixed shell polymeric micelles:Tuning the surface hydrophobic/hydrophilic balance toward efficient artificial chaperones . Langmuir , 2016 . 32 ( 11 ): 2737 - 2749 . DOI: 10.1021/acs.langmuir.6b00356 http://doi.org/10.1021/acs.langmuir.6b00356 .

F. Huang , L. Shen , J. Wang , A. Qu . Effect of the surface charge of artificial chaperones on the refolding of thermally denatured lysozymes . ACS Appl. Mater. Interfaces , 2016 . 8 ( 6 ): 3669 - 3678 . DOI: 10.1021/acsami.5b08843 http://doi.org/10.1021/acsami.5b08843 .

J. Wang , T. Yin , F. Huang , Y. Song . Artificial chaperones based on mixed shell polymeric micelles:Insight into the mechanism of the interaction of the chaperone with substrate proteins using forster resonance energy transfer . ACS Appl. Mater. Interfaces , 2015 . 7 ( 19 ): 10238 - 10249 . DOI: 10.1021/acsami.5b00684 http://doi.org/10.1021/acsami.5b00684 .

K. Watanabe , K. Nakamura , S. Akikusa , T. Okada . Inhibitors of fibril formation and cytotoxicity of beta-amyloid peptide composed of KLVFF recognition element and flexible hydrophilic disrupting element . Biochem. Biophys. Res. Commun. , 2002 . 290 ( 1 ): 121 - 124 . DOI: 10.1006/bbrc.2001.6191 http://doi.org/10.1006/bbrc.2001.6191 .

L. O. Tjernberg , J. Naslund , F. Lindqvist , J. Johansson . Arrest of beta-amyloid fibril formation by a pentapeptide ligand . J. Biol. Chem. , 1996 . 271 ( 15 ): 8545 - 8 . DOI: 10.1074/jbc.271.15.8545 http://doi.org/10.1074/jbc.271.15.8545 .

F. F. Liu , W. J. Du , Y. Sun , J. Zheng . Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-beta protein . Front. Chem. Sci. Eng. , 2014 . 8 ( 4 ): 433 - 444 . DOI: 10.1007/s11705-014-1454-6 http://doi.org/10.1007/s11705-014-1454-6 .

A. T. Qu , F. Huang , A. Li , H. R. Yang . The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity . Chem. Commun. , 2017 . 53 ( 7 ): 1289 - 1292 . DOI: 10.1039/C6CC07803F http://doi.org/10.1039/C6CC07803F .

L. Vonghia , L. Leggio , A. Ferrulli , M. Bertini . Acute alcohol intoxication . Eur. J. Intern. Med. , 2008 . 19 ( 8 ): 561 - 567 . DOI: 10.1016/j.ejim.2007.06.033 http://doi.org/10.1016/j.ejim.2007.06.033 .

S. P. Kantrow , Z. Shen , P. Zhang , J. Ramsey . Acute alcohol intoxication, lung permeability and host defense . Alcohol. Clin. Exp. Res. , 2008 . 32 ( 6 ): 172a - 172a . .

M. D. Gerstman , A. F. Merry , D. R. McIlroy , J. A. Hannam . Acute alcohol intoxication and bispectral index monitoring . Acta Anaesth. Scand. , 2015 . 59 ( 8 ): 1015 - 1021 . DOI: 10.1111/aas.2015.59.issue-8 http://doi.org/10.1111/aas.2015.59.issue-8 .

E. M. Sellers , H. Kalant . Drug-therapy-alcohol intoxication and withdrawal . New Eng. J. of Med. , 1976 . 294 ( 14 ): 757 - 762 . DOI: 10.1056/NEJM197604012941405 http://doi.org/10.1056/NEJM197604012941405 .

C. C. Robertson , E. M. Sellers . Alcohol intoxication and alcohol withdrawal syndrome . Postgrad. Med. , 1978 . 64 ( 6 ): 133 - 138 . DOI: 10.1080/00325481.1978.11715005 http://doi.org/10.1080/00325481.1978.11715005 .

E. M. Sellers , H. Kalant . Alcohol intoxication and withdrawal . New. Engl. J. Med. , 1976 . 294 ( 14 ): 757 - 762 . DOI: 10.1056/NEJM197604012941405 http://doi.org/10.1056/NEJM197604012941405 .

L. S. Shpilenya , A. P. Muzychenko , G. Gasbarrini , G. Addolorato . Metadoxine in acute alcohol intoxication:A double-blind, randomized, placebo-controlled study . Alcohol. Clin. Exp. Res. , 2002 . 26 ( 3 ): 340 - 346 . DOI: 10.1111/acer.2002.26.issue-3 http://doi.org/10.1111/acer.2002.26.issue-3 .

Y. Liu , J. J. Du , M. Yan , M. Y. Lau . Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication . Nat. Nanotechnol. , 2013 . 8 ( 3 ): 187 - 192 . DOI: 10.1038/nnano.2012.264 http://doi.org/10.1038/nnano.2012.264 .

A. Munoz-Bonilla , M. Fernandez-Garcia . Polymeric materials with antimicrobial activity . Prog. Polym. Sci. , 2012 . 37 ( 2 ): 281 - 339 . DOI: 10.1016/j.progpolymsci.2011.08.005 http://doi.org/10.1016/j.progpolymsci.2011.08.005 .

R. Y. Pelgrift , A. J. Friedman . Nanotechnology as a therapeutic tool to combat microbial resistance . Adv. Drug Deliv. Rev. , 2013 . 65 ( 13-14 ): 1803 - 1815 . DOI: 10.1016/j.addr.2013.07.011 http://doi.org/10.1016/j.addr.2013.07.011 .

L. Zhang , D. Pornpattananangkul , C. M. J. Hu , C. M. Huang . Development of nanoparticles for antimicrobial drug delivery . Currt. Med. Chem. , 2010 . 17 ( 6 ): 585 - 594 . DOI: 10.2174/092986710790416290 http://doi.org/10.2174/092986710790416290 .

Y. Zhang , H. F. Chan , K. W. Leong . Advanced materials and processing for drug delivery:the past and the future . Adv. Drug Deliv. Rev. , 2013 . 65 ( 1 ): 104 - 120 . DOI: 10.1016/j.addr.2012.10.003 http://doi.org/10.1016/j.addr.2012.10.003 .

L. I. Peltonen , T. J. Kinnari , A. A. Aarnisalo , P. Kuusela . Comparison of bacterial adherence to polylactides, silicone, and titanium . Acta Oto-Laryngologica , 2007 . 127 ( 6 ): 587 - 593 . DOI: 10.1080/00016480600987792 http://doi.org/10.1080/00016480600987792 .

K. S. Kornman . Controlled-release local delivery antimicrobials in periodontics:prospects for the future . J Periodontol. , 1993 . 64 ( 8 Suppl ): 782 - 791 . http://www.ncbi.nlm.nih.gov/pubmed/8410618 http://www.ncbi.nlm.nih.gov/pubmed/8410618 , .

A. W. Smith . Biofilms and antibiotic therapy:Is there a role for combating bacterial resistance by the use of novel drug delivery systems? . Adv. Drug Deliv. Rev. , 2005 . 57 ( 10 ): 1539 - 1550 . DOI: 10.1016/j.addr.2005.04.007 http://doi.org/10.1016/j.addr.2005.04.007 .

M. Hittinger , J. Juntke , S. Kletting , N. Schneider-Daum . Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models . Adv. Drug Deliv. Rev. , 2015 . 85 44 - 56 . DOI: 10.1016/j.addr.2014.10.011 http://doi.org/10.1016/j.addr.2014.10.011 .

T. D. Arthur , V. L. Cavera , M. L. Chikindas . On bacteriocin delivery systems and potential applications . Future Microbiol. , 2014 . 9 ( 2 ): 235 - 248 . DOI: 10.2217/fmb.13.148 http://doi.org/10.2217/fmb.13.148 .

R. Herbrecht , D. W. Denning , T. F. Patterson , J. E. Bennett . Voriconazole versus amphotericin b for primary therapy of invasive aspergillosis . New Engl. J. Med. , 2002 . 347 ( 6 ): 408 - 415 . DOI: 10.1056/NEJMoa020191 http://doi.org/10.1056/NEJMoa020191 .

T. J. Walsh , H. Teppler , G. R. Donowitz , J. A. Maertens . Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia . New Engl. J. Med. , 2004 . 351 ( 14 ): 1391 - 1402 . DOI: 10.1056/NEJMoa040446 http://doi.org/10.1056/NEJMoa040446 .

H. J. Kim , M. N. Jones . The delivery of benzyl penicillin to staphylococcus aureus biofilms by use of liposomes . J. Liposome Res. , 2004 . 14 ( 3-4 ): 123 - 139 . DOI: 10.1081/LPR-200029887 http://doi.org/10.1081/LPR-200029887 .

H. Pinto-Alphandary , A. Andremont , P. Couvreur . Targeted delivery of antibiotics using liposomes and nanoparticles:Research and applications . Int. J. Antimicrob. Agents , 2000 . 13 ( 3 ): 155 - 168 . DOI: 10.1016/S0924-8579(99)00121-1 http://doi.org/10.1016/S0924-8579(99)00121-1 .

C. O. Onyeji , C. H. Nightingale , M. N. Marangos . Enhanced killing of methicillin-resistant staphylococcus aureus in human macrophages by liposome-entrapped vancomycin and teicoplanin . Infection , 1994 . 22 ( 5 ): 338 - 342 . DOI: 10.1007/BF01715542 http://doi.org/10.1007/BF01715542 .

I. Schumacher , R. Margalit . Liposome-encapsulated ampicillin:Physicochemical and antibacterial properties . J. Pharm. Sci. , 1997 . 86 ( 5 ): 635 - 641 . DOI: 10.1021/js9503690 http://doi.org/10.1021/js9503690 .

F. Huang , Y. Gao , Y. Zhang , T. Cheng . Silver-decorated polymeric micelles combined with curcumin for enhanced antibacterial activity . ACS Appl. Mater. Interfaces , 2017 . 9 ( 20 ): 16881 - 16890 . http://pubs.acs.org/doi/pdf/10.1021/acsami.7b03347 http://pubs.acs.org/doi/pdf/10.1021/acsami.7b03347 , .

L. Chu , H. Gao , T. Cheng , Y. Zhang . A charge-adaptive nanosystem for prolonged enhanced in vivo antibiotic delivery . Chem. Commun. , 2016 . 52 ( 37 ): 6265 - 6268 . DOI: 10.1039/C6CC01269H http://doi.org/10.1039/C6CC01269H .

L. K. Shah , M. M. Amiji . Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS . Pharm. Res. , 2006 . 23 ( 11 ): 2638 - 2645 . DOI: 10.1007/s11095-006-9101-7 http://doi.org/10.1007/s11095-006-9101-7 .

V. C. F. Mosqueira , P. M. Loiseau , C. Bories , P. Legrand . Efficacy and pharmacokinetics of intravenous nanocapsule formulations of halofantrine in plasmodium berghei-infected mice . Antimicrob. Agents Ch. , 2004 . 48 ( 4 ): 1222 - 1228 . DOI: 10.1128/AAC.48.4.1222-1228.2004 http://doi.org/10.1128/AAC.48.4.1222-1228.2004 .

Y. Liu , H. J. Busscher , B. R. Zhao , Y. Li . F . Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms. ACS Nano , 2016 . 10 ( 4 ): 4779 - 4789 . http://www.ncbi.nlm.nih.gov/pubmed/26998731 http://www.ncbi.nlm.nih.gov/pubmed/26998731 , .

Y. M. Li , G. H. Liu , X. R. Wang , J. M. Hu . Enzyme-responsive polymeric vesicles for bacterial-strainselective delivery of antimicrobial agents . Angew. Chem. Int. Ed. , 2016 . 55 ( 5 ): 1760 - 1764 . DOI: 10.1002/anie.201509401 http://doi.org/10.1002/anie.201509401 .

J. Hasan , R. J. Crawford , E. P. Lvanova . Antibacterial surfaces:the quest for a new generation of biomaterials . Trends Biotechnol. , 2013 . 31 ( 5 ): 31 - 40 . http://www.sciencedirect.com/science/article/pii/S0167779913000309 http://www.sciencedirect.com/science/article/pii/S0167779913000309 , .

I. Insua , E. Liamas , Z. Y. Zhang , A. F. A. Peacock . Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers . Polym. Chem. , 2016 . 7 ( 15 ): 2684 - 2690 . DOI: 10.1039/C6PY00146G http://doi.org/10.1039/C6PY00146G .

Views

124

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Boosting Blood-Brain Barrier Crossing with a Mannosylated Nanocarrier

Nanopore-based Manipulation and Separation of Single-stranded DNA Molecules through Tuning pH Values

Selective Antifungal Activity of Hyperbranched Polylysine Mediated by Charge-dependent Membrane Interactions

Bioinspired Zinc-doped Nano Hydroxyapatite Reinforced Poly(lactic acid) Composites for Bone Repair

Sliding Dynamics of Ring Chain on a Rod-Coil Block Copolymer in Rotaxane

Related Author

Nan-Nan Gu

Ping Wei

Jin-Hui Jiang

Jing-Hua Chen

Cheng-Kai Zhou

Sheng-Wen Miao

Li-Zhen Sun

Yi-Wei Wang

Related Institution

School of Life Sciences and Health Engineering, Jiangnan University

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University

School of Physics, Zhejiang University of Technology

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

School of Applied Chemistry and Engineering, University of Science and Technology of China

⁰