Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications

Wen-Ming Zhang; Jian Zhang; Zhu Qiao; Jun Yin

doi:10.1007/s10118-018-2035-9

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Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications

FEATURE ARTICLES | Updated：2021-02-18

- Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications
- Chinese Journal of Polymer Science Vol. 36, Issue 3, Pages: 273-287(2018)
- Affiliations：
  
  Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, Hefei 230009, China
- Author bio：
  
  Jun Yin, E-mail yinjun@hfut.edu.cn
- Funds：
- DOI：10.1007/s10118-018-2035-9
  CLC：
- Received：17 August 2017，
  
  Accepted：05 September 2017，
  
  Online First：20 December 2017，
  
  Published：05 March 2018
- Accepted：
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Wen-Ming Zhang, Jian Zhang, Zhu Qiao, et al. Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications[J]. Chinese Journal of Polymer Science, 2018, 36(3): 273-287.
DOI：

Wen-Ming Zhang, Jian Zhang, Zhu Qiao, et al. Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications[J]. Chinese Journal of Polymer Science, 2018, 36(3): 273-287. DOI： 10.1007/s10118-018-2035-9.

摘要

Abstract

The excellent drug encapsulation

prolonged

in vivo

circulation time

enhanced pharmacokinetics

and reduced adverse effects make the polymeric assemblies ideal carriers in nanomedicine

and become an emerging research field with rapid development.

In vivo

the polymer nanoassemblies will experience five steps

including circulation in the blood

accumulation in the tumoral site

penetration into the deep tumor tissue to reach cancer cells

internalization into cancer cells

and intracellular drug release. However

although tremendous efforts have been made to the material design

currently available carriers still have difficulties in fulfilling all of the requirements. Moreover

the long-standing dilemma of the synchronized stability and permeability of vesicles is still a big challenge

which confused researchers for a long time. This feature article focuses on the recent progress of single-or multi-stimuli triggered theranostic platforms

and the extracellularly reengineered shell-sheddable polymeric nanocarriers are systematically discussed. The perspectives for future developments in the nanocarriers functioned with artificial helical polymers (the potential cell-penetrating peptides mimics) are also proposed. We speculate that this feature article can fit the interesting of diverse readers and a guideline for the design of next generation of drug nanocarriers.

关键词

Keywords

references

J. S. Ross , D. P. Schenkein , R. Pietrusko , M. Rolfe , G. P. Linette , J. Stec , N. E. Stagliano , G. S. Ginsburg , W. F. Symmans , L. Pusztai , G. N. Hortobagyi . Targeted therapies for cancer . Am. J. Clin. Pathol. , 2004 . 122 ( 4 ): 598 - 609 . DOI: 10.1309/5CWPU41AFR1VYM3F http://doi.org/10.1309/5CWPU41AFR1VYM3F .

R. Langer , D. A. Tirrell . Designing materials for biology and medicine . Nature , 2004 . 428 487 - 492 . DOI: 10.1038/nature02388 http://doi.org/10.1038/nature02388 .

J. M. Hu , S. Y. Liu . Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications . Acc. Chem. Res. , 2014 . 47 ( 7 ): 2084 - 2095 . DOI: 10.1021/ar5001007 http://doi.org/10.1021/ar5001007 .

J. Yin , H. B. Hu , Y. H. Wu , S. Y. Liu . Thermo-and light-regulated fluorescence resonance energy transfer processes within dually responsive microgels . Polym. Chem. , 2011 . 2 363 - 371 . DOI: 10.1039/C0PY00254B http://doi.org/10.1039/C0PY00254B .

J. M. Hu , S. Y. Liu . Recent advances towards the fabrication and biomedical applications of responsive polymeric assemblies and nanoparticle hybrid superstructures . Dalton Trans. , 2015 . 44 3904 - 3922 . DOI: 10.1039/C4DT03609C http://doi.org/10.1039/C4DT03609C .

J. Yin , Y. Chen , Z. H. Zhang , X. Han . Stimuli-responsive block copolymer-based assemblies for cargo delivery and theranostic applications . Polymers , 2016 . 8 ( 7 ): 268 - 296 . http://www.mdpi.com/2073-4360/8/7/268 http://www.mdpi.com/2073-4360/8/7/268 , .

X. C. Zheng , X. Wang , H. Mao , W. Wu , B. R. Liu , X. Q. Jiang . Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo . Nat. Commun. , 2015 . 6 DOI: 10.1038/ncomms6834 http://doi.org/10.1038/ncomms6834 .

J. Yin , J. M. Hu , G. Y. Zhang , S. Y. Liu . Schizophrenic core-shell microgels:thermoregulated core and shell swelling/collapse by combining ucst and lcst phase transitions . Langmuir , 2014 . 30 ( 9 ): 2551 - 2558 . DOI: 10.1021/la500133y http://doi.org/10.1021/la500133y .

X. C. Zheng , H. Mai , D. Huo , W. Wu , B. R. Liu , X. Q. Jiang . Successively activatable ultrasensitive probe for imaging tumour acidity and hypoxia . Nat. Biomed. Eng. , 2017 . 1 DOI: 10.1038/s41551-017-0057 http://doi.org/10.1038/s41551-017-0057 .

J. Yin , Y. G. He , W. Li , Z. Q. Wu , Y. S. Ding . Wide range temperature detection with hybrid nanoparticles traced by surface-enhanced Raman scattering . Sci. China Chem. , 2014 . 57 ( 3 ): 417 - 425 . DOI: 10.1007/s11426-013-4974-x http://doi.org/10.1007/s11426-013-4974-x .

L. Z. Zhang , Y. J. Zhang , W. Wu , X. Q. Jiang . Doxorubicin-loaded boron-rich polymer nanoparticles for orthotopically implanted liver tumor treatment . Chinese J. Polym. Sci. , 2013 . 31 ( 5 ): 778 - 786 . DOI: 10.1007/s10118-013-1267-y http://doi.org/10.1007/s10118-013-1267-y .

C. Y. Long , M. M. Sheng , B. He , Y. Wu , G. Wang , Z. W. Gu . Comparison of drug delivery properties of PEG-b-PDHPC micelles with different compositions . Chinese J. Polym. Sci. , 2012 . 30 ( 3 ): 387 - 396 . DOI: 10.1007/s10118-012-1138-y http://doi.org/10.1007/s10118-012-1138-y .

Y. Lu , A. A. Aimetti , R. Langer , Z. Gu . Bioresponsive materials . Nat. Rev. Mater. , 2017 . 2 ( 1 ): 16075 http://www.nature.com/articles/natrevmats201675 http://www.nature.com/articles/natrevmats201675 , .

J. M. Hu , G. Q. Zhang , S. Y. Liu . Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels . Chem. Soc. Rev. , 2012 . 41 5933 - 5949 . DOI: 10.1039/c2cs35103j http://doi.org/10.1039/c2cs35103j .

J. Yin , S. Y. Shi , J. M. Hu , S. Y. Liu . Construction of polyelectrolyte-responsive microgels, and polyelectrolyte concentration and chain length-dependent adsorption kinetics . Langmuir , 2014 . 30 ( 31 ): 9551 - 9559 . DOI: 10.1021/la501918s http://doi.org/10.1021/la501918s .

Y. Z. Wu , Z. H. Zhang , X. Han , J. Zhang , W. M. Zhang , J. Yin . Affinity switching for lysozyme and dual-responsive microgels by stopped-flow technique:kinetic control and activity evaluation . Chinese J. Polym. Sci. , 2017 . 35 ( 8 ): 950 - 960 . DOI: 10.1007/s10118-017-1948-z http://doi.org/10.1007/s10118-017-1948-z .

Z. Y. Deng , J. M. Hu , S. Y. Liu . Reactive oxygen, nitrogen, and sulfur species (RONSS)-responsive polymersomes for triggered drug release . Macromol. Rapid Commun. , 2017 . 38 ( 11 ): DOI: 10.1002/marc.201600685 http://doi.org/10.1002/marc.201600685 .

Z. S. Ge , S. Y. Liu . Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance . Chem. Soc. Rev. , 2013 . 42 7289 - 7325 . DOI: 10.1039/c3cs60048c http://doi.org/10.1039/c3cs60048c .

Y. Barenholz . Doxil ® -The first FDA-approved nano-drug:lessons learned . J. Control. Release , 2012 . 160 117 - 134 . DOI: 10.1016/j.jconrel.2012.03.020 http://doi.org/10.1016/j.jconrel.2012.03.020 .

D. D. Von Hoff , R. K. Ramanathan , M. J. Borad , D. A. Laheru , L. S. Smith , T. E. Wood , R. L. Korn , N. Desai , V. Trieu , J. L. Iglesias , H. Zhang , P. Soon-Shiong , T. Shi , N. V. Rajeshkumar , A Maitra , M. J. Hidalgo . Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer:a phase Ⅰ/Ⅱ trial . Clin. Oncol. , 2011 . 29 ( 34 ): 4548 - 4554 . DOI: 10.1200/JCO.2011.36.5742 http://doi.org/10.1200/JCO.2011.36.5742 .

E. A. Forssen . The design and development of DaunoXome ® for solid tumor targeting in vivo . Adv. Drug Delivery Rev. , 1997 . 24 133 - 150 . DOI: 10.1016/S0169-409X(96)00453-X http://doi.org/10.1016/S0169-409X(96)00453-X .

L. Bregoli , D. Movia , J. D. Gavigan-Imedio , J. Lysaght , J. Reynolds , A. Prina-Mello . Nanomedicine applied to translational oncology:a future perspective on cancer treatment . Nanomed. Nanotechnol. Biol. Med. , 2016 . 12 81 - 103 . DOI: 10.1016/j.nano.2015.08.006 http://doi.org/10.1016/j.nano.2015.08.006 .

Q. Sun , Z. Zhou , N. Qiu , Y. Shen . Rational design of cancer nanomedicine:nanoproperty integration and synchronization . Adv. Mater. , 2017 . 29 ( 14 ): DOI: 10.1002/adma.201606628 http://doi.org/10.1002/adma.201606628 .

Q. Sun , M. Radosz , Y. J. Shen . Challenges in design of translational nanocarriers . J. Control. Release , 2012 . 164 156 - 169 . DOI: 10.1016/j.jconrel.2012.05.042 http://doi.org/10.1016/j.jconrel.2012.05.042 .

H. Otsuka , Y. Nagasaki , K. Kataoka . PEGylated nanoparticles for biological and pharmaceutical applications . Adv. Drug Delivery Rev. , 2003 . 55 403 - 419 . DOI: 10.1016/S0169-409X(02)00226-0 http://doi.org/10.1016/S0169-409X(02)00226-0 .

M. Talelli , C. J. F. Rijcken , N. C. F. Van , G. Storm , W. E. Hennink . Micelles based on HPMA copolymers . Adv. Drug Delivery Rev. , 2010 . 62 231 - 239 . DOI: 10.1016/j.addr.2009.11.029 http://doi.org/10.1016/j.addr.2009.11.029 .

C.Y. Sun , S. Shen , C. F. Xu , H. J. Li , Y. Liu , Z. T. Cao , X. Z. Yang , J. X. Xia , J. Wang . Tumor acidity-sensitive polymeric vector for active targeted siRNA delivery . J. Am. Chem. Soc. , 2015 . 137 ( 48 ): 15217 - 15224 . DOI: 10.1021/jacs.5b09602 http://doi.org/10.1021/jacs.5b09602 .

V. A. Sethuraman , K. Na , Y. H. Bae . pH-Responsive sulfonamide/PEI system for tumor specific gene delivery:an in vitro study . Biomacromolecules , 2006 . 7 ( 1 ): 64 - 70 . DOI: 10.1021/bm0503571 http://doi.org/10.1021/bm0503571 .

L. Zhu , T. Wang , F. Perche , A. Taigind , V. P. Torchilin . Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety . Proc. Natl. Acad. Sci. USA , 2013 . 110 ( 42 ): 17047 - 17052 . DOI: 10.1073/pnas.1304987110 http://doi.org/10.1073/pnas.1304987110 .

X. Z. Yang , J. Z. Du , S. Dou , C. Q. Mao , H. Y. Long , J. Wang . Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery . ACS Nano , 2012 . 6 ( 1 ): 771 - 781 . DOI: 10.1021/nn204240b http://doi.org/10.1021/nn204240b .

C. Y. Sun , Y. Liu , J. Z. Du , Z. T. Cao , C. F. Xu , J. Wang . Facile generation of tumor-pH-Labile linkage-bridged block copolymers for chemotherapeutic delivery . Angew. Chem. Int. Ed. , 2016 . 55 ( 3 ): 1010 - 1014 . http://onlinelibrary.wiley.com/doi/10.1002/anie.201509507/pdf http://onlinelibrary.wiley.com/doi/10.1002/anie.201509507/pdf , .

J. J. Chen , J. X. Ding , C. S. Xiao , X. L. Zhuang , X. S. Chen . Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers . Biomater. Sci. , 2015 . 3 988 - 1001 . DOI: 10.1039/C5BM00044K http://doi.org/10.1039/C5BM00044K .

J. J. Liu , Q. Chen , W. W. Zhu , X. Yi , Y. Yang , Z. L. Dong , Z. Liu . Nanoscale-coordination-polymer-shelled manganese dioxide composite nanoparticles:a multistage Redox/pH/H 2 O 2 -responsive cancer theranostic nanoplatform . Adv. Funct. Mater. , 2017 . 27 ( 10 ): 1605926 DOI: 10.1002/adfm.v27.10 http://doi.org/10.1002/adfm.v27.10 .

V. P. Torchilin . TAT peptide-mediated intracellular delivery of pharmaceutical nanocarriers . Adv. Drug Delivery Rev. , 2008 . 60 548 - 558 . DOI: 10.1016/j.addr.2007.10.008 http://doi.org/10.1016/j.addr.2007.10.008 .

W. W. Wang , D. Cheng , F. M. Gong , X. M. Miao , X. T. Shuai . Design of multifunctional micelle for tumor-targeted intracellular drug release and fluorescent imaging . Adv. Mater. , 2012 . 24 ( 1 ): 115 - 120 . DOI: 10.1002/adma.201104066 http://doi.org/10.1002/adma.201104066 .

B. K. C. Remant , V. Chandrashekaran , B. Cheng , H. Chen , M. M. O. Peña , J. Zhang , J. Montgomery , P. S. Xu . Redox potential ultrasensitive nanoparticle for the targeted delivery of camptothecin to HER2-positive cancer cells . Mol. Pharm. , 2014 . 11 ( 6 ): 1897 - 1905 . DOI: 10.1021/mp5000482 http://doi.org/10.1021/mp5000482 .

P. Xu , E. A. van Kirk , Y. Zhan , W. J. Murdoch , M. Radosz , Y. Shen . Targeted charge-reversal nanoparticles for nuclear drug delivery . Angew. Chem. Int. Ed. , 2007 . 46 ( 26 ): 4999 - 5002 . http://europepmc.org/abstract/MED/17526044 http://europepmc.org/abstract/MED/17526044 , .

J. Z. Du , X. J. Du , C. Q. Mao , J. Wang . Tailor-made dual ph-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery . J. Am. Chem. Soc. , 2011 . 133 ( 44 ): 17560 - 17563 . DOI: 10.1021/ja207150n http://doi.org/10.1021/ja207150n .

S. S. Han , Z. Y. Li , J. Y. Zhu , K. Han , Z. Y. Zeng , W. Hong , W. X. Li , H. Z. Jia , Y. Liu , R. X. Zhuo . Dual-pH sensitive charge-reversal polypeptide micelles for tumor-triggered targeting uptake and nuclear drug delivery . Small , 2015 . 11 ( 21 ): 2543 - 2554 . http://www.ncbi.nlm.nih.gov/pubmed/25626995 http://www.ncbi.nlm.nih.gov/pubmed/25626995 , .

M. H. Sui , W. W. Liu , Y. Q. Shen . Nuclear drug delivery for cancer chemotherapy . J. Control. Release , 2011 . 155 227 - 236 . http://www.sciencedirect.com/science/article/pii/S0168365911005682 http://www.sciencedirect.com/science/article/pii/S0168365911005682 , .

N. Wang , A. J. Dong , H. D. Tang , E. A. van Kirk , P. A. Johnson , W. J. Murdoch , M. Radosz , Y. Q. Shen . Synthesis of degradable functional poly(ethylene glycol) analogs as versatile drug delivery carriers . Macromol. Biosci. , 2007 . 7 ( 11 ): 1187 - 1198 . DOI: 10.1002/(ISSN)1616-5195 http://doi.org/10.1002/(ISSN)1616-5195 .

V. A. Sethuraman1 , Y. H. Bae . TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors . J. Control. Release , 2007 . 118 216 - 224 . DOI: 10.1016/j.jconrel.2006.12.008 http://doi.org/10.1016/j.jconrel.2006.12.008 .

Y. Zhang , X. J. Wang , M. Guo , H. S. Yan , C. H. Wang , K. L. Liu . Cisplatin-loaded polymer/magnetite composite nanoparticles as multifunctional therapeutic nanomedicine . Chinese J. Polym. Sci. , 2014 . 32 ( 10 ): 1329 - 1337 . DOI: 10.1007/s10118-014-1510-1 http://doi.org/10.1007/s10118-014-1510-1 .

F. Yuan , M. Dellian , D. Fukumura , M. Leunig , D. A. Berk , V. P. Torchilin , R. K. Jain . Vascular permeability in a human tumor xenograft:molecular size dependence and cutoff size . Cancer Res. , 1995 . 55 ( 17 ): 3752 - 3756 . http://europepmc.org/abstract/MED/7641188 http://europepmc.org/abstract/MED/7641188 , .

H. Cabral , Y. Matsumoto , K. Mizuno , Q. Chen , M. Murakami , M. Kimura , Y. Terada , M. R. Kano , K. Miyazono , M. Uesaka , N. Nishiyama , K. Kataoka . Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size . Nat. Nanotechnol. , 2011 . 6 815 - 823 . DOI: 10.1038/nnano.2011.166 http://doi.org/10.1038/nnano.2011.166 .

V. P. Chauhan , T. Stylianopoulos , J. D. Martin , Z. Popovic , O. Chen , W. S. Kamoun , M. G. Bawendi , D. Fukumura , R. K. Jain . Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner . Nat. Nanotechnol. , 2012 . 7 383 - 388 . DOI: 10.1038/nnano.2012.45 http://doi.org/10.1038/nnano.2012.45 .

Q. H. Sun , X. R. Sun , X.P. Ma , Z. X. Zhou , E. L. Jin , B. Zhang , Y. Q. Shen , E. van Kirk , W. J. Murdoch , J. P. Lott , T. P. Lodge , M. Radosz , Y. L. Zhao . Integration of nanoassembly functions for an effective delivery cascade for cancer drugs . Adv. Mater. , 2014 . 26 ( 45 ): 7615 - 7621 . DOI: 10.1002/adma.v26.45 http://doi.org/10.1002/adma.v26.45 .

G. Piedrafita , M. A. Keller , M. Ralser . The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (oxidative) stress conditions . Biomolecules , 2015 . 5 ( 3 ): 2101 - 2122 . http://europepmc.org/articles/PMC4598790 http://europepmc.org/articles/PMC4598790 , .

J. E. Ghadiali , M. M. Stevens . Enzyme-responsive nanoparticle systems . Adv. Mater. , 2008 . 20 ( 22 ): 4359 - 4363 . DOI: 10.1002/adma.v20:22 http://doi.org/10.1002/adma.v20:22 .

M. E. Hahn , N. C. Gianneschi . Enzyme-directed assembly and manipulation of organic nanomaterials . Chem. Commun. , 2011 . 47 11814 - 11821 . DOI: 10.1039/c1cc15220c http://doi.org/10.1039/c1cc15220c .

R. V. Ulijn . Enzyme-responsive materials:a new class of smart biomaterials . J. Mater. Chem. , 2006 . 16 2217 - 2225 . DOI: 10.1039/b601776m http://doi.org/10.1039/b601776m .

Y. M. Li , G. H. Liu , ng Wa , R; X. , J. M. Hu , S. Y. Liu . Enzyme-responsive polymeric vesicles for bacterial-strain-selective delivery of antimicrobial agents . Angew. Chem. Int. Ed. , 2016 . 55 ( 5 ): 1760 - 1764 . http://europepmc.org/abstract/MED/26694087 http://europepmc.org/abstract/MED/26694087 , .

E. Gullotti , J. Park , Y. Yeo . Polydopamine-based surface modification for the development of peritumorally activatable nanoparticles . Pharm. Res. , 2013 . 30 ( 8 ): 1956 - 1967 . DOI: 10.1007/s11095-013-1039-y http://doi.org/10.1007/s11095-013-1039-y .

D. D. Li , Y. C. Ma , J. Z. Du , W. Tao , X. J. Du , X. Z. Yang , J. Wang . Tumor acidity/NIR controlled interaction of transformable nanoparticle with biological systems for cancer therapy . Nano Lett. , 2017 . 17 ( 5 ): 2871 - 2878 . DOI: 10.1021/acs.nanolett.6b05396 http://doi.org/10.1021/acs.nanolett.6b05396 .

E. L. Jin , B. Zhang , X. R. Sun , Z. X. Zhou , X. P. Ma , Q. H. Sun , J. B. Tang , Y. Q. Shen , E. Van Kirk , W. J. Murdoch , M. Radosz . Acid-active cell-penetrating peptides for in vivo tumor-targeted drug delivery . J. Am. Chem. Soc. , 2013 . 135 ( 2 ): 933 - 940 . http://europepmc.org/abstract/med/23253016 http://europepmc.org/abstract/med/23253016 , .

Y. M. Li , J. H. Yang , B. Xu , F. Gao , W. Wang , W. G. Liu . Enhanced therapeutic siRNA to tumor cells by a pH-sensitive agmatine-chitosan bioconjugate . ACS Appl. Mater. Interfaces , 2015 . 7 ( 5 ): 8114 - 8124 . http://pubs.acs.org/doi/suppl/10.1021/acsami.5b00851 http://pubs.acs.org/doi/suppl/10.1021/acsami.5b00851 , .

S. X. Huang , K. Shao , Y. Liu , Y. Y. Kuang , J. F. Li , S. An , Y. B. Guo , H. J. Ma , C. Jiang . Tumor-targeting and microenvironment-responsive smart nanoparticles for combination therapy of antiangiogenesis and apoptosis . ACS Nano , 2013 . 7 ( 3 ): 2860 - 2871 . DOI: 10.1021/nn400548g http://doi.org/10.1021/nn400548g .

E. L. Jin , B. Zhang , X. R. Sun , Z. X. Zhou , X. P. Ma , Q. H. Sun , J. B. Tang , Y. Q. Shen , E. V. Kirk , W. J. Murdoch , M. Radosz . Acid-active cell-penetrating peptides for in vivo tumor-targeted drug delivery . J. Am. Chem. Soc. , 2013 . 135 ( 2 ): 933 - 940 . http://europepmc.org/abstract/med/23253016 http://europepmc.org/abstract/med/23253016 , .

D. Y. Xia , G. C. Yu , J. Y. Li , F. H. Huang . Photo-responsive self-assembly based on a water-soluble pillar[6]arene and an azobenzene-containing amphiphile in water . Chem. Commun. , 2014 . 50 3606 - 3608 . DOI: 10.1039/c3cc49686d http://doi.org/10.1039/c3cc49686d .

D. Y. Xia , P. F. Wei , B. B. Shi , F. H. Huang . A pillar[6]arene-based[2]pseudorotaxane in solution and in the solid state and its photo-responsive self-assembly behavior in solution . Chem. Commun. , 2016 . 52 513 - 516 . DOI: 10.1039/C5CC08038J http://doi.org/10.1039/C5CC08038J .

Y. Zhao . Light-responsive block copolymer micelles . Macromolecules , 2012 . 45 ( 9 ): 3647 - 3657 . DOI: 10.1021/ma300094t http://doi.org/10.1021/ma300094t .

Y. M. Li , Y. F. Qian , T. Liu , G. Y. Zhang , S. Y. Liu . Light-triggered concomitant enhancement of magnetic resonance imaging contrast performance and drug release rate of functionalized amphiphilic diblock copolymer micelles . Biomacromolecules , 2012 . 13 ( 11 ): 3877 - 2886 . DOI: 10.1021/bm301425j http://doi.org/10.1021/bm301425j .

M. Karimi , P. S. Zangabad , S. Baghaee-Ravari , M. Ghazadeh , H. Mirshekari , M. R. Hamblin . Smart nanostructures for cargo delivery:uncaging and activating by light . J. Am. Chem. Soc. , 2017 . 139 ( 13 ): 4584 - 4610 . http://europepmc.org/abstract/MED/28192672 http://europepmc.org/abstract/MED/28192672 , .

J. J. Hu , Y. H. Chen , Y. Q. Li , Z. G. Zhou , Y. Y. Cheng . A thermo-degradable hydrogel with light-tunable degradation and drug release . Biomaterials , 2017 . 112 133 - 140 . DOI: 10.1016/j.biomaterials.2016.10.015 http://doi.org/10.1016/j.biomaterials.2016.10.015 .

Q. Chen , L. G. Xu , C. Liang , C. Wang , R. Peng , Z. Liu . Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy . Nat. Commum. , 2016 . 7 DOI: 10.1038/ncomms13193 http://doi.org/10.1038/ncomms13193 .

T. Dvir , M. R. Banghart , B. P. Timko , R. Langer , D. S. Kohane . Photo-targeted nanoparticles . Nano Lett. , 2010 . 10 ( 1 ): 250 - 254 . DOI: 10.1021/nl903411s http://doi.org/10.1021/nl903411s .

N. C. Fan , F. Y. Cheng , J. A. Ho , C. S. Yeh . Photocontrolled targeted drug delivery:photocaged biologically active folic acid as a light-responsive tumor-targeting molecule . Angew. Chem. Int. Ed. , 2012 . 51 ( 35 ): 8806 - 8810 . DOI: 10.1002/anie.v51.35 http://doi.org/10.1002/anie.v51.35 .

D. Cui , C. Xie , C. Y. Pu . Development of semiconducting polymer nanoparticles for photoacoustic imaging . Macromol. Rapid Commun. , 2017 . 38 ( 12 ): DOI: 10.1002/marc.201700125 http://doi.org/10.1002/marc.201700125 .

B. J. Hong , E. P. Swindell , K. W. MacRenaris , P. L. Hankins. , A, J. Chipre , D. Mastarone , R. W. Ahn , T. J. Meade , T. V. O'Halloran , S. T. Nguyen . pH-responsive theranostic polymer-caged nanobins:enhanced cytotoxicity and T1 MRI contrast by HER2 targeting . Part. Syst. Charact. , 2013 . 30 ( 9 ): 770 - 774 . DOI: 10.1002/ppsc.v30.9 http://doi.org/10.1002/ppsc.v30.9 .

B. Li . A novel upconversion nanotheranostic agent for multi-modality imaging-guided chemotherapy with on-demand drug release . Sci. China Chem. , 2015 . 58 ( 6 ): 970 - 70 . DOI: 10.1007/s11426-015-5428-4 http://doi.org/10.1007/s11426-015-5428-4 .

A. Langer . A systematic review of PET and PET/CT in oncology:a way to personalize cancer treatment in a cost-effective manner? . BMC Health Serv.Res. , 2010 . 10 DOI: 10.1186/1472-6963-10-283 http://doi.org/10.1186/1472-6963-10-283 .

C. Y. Ke , C. J. Mathias , M. A. Green . Folate-receptor-targeted radionuclide imaging agents . Adv. Drug Delivery Rev. , 2004 . 56 1143 - 1160 . DOI: 10.1016/j.addr.2004.01.004 http://doi.org/10.1016/j.addr.2004.01.004 .

B. R. Smith , S. S. Gambhir . Nanomaterials for in vivo imaging . Chem. Rev. , 2017 . 117 ( 3 ): 901 - 986 . DOI: 10.1021/acs.chemrev.6b00073 http://doi.org/10.1021/acs.chemrev.6b00073 .

Y. F. Ma , J. Huang , S. J. Song , H. B. Chen , Z. J. Zhang . Cancer-targeted nanotheranostics:recent advances and perspectives . Small , 2016 . 12 ( 36 ): 4936 - 4954 . DOI: 10.1002/smll.v12.36 http://doi.org/10.1002/smll.v12.36 .

X. S. Li , J. H. Kim , J. Y. Yoon , X. Chen . Y . Cancer-associated, stimuli-driven, turn on theranostics for multimodality imaging and therapy. Adv. Mater. , 2017 . 29 ( 23 ): 1606857(1-24) http://europepmc.org/abstract/MED/28370546 http://europepmc.org/abstract/MED/28370546 , .

S. Wang , P. Huang , X. Y. Chen . Stimuli-responsive programmed specific targeting in nanomedicine . ACS Nano , 2016 . 10 ( 3 ): 2991 - 2994 . DOI: 10.1021/acsnano.6b00870 http://doi.org/10.1021/acsnano.6b00870 .

J. Deng , C. Y. Gao . Recent advances in interactions of designed nanoparticles and cells with respect to cellular uptake, intracellular fate, degradation and cytotoxicity . Nanotechnology , 2016 . 27 ( 41 ): 412002 DOI: 10.1088/0957-4484/27/41/412002 http://doi.org/10.1088/0957-4484/27/41/412002 .

M. Guo , H. J. Mao , Y. L. Li , A. J. Zhu , H. He , H. Yang , Y. Y. Wang , X. Tian , C. C. Ge , Q. L. Peng , X. Y. Wang , X. L. Yang , X. Y. Chen , G. Liu , H. B. Chen . Dual imaging-guided photothermal/photodynamic therapy using micelles . Biomaterials , 2014 . 35 4656 - 4666 . DOI: 10.1016/j.biomaterials.2014.02.018 http://doi.org/10.1016/j.biomaterials.2014.02.018 .

Z. H. Wan , H. J. Mao , M. Guo , Y. L. Li , A. J. Zhu , H. Yang , H. He , J. K. Shen , L. J. Zhou , Z. Jiang , C. C. Ge , X. Y. Chen , X. L. Yang , G. Liu , H. B. Chen . Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication . Theranostics , 2014 . 4 ( 4 ): 399 - 411 . DOI: 10.7150/thno.8171 http://doi.org/10.7150/thno.8171 .

Y. Li , Y. Deng , X. Tian , H. Ke , M. Guo , A. J. Zhu , T. Yang , Z. Q. Guo , Z. S. Ge , X. L. Yang , H. B. Chen . Multipronged design of light-triggered nanoparticles to overcome cisplatin resistance for efficient ablation of resistant tumor . ACS Nano , 2015 . 9 ( 10 ): 9626 - 9637 . DOI: 10.1021/acsnano.5b05097 http://doi.org/10.1021/acsnano.5b05097 .

A. J. Zhu , K. Miao , Y. B. Deng , H. T. Ke , H. He , T. Yang , M. Guo , Y. L. Li , Z. Q. Guo , Y. Y. Wang , X. L. Yang , Y. L. Zhao , H. B. Chen . Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermochemotherapy-synergized tumor ablation . ACS Nano , 2015 . 9 ( 8 ): 7874 - 7885 . DOI: 10.1021/acsnano.5b02843 http://doi.org/10.1021/acsnano.5b02843 .

G. H. Liu , X. R. Wang , J. M. Hu , G. Y. Zhang , S. Y. Liu . Self-immolative polymersomes for high-efficiency triggered release and programmed enzymatic reactions . J. Am. Chem. Soc. , 2014 . 136 ( 20 ): 7492 - 7497 . DOI: 10.1021/ja5030832 http://doi.org/10.1021/ja5030832 .

G. H. Liu , G. F. Zhang , J. M. Hu , X. R. Wang , M. Q. Zhu , S. Y. Liu . Hyperbranched self-immolative polymers (hSIPs) for programmed payload delivery and ultrasensitive detection . J. Am. Chem. Soc. , 2015 . 137 ( 36 ): 11645 - 11655 . DOI: 10.1021/jacs.5b05060 http://doi.org/10.1021/jacs.5b05060 .

B. J. Frogley , L. J. Wright . Cover picture:a metallaanthracene and derived metallaanthraquinone . Angew. Chem. Int. Ed. , 2017 . 56 ( 1 ): 143 - 147 . http://onlinelibrary.wiley.com/doi/10.1002/anie.201611453/abstract http://onlinelibrary.wiley.com/doi/10.1002/anie.201611453/abstract , .

S. Y. Shi , Y. J. Liu , Y. Chen , Z. H. Zhang , Y. S. Ding , Z. Q. Wu , J. Yin , L. M. Nie . Versatile pH-response micelles with high cell-penetrating helical diblock copolymers for photoacoustic imaging guided synergistic chemo-photothermal therapy . Theranostics , 2016 . 6 ( 12 ): 2170 - 2182 . DOI: 10.7150/thno.16633 http://doi.org/10.7150/thno.16633 .

P. H. Zhang , Y. Wang , J. Lian , Q. Shen , C. Wang , B. Ma , Y. C. Zhang , T. T. Xu , J. X. Li , Y. P. Shao , F. Xu , J. J. Zhu . Engineering the surface of smart nanocarriers using a pH-/thermal-/GSH-responsive polymer zipper for precise tumor targeting therapy in vivo . Adv. Mater. , 2017 . 29 1702311 DOI: 10.1002/adma.201702311 http://doi.org/10.1002/adma.201702311 .

Y. Kakizawa , A. Harada , K. Kataoka . Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond . J. Am. Chem. Soc. , 1999 . 121 ( 48 ): 11247 - 11248 . DOI: 10.1021/ja993057y http://doi.org/10.1021/ja993057y .

Z. Wu , J. B. Huang , Y. Yan . Electrostatic polyion micelles with fluorescence and MRI dual functions . Langmuir , 2015 . 31 ( 29 ): 7926 - 7933 . DOI: 10.1021/acs.langmuir.5b01516 http://doi.org/10.1021/acs.langmuir.5b01516 .

V. T. Huynh , G. J. Chen , S. P. De , M. H. Stenzel . Thiol-yne and Thiol-ene "click" chemistry as a tool for a variety of platinum drug delivery carriers, from statistical copolymers to crosslinked micelles . Biomacromolecules , 2011 . 12 ( 5 ): 1738 - 1751 . DOI: 10.1021/bm200135e http://doi.org/10.1021/bm200135e .

R. K. O'Reilly , M. J. Joralemon , C. J. Hawker , K. L. Wooley . Preparation of orthogonally-functionalized core Click cross-linked nanoparticles . New J. Chem. , 2007 . 31 718 - 724 . DOI: 10.1039/B616103K http://doi.org/10.1039/B616103K .

Z. H. Zhang , L. C. Yin , C. L. Tu , Z. Y. Song , Y. F. Zhang , Y. X. Xu , R. Tong , Q. Zhou , J. Ren , J. Cheng . J . Redox-responsive, core cross-linked polyester micelles. ACS Macro. Lett. , 2013 . 2 ( 1 ): 40 - 44 . http://pubmedcentralcanada.ca/pmcc/articles/PMC3606897/ http://pubmedcentralcanada.ca/pmcc/articles/PMC3606897/ , .

Z. Y. Deng , Y. F. Qian , Y. Q. Yu , G. H. Liu , J. M. Hu , G. Y. Zhang , S. Y. Liu . Engineering intracellular delivery nanocarriers and nanoreactors from oxidation-responsive polymersomes via synchronized bilayer cross-linking and permeabilizing inside live cells . J. Am. Chem. Soc. , 2016 . 138 ( 33 ): 10452 - 10466 . DOI: 10.1021/jacs.6b04115 http://doi.org/10.1021/jacs.6b04115 .

X. R. Wang , G. H. Liu , J. M. Hu , G. Y. Zhang , S. Y. Liu . Concurrent block copolymer polymersome stabilization and bilayer permeabilization by stimuli-regulated "traceless" crosslinking . Angew. Chem. lnt. Ed. , 2014 . 53 ( 12 ): 3138 - 3142 . DOI: 10.1002/anie.201310589 http://doi.org/10.1002/anie.201310589 .

X. R. Wang , J. M. Hu , G. H. Liu , J. Tian , H. J. Wang , M. Gong , S. Y. Liu . Reversibly switching bilayer permeability and release modules of photochromic polymersomes stabilized by cooperative noncovalent interactions . J. Am. Chem. Soc. , 2015 . 137 ( 48 ): 15262 - 15275 . DOI: 10.1021/jacs.5b10127 http://doi.org/10.1021/jacs.5b10127 .

J. D. Luo , Z. L. Xie , J. W. Y. Lam , L. Cheng , H. Y. Chen , C. F. Qiu , H. S. Kwok , X. W. Zhan , Y. Q. Liu , D. B. Zhu , B. Z. Tang . Aggregation-induced emission of 1-methyl-1, 2, 3, 4, 5-pentaphenylsilole . Chem. Commun. , 2001 . 18 1740 - 1741 . http://onlinelibrary.wiley.com/resolve/reference/PMED?id=12240292 http://onlinelibrary.wiley.com/resolve/reference/PMED?id=12240292 , .

Z. Wang , T. Y. Yong , J. S. Wan , Z. H. Li , H. Zhao , Y. B. Zhao , L. Gan , X. Y. Yang , H. B. Xu , C. Zhang . Temperature-sensitive fluorescent organic nanoparticles with aggregation-induced emission for long-term cellular tracing . ACS Appl. Mater. Interfaces , 2015 . 7 ( 5 ): 3420 - 3425 . DOI: 10.1021/am509161y http://doi.org/10.1021/am509161y .

B. P. Jiang , X. Y. Tan , X. C. Shen , W. Q. Lei , W. Q. Liang , S. C. Ji , H. Liang . One-step fabrication of a multifunctional aggregation-induced emission nanoaggregate for targeted cell imaging and enzyme-triggered cancer chemotherapy . ACS Macro Lett. , 2016 . 5 ( 4 ): 450 - 454 . DOI: 10.1021/acsmacrolett.6b00154 http://doi.org/10.1021/acsmacrolett.6b00154 .

X. Wang , Y. Y. Yang , Y. P. Zhuang , P. Y. Gao , F. Yang , H. Shen , H. X. Guo , D. C. Wu . Fabrication of pH-responsive nanoparticles with an AIE feature for imaging intracellular drug delivery . Biomacromolecules , 2016 . 17 ( 9 ): 2920 - 2929 . DOI: 10.1021/acs.biomac.6b00744 http://doi.org/10.1021/acs.biomac.6b00744 .

H. B. Shi , R. T. K. Kwok , J. Z. Liu , B. G. Xing , B. Z. Tang , B. Liu . Real-time monitoring of cell apoptosis and drug screening using fluorescent light-up probe with aggregation-induced emission characteristics . J. Am. Chem. Soc. , 2012 . 134 ( 43 ): 17972 - 17981 . DOI: 10.1021/ja3064588 http://doi.org/10.1021/ja3064588 .

B. P. Jiang , D. S. Guo , Y. C. Liu , K. P. Wang , Y. Liu . Photomodulated fluorescence of supramolecular assemblies of sulfonatocalixarenes and tetraphenylethene . ACS Nano , 2014 . 8 ( 2 ): 1609 - 1618 . DOI: 10.1021/nn405923b http://doi.org/10.1021/nn405923b .

Y. G. He , S. Y. Shi , N. Liu , Y. S. Ding , J. Yin , Z. Q. Wu . Tetraphenylethene-functionalized conjugated helical poly(phenyl isocyanide) with tunable light emission, assembly morphology, and specific applications . Macromolecules , 2016 . 49 ( 1 ): 48 - 58 . DOI: 10.1021/acs.macromol.5b02412 http://doi.org/10.1021/acs.macromol.5b02412 .

X. Han , J. Zhang , C. Y. Qiao , W. M. Zhang , J. Yin , Z. Q. Wu . High-efficiency cell-penetrating helical poly(phenyl isocyanide) chains modified cellular tracer and nanovectors with thiol ratiometric fluorescence imaging performance . Macromolecules , 2017 . 50 ( 11 ): 4114 - 4125 . DOI: 10.1021/acs.macromol.7b00669 http://doi.org/10.1021/acs.macromol.7b00669 .

Y. Chen , Z. Z. Zhang , X. Han , J. Yin , Z. Q. Wu . Oxidation and acid milieu-disintegratable nanovectors with rapid cell-penetrating helical polymer chains for programmed drug release and synergistic chemo-photothermal therapy . Macromolecules , 2016 . 49 ( 20 ): 7718 - 7727 . DOI: 10.1021/acs.macromol.6b02063 http://doi.org/10.1021/acs.macromol.6b02063 .

A. K. Rajora , D. Ravishankar , H. M. I. Osborn , F. Greco . Impact of the enhanced permeability and retention (EPR) Effect and cathepsins levels on the activity of polymer-drug conjugates . Polymers , 2014 . 6 ( 8 ): 2186 - 2220 . http://www.mendeley.com/research/impact-enhanced-permeability-retention-epr-effect-cathepsins-levels-activity-polymerdrug-conjugates/ http://www.mendeley.com/research/impact-enhanced-permeability-retention-epr-effect-cathepsins-levels-activity-polymerdrug-conjugates/ , .

M. M. Huang , K. J. Zhao , L. Wang , S. Q. Lin , J. J. Li , J. B. Chen , C. G. Zhao , Z. S. Ge . Dual stimuli-responsive polymer prodrugs quantitatively loaded by nanoparticles for enhanced cellular internalization and triggered drug release . ACS Appl. Mater. Interfaces , 2016 . 8 ( 18 ): 11226 - 11236 . DOI: 10.1021/acsami.5b12227 http://doi.org/10.1021/acsami.5b12227 .

X. L. Hu , J. M. Hu , J. Tian , Z. S Ge , G. Y. Zhang , K. F. Luo , S. Y. Liu . Polyprodrug amphiphiles:hierarchical assemblies for shape-regulated cellular internalization, trafficking, and drug delivery . J. Am. Chem. Soc. , 2013 . 135 ( 46 ): 17617 - 17629 . DOI: 10.1021/ja409686x http://doi.org/10.1021/ja409686x .

X. L. Hu , G. H. Liu , Y. Li , X. R. Wang , S. Y. Liu . Cell-penetrating hyperbranched polyprodrug amphiphiles for synergistic reductive milieu-triggered drug release and enhanced magnetic resonance signals . J. Am. Chem. Soc. , 2015 . 137 ( 1 ): 362 - 368 . http://pubs.acs.org/doi/pdf/10.1021/ja5105848 http://pubs.acs.org/doi/pdf/10.1021/ja5105848 , .

K. M. Cai , X. He , Z. Y. Song , Q. Yin , Y. F. Zhang , F. M. Uckun , C. Jiang , J. J. Cheng . Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency . J. Am. Chem. Soc. , 2015 . 137 ( 10 ): 3458 - 3461 . http://pubs.acs.org/doi/pdf/10.1021/ja513034e http://pubs.acs.org/doi/pdf/10.1021/ja513034e , .

M. C. Morris , J. Depollier , J. Mery , F. Heitz , G. Divita . A peptide carrier for the delivery of biologically active proteins into mammalian cells . Nature Biotechnol. , 2001 . 19 1173 - 1176 . DOI: 10.1038/nbt1201-1173 http://doi.org/10.1038/nbt1201-1173 .

D. S. Daniels , A. Schepartz . Intrinsically cell-permeable miniature proteins based on a minimal cationic PPⅡ motif . J. Am. Chem. Soc. , 2007 . 129 ( 47 ): 14578 - 14579 . DOI: 10.1021/ja0772445 http://doi.org/10.1021/ja0772445 .

B. A. Smith , D. S. Daniels , A. E. Coplin , G. E. Jordan , L. M. A. McGregor . Minimally cationic cell-permeable miniature proteins via α -helical arginine display . J. Am. Chem. Soc. , 2008 . 130 ( 10 ): 2948 - 2949 . http://europepmc.org/abstract/MED/18271592 http://europepmc.org/abstract/MED/18271592 , .

H. Y. Tang , L. C. Yin , K. H. Kim , J. J. Cheng . Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties . Chem. Sci. , 2013 . 4 3839 - 3844 . DOI: 10.1039/c3sc51328a http://doi.org/10.1039/c3sc51328a .

W. H. Yang , C. M. Yu , S. Q. Yao , S. Z. Wu . Cell-penetrating poly(disulfide)-based star polymers for simultaneous intracellular delivery of miRNAs and small molecule drugs . Polym. Chem. , 2017 . 8 4043 - 4051 . DOI: 10.1039/C7PY00666G http://doi.org/10.1039/C7PY00666G .

M. M. Green , J. W. Park , T. Sato , A. Teramoto , S. Lifson , R. L. B. Selinger , J. V. Selinger . The macromolecular route to chiral amplification . Angew. Chem. Int. Ed. , 1999 . 38 ( 21 ): 3138 - 3154 . DOI: 10.1002/(ISSN)1521-3773 http://doi.org/10.1002/(ISSN)1521-3773 .

K. Maeda , S. Wakasone , K. Shimomura , T. Ikai , S. Kanoh . Helical polymer brushes with a preferred-handed helix-sense triggered by a terminal optically active group in the pendant . Chem. Commun. , 2012 . 48 3342 - 3344 . DOI: 10.1039/c2cc00024e http://doi.org/10.1039/c2cc00024e .

M. P. Nieh , A. A. Goodwin , J. R. Stewart , B. M. Novak , D. A. Hoagland . Chain stiffness of a high molecular weight polyguanidine prepared by living polymerization . Macromolecules , 1998 . 31 ( 9 ): 3151 - 3154 . DOI: 10.1021/ma9718006 http://doi.org/10.1021/ma9718006 .

J. F. Reuther , M. P. Bhatt , G. Tian , B. L. Batchelor , R. Campos , B. M. Novak . Controlled living polymerization of carbodiimides using versatile, air-stable nickel(Ⅱ) initiators:facile incorporation of helical, rod-like materials . Macromolecules , 2014 . 47 ( 14 ): 4587 - 4595 . DOI: 10.1021/ma5009429 http://doi.org/10.1021/ma5009429 .

S. Y. Shi , Y. G. He , W. W. Chen , N. Liu , Y. Y. Zhu , Y. S. Ding , J. Yin , Z. Q. Wu . Polypeptide- b -poly(phenyl isocyanide) hybrid rod-rod copolymers:one-pot synthesis, self-assembly, and cell imaging . Macromol. Rapid Commun. , 2015 . 36 ( 16 ): 1511 - 1520 . DOI: 10.1002/marc.201500185 http://doi.org/10.1002/marc.201500185 .

Y. G. He , S. Y. Shi , N. Liu , Y. Y. Zhu , Y. S. Ding , J. Yin , Z. Q. Wu . Fabrication of SERS-active conjugated copolymers/gold nanoparticles composite films by interface-directed assembly . RSC Adv. , 2015 . 5 39697 - 39704 . DOI: 10.1039/C5RA05430C http://doi.org/10.1039/C5RA05430C .

W. Li , Y. G. He , S. Y. Shi , N. Liu , Y. Y. Zhu , Y. S. Ding , J. Yin , Z. Q. Wu . Fabrication of a multi-charge generable poly(phenyl isocyanide)-block-poly(3-hexylthiophene) rod-rod conjugated copolymer . Polym. Chem. , 2015 . 6 2348 - 2355 . DOI: 10.1039/C4PY01624F http://doi.org/10.1039/C4PY01624F .

J. Yin , L. Xu , X. Han , L. Zhou , C. L. Li , Z. Q. Wu . A facile synthetic route to stereoregular helical poly(phenyl isocyanide)s with defined pendants and controlled helicity . Polym. Chem. , 2017 . 8 545 - 556 . DOI: 10.1039/C6PY01881E http://doi.org/10.1039/C6PY01881E .

Z. Z. Zhang , C. Y. Qiao , J. Zhang , W. M. Zhang , J. Yin , Z. Q. Wu . Synthesis of unimolecular micelles with incorporated hyperbranched boltorn h30 polyester modified with hyperbranched helical poly(phenyl isocyanide) chains and their enantioselective crystallization performance . Macromol. Rapid Commun. , 2017 . 38 DOI: 10.1002/marc.201700315 http://doi.org/10.1002/marc.201700315 .

H. Engelkamp , S. Middelbeek , R. J. M. Nolte . Self-assembly of disk-shaped molecules to coiled-coil aggregates with tunable helicity . Science , 1999 . 284 ( 5415 ): 785 - 788 . DOI: 10.1126/science.284.5415.785 http://doi.org/10.1126/science.284.5415.785 .

T. Kajitani , H. Onouchi , S. I. Sakurai , K. Nagai , K. Okoshi , K. Onitsuka , E. Yashima . Latticelike smectic liquid crystal phase in a rigid-rod helical polyisocyanide with mesogenic pendants . J. Am. Chem. Soc. , 2011 . 133 ( 24 ): 9156 - 9159 . DOI: 10.1021/ja201133d http://doi.org/10.1021/ja201133d .

A. Q. Xu , G. X. Hu , Y. L. Hu , X. Q. Zhang , K. Liu , G. C. Kuang , A. F. Zhang . Remarkable structure effects on chiroptical properties of polyisocyanides carrying proline pendants . Chem. Asian J. , 2013 . 8 ( 9 ): 2003 - 2014 . DOI: 10.1002/asia.201300297 http://doi.org/10.1002/asia.201300297 .

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