CO<sub>2</sub>-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

Xian-Wu Jing; Zhi-Yu Huang; Hong-Sheng Lu; Bao-Gang Wang

doi:10.1007/s10118-018-2008-z

Your Location：

Home >

Browse articles >

CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

Papers | Updated：2021-02-18

- CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle
- Chinese Journal of Polymer Science Vol. 36, Issue 1, Pages: 18-24(2018)
- Affiliations：
  
  a.College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China
  b.Engineering Research Center of Oilfield Chemistry, Ministry of Education, Chengdu 610500, China
- Author bio：
  
  E-mail hzy3019@163.com (Z.Y.H.)
  E-mail hshlu@swpu.edu.cn (H.S.L.)
- Funds：
- DOI：10.1007/s10118-018-2008-z
  CLC：
- Received：25 April 2017，
  
  Revised：2017-7-5，
  
  Accepted：05 July 2017，
  
  Online First：20 October 2017，
  
  Published：05 January 2018
- Accepted：
Scan QR Code
Xian-Wu Jing, Zhi-Yu Huang, Hong-Sheng Lu, et al. CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle[J]. Chinese Journal of Polymer Science, 2018, 36(1): 18-24. DOI: 10.1007/s10118-018-2008-z.
DOI：

Xian-Wu Jing, Zhi-Yu Huang, Hong-Sheng Lu, et al. CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle[J]. Chinese Journal of Polymer Science, 2018, 36(1): 18-24. DOI: 10.1007/s10118-018-2008-z. DOI：

摘要

Abstract

A series of triblock copolymers

containing a CO

-switchable block poly(2-(dimethylamino)ethyl methacrylate) (PDM) block and two symmetrical hydrophilic blocks polyacrylamide (PAM)

were synthesized using atom transfer radical polymerization (ATRP) method. The pH and conductivity tests showed that the triblock copolymer exhibited switchable responsiveness to CO

i.e

. a relatively low conductivity of solution could be switched on and off by bubbling and removing of CO

and the triblock copolymer aqueous solution displayed a CO

-switchable viscosity variation. The changes were all attributed to protonation of tertiary amine groups in PDM blocks and proven by

H-NMR. Cryogenic transmission electron microscopy and dynamic light scattering characterization demonstrated that the viscosity variation was the result of a unilamellar vesicle-network aggregate structure transition. The release of rhodamine B from the vesicles with and without CO

stimuli showed the potential application in drug delivery domains; after CO

bubbling

the drug release rate could be accelerated. Finally

reasonable mechanism of CO

-switchable morphology changes and CO

-induced drug release was proposed.

关键词

Keywords

references

J. S. Wang , K. Matyjaszewski . Controlled/"living" radical polymerization. atom transfer radical polymerization in the presence of transition-metal complexes . J. Am. Chem. Soc. , 1995 . 117 ( 20 ): 127 - 134 . .

M. Kato , M. Kamigaito , M. Sawamoto , T. Higashimura . Polymerization of methyl methacrylate with the carbon tetrachloride/dichlorotris-(triphenylphosphine)ruthenium(Ⅱ)/methylaluminum bis(2, 6-di- tert -butylphenoxide) initiating system:possibility of living radical polymerization . Macromolecules , 1995 . 28 ( 5 ): 1721 - 1723 . DOI: 10.1021/ma00109a056 http://doi.org/10.1021/ma00109a056 .

Z. Gao , S. K. Varshney , S. Wong , A. Eisenberg . Block copolymer "crew-cut" micelles in water . Macromolecules , 1994 . 27 ( 26 ): 7923 - 7927 . DOI: 10.1021/ma00104a058 http://doi.org/10.1021/ma00104a058 .

J. Du , R. K. O'Reilly . Advances and challenges in smart and functional polymer vesicles . Soft Matter , 2009 . 5 ( 19 ): 3544 - 3561 . DOI: 10.1039/b905635a http://doi.org/10.1039/b905635a .

C. Fernyhough , A. J. Ryan , G. Battaglia . pH controlled assembly of a polybutadiene-poly(methacrylic acid) copolymer in water:packing considerations and kinetic limitations . Soft Matter , 2009 . 5 ( 8 ): 1674 - 1682 . DOI: 10.1039/b817218h http://doi.org/10.1039/b817218h .

N. J. Warren , O. O. Mykhaylyk , D. Mahmood , A. J. Ryan , S. P. Armes . RAFT aqueous dispersion polymerization yields poly(ethylene glycol)-based diblock copolymer nano-objects with predictable single phase morphologies . J. Am. Chem. Soc. , 2014 . 136 ( 3 ): 1023 - 1033 . DOI: 10.1021/ja410593n http://doi.org/10.1021/ja410593n .

A. H. Groschel , A. Walther , T. I. Lobling , J. Schmelz , A. Hanisch , H. Schmalz , A.H. E. Muller . Facile, solution-based synthesis of soft, nanoscale Janus particles with tunable Janus balance . J. Am. Chem. Soc. , 2012 . 134 ( 33 ): 13850 - 13860 . DOI: 10.1021/ja305903u http://doi.org/10.1021/ja305903u .

M. Li , G. L. Li , Z. Zhang , J. Li , K. G. Neoh , E. T. Kang . Self-assembly of pH-responsive and fluorescent comb-like amphiphilic copolymers in aqueous media . Polymer , 2010 . 51 ( 15 ): 3377 - 3386 . DOI: 10.1016/j.polymer.2010.05.032 http://doi.org/10.1016/j.polymer.2010.05.032 .

Y. Morishima . Thermally responsive polymer vesicles . Angew. Chem. Int. Ed. , 2007 . 46 ( 9 ): 1370 - 1372 . DOI: 10.1002/(ISSN)1521-3773 http://doi.org/10.1002/(ISSN)1521-3773 .

B. M. Discher , Y. Y. Won , D. S. Ege , J. C. Lee , F. S. Bates , D. E. Discher , D. A. Hammer . Polymersomes:tough vesicles made from diblock copolymers . Science , 1999 . 284 ( 5417 ): 1143 - 1146 . DOI: 10.1126/science.284.5417.1143 http://doi.org/10.1126/science.284.5417.1143 .

S. J. Byard , M. Williams , B. E. McKenzie , A. Blanazs , S. P. Armes . Preparation and cross-linking of all-acrylamide diblock copolymer nano-objects via polymerization-induced self-assembly in aqueous solution . Macromolecules , 2017 . 50 ( 4 ): 1482 - 1493 . DOI: 10.1021/acs.macromol.6b02643 http://doi.org/10.1021/acs.macromol.6b02643 .

J. Hu , S. Liu . Responsive polymers for detection and sensing applications:current status and future developments . Macromolecules , 2015 . 43 ( 20 ): 8315 - 8330 . http://pubs.acs.org/doi/pdf/10.1021/ma1005815 http://pubs.acs.org/doi/pdf/10.1021/ma1005815 , .

D. Xiong , Y. An , Z. Li , R. Ma , Y. Liu , C. Wu , L. Zou , L. Shi , J. Zhang . Nanometer-scaled hollow spherical micelles with hydrophilic channels and the controlled release of ibuprofen . Macromol. Rapid Commum. , 2008 . 29 ( 23 ): 1895 - 1901 . DOI: 10.1002/marc.v29:23 http://doi.org/10.1002/marc.v29:23 .

H. Yin , H. C. Kang , K. M. Huh , Y. H. Bae . Biocompatible, pH-sensitive AB 2 miktoarm polymer-based polymersomes:preparation, characterization, and acidic pH-activated nanostructural transformation . J. Mater. Chem. , 2012 . 22 ( 36 ): 19168 DOI: 10.1039/c2jm33750a http://doi.org/10.1039/c2jm33750a .

T. Liu , Y. F. Zhang , S. Y. Liu . Drug and plasmid DNA co-delivery nanocarriers based on ABC type polypeptide hybrid miktoarm star copolymers . Chinese J. Polym. Sci. , 2013 . 31 ( 6 ): 924 - 937 . DOI: 10.1007/s10118-013-1281-0 http://doi.org/10.1007/s10118-013-1281-0 .

S. Mura , J. Nicolas , P. Couvreur . Stimuli-responsive nanocarriers for drug delivery . Nat. Mater. , 2013 . 12 ( 11 ): 991 - 1003 . DOI: 10.1038/nmat3776 http://doi.org/10.1038/nmat3776 .

X. Su , M. F. Cunningham , P. G. Jessop . Use of a switchable hydrophobic associative polymer to create an aqueous solution of CO 2 -switchable viscosity . Polym. Chem. , 2013 . 5 ( 3 ): 940 - 944 . http://pubs.rsc.org/en/Content/ArticlePDF/2014/PY/c3py01382k http://pubs.rsc.org/en/Content/ArticlePDF/2014/PY/c3py01382k , .

Z. Guo , Y. Feng , Y. Wang , J. Wang , Y. Wu , Y. Zhang . A novel smart polymer responsive to CO 2 . Chem. Commun. , 2011 . 47 ( 33 ): 9348 - 9350 . DOI: 10.1039/c1cc12388b http://doi.org/10.1039/c1cc12388b .

D. Han , X. Tong , O. Boissière , Y. Zhao . General strategy for making CO 2 -switchable polymers . ACS Macro Lett. , 2011 . 1 ( 1 ): 57 - 61 . http://pubs.acs.org/doi/abs/10.1021/mz2000175 http://pubs.acs.org/doi/abs/10.1021/mz2000175 , .

Q. Yan , R. Zhou , C. Fu , H. Zhang , Y. Yin , J. Yuan . CO 2 -responsive polymeric vesicles that breathe . Angew. Chem. Int. Ed. , 2011 . 50 ( 21 ): 4923 - 4927 . DOI: 10.1002/anie.v50.21 http://doi.org/10.1002/anie.v50.21 .

Q. Yan , J. Wang , Y. Yin , J. Yuan . Breathing polymersomes:CO 2 -tuning membrane permeability for size-selective release, separation, and reaction . Angew. Chem. Int. Ed. , 2013 . 52 ( 19 ): 5070 - 5073 . DOI: 10.1002/anie.201300397 http://doi.org/10.1002/anie.201300397 .

B. Yan , D. Han , O. Boissiere , P. Ayotte , Y. Zhao . Manipulation of block copolymer vesicles using CO 2 :dissociation or "breathing" . Soft Matter , 2013 . 9 ( 6 ): 2011 - 2016 . DOI: 10.1039/c2sm27469h http://doi.org/10.1039/c2sm27469h .

X. Wang , G. Jiang , Z. Wei , X. Li , B. Tang . Preparation and drug release property of CO 2 stimulus-sensitive poly( N , N -dimethylaminoethyl methacrylate)- b -polystyrene nanoparticles . Eur. Polym. J. , 2013 . 49 ( 10 ): 3165 - 3170 . DOI: 10.1016/j.eurpolymj.2013.07.024 http://doi.org/10.1016/j.eurpolymj.2013.07.024 .

S. Das , D. P. Chatterjee , R. Ghosh , P. Das , A. K. Nandi . Water soluble stimuli-responsive star copolymers with multiple encapsulation and release properties . RSC Adv. , 2016 . 6 ( 11 ): 8773 - 8785 . DOI: 10.1039/C5RA26144A http://doi.org/10.1039/C5RA26144A .

C. I. Fowler , P. G. Jessop , M. F. Cunningham . Aryl amidine and tertiary amine switchable surfactants and their application in the emulsion polymerization of methyl methacrylate . Macromolecules , 2012 . 45 ( 7 ): 2955 - 2962 . DOI: 10.1021/ma2027484 http://doi.org/10.1021/ma2027484 .

W. Yuan , J. Zhang , J. Wei , C. Zhang , J. Ren . Synthesis and self-assembly of pH-responsive amphiphilic dendritic star-block terpolymer by the combination of ROP, ATRP and click chemistry . Eur. Polym. J. , 2011 . 47 ( 5 ): 949 - 958 . DOI: 10.1016/j.eurpolymj.2011.01.002 http://doi.org/10.1016/j.eurpolymj.2011.01.002 .

J. Jiang , Q. Shu , X. Chen , Y. Yang , C. Yi , X. Song , X. Liu , M. Chen . Photoinduced morphology switching of polymer nanoaggregates in aqueous solution . Langmuir , 2010 . 26 ( 17 ): 14247 - 14254 . DOI: 10.1021/la102771h http://doi.org/10.1021/la102771h .

Q. Yan , J. Yuan , Z. Cai , Y. Xin , Y. Kang , Y. Yin . Voltage-responsive vesicles based on orthogonal assembly of two homopolymers . J. Am. Chem. Soc. , 2010 . 132 ( 27 ): 9268 - 9270 . DOI: 10.1021/ja1027502 http://doi.org/10.1021/ja1027502 .

Views

310

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

The Application of Controlled/Living Radical Polymerization in Modification of PVDF-based Fluoropolymer

Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications

pH-responsive AIE-active Polyethylene-based Block Copolymers

Molecularly Engineered Polyimide Films with Switchable Cavitation for Bidirectional Passive Thermal Regulation

Related Author

Guo-Hua Jiang

Chao Cen

Zai-Zai Tong

Song-Yue Cheng

Wen-Di Fan

Yi-Kun Jiang

Ya-Wei Su

Wei Hu

Related Institution

College of Materials Science and Engineering and Institute of Smart Biomedical Materials, Zhejiang Sci-Tech University

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine

Xi’an Key Laboratory of Sustainable Energy Materials Chemistry, Department of Applied Chemistry, School of Chemistry, Xi’an Jiaotong University

Xi’an Jiaotong University Suzhou Academy

State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology

⁰

CO2-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

DOI：10.1007/s10118-018-2008-z

摘要

Abstract

关键词

Keywords

references

CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle