Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators

Hao Su; Yuzhu Wang; Caleb F. Anderson; Jin Mo Koo; Han Wang; Honggang Cui

doi:10.1007/s10118-017-1998-2

Your Location：

Home >

Browse articles >

Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators

Reviews | Updated：2021-02-18

- Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators
- Chinese Journal of Polymer Science Vol. 35, Issue 10, Pages: 1194-1211(2017)
- Affiliations：
  
  a.Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
  b.Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
  c.Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
  d.Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
- Author bio：
  
  Honggang Cui, E-mail:hcui6@jhu.edu
- Funds：
- DOI：10.1007/s10118-017-1998-2
  CLC：
Scan for full text
Hao Su, Yuzhu Wang, Caleb F. Anderson, et al. Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators. [J]. Chinese Journal of Polymer Science 35(10):1194-1211(2017)
DOI：

Hao Su, Yuzhu Wang, Caleb F. Anderson, et al. Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators. [J]. Chinese Journal of Polymer Science 35(10):1194-1211(2017) DOI： 10.1007/s10118-017-1998-2.

摘要

Abstract

Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their inherent biodegradability and biocompatibility, as well as versatility in molecular design and ease of synthesis. Built upon the directional, intermolecular interactions such as hydrogen bonding and ,π-π, stacking, peptide-based molecular units can associate in aqueous solution into filamentous assemblies of various sizes and shapes. Under appropriate conditions, these filamentous assemblies can percolate into a 3D network with materials properties tailorable for specific biomedical applications. In this review, we survey the literature published over the past three years in the development of peptide-based hydrogelators for biomedical applications. We highlight several representative examples and center our discussion on the fundamentals of molecular design, assembly, and gelation conditions.

关键词

Keywords

PeptideHydrogelsPeptide conjugatesSupramolecular nanostructuresMolecular assembly

references

E.A. Appel , J. del Barrio , X.J. Loh , O.A. Scherman . Chem. Soc. Rev. , 2012 . 41 (18 ):6195 DOI:10.1039/c2cs35264hhttp://doi.org/10.1039/c2cs35264h.

X.W. Du , J. Zhou , J.F. Shi , B. Xu . Chem. Rev. , 2015 . 115 (24 ):13165 DOI:10.1021/acs.chemrev.5b00299http://doi.org/10.1021/acs.chemrev.5b00299.

A.S. Hoffman . Adv. Drug Deliver. Rev. , 2012 . 64 18 DOI:10.1016/j.addr.2012.09.010http://doi.org/10.1016/j.addr.2012.09.010.

H.K. Lau , K.L. Kiick . Biomacromolecules , 2015 . 16 (1 ):28 DOI:10.1021/bm501361chttp://doi.org/10.1021/bm501361c.

N. Eslahi , M. Abdorahim , A. Simchi . Biomacromolecules , 2016 . 17 (11 ):3441 DOI:10.1021/acs.biomac.6b01235http://doi.org/10.1021/acs.biomac.6b01235.

J.L. Drury , D.J. Mooney . Biomaterials , 2003 . 24 (24 ):4337 DOI:10.1016/S0142-9612(03)00340-5http://doi.org/10.1016/S0142-9612(03)00340-5.

K.Y. Lee , D.J. Mooney . Chem. Rev. , 2001 . 101 (7 ):1869 DOI:10.1021/cr000108xhttp://doi.org/10.1021/cr000108x.

E. Jabbari , J. Leijten , Q.B. Xu , A. Khademhosseini . Mater. Today , 2016 . 19 (4 ):190 DOI:10.1016/j.mattod.2015.10.005http://doi.org/10.1016/j.mattod.2015.10.005.

S.L. Vega , M.Y. Kwon , J.A. Burdick . Eur. Cells. Mater. , 2017 . 33 59 DOI:10.22203/eCMhttp://doi.org/10.22203/eCM.

N. Annabi , A. Tamayol , J.A. Uquillas , M. Akbari , L.E. Bertassoni , C. Cha , G. Camci-Unal , M.R. Dokmeci , N.A. Peppas , A. Khademhosseini . Adv. Mater. , 2014 . 26 (1 ):85 DOI:10.1002/adma.201303233http://doi.org/10.1002/adma.201303233.

R.A. Holmes , X. Yang , G. Tronci , D. Wood . Tissue Eng. Pt. A , 2016 . 22 S126 .

B.V. Slaughter , S.S. Khurshid , O.Z. Fisher , A. Khademhosseini , N.A. Peppas . Adv. Mater. , 2009 . 21 (32-33 ):3307 DOI:10.1002/adma.v21:32/33http://doi.org/10.1002/adma.v21:32/33.

J.A. Yang , J. Yeom , B.W. Hwang , A.S. Hoffman , S.K. Hahn . Prog. Polym. Sci. , 2014 . 39 (12 ):1973 DOI:10.1016/j.progpolymsci.2014.07.006http://doi.org/10.1016/j.progpolymsci.2014.07.006.

A. Singh , N.A. Peppas . Adv. Mater. , 2014 . 26 (38 ):6530 DOI:10.1002/adma.v26.38http://doi.org/10.1002/adma.v26.38.

Y. Wen , A. Waltman , H.F. Han , J.H. Collier . ACS Nano , 2016 . 10 (10 ):9274 DOI:10.1021/acsnano.6b03409http://doi.org/10.1021/acsnano.6b03409.

J.S. Rudra , T. Sun , K.C. Bird , M.D. Daniels , J.Z. Gasiorowski , A.S. Chong , J.H. Collier . ACS Nano , 2012 . 6 (2 ):1557 DOI:10.1021/nn204530rhttp://doi.org/10.1021/nn204530r.

J.C. Barrett , B.D. Ulery , A. Trent , S. Liang , N.A. David , M.V. Tirrell . ACS. Biomater. Sci. Eng. , 2017 . 3 (2 ):144 DOI:10.1021/acsbiomaterials.6b00422http://doi.org/10.1021/acsbiomaterials.6b00422.

A. Vashist , A. Vashist , Y.K. Gupta , S. Ahmad . J. Mater. Chem. B , 2014 . 2 (2 ):147 DOI:10.1039/C3TB21016Bhttp://doi.org/10.1039/C3TB21016B.

T.R. Hoare , D.S. Kohane . Polymer , 2008 . 49 (8 ):1993 DOI:10.1016/j.polymer.2008.01.027http://doi.org/10.1016/j.polymer.2008.01.027.

G.W. Ashley , J. Henise , R. Reid , D.V. Santi . Proc. Natl. Acad. Sci. U.S.A. , 2013 . 110 (6 ):2318 DOI:10.1073/pnas.1215498110http://doi.org/10.1073/pnas.1215498110.

N.K. Singh , D.S. Lee . J. Control. Release , 2014 . 193 214 DOI:10.1016/j.jconrel.2014.04.056http://doi.org/10.1016/j.jconrel.2014.04.056.

Y.F. Zhang , R. Wang , Y.Y. Hua , R. Baumgartner , J.J. Cheng . ACS Macro Lett. , 2014 . 3 (7 ):693 DOI:10.1021/mz500277jhttp://doi.org/10.1021/mz500277j.

B.P. Purcell , D. Lobb , M.B. Charati , S.M. Dorsey , R.J. Wade , K.N. Zellars , H. Doviak , S. Pettaway , C.B. Logdon , J.A. Shuman , P.D. Freels , J.H. Gorman , R.C. Gorman , F.G. Spinale , J.A. Burdick . Nat. Mater. , 2014 . 13 (6 ):653 DOI:10.1038/nmat3922http://doi.org/10.1038/nmat3922.

M. Hartlieb , K. Kempe , U.S. Schubert . J. Mater. Chem. B , 2015 . 3 (4 ):526 DOI:10.1039/C4TB01660Bhttp://doi.org/10.1039/C4TB01660B.

Q.V. Nguyen , D.P. Huynh , J.H. Park , D.S. Lee . Eur. Polym. J. , 2015 . 72 602 DOI:10.1016/j.eurpolymj.2015.03.016http://doi.org/10.1016/j.eurpolymj.2015.03.016.

X.L. Wu , C.L. He , Y.D. Wu , X.S. Chen , J.J. Cheng . Adv. Funct. Mater. , 2015 . 25 (43 ):6744 DOI:10.1002/adfm.201502742http://doi.org/10.1002/adfm.201502742.

X.H. Fu , Y. Shen , Y.A. Ma , W.X. Fu , Z.B. Li . Sci. China-Chem. , 2015 . 58 (6 ):1005 DOI:10.1007/s11426-014-5297-2http://doi.org/10.1007/s11426-014-5297-2.

Y.N. Ma , X.H. Fu , Y. Shen , W.X. Fu , Z.B. Li . Macromolecules , 2014 . 47 (14 ):4684 DOI:10.1021/ma501104shttp://doi.org/10.1021/ma501104s.

S.S. Zhang , W.X. Fu , Z.B. Li . Polym. Chem. , 2014 . 5 (10 ):3346 DOI:10.1039/C4PY00016Ahttp://doi.org/10.1039/C4PY00016A.

S. Srivastava , M. Andreev , A.E. Levi , D.J. Goldfeld , J. Mao , W.T. Heller , V.M. Prabhu , J.J. de Pablo , M.V. Tirrell . Nat. Commun. , 2017 . 8 14131 DOI:10.1038/ncomms14131http://doi.org/10.1038/ncomms14131.

J. Whittaker , R. Balu , N.R. Choudhury , N.K. Dutta . Polym. Int. , 2014 . 63 (9 ):1545 DOI:10.1002/pi.2014.63.issue-9http://doi.org/10.1002/pi.2014.63.issue-9.

Y. Zhao , T. Nakajima , J.J. Yang , T. Kurokawa , J. Liu , J. Lu , S. Mizumoto , K. Sugahara , N. Kitamura , K. Yasuda , A.U.D. Daniels , J.P. Gong . Adv. Mater. , 2014 . 26 (3 ):436 DOI:10.1002/adma.201303387http://doi.org/10.1002/adma.201303387.

J. Li , L.T. Mo , C.H. Lu , T. Fu , H.H. Yang , W.H. Tan . Chem. Soc. Rev. , 2016 . 45 (5 ):1410 DOI:10.1039/C5CS00586Hhttp://doi.org/10.1039/C5CS00586H.

S.H. Um , J.B. Lee , N. Park , S.Y. Kwon , C.C. Umbach , D. Luo . Nat. Mater. , 2006 . 5 (10 ):797 DOI:10.1038/nmat1741http://doi.org/10.1038/nmat1741.

X.L. Xiong , C.C. Wu , C.S. Zhou , G.Z. Zhu , Z. Chen , W.H. Tan . Macromol. Rapid Commun. , 2013 . 34 (16 ):1271 DOI:10.1002/marc.v34.16http://doi.org/10.1002/marc.v34.16.

J.S. Kahn , Y.W. Hu , I. Willner . Accounts Chem. Res. , 2017 . 50 (4 ):680 DOI:10.1021/acs.accounts.6b00542http://doi.org/10.1021/acs.accounts.6b00542.

N. Singh , M. Kumar , J.F. Miravet , R.V. Ulijn , B. Escuder . Chem. Eur. J. , 2017 . 23 (5 ):981 DOI:10.1002/chem.201602624http://doi.org/10.1002/chem.201602624.

H. Cui , M.J. Webber , S.I. Stupp . Biopolymers , 2010 . 94 (1 ):1 DOI:10.1002/bip.21328http://doi.org/10.1002/bip.21328.

J. Zhou , J. Li , X.W. Du , B. Xu . Biomaterials , 2017 . 129 1 DOI:10.1016/j.biomaterials.2017.03.014http://doi.org/10.1016/j.biomaterials.2017.03.014.

A.M. Jonker , D.W.P.M. Lowik , J.C.M. van Hest . Chem. Mater. , 2012 . 24 (5 ):759 DOI:10.1021/cm202640whttp://doi.org/10.1021/cm202640w.

S. Sathaye , A. Mbi , C. Sonmez , Y.C. Chen , D.L. Blair , J.P. Schneider , D.J. Pochan . Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. , 2015 . 7 (1 ):34 DOI:10.1002/wnan.2015.7.issue-1http://doi.org/10.1002/wnan.2015.7.issue-1.

A. Altunbas , D.J. Pochan . Top. Curr. Chem. , 2012 . 310 135 .

I.C. Li , A.N. Moore , J.D. Hartgerink . Biomacromolecules , 2016 . 17 (6 ):2087 DOI:10.1021/acs.biomac.6b00309http://doi.org/10.1021/acs.biomac.6b00309.

J.K.F. Suh , H.W.T. Matthew . Biomaterials , 2000 . 21 (24 ):2589 DOI:10.1016/S0142-9612(00)00126-5http://doi.org/10.1016/S0142-9612(00)00126-5.

S. van Vlierberghe , P. Dubruel , E. Schacht . Biomacromolecules , 2011 . 12 (5 ):1387 DOI:10.1021/bm200083nhttp://doi.org/10.1021/bm200083n.

X.P. Shen , J.L. Shamshina , P. Berton , G. Gurau , R.D. Rogers . Green. Chem. , 2016 . 18 (1 ):53 DOI:10.1039/C5GC02396Chttp://doi.org/10.1039/C5GC02396C.

X.L. Zhang , C.M. Dong , W.Y. Huang , H.M. Wang , L. Wang , D. Ding , H. Zhou , J.F. Long , T.L. Wang , Z.M. Yang . Nanoscale , 2015 . 7 (40 ):16666 DOI:10.1039/C5NR05213Khttp://doi.org/10.1039/C5NR05213K.

M. Patenaude , N.M.B. Smeets , T. Hoare . Macromol. Rapid Commun. , 2014 . 35 (6 ):598 DOI:10.1002/marc.v35.6http://doi.org/10.1002/marc.v35.6.

W.E. Hennink , C.F. van Nostrum . Adv. Drug Deliver. Rev. , 2012 . 64 223 DOI:10.1016/j.addr.2012.09.009http://doi.org/10.1016/j.addr.2012.09.009.

M.D. Konieczynska , M.W. Grinstaff . Accounts Chem. Res. , 2017 . 50 (2 ):151 DOI:10.1021/acs.accounts.6b00547http://doi.org/10.1021/acs.accounts.6b00547.

J.L. Holloway , H. Ma , R. Rai , K.D. Hankenson , J.A. Burdick . Macromol. Biosci. , 2015 . 15 (9 ):1218 DOI:10.1002/mabi.201500178http://doi.org/10.1002/mabi.201500178.

S. Khetan , M. Guvendiren , W.R. Legant , D.M. Cohen , C.S. Chen , J.A. Burdick . Nat. Mater. , 2013 . 12 (5 ):458 DOI:10.1038/nmat3586http://doi.org/10.1038/nmat3586.

C.B. Rodell , R.J. Wade , B.P. Purcell , N.N. Dusaj , J.A. Burdick . ACS. Biomater. Sci. Eng. , 2015 . 1 (4 ):277 DOI:10.1021/ab5001673http://doi.org/10.1021/ab5001673.

R.J. Wade , E.J. Bassin , C.B. Rodell , J.A. Burdick . Nat. Commun. , 2015 . 6 6639 DOI:10.1038/ncomms7639http://doi.org/10.1038/ncomms7639.

A.M. Kloxin , A.M. Kasko , C.N. Salinas , K.S. Anseth . Science , 2009 . 324 (5923 ):59 DOI:10.1126/science.1169494http://doi.org/10.1126/science.1169494.

T.E. Brown , I.A. Marozas , K.S. Anseth . Adv. Mater. , 2017 . 29 (11 ):1605001 DOI:10.1002/adma.201605001http://doi.org/10.1002/adma.201605001.

J.C. Grim , I.A. Marozas , K.S. Anseth . J. Control. Release , 2015 . 219 95 DOI:10.1016/j.jconrel.2015.08.040http://doi.org/10.1016/j.jconrel.2015.08.040.

D.D. McKinnon , T.E. Brown , K.A. Kyburz , E. Kiyotake , K.S. Anseth . Biomacromolecules , 2014 . 15 (7 ):2808 DOI:10.1021/bm500731bhttp://doi.org/10.1021/bm500731b.

A.M. Rosales , K.S. Anseth . Nat. Rev. Mater. , 2016 . 1 (2 ):15012 DOI:10.1038/natrevmats.2015.12http://doi.org/10.1038/natrevmats.2015.12.

B.V. Sridhar , J.L. Brock , J.S. Silver , J.L. Leight , M.A. Randolph , K.S. Anseth . Adv. Healthc. Mater. , 2015 . 4 (5 ):702 DOI:10.1002/adhm.v4.5http://doi.org/10.1002/adhm.v4.5.

M.J. Webber , E.A. Appel , E.W. Meijer , R. Langer . Nat. Mater. , 2016 . 15 (1 ):13 .

J.E.P. Sun , B. Stewart , A. Litan , S.J. Lee , J.P. Schneider , S.A. Langhans , D.J. Pochan . Biomater. Sci. , 2016 . 4 (5 ):839 DOI:10.1039/C5BM00538Hhttp://doi.org/10.1039/C5BM00538H.

R.J. Dong , Y. Pang , Y. Su , X.Y. Zhu . Biomater. Sci. , 2015 . 3 (7 ):937 DOI:10.1039/C4BM00448Ehttp://doi.org/10.1039/C4BM00448E.

F. Zhao , M.L. Ma , B. Xu . Chem. Soc. Rev. , 2009 . 38 (4 ):883 DOI:10.1039/b806410phttp://doi.org/10.1039/b806410p.

T. Aida , E.W. Meijer , S.I. Stupp . Science , 2012 . 335 (6070 ):813 DOI:10.1126/science.1205962http://doi.org/10.1126/science.1205962.

L. Voorhaar , R. Hoogenboom . Chem. Soc. Rev. , 2016 . 45 (14 ):4013 DOI:10.1039/C6CS00130Khttp://doi.org/10.1039/C6CS00130K.

S. Seiffert , J. Sprakel . Chem. Soc. Rev. , 2012 . 41 (2 ):909 DOI:10.1039/C1CS15191Fhttp://doi.org/10.1039/C1CS15191F.

C.B. Rodell , A.L. Kaminski , J.A. Burdick . Biomacromolecules , 2013 . 14 (11 ):4125 DOI:10.1021/bm401280zhttp://doi.org/10.1021/bm401280z.

T. Kakuta , Y. Takashima , M. Nakahata , M. Otsubo , H. Yamaguchi , A. Harada . Adv. Mater. , 2013 . 25 (20 ):2849 DOI:10.1002/adma.201205321http://doi.org/10.1002/adma.201205321.

Z.M. Yang , H.W. Gu , D.G. Fu , P. Gao , J.K. Lam , B. Xu . Adv. Mater. , 2004 . 16 (16 ):1440 DOI:10.1002/(ISSN)1521-4095http://doi.org/10.1002/(ISSN)1521-4095.

E.A. Appel , M.W. Tibbitt , M.J. Webber , B.A. Mattix , O. Veiseh , R. Langer . Nat. Commun. , 2015 . 6 7295 DOI:10.1038/ncomms8295http://doi.org/10.1038/ncomms8295.

L.L. Lock , Y. Li , X. Mao , H. Chen , V. Staedtke , R. Bai , W. Ma , R. Lin , Y. Li , G. Liu , H. Cui . ACS Nano , 2017 . 11 (1 ):797 DOI:10.1021/acsnano.6b07196http://doi.org/10.1021/acsnano.6b07196.

Y. Hu , R. Lin , K. Patel , A.G. Cheetham , C. Kan , H. Cui . Coordin. Chem. Rev. , 2016 . 320 2 .

Z. Wang , Y.W. Li , Y.R. Huang , M.P. Thompson , C.L.M. LeGuyader , S. Sahu , N.C. Gianneschi . Chem. Commun. , 2015 . 51 (96 ):17108 DOI:10.1039/C5CC05653Ehttp://doi.org/10.1039/C5CC05653E.

C.F. Anderson , H. Cui . Ind. Eng. Chem. Res. , 2017 . 56 (20 ):5761 DOI:10.1021/acs.iecr.7b00990http://doi.org/10.1021/acs.iecr.7b00990.

Y.A. Lin , Y.C. Ou , A.G. Cheetham , H. Cui . ACS Macro Lett. , 2013 . 2 (12 ):1088 DOI:10.1021/mz400535ghttp://doi.org/10.1021/mz400535g.

Y.A. Lin , Y.C. Ou , A.G. Cheetham , H. Cui . Biomacromolecules , 2014 . 15 (4 ):1419 DOI:10.1021/bm500020jhttp://doi.org/10.1021/bm500020j.

L.L. Lock , C.D. Reyes , P. Zhang , H. Cui . J. Am. Chem. Soc. , 2016 . 138 (10 ):3533 DOI:10.1021/jacs.6b00073http://doi.org/10.1021/jacs.6b00073.

P.C. Zhang , A.G. Cheetham , Y.A. Lin , H. Cui . ACS Nano , 2013 . 7 (7 ):5965 DOI:10.1021/nn401667zhttp://doi.org/10.1021/nn401667z.

J.M. Carter , Y. Qian , J.C. Foster , J.B. Matson . Chem. Commun. , 2015 . 51 (66 ):13131 DOI:10.1039/C5CC04883Dhttp://doi.org/10.1039/C5CC04883D.

R.J. Mart , R.D. Osborne , M.M. Stevens , R.V. Ulijn . Soft Matter , 2006 . 2 (10 ):822 DOI:10.1039/b607706dhttp://doi.org/10.1039/b607706d.

S. Wong , M.S. Shim , Y.J. Kwon . J. Mater. Chem. B , 2014 . 2 (6 ):595 DOI:10.1039/C3TB21344Ghttp://doi.org/10.1039/C3TB21344G.

S. Choe , C.W. Bond , D.A. Harrington , S.I. Stupp , K.T. McVary , C.A. Podlasek . Nanomed. Nanotechnol. Biol. Med. , 2017 . 13 (1 ):95 DOI:10.1016/j.nano.2016.08.032http://doi.org/10.1016/j.nano.2016.08.032.

G. Fichman , E. Gazit . Acta Biomater. , 2014 . 10 (4 ):1671 DOI:10.1016/j.actbio.2013.08.013http://doi.org/10.1016/j.actbio.2013.08.013.

Z.Q. Yu , Q. Xu , C.B. Dong , S.S. Lee , L.Q. Gao , Y.W. Li , M. D'Ortenzio , J. Wu . Curr. Pharm. Design. , 2015 . 21 (29 ):4342 DOI:10.2174/1381612821666150901104821http://doi.org/10.2174/1381612821666150901104821.

Y. Qian , J.B. Matson . Adv. Drug Deliver. Rev. , 2017 . 110-111 137 DOI:10.1016/j.addr.2016.06.017http://doi.org/10.1016/j.addr.2016.06.017.

P. Worthington , S. Langhans , D. Pochan . Adv. Drug Deliver. Rev. , 2017 . 110-111 127 DOI:10.1016/j.addr.2017.02.002http://doi.org/10.1016/j.addr.2017.02.002.

A.N. Moore , J.D. Hartgerink . Accounts Chem. Res. , 2017 . 50 (4 ):714 DOI:10.1021/acs.accounts.6b00553http://doi.org/10.1021/acs.accounts.6b00553.

E.J. Berns , S. Sur , L.L. Pan , J.E. Goldberger , S. Suresh , S.M. Zhang , J.A. Kessler , S.I. Stupp . Biomaterials , 2014 . 35 (1 ):185 DOI:10.1016/j.biomaterials.2013.09.077http://doi.org/10.1016/j.biomaterials.2013.09.077.

S. Choe , D. Veliceasa , C.W. Bond , D.A. Harrington , S.I. Stupp , K.T. McVary , C.A. Podlasek . Acta Biomater. , 2016 . 32 89 DOI:10.1016/j.actbio.2016.01.014http://doi.org/10.1016/j.actbio.2016.01.014.

H. Acar , S. Srivastava , E.J. Chung , M.R. Schnorenberg , J.C. Barrett , J.L. LaBelle , M. Tirrell . Adv. Drug Deliver. Rev. , 2017 . 110-111 65 DOI:10.1016/j.addr.2016.08.006http://doi.org/10.1016/j.addr.2016.08.006.

S. Fleming , R.V. Ulijn . Chem. Soc. Rev. , 2014 . 43 (23 ):8150 DOI:10.1039/C4CS00247Dhttp://doi.org/10.1039/C4CS00247D.

J. Raeburn , D.J. Adams . Chem. Commun. , 2015 . 51 (25 ):5170 DOI:10.1039/C4CC08626Khttp://doi.org/10.1039/C4CC08626K.

H. Su , J.M. Koo , H. Cui . J. Control. Release , 2015 . 219 383 DOI:10.1016/j.jconrel.2015.09.056http://doi.org/10.1016/j.jconrel.2015.09.056.

Y. Wang , A.G. Cheetham , G. Angacian , H. Su , L. Xie , H. Cui . Adv. Drug Deliver. Rev. , 2017 . 110-111 112 DOI:10.1016/j.addr.2016.06.015http://doi.org/10.1016/j.addr.2016.06.015.

R.W. Chakroun , P. Zhang , R. Lin , P. Schiapparelli , A. Quinones-Hinojosa , H. Cui . Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. , 2017 . DOI:10.1002/wnan.1479http://doi.org/10.1002/wnan.1479 .

L.L. Lock , M. LaComb , K. Schwarz , A.G. Cheetham , Y.A. Lin , P. Zhang , H. Cui . Faraday Discuss. , 2013 . 166 285 DOI:10.1039/c3fd00099khttp://doi.org/10.1039/c3fd00099k.

R. Lin , P. Zhang , A.G. Cheetham , J. Walston , P. Abadir , H. Cui . Bioconjug. Chem. , 2015 . 26 (1 ):71 DOI:10.1021/bc500408phttp://doi.org/10.1021/bc500408p.

L.L. Lock , Z. Tang , D. Keith , C. Reyes , H. Cui . ACS Macro Lett. , 2015 . 4 (5 ):552 DOI:10.1021/acsmacrolett.5b00170http://doi.org/10.1021/acsmacrolett.5b00170.

P. Zhang , L.L. Lock , A.G. Cheetham , H. Cui . Mol. Pharm. , 2014 . 11 (3 ):964 DOI:10.1021/mp400619vhttp://doi.org/10.1021/mp400619v.

A. Lampel , S.A. McPhee , H.A. Park , G.G. Scott , S. Humagain , D.R. Hekstra , B. Yoo , P. Frederix , T.D. Li , R.R. Abzalimov , S.G. Greenbaum , T. Tuttle , C. Hu , C.J. Bettinger , R.V. Ulijn . Science , 2017 . 356 (6342 ):1064 DOI:10.1126/science.aal5005http://doi.org/10.1126/science.aal5005.

C.A.E. Hauser , S.G. Zhang . Chem. Soc. Rev. , 2010 . 39 (8 ):2780 DOI:10.1039/b921448hhttp://doi.org/10.1039/b921448h.

X.B. Zhao , F. Pan , H. Xu , M. Yaseen , H.H. Shan , C.A.E. Hauser , S.G. Zhang , J.R. Lu . Chem. Soc. Rev. , 2010 . 39 (9 ):3480 DOI:10.1039/b915923chttp://doi.org/10.1039/b915923c.

T.C. Holmes , S. de Lacalle , X. Su , G.S. Liu , A. Rich , S.G. Zhang . Proc. Natl. Acad. Sci. U.S.A. , 2000 . 97 (12 ):6728 DOI:10.1073/pnas.97.12.6728http://doi.org/10.1073/pnas.97.12.6728.

Y. Nagai , L.D. Unsworth , S. Koutsopoulos , S.G. Zhang . J. Control. Release , 2006 . 115 (1 ):18 DOI:10.1016/j.jconrel.2006.06.031http://doi.org/10.1016/j.jconrel.2006.06.031.

S. Koutsopoulos , L.D. Unsworth , Y. Nagai , S.G. Zhang . Proc. Natl. Acad. Sci. U.S.A. , 2009 . 106 (12 ):4623 DOI:10.1073/pnas.0807506106http://doi.org/10.1073/pnas.0807506106.

S. Koutsopoulos , S.G. Zhang . J. Control. Release , 2012 . 160 (3 ):451 DOI:10.1016/j.jconrel.2012.03.014http://doi.org/10.1016/j.jconrel.2012.03.014.

A. Altunbas , S.J. Lee , S.A. Rajasekaran , J.P. Schneider , D.J. Pochan . Biomaterials , 2011 . 32 (25 ):5906 DOI:10.1016/j.biomaterials.2011.04.069http://doi.org/10.1016/j.biomaterials.2011.04.069.

M.C. Branco , D.J. Pochan , N.J. Wagner , J.P. Schneider . Biomaterials , 2009 . 30 (7 ):1339 DOI:10.1016/j.biomaterials.2008.11.019http://doi.org/10.1016/j.biomaterials.2008.11.019.

L. Haines-Butterick , K. Rajagopal , M. Branco , D. Salick , R. Rughani , M. Pilarz , M.S. Lamm , D.J. Pochan , J.P. Schneider . Proc. Natl. Acad. Sci. U.S.A. , 2007 . 104 (19 ):7791 DOI:10.1073/pnas.0701980104http://doi.org/10.1073/pnas.0701980104.

R.V. Rughani , M.C. Branco , D. Pochan , J.P. Schneider . Macromolecules , 2010 . 43 (19 ):7924 DOI:10.1021/ma1014808http://doi.org/10.1021/ma1014808.

E.L. Bakota , Y. Wang , F.R. Danesh , J.D. Hartgerink . Biomacromolecules , 2011 . 12 (5 ):1651 DOI:10.1021/bm200035rhttp://doi.org/10.1021/bm200035r.

J.A. Fallas , L.E.R. O'Leary , J.D. Hartgerink . Chem. Soc. Rev. , 2010 . 39 (9 ):3510 DOI:10.1039/b919455jhttp://doi.org/10.1039/b919455j.

L.E.R. O'Leary , J.A. Fallas , E.L. Bakota , M.K. Kang , J.D. Hartgerink . Nat. Chem. , 2011 . 3 (10 ):821 DOI:10.1038/nchem.1123http://doi.org/10.1038/nchem.1123.

E.L. Bakota , L. Aulisa , K.M. Galler , J.D. Hartgerink . Biomacromolecules , 2011 . 12 (1 ):82 DOI:10.1021/bm1010195http://doi.org/10.1021/bm1010195.

L. Aulisa , H. Dong , J.D. Hartgerink . Biomacromolecules , 2009 . 10 (9 ):2694 DOI:10.1021/bm900634xhttp://doi.org/10.1021/bm900634x.

S. Lindsey , J.H. Piatt , P. Worthington , C. Sonmez , S. Satheye , J.P. Schneider , D.J. Pochan , S.A. Langhans . Biomacromolecules , 2015 . 16 (9 ):2672 DOI:10.1021/acs.biomac.5b00541http://doi.org/10.1021/acs.biomac.5b00541.

S.H. Medina , S. Li , O.M.Z. Howard , M. Dunlap , A. Trivett , J.P. Schneider , J.J. Oppenheim . Biomaterials , 2015 . 53 545 DOI:10.1016/j.biomaterials.2015.02.125http://doi.org/10.1016/j.biomaterials.2015.02.125.

D.J. Smith , G.A. Brat , S.H. Medina , D. Tong , Y. Huang , J. Grahammer , G.J. Furtmuller , B.C. Oh , K.J. Nagy-Smith , P. Walczak , G. Brandacher , J.P. Schneider . Nat. Nanotechnol. , 2016 . 11 (1 ):95 .

P.W. Frederix , G.G. Scott , Y.M. Abul-Haija , D. Kalafatovic , C.G. Pappas , N. Javid , N.T. Hunt , R.V. Ulijn , T. Tuttle . Nat. Chem. , 2015 . 7 (1 ):30 .

V.A. Kumar , S. Shi , B.K. Wang , I.C. Li , A.A. Jalan , B. Sarkar , N.C. Wickremasinghe , J.D. Hartgerink . J. Am. Chem. Soc. , 2015 . 137 (14 ):4823 DOI:10.1021/jacs.5b01549http://doi.org/10.1021/jacs.5b01549.

C.G. Pappas , P.W.J.M. Frederix , T. Mutasa , S. Fleming , Y.M. Abul-Haija , S.M. Kelly , A. Gachagan , D. Kalafatovic , J. Trevino , R.V. Ulijn , S. Bai . Chem. Commun. , 2015 . 51 (40 ):8465 DOI:10.1039/C5CC02049Bhttp://doi.org/10.1039/C5CC02049B.

M.P. Conte , N. Singh , I.R. Sasselli , B. Escuder , R.V. Ulijn . Chem. Commun. , 2016 . 52 (96 ):13889 DOI:10.1039/C6CC05821Chttp://doi.org/10.1039/C6CC05821C.

V.A. Kumar , N.L. Taylor , S.Y. Shi , N.C. Wickremasinghe , R.N. D'Souza , J.D. Hartgerink . Biomaterials , 2015 . 52 71 DOI:10.1016/j.biomaterials.2015.01.079http://doi.org/10.1016/j.biomaterials.2015.01.079.

M.K. Kang , J.S. Colombo , R.N. D'Souza , J.D. Hartgerink . Biomacromolecules , 2014 . 15 (6 ):2004 DOI:10.1021/bm500075rhttp://doi.org/10.1021/bm500075r.

V.A. Kumar , Q. Liu , N.C. Wickremasinghe , S.Y. Shi , T.T. Cornwright , Y.X. Deng , A. Azares , A.N. Moore , A.M. Acevedo-Jake , N.R. Agudo , S. Pan , D.G. Woodside , P. Vanderslice , J.T. Willerson , R.A. Dixon , J.D. Hartgerink . Biomaterials , 2016 . 98 113 DOI:10.1016/j.biomaterials.2016.04.032http://doi.org/10.1016/j.biomaterials.2016.04.032.

V.A. Kumar , N.L. Taylor , S.Y. Shi , B.K. Wang , A.A. Jalan , M.K. Kang , N.C. Wickremasinghe , J.D. Hartgerink . ACS Nano , 2015 . 9 (1 ):860 DOI:10.1021/nn506544bhttp://doi.org/10.1021/nn506544b.

N.C. Wickremasinghe , V.A. Kumar , S.Y. Shi , J.D. Hartgerink . ACS Biomater. Sci. Eng. , 2015 . 1 (9 ):845 DOI:10.1021/acsbiomaterials.5b00210http://doi.org/10.1021/acsbiomaterials.5b00210.

H. Cui , E.T. Pashuck , Y.S. Velichko , S.J. Weigand , A.G. Cheetham , C.J. Newcomb , S.I. Stupp . Science , 2010 . 327 (5965 ):555 DOI:10.1126/science.1182340http://doi.org/10.1126/science.1182340.

J.D. Hartgerink , E. Beniash , S.I. Stupp . Science , 2001 . 294 (5547 ):1684 DOI:10.1126/science.1063187http://doi.org/10.1126/science.1063187.

G.A. Silva , C. Czeisler , K.L. Niece , E. Beniash , D.A. Harrington , J.A. Kessler , S.I. Stupp . Science , 2004 . 303 (5662 ):1352 DOI:10.1126/science.1093783http://doi.org/10.1126/science.1093783.

E.J. Chung , Y. Cheng , R. Morshed , K. Nord , Y. Han , M.L. Wegscheid , B. Auffinger , D.A. Wainwright , M.S. Lesniak , M.V. Tirrell . Biomaterials , 2014 . 35 (4 ):1249 DOI:10.1016/j.biomaterials.2013.10.064http://doi.org/10.1016/j.biomaterials.2013.10.064.

E.J. Chung , L.B. Mlinar , M.J. Sugimoto , K. Nord , B.B. Roman , M. Tirrell . Nanomed. Nanotechnol. Biol. Med. , 2015 . 11 (2 ):479 DOI:10.1016/j.nano.2014.08.006http://doi.org/10.1016/j.nano.2014.08.006.

L.B. Mlinar , E.J. Chung , E.A. Wonder , M. Tirrell . Biomaterials , 2014 . 35 (30 ):8678 DOI:10.1016/j.biomaterials.2014.06.054http://doi.org/10.1016/j.biomaterials.2014.06.054.

A. Trent , B.D. Ulery , M.J. Black , J.C. Barrett , S. Liang , Y. Kostenko , N.A. David , M.V. Tirrell . AAPS J. , 2015 . 17 (2 ):380 DOI:10.1208/s12248-014-9707-3http://doi.org/10.1208/s12248-014-9707-3.

D.W.P.M. Lowik , J.C.M. van Hest . Chem. Soc. Rev. , 2004 . 33 (4 ):234 DOI:10.1039/B212638Ahttp://doi.org/10.1039/B212638A.

den Heuvel M. van , H. Baptist , P. Venema , E. van der Linden , D.W.P.M. Lowik , J.C.M. van Hest . Soft Matter , 2011 . 7 (20 ):9737 DOI:10.1039/c1sm05642ehttp://doi.org/10.1039/c1sm05642e.

I.W. Hamley , V. Castelletto . Bioconjug. Chem. , 2017 . 28 (3 ):731 DOI:10.1021/acs.bioconjchem.6b00284http://doi.org/10.1021/acs.bioconjchem.6b00284.

J.F. Miravet , B. Escuder , M.D. Segarra-Maset , M. Tena-Solsona , I.W. Hamley , A. Dehsorkhi , V. Castelletto . Soft Matter , 2013 . 9 (13 ):3558 DOI:10.1039/c3sm27899ahttp://doi.org/10.1039/c3sm27899a.

I.W. Hamley . Soft Matter , 2011 . 7 (9 ):4122 DOI:10.1039/c0sm01218ahttp://doi.org/10.1039/c0sm01218a.

D.A. Harrington , E.Y. Cheng , M.O. Guler , L.K. Lee , J.L. Donovan , R.C. Claussen , S.I. Stupp . J. Biomed. Mater. Res. A , 2006 . 78 .

M.J. Webber , J.A. Kessler , S.I. Stupp . J. Intern. Med. , 2010 . 267 (1 ):71 DOI:10.1111/jim.2009.267.issue-1http://doi.org/10.1111/jim.2009.267.issue-1.

J. Boekhoven , S.I. Stupp . Adv. Mater. , 2014 . 26 (11 ):1642 DOI:10.1002/adma.201304606http://doi.org/10.1002/adma.201304606.

B.F. Lin , K.A. Megley , N. Viswanathan , D.V. Krogstad , L.B. Drews , M.J. Kade , Y.C. Qian , M.V. Tirrell . J. Mater. Chem. , 2012 . 22 (37 ):19447 DOI:10.1039/c2jm31745ahttp://doi.org/10.1039/c2jm31745a.

M. Black , A. Trent , Y. Kostenko , J.S. Lee , C. Olive , M. Tirrell . Adv. Mater. , 2012 . 24 (28 ):3845 DOI:10.1002/adma.v24.28http://doi.org/10.1002/adma.v24.28.

S. Soukasene , D.J. Toft , T.J. Moyer , H.M. Lu , H.K. Lee , S.M. Standley , V.L. Cryns , S.I. Stupp . ACS Nano , 2011 . 5 (11 ):9113 DOI:10.1021/nn203343zhttp://doi.org/10.1021/nn203343z.

J.B. Matson , S.I. Stupp . Chem. Commun. , 2011 . 47 (28 ):7962 DOI:10.1039/c1cc12570bhttp://doi.org/10.1039/c1cc12570b.

A. Dehsorkhi , V. Castelletto , I.W. Hamley . J. Pept. Sci. , 2014 . 20 (7 ):453 DOI:10.1002/psc.v20.7http://doi.org/10.1002/psc.v20.7.

I.W. Hamley . Angew. Chem. Int. Ed. , 2007 . 46 (43 ):8128 DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773.

V.M. Tysseling-Mattiace , V. Sahni , K.L. Niece , D. Birch , C. Czeisler , M.G. Fehlings , S.I. Stupp , J.A. Kessler . J. Neurosci. , 2008 . 28 (14 ):3814 DOI:10.1523/JNEUROSCI.0143-08.2008http://doi.org/10.1523/JNEUROSCI.0143-08.2008.

A. Li , A. Hokugo , A. Yalom , E.J. Berns , N. Stephanopoulos , M.T. McClendon , L.A. Segovia , I. Spigelman , S.I. Stupp , R. Jarrahy . Biomaterials , 2014 . 35 (31 ):8780 DOI:10.1016/j.biomaterials.2014.06.049http://doi.org/10.1016/j.biomaterials.2014.06.049.

E.J. Berns , Z. Alvarez , J.E. Goldberger , J. Boekhoven , J.A. Kessler , H.G. Kuhn , S.I. Stupp . Acta. Biomater. , 2016 . 37 50 DOI:10.1016/j.actbio.2016.04.010http://doi.org/10.1016/j.actbio.2016.04.010.

K.A. Black , B.F. Lin , E.A. Wonder , S.S. Desai , E.J. Chung , B.D. Ulery , R.S. Katari , M.V. Tirrell . Tissue Eng. Part A , 2015 . 21 (7-8 ):1333 DOI:10.1089/ten.tea.2014.0297http://doi.org/10.1089/ten.tea.2014.0297.

G. Cinar , A. Ozdemir , S. Hamsici , G. Gunay , A. Dana , A.B. Tekinay , M.O. Guler . Biomater. Sci. , 2017 . 5 (1 ):67 DOI:10.1039/C6BM00656Fhttp://doi.org/10.1039/C6BM00656F.

Y.M. Wan , Z.N. Wang , J. Sun , Z.B. Li . Langmuir , 2016 . 32 (30 ):7512 DOI:10.1021/acs.langmuir.6b00727http://doi.org/10.1021/acs.langmuir.6b00727.

Y.M. Wan , L.B. Liu , S.S. Yuan , J. Sun , Z.B. Li . Langmuir , 2017 . 33 (13 ):3234 DOI:10.1021/acs.langmuir.6b03986http://doi.org/10.1021/acs.langmuir.6b03986.

Y. Kuang , J.F. Shi , J. Li , D. Yuan , K.A. Alberti , Q.B. Xu , B. Xu . Angew. Chem. Int. Ed. , 2014 . 53 (31 ):8104 DOI:10.1002/anie.201402216http://doi.org/10.1002/anie.201402216.

Y.M. Abul-Haija , S. Roy , P.W.J.M. Frederix , N. Javid , V. Jayawarna , R.V. Ulijn . Small , 2014 . 10 (5 ):973 DOI:10.1002/smll.201301668http://doi.org/10.1002/smll.201301668.

E.R. Draper , E.G.B. Eden , T.O. McDonald , D.J. Adams . Nat. Chem. , 2015 . 7 (10 ):849 .

R. Vegners , I. Shestakova , I. Kalvinsh , R. Ezzell , P. Janmey . J. Pept. Sci. , 1995 . 1 (6 ):371 DOI:10.1002/(ISSN)1099-1387http://doi.org/10.1002/(ISSN)1099-1387.

Y. Shi , J. Wang , H. Wang , Y. Hu , X. Chen , Z. Yang . PloS one , 2014 . 9 (9 ):106968 DOI:10.1371/journal.pone.0106968http://doi.org/10.1371/journal.pone.0106968.

Y. Kuang , X.W. Du , J. Zhou , B. Xu . Adv. Healthc. Mater. , 2014 . 3 (8 ):1217 DOI:10.1002/adhm.v3.8http://doi.org/10.1002/adhm.v3.8.

J. Li , Y. Kuang , J.F. Shi , J. Zhou , J.E. Medina , R. Zhou , D. Yuan , C.H. Yang , H.M. Wang , Z.M. Yang , J.F. Liu , D.M. Dinulescu , B. Xu . Angew. Chem. Int. Ed. , 2015 . 54 (45 ):13307 DOI:10.1002/anie.201507157http://doi.org/10.1002/anie.201507157.

J. Li , J. Shi , J.E. Medina , J. Zhou , X. Du , H. Wang , C. Yang , J. Liu , Z. Yang , D.M. Dinulescu , B. Xu . Adv. Healthc. Mater. , 2017 .

J. Zhou , X.W. Du , N. Yamagata , B. Xu . J. Am. Chem. Soc. , 2016 . 138 (11 ):3813 DOI:10.1021/jacs.5b13541http://doi.org/10.1021/jacs.5b13541.

J. Zhou , X.W. Du , Y. Gao , J.F. Shi , B. Xu . J. Am. Chem. Soc. , 2014 . 136 (8 ):2970 DOI:10.1021/ja4127399http://doi.org/10.1021/ja4127399.

V. Jayawarna , M. Ali , T.A. Jowitt , A.E. Miller , A. Saiani , J.E. Gough , R.V. Ulijn . Adv. Mater. , 2006 . 18 (5 ):611 DOI:10.1002/(ISSN)1521-4095http://doi.org/10.1002/(ISSN)1521-4095.

A. Mahler , M. Reches , M. Rechter , S. Cohen , E. Gazit . Adv. Mater. , 2006 . 18 (11 ):1365 DOI:10.1002/(ISSN)1521-4095http://doi.org/10.1002/(ISSN)1521-4095.

S. Fleming , S. Debnath , P.W.J.M. Frederix , N.T. Hunt , R.V. Ulijn . Biomacromolecules , 2014 . 15 (4 ):1171 DOI:10.1021/bm401720zhttp://doi.org/10.1021/bm401720z.

C.G. Pappas , Y.M. Abul-Haija , A. Flack , P.W.J.M. Frederix , R.V. Ulijn . Chem. Commun. , 2014 . 50 (73 ):10630 DOI:10.1039/C4CC04926Hhttp://doi.org/10.1039/C4CC04926H.

J. Raeburn , B. Alston , J. Kroeger , T.O. McDonald , J.R. Howse , P.J. Cameron , D.J. Adams . Mater. Horizons , 2014 . 1 (2 ):241 DOI:10.1039/C3MH00150Dhttp://doi.org/10.1039/C3MH00150D.

E.R. Draper , M. Wallace , R. Schweins , R.J. Poole , D.J. Adams . Langmuir , 2017 . 33 (9 ):2387 DOI:10.1021/acs.langmuir.7b00326http://doi.org/10.1021/acs.langmuir.7b00326.

A.G. Cheetham , P. Zhang , Y.A. Lin , L.L. Lock , H. Cui . J. Am. Chem. Soc. , 2013 . 135 (8 ):2907 DOI:10.1021/ja3115983http://doi.org/10.1021/ja3115983.

R. Lin , H. Cui . Curr. Opin. Chem. Eng. , 2015 . 7 75 DOI:10.1016/j.coche.2014.11.005http://doi.org/10.1016/j.coche.2014.11.005.

A.G. Cheetham , Y.C. Ou , P. Zhang , H. Cui . Chem. Commun. , 2014 . 50 (45 ):6039 DOI:10.1039/C3CC49453Ehttp://doi.org/10.1039/C3CC49453E.

Y.A. Lin , A.G. Cheetham , P. Zhang , Y.C. Ou , Y. Li , G. Liu , D. Hermida-Merino , I.W. Hamley , H. Cui . ACS Nano , 2014 . 8 (12 ):12690 DOI:10.1021/nn505688bhttp://doi.org/10.1021/nn505688b.

W. Ma , A.G. Cheetham , H. Cui . Nano Today , 2016 . 11 (1 ):13 DOI:10.1016/j.nantod.2015.11.003http://doi.org/10.1016/j.nantod.2015.11.003.

A.G. Cheetham , Y.A. Lin , R. Lin , H. Cui . Acta Pharmacol. Sin. , 2017 . 38 (6 ):874 DOI:10.1038/aps.2016.151http://doi.org/10.1038/aps.2016.151.

R. Lin , A.G. Cheetham , P. Zhang , Y.A. Lin , H. Cui . Chem. Commun. , 2013 . 49 (43 ):4968 DOI:10.1039/c3cc41896khttp://doi.org/10.1039/c3cc41896k.

A.G. Cheetham , P. Zhang , Y.A. Lin , R. Lin , H. Cui . J. Mater. Chem. B , 2014 . 2 (42 ):7316 DOI:10.1039/C4TB01084Ahttp://doi.org/10.1039/C4TB01084A.

H. Su , P. Zhang , A.G. Cheetham , J.M. Koo , R. Lin , A. Masood , P. Schiapparelli , A. Quinones-Hinojosa , H. Cui . Theranostics , 2016 . 6 (7 ):1065 DOI:10.7150/thno.15420http://doi.org/10.7150/thno.15420.

W. Ma , H. Su , A.G. Cheetham , W. Zhang , Q. Kan , H. Cui . J. Control. Release , 2017 . DOI:10.1016/j.jconrel.2017.01.015http://doi.org/10.1016/j.jconrel.2017.01.015 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Intestine Enzyme-responsive Polysaccharide-based Hydrogel to Open Epithelial Tight Junctions for Oral Delivery of Imatinib against Colon Cancer

Highly Stretchable, Compressible, Adhesive, Conductive Self-healing Composite Hydrogels with Sensor Capacity

Bioinspired Adaptive Gel Materials with Synergistic Heterostructures

The Physical Chemistry for the Self-assembly of Peptide Hydrogels

Related Author

No data

Related Institution

Department of Gynaecology and Obstetrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University

State Key Laboratory of Biobased Material and Green Papermaking, School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of Sciences)

Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University

International Research Institute for Multidisciplinary Science, Beihang University

⁰