Dual Thermal-and pH-responsive Polypeptide-based Hydrogels

Fan-dong Meng; Yun-xia Ni; Si-fan Ji; Xiao-hui Fu; Yu-han Wei; Jing Sun; Zhi-bo Li

doi:10.1007/s10118-017-1959-9

Your Location：

Home >

Browse articles >

Dual Thermal-and pH-responsive Polypeptide-based Hydrogels

Papers | Updated：2021-02-18

- Dual Thermal-and pH-responsive Polypeptide-based Hydrogels
- Chinese Journal of Polymer Science Vol. 35, Issue 10, Pages: 1243-1252(2017)
- Affiliations：
  
  School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
- Author bio：
  
  Jing Sun (孙静), E-mail:jingsun@qust.edu.cn
  Zhi-bo Li (李志波), E-mail:zbli@qust.edu.cn
- Funds：
- DOI：10.1007/s10118-017-1959-9
  CLC：
- Received：07 April 2017，
  
  Revised：2017-4-26，
  
  Accepted：26 April 2017，
  
  Published：05 October 2017
- Accepted：
Scan QR Code
Fan-dong Meng, Yun-xia Ni, Si-fan Ji, et al. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, 2017, 35(10): 1243-1252.
DOI：

Fan-dong Meng, Yun-xia Ni, Si-fan Ji, et al. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, 2017, 35(10): 1243-1252. DOI： 10.1007/s10118-017-1959-9.

摘要

Abstract

Smart hydrogels have received increasing attention for their great potential for the applications in many fields. Herein

we report a facile approach to prepare a class of dual-responsive hydrogels assembled from synthetic statistical/block thermal-responsive copoly(L-glutamate)s copolymerized with poly(ethylene glycol)

which were prepared by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of oligo(ethylene glycol) (OEG) and glutamic acid residues offers the gels with thermal- and pH-responsive properties simultaneously. We have systematically studied the influence of both temperature and pH on the gelation behaviors of these copolymers. It is found that the increase of glutamic acid content and solution pH values can significantly suppress the gelation ability of the samples. Circular dichroism (CD) results show that the

-helix conformation appears to be the dominant secondary conformation. More interestingly

the gelation property of the block copolymer with statistical thermal-responsive copoly(L-glutamate)s shows greater dependence on pH as compared to that with block segments due to the distinct morphology of the self-assemblies. The obtained hydrogels exhibit pH-dependent and thermal-responsive gelation behaviors

which enable them as an ideal smart hydrogel system for biomedical applications.

关键词

Keywords

references

J. Kopecek . Biomaterials , 2007 . 28 ( 34 ): 5185 DOI: 10.1016/j.biomaterials.2007.07.044 http://doi.org/10.1016/j.biomaterials.2007.07.044 .

Y. Li , J. Rodrigues , H. Tomas . Chem. Soc. Rev. , 2011 . 41 ( 6 ): 2193 http://europepmc.org/abstract/med/22116474 http://europepmc.org/abstract/med/22116474 , .

A.P. Nowak , V. Breedveld , L. Pakstis , B. Ozbas , D.J. Pine , D. Pochan , T.J. Deming . Nature , 2002 . 417 ( 6887 ): 424 DOI: 10.1038/417424a http://doi.org/10.1038/417424a .

E.R. Wright , R.A. Mcmillan , A. Cooper , R.P. Apkarian , V.P. Conticello . Adv. Funct. Mater. , 2002 . 12 ( 2 ): 149 DOI: 10.1002/(ISSN)1616-3028 http://doi.org/10.1002/(ISSN)1616-3028 .

L. Yu , J. Ding . Chem. Soc. Rev. , 2008 . 37 ( 8 ): 1473 DOI: 10.1039/b713009k http://doi.org/10.1039/b713009k .

T.R. Chan , P.J. Stahl , S.M. Yu . Adv. Funct. Mater. , 2011 . 21 ( 22 ): 4252 DOI: 10.1002/adfm.201101163 http://doi.org/10.1002/adfm.201101163 .

P.R. Nagarkar , A.R. Hule , J.D. Pochan , P.J. Schneider . J. Am. Chem. Soc. , 2008 . 130 ( 13 ): 4466 DOI: 10.1021/ja710295t http://doi.org/10.1021/ja710295t .

T.J. Deming . Prog. Polym. Sci. , 2007 . 32 ( 8-9 ): 858 DOI: 10.1016/j.progpolymsci.2007.05.010 http://doi.org/10.1016/j.progpolymsci.2007.05.010 .

Y. Shen , X. Fu , W. Fu , Z. Li . Chem. Soc. Rev. , 2015 . 44 612 DOI: 10.1039/C4CS00271G http://doi.org/10.1039/C4CS00271G .

A. Altunbas , D.J. Pochan . Top. Curr. Chem. , 2011 . 310 ( 5 ): 135 http://rd.springer.com/chapter/10.1007/128_2011_206 http://rd.springer.com/chapter/10.1007/128_2011_206 , .

C. Yan , D.J. Pochan . Chem. Soc. Rev. , 2010 . 39 ( 9 ): 3528 DOI: 10.1039/b919449p http://doi.org/10.1039/b919449p .

M.B. Charati , I. Lee , K.C. Hribar , J.A. Burdick . Small , 2010 . 6 ( 15 ): 1608 DOI: 10.1002/smll.v6:15 http://doi.org/10.1002/smll.v6:15 .

L.Y. Wu , L. Yu , X.H. Fu , Z.B. Li . Chinese J. Polym. Sci. , 2015 . 33 ( 8 ): 1140 DOI: 10.1007/s10118-015-1640-0 http://doi.org/10.1007/s10118-015-1640-0 .

X. Wang , D. Li , F. Yang , H. Shen , Z. Li , D. Wu . Polym. Chem. , 2013 . 4 ( 17 ): 4596 DOI: 10.1039/c3py00811h http://doi.org/10.1039/c3py00811h .

G.C. Bo , H.P. Min , S.H. Cho , K.J. Min , H.J. Oh , E.H. Kim , K. Park , K.H. Dong , B Jeong . Biomaterials , 2010 . 31 ( 35 ): 9266 DOI: 10.1016/j.biomaterials.2010.08.067 http://doi.org/10.1016/j.biomaterials.2010.08.067 .

Z. Fan , Y. Zhang , J. Ji , X. Li . RSC Adv. , 2015 . 5 ( 22 ): 16740 DOI: 10.1039/C4RA16490C http://doi.org/10.1039/C4RA16490C .

J. Huang , C.L. Hastings , G.P. Duffy , H.M. Kelly , J. Raeburn , D.J. Adams , A. Heise . Biomacromolecules , 2013 . 14 ( 1 ): 200 DOI: 10.1021/bm301629f http://doi.org/10.1021/bm301629f .

D.L. Liu , X. Chang , C.M. Dong . Chem. Commun. , 2013 . 49 ( 12 ): 1229 DOI: 10.1039/c2cc38343h http://doi.org/10.1039/c2cc38343h .

X.H. Fu , Y.N. Ma , J. Sun , Z.B. Li . Chinese J. Polym. Sci. , 2016 . 34 ( 12 ): 1436 DOI: 10.1007/s10118-016-1861-x http://doi.org/10.1007/s10118-016-1861-x .

Y. Cheng , C. He , J. Ding , C. Xiao , X. Zhuang , X. Chen . Biomaterials , 2013 . 34 ( 38 ): 10338 DOI: 10.1016/j.biomaterials.2013.09.064 http://doi.org/10.1016/j.biomaterials.2013.09.064 .

H.P. Min , K.J. Min , G.C. Bo , B. Jeong . Acc. Chem. Res. , 2012 . 45 ( 3 ): 424 DOI: 10.1021/ar200162j http://doi.org/10.1021/ar200162j .

C. Chen , Z. Wang , Z. Li . Biomacromolecules , 2011 . 12 ( 8 ): 2859 DOI: 10.1021/bm200849m http://doi.org/10.1021/bm200849m .

S. Zhang , W. Fu , Z. Li . Polym. Chem. , 2014 . 5 ( 10 ): 3346 DOI: 10.1039/C4PY00016A http://doi.org/10.1039/C4PY00016A .

C. Chen , D. Wu , W. Fu , Z. Li . Biomacromolecules , 2013 . 14 ( 8 ): 2494 DOI: 10.1021/bm4008259 http://doi.org/10.1021/bm4008259 .

H. Cui , X. Zhuang , C. He , Y. Wei , X. Chen . Acta Biomater. , 2015 . 11 ( 1 ): 183 http://www.ncbi.nlm.nih.gov/pubmed/25242655 http://www.ncbi.nlm.nih.gov/pubmed/25242655 , .

Z. Yang , Y. Zhang , P. Markland , V.C. Yang . J. Biomed. Mater. Res. , 2002 . 62 ( 1 ): 14 DOI: 10.1002/(ISSN)1097-4636 http://doi.org/10.1002/(ISSN)1097-4636 .

C. Yi , X.H. Pang , C.M. Dong . Adv. Funct. Mater. , 2010 . 20 ( 4 ): 579 DOI: 10.1002/adfm.v20:4 http://doi.org/10.1002/adfm.v20:4 .

Y. Wan , L. Liu , S. Yuan , J. Sun , Z. Li . Langmuir , 2017 . 33 ( 13 ): 3234 DOI: 10.1021/acs.langmuir.6b03986 http://doi.org/10.1021/acs.langmuir.6b03986 .

X. Fu , Y. Ma , J. Sun , Z. Li . RSC Adv. , 2016 . 6 ( 74 ): 70243 DOI: 10.1039/C6RA17427B http://doi.org/10.1039/C6RA17427B .

K.S. Krannig , J. Sun , H. Schlaad . Biomacromolecules , 2014 . 15 ( 3 ): 978 DOI: 10.1021/bm401883p http://doi.org/10.1021/bm401883p .

J. Sun , P. Černoch , A. Völkel , Y. Wei , J. Ruokolainen , H. Schlaad . Macromolecules , 2016 . 49 ( 15 ): 5494 DOI: 10.1021/acs.macromol.6b00817 http://doi.org/10.1021/acs.macromol.6b00817 .

E.Y. Kang , B. Yeon , H.J. Moon , B. Jeong . Macromolecules , 2012 . 45 ( 4 ): 2007 DOI: 10.1021/ma202809c http://doi.org/10.1021/ma202809c .

F. Meng , X. Fu , J. Sun , Z. Li . Polymer , 2017 . 118 173 DOI: 10.1016/j.polymer.2017.04.059 http://doi.org/10.1016/j.polymer.2017.04.059 .

N. Greenfield , G.D. Fasman . Biochemistry , 1969 . 8 ( 10 ): 4108 DOI: 10.1021/bi00838a031 http://doi.org/10.1021/bi00838a031 .

C.D. Vacogne , M. Schopferer , H. Schlaad . Biomacromolecules , 2016 . 17 ( 7 ): 2384 DOI: 10.1021/acs.biomac.6b00427 http://doi.org/10.1021/acs.biomac.6b00427 .

H. Kukula , H. Schlaad , M. Antonietti , S. Förster . J. Am. Chem. Soc. , 2002 . 124 ( 8 ): 1658 DOI: 10.1021/ja012091l http://doi.org/10.1021/ja012091l .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

Green Fabrication of High-strength Silk Fibroin Hydrogels via Thermal Oscillation in All-aqueous Media

Polyoxometalate-doped Chitosan Quaternary Ammonium/Polyacrylamide Interpenetrating Hydrogels with Enhanced Mechanical and Tribological Properties

Direct Ink Writing 3D Printing of Hydrogel Bioelectronics

Anti-biofouling Hydrogels: Surface Hydration, Classification, and Biomedical Applications

Related Author

Ze-chuan Yang

Yan-chun Li

Fan Li

Qing-rong Huang

Guo Zhang

Tong-fei Shi

Yu-Si Long

Mei-Yi Lu

Related Institution

Institute of Materials Science and Engineering, Jilin University

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

Department of Pediatric Respiratory Medicine, First Hospital of Jilin University

Food Science Department, Cook College Rutgers University, New Brunswick

State Key Laboratory of Integrated Optoelectronics, Key Laboratory of UV Light-Emitting Materials and Technology of Ministry of Education, School of Physics, Northeast Normal University

⁰