Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System

Ni-jia Song; Li-juan Zhou; Wen-kai Liu; Xue-ling He; Zhi-cheng Pan; Ming-ming Ding; Xin-yuan Wan; Jie-hua Li; Hong Tan; Feng Luo; Qiang Fu

doi:10.1007/s10118-017-1952-3

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Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System

Papers | Updated：2021-02-18

- Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System
- Chinese Journal of Polymer Science Vol. 35, Issue 8, Pages: 909-923(2017)
- Affiliations：
  
  a.College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
  b.Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science & Technology, Qingdao 266042, China
  c.Laboratory Animal Center of Sichuan University, Huaxi Clinical College, Sichuan University, Chengdu 610040, China
- Author bio：
  
  Jie-hua Li (李洁华), E-mail:jiehua_li@scu.edu.cn
  Hong Tan (谭鸿), E-mail:hongtan@scu.edu.cn
- Funds：
- DOI：10.1007/s10118-017-1952-3
  CLC：
- Received：12 February 2017，
  
  Revised：2017-3-13，
  
  Accepted：13 March 2017，
  
  Published：2017-08
- Accepted：
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Ni-jia Song, Li-juan Zhou, Wen-kai Liu, et al. Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System[J]. Chinese Journal of Polymer Science, 2017, 35(8): 909-923.
DOI：

Ni-jia Song, Li-juan Zhou, Wen-kai Liu, et al. Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System[J]. Chinese Journal of Polymer Science, 2017, 35(8): 909-923. DOI： 10.1007/s10118-017-1952-3.

摘要

Abstract

Polyurethane micelles (PM)-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors. However

the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood. In this contribution

the actively-targeted PM were developed using trastuzumab as a model targeting group. It was found that PM were mainly taken up by SKOV-3 tumor cells

via

a micropinocytosis process

while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells

leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both

in vitro

and

in vivo

. This study is advantageous to the understanding of the action mechanism of trastuzumab

and significant for the construction of improved formulations for targeted delivery and precise therapy.

关键词

Keywords

references

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