Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-<italic style="font-style: italic">g</italic>-Poly(D, L-lactide)

Le-yuan Song; Ni Jiang; Zhi-hua Gan

doi:10.1007/s10118-017-1940-7

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Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)

Papers | Updated：2021-02-18

- Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)
- Chinese Journal of Polymer Science Vol. 35, Issue 7, Pages: 837-845(2017)
- Affiliations：
  
  State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  Ni Jiang (蒋妮), E-mail: jiangni@mail.buct.edu.cn
  Zhi-hua Gan (甘志华), E-mail: zhgan@mail.buct.edu.cn
- Funds：
- DOI：10.1007/s10118-017-1940-7
  CLC：
- Received：17 November 2016，
  
  Revised：2016-12-5，
  
  Accepted：06 December 2016，
  
  Published：05 July 2017
- Accepted：
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Le-yuan Song, Ni Jiang, Zhi-hua Gan. Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)[J]. Chinese Journal of Polymer Science, 2017, 35(7): 837-845. DOI: 10.1007/s10118-017-1940-7.
DOI：

Le-yuan Song, Ni Jiang, Zhi-hua Gan. Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)[J]. Chinese Journal of Polymer Science, 2017, 35(7): 837-845. DOI: 10.1007/s10118-017-1940-7. DOI：

摘要

Abstract

Porous hybrid microspheres were fabricated by the synthesized calcium gluconate-

-poly(D

L-lactide) (CG-

-PDLLA) composites. These hybrid microspheres were treated with an alkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the surface. The microspheres were then incubated in a supersaturated simulated body fluid (1.5 SBF) solution for different time to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology

a similar crystal structure and chemical structure to natural hydroxyapatite

and a medium Ca/P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicate that the nucleation and growth of apatite on the surface are influenced by the induced carboxylate groups and the remained CG. The hybrid CG-

-PDLLA microspheres have the potential as a novel alternative in bone tissue engineering.

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Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)

DOI：10.1007/s10118-017-1940-7

摘要

Abstract

关键词

Keywords

references