Poly(<italic style="font-style: italic">β</italic>-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

Xiang-ru Feng; Jian-xun Ding; Ruxandra Gref; Xue-si Chen

doi:10.1007/s10118-017-1932-7

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Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

Rapid Communications | Updated：2021-02-18

- Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery
- Chinese Journal of Polymer Science Vol. 35, Issue 6, Pages: 693-699(2017)
- Affiliations：
  
  a.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  b.Institute of Molecular Sciences, CNRS, Université Paris-Sud, Université Paris Saclay, Orsay 91400, France
- Author bio：
  
  Jian-xun Ding (丁建勋), E-mail: jxding@caic.ac.cn
  Ruxandra Gref, E-mail: ruxandra.gref@u-psud.fr
- Funds：
- DOI：10.1007/s10118-017-1932-7
  CLC：
- Received：27 December 2016，
  
  Revised：2017-1-20，
  
  Accepted：23 January 2017，
  
  Published：05 June 2017
- Accepted：
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Xiang-ru Feng, Jian-xun Ding, Ruxandra Gref, et al. Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(6): 693-699. DOI: 10.1007/s10118-017-1932-7.
DOI：

Xiang-ru Feng, Jian-xun Ding, Ruxandra Gref, et al. Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(6): 693-699. DOI: 10.1007/s10118-017-1932-7. DOI：

摘要

Abstract

A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared

via

the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-

-PLLA/PDLA-CHOL) and poly(

-cyclodextrin) (PCD) with the molar ratios of CHOL/

-CD at 1:0.5

1:1

and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/

-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release

cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.

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⁰

Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

DOI：10.1007/s10118-017-1932-7

摘要

Abstract

关键词

Keywords

references