Temperature and pH Dually-responsive Poly (<italic style="font-style: italic">β</italic>-amino ester) Nanoparticles for Drug Delivery

Xiao-ju Lu; Xiang-yu Yang; Yuan Meng; Shao-zhen Li

doi:10.1007/s10118-017-1916-7

Your Location：

Home >

Browse articles >

Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery

Papers | Updated：2021-02-18

- Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery
- Chinese Journal of Polymer Science Vol. 35, Issue 4, Pages: 534-546(2017)
- Affiliations：
  
  School of Chemical and Material Engineering and Institute of Quantum Materials, Hubei Polytechnic University, Huangshi 435003, China
- Author bio：
  
  Xiao-ju Lu (卢小菊), E-mail:xiaoju_lu@163.com
- Funds：
- DOI：10.1007/s10118-017-1916-7
  CLC：
- Received：11 August 2016，
  
  Revised：2016-10-21，
  
  Accepted：22 October 2016，
  
  Published：2017-04
- Accepted：
Scan QR Code
Xiao-ju Lu, Xiang-yu Yang, Yuan Meng, et al. Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(4): 534-546. DOI: 10.1007/s10118-017-1916-7.
DOI：

Xiao-ju Lu, Xiang-yu Yang, Yuan Meng, et al. Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(4): 534-546. DOI: 10.1007/s10118-017-1916-7. DOI：

摘要

Abstract

Stimuli-responsive polymers have undoubtedly been of great interest in the past decades due to a variety of their potential applications in biomedical territory. However

their non-degradability limits their

in vivo

applications. Herein

we report a novel pH and temperature dual-stimuli responsive-poly (

-amino ester). The pH/temperature sensitivities are interrelated and can be easily tuned by changing PEG-diacrylate chain length and the percentage of biamines in the feed ratio. These dual-responsive polymers are very useful in drug delivery. Reaction of methyl ether poly (ethylene glycol) (MPEG) and poly (

-amino ester) resulted in an amphiphilic MPEG-PBAE block copolymer which could form nanoparticles by self-assembly. A hydrophobic drug (DOX) was loaded in the self-assembled nanoparticles at low temperature without using organic solvents. The loaded drug was released very slowly and steadily at 37℃ under physiological conditions (pH 7.4)

but rapidly released from the micelles in weakly acidic environments (pH 6.4 and 5.0) for intracellular drug release. Thus

these poly (

-amino ester) polymers constitute ideal drug carriers since their thermal sensitivity allows the drug loadings without using organic solvent and their pH sensitivity permits fast intracellular drug release.

关键词

Keywords

references

D. Schmaljohann . . Adv. Drug Deliv. Rev. , 2006 . 58 1655 DOI: 10.1016/j.addr.2006.09.020 http://doi.org/10.1016/j.addr.2006.09.020 .

J. Kost , R. Langer . . Adv. Drug Deliv. Rev. , 2012 . 64 327 DOI: 10.1016/j.addr.2012.09.014 http://doi.org/10.1016/j.addr.2012.09.014 .

M.T. Calejo , A.M. Cardoso , A.L. Kjøniksen , K.Z. Zhu , C.M. Morais , S.A. Sande , A.L. Cardoso , M.C. Lima , A. Jurado , B. Nyström . . Int. J. Pharm. , 2013 . 448 105 DOI: 10.1016/j.ijpharm.2013.03.028 http://doi.org/10.1016/j.ijpharm.2013.03.028 .

H.Y. Tian , Z.P. Guo , L. Lin , Z.X. Jiao , J. Chen , S.Q. Gao , X.J. Zhu , X.S. Chen . . J. Control. Release , 2014 . 174 117 DOI: 10.1016/j.jconrel.2013.11.008 http://doi.org/10.1016/j.jconrel.2013.11.008 .

E.S. Gil , S.M. Hudson . . Prog. Polym. Sci. , 2004 . http://www.sciencedirect.com/science/article/pii/S0079670004000826 http://www.sciencedirect.com/science/article/pii/S0079670004000826 , .

Y. Zhang , W. Yang , C. Wang , W. Wu , S. Fu . . J. Nanosci. Nanotechnol. , 2006 . 6 2896 DOI: 10.1166/jnn.2006.437 http://doi.org/10.1166/jnn.2006.437 .

M. Nakayama , N. Yamada , Y. Kumashiro , H. Kanazawa , M. Yamato , T. Okano . . Macromol. Biosci. , 2012 . 12 751 DOI: 10.1002/mabi.v12.6 http://doi.org/10.1002/mabi.v12.6 .

Y. Bai , J. Wei , L.P. Yang , C.B. He , X.H. Lu . . Colloid Polym. Sci. , 2012 . 290 507 DOI: 10.1007/s00396-011-2562-1 http://doi.org/10.1007/s00396-011-2562-1 .

C. Kojima , K. Yoshimura , A. Harada , Y. Sakanishi , K. Kono . . Polym. Chem. , 2010 . 48 4047 DOI: 10.1002/pola.24190 http://doi.org/10.1002/pola.24190 .

Y.L. Cheng , C.L. He , C.S. Xiao , J.X. Ding , X.L. Zhuang , X.S. Chen . . Polym. Chem. , 2011 . 2 2627 DOI: 10.1039/c1py00281c http://doi.org/10.1039/c1py00281c .

S.S. Halacheva , T.J. Freemont , B.R. Saunders . . J. Mater. Chem. , 2013 . 1 4065 DOI: 10.1039/c3tb20758g http://doi.org/10.1039/c3tb20758g .

Y.L. Luo , X.L. Yang , F. Xu , Y.S. Chen , X. Zhao . . Colloid Polym. Sci. , 2014 . 292 1061 DOI: 10.1007/s00396-013-3149-9 http://doi.org/10.1007/s00396-013-3149-9 .

X.Y. Jiang , G.L. Lu , C. Feng , Y.J. Li , X.Y. Huang . . Polym. Chem. , 2013 . 4 3876 DOI: 10.1039/c3py00415e http://doi.org/10.1039/c3py00415e .

Y. Bai , Z. Zhang , A. Zhang , L. Chen , C. He , X. Zhuang . . Carbohydr. Polym. , 2012 . 89 1207 DOI: 10.1016/j.carbpol.2012.03.095 http://doi.org/10.1016/j.carbpol.2012.03.095 .

G. Fundueanu , M. Constantin , C. Stanciu , G. Theodoridis , P. Ascenzi . . J. Mater. Sci. Mater. Med. , 2009 . 20 2465 DOI: 10.1007/s10856-009-3807-0 http://doi.org/10.1007/s10856-009-3807-0 .

S.Z. Luo , M.C. Han , Y.H. Cao , C.X. Ling , Y.Y. Zhang . . Colloid Polym. Sci. , 2011 . 289 1243 DOI: 10.1007/s00396-011-2448-2 http://doi.org/10.1007/s00396-011-2448-2 .

V. Singh , P. Khullar , P.N. Dave , A. Kaura , M.S. Bakshi , G. Kaur . . Phys. Chem. Chem. Phys. , 2014 . 16 4728 DOI: 10.1039/c3cp55079f http://doi.org/10.1039/c3cp55079f .

R. Cheng , F. Meng , C. Deng , H.A. Klok , Z. Zhong . . Biomaterials , 2013 . 34 3647 DOI: 10.1016/j.biomaterials.2013.01.084 http://doi.org/10.1016/j.biomaterials.2013.01.084 .

D.M. Lynn , R. Langer . . J. Am. Chem. Soc. , 2000 . 122 10761 DOI: 10.1021/ja0015388 http://doi.org/10.1021/ja0015388 .

T.H. Cong , K.N. Minh , P.H. Dai , S.L. Doo . . Colloid Polym. Sci. , 2011 . 289 301 DOI: 10.1007/s00396-010-2349-9 http://doi.org/10.1007/s00396-010-2349-9 .

P.H. Dai , S.L. Doo , K. Park , Y.S. Kim , M.S. Kim , J.K. Han , K. Kim , R.W. Park , I.S. Kim , H.K. Song , D.S. Lee , I.C. Kwon . . J. Control. Release , 2007 . 23 109 .

S.A. Meenach , C.G. Out , K.W. Anderson , J.Z. Hilt . . Int. J. Pharm. , 2012 . 10 177 http://www.sciencedirect.com/science/article/pii/S0378517312001068 http://www.sciencedirect.com/science/article/pii/S0378517312001068 , .

A.A. Eltoukhy , D.J. Siegwart , C.A. Alabib , J.S. Rajan , R. Langera , D.G. Anderson . . Biomaterials , 2012 . 33 3594 DOI: 10.1016/j.biomaterials.2012.01.046 http://doi.org/10.1016/j.biomaterials.2012.01.046 .

J.Z. Deng , Y.X. Sun , H.Y. Wang , C. Li , F.W. Huang , S.X. Cheng , R.X. Zhuo , X.Z. Zhang . . Acta Biomater. , 2011 . 7 2200 DOI: 10.1016/j.actbio.2011.02.003 http://doi.org/10.1016/j.actbio.2011.02.003 .

H.B. Wang , F.M. Xu , Y. Wang , X.S. Liu , Q. Jin , J. Ji . . Polym. Chem. , 2013 . 4 3012 DOI: 10.1039/c3py00139c http://doi.org/10.1039/c3py00139c .

W.T. Song , Z.H. Tang , M.Q. Li , S.X. Lv , H.Y. Yu , L.L. Ma , X.L. Zhuang , Y.B. Huang , X.S. Chen . . Macromol. Biosci. , 2012 . 12 1375 DOI: 10.1002/mabi.v12.10 http://doi.org/10.1002/mabi.v12.10 .

P.D. Fisher , P. Palomino , T.A. Milbrandt , J.Z. Hilt , D.A. Puleo . . J. Biomater. Sci. Polym. Ed. , 2014 . 25 1174 DOI: 10.1080/09205063.2014.923368 http://doi.org/10.1080/09205063.2014.923368 .

S. Tang , Q. Yin , Z. Zhang , W. Gu , L. Chen , H. Yu , Y. Huang , X. Chen , M. Xu , Y. Li . . Biomaterials , 2014 . 35 6047 DOI: 10.1016/j.biomaterials.2014.04.025 http://doi.org/10.1016/j.biomaterials.2014.04.025 .

J. Kim , J.C. Sunshine , J.J. Green . . Bioconjug. Chem. , 2014 . 25 ( 1 ): 43 DOI: 10.1021/bc4002322 http://doi.org/10.1021/bc4002322 .

M. Keeney , S.G. Ong , A. Padilla , Z. Yao , S. Goodman , J.C. Wu , F. Yang . . ACS Nano , 2013 . 7 ( 8 ): 7241 DOI: 10.1021/nn402657d http://doi.org/10.1021/nn402657d .

C.T. Huynh , M.K. Nguyen , J.H. Kim , S.W. Kang , B.S. Kim , D.S. Lee . . Soft Matter , 2011 . 7 4974 DOI: 10.1039/c1sm05080j http://doi.org/10.1039/c1sm05080j .

C.T. Huynh , M.K. Nguyen , D.S. Lee . . Acta Biomater. , 2011 . 7 3123 DOI: 10.1016/j.actbio.2011.05.004 http://doi.org/10.1016/j.actbio.2011.05.004 .

N. Wang , A. Dong , M. Radosz , Y. Shen . . J. Biomed. Mater. Res. A , 2007 . 84 https://www.ncbi.nlm.nih.gov/pubmed/17600338 https://www.ncbi.nlm.nih.gov/pubmed/17600338 , .

N. Wang , A. Dong , E.A. van Kirk , H. Tang , W. Murdoch , M. Radosz , Y. Shen . . Macromol. Biosci. , 2007 . 7 1187 DOI: 10.1002/(ISSN)1616-5195 http://doi.org/10.1002/(ISSN)1616-5195 .

W. Chen , P. Zhong , F. Meng , R. Cheng , C. Deng , J. Feijen , Z. Zhong . . J. Control. Release , 2013 . 169 ( 3 ): 171 DOI: 10.1016/j.jconrel.2013.01.001 http://doi.org/10.1016/j.jconrel.2013.01.001 .

M.S. Kim , G.H. Gao , S.W. Kang , D.S. Lee . . Macromol. Biosci. , 2011 . 11 ( 7 ): 946 DOI: 10.1002/mabi.v11.7 http://doi.org/10.1002/mabi.v11.7 .

K.H. Min , J.H. Kim , S.M. Bae , H. Shin , M.S. Kim , S. Park , H. Lee , R.W. Park , I.S. Kim , K. Kim , I.C. Kwon , S.Y. Jeong , D.S. Lee . . J. Control. Release , 2010 . 144 ( 2 ): 259 DOI: 10.1016/j.jconrel.2010.02.024 http://doi.org/10.1016/j.jconrel.2010.02.024 .

X.L. Wu , J.H. Kim , H. Koo , S.M. Bae , H. Shin , M.S. Kim , B.H. Lee , R.W. Park , I.S. Kim , K. Choi , I.C. Kwon , K. Kim , D.S. Lee . . Bioconjug. Chem. , 2010 . 21 ( 2 ): 208 DOI: 10.1021/bc9005283 http://doi.org/10.1021/bc9005283 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Mesoscopic Simulation on Self-assembly of Diphenylalanine-based Analogue with Ethylenediamine Linker

Temperature-sensitive Micelles as Artificial Chaperones for Insulin Protection

Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

Sequence-encoded Conformation Pathways in Viscoelastic Microphase Separation of Multiblock Copolymers

2026-9 Contents

Related Author

Xin-Yi Zhao

Si-Qi Sun

Ning Zhou

Xiao-Jun Xu

Yan Wang

Ting-Ting Sun

Jia-Wen Chen

Yan Xiao

Related Institution

Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology

Department of Physics, Zhejiang University of Science and Technology

Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology

Qingdao Research Academy of Environmental Science

Key Laboratory of Rubber-plastics, Ministry of Education, School of Polymer Science and Engineering, Qingdao University of Science and Technology

⁰

Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery

DOI：10.1007/s10118-017-1916-7

摘要

Abstract

关键词

Keywords

references