Thermal and Redox Dual Responsive Poly (L-glutamate) with Oligo (ethylene glycol) Side-chains

Xiao-hui Fu; Yi-nan Ma; Jing Sun; Zhi-bo Li

doi:10.1007/s10118-016-1861-x

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Thermal and Redox Dual Responsive Poly (L-glutamate) with Oligo (ethylene glycol) Side-chains

Papers | Updated：2021-05-12

- Thermal and Redox Dual Responsive Poly (L-glutamate) with Oligo (ethylene glycol) Side-chains
- Chinese Journal of Polymer Science Vol. 34, Issue 12, Pages: 1436-1447(2016)
- Affiliations：
  
  a.School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
  b.Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
- Author bio：
  
  Jing Sun (孙静), E-mail:jingsun@qust.edu.cn
  Zhi-bo Li (李志波), E-mail:zbli@qust.edu.cn
- Funds：
- DOI：10.1007/s10118-016-1861-x
  CLC：
- Received：30 August 2016，
  
  Revised：2016-9-15，
  
  Accepted：15 September 2016，
  
  Published：2016-12
- Accepted：
Scan QR Code
Xiao-hui Fu, Yi-nan Ma, Jing Sun, et al. Thermal and Redox Dual Responsive Poly (L-glutamate) with Oligo (ethylene glycol) Side-chains[J]. Chinese Journal of Polymer Science, 2016, 34(12): 1436-1447.
DOI：

Xiao-hui Fu, Yi-nan Ma, Jing Sun, et al. Thermal and Redox Dual Responsive Poly (L-glutamate) with Oligo (ethylene glycol) Side-chains[J]. Chinese Journal of Polymer Science, 2016, 34(12): 1436-1447. DOI： 10.1007/s10118-016-1861-x.

摘要

Abstract

A series of poly (L-glutamate) s grafted with oligo (ethylene glycol) (OEG) side-chains through the thioether linkages (PALG

-EG

3 and 4) were prepared by ring-opening polymerization (ROP) of

-allyl-L-glutamate

-carboxyanhydride (ALG-NCA) and thiol-ene photoaddition. The chemical structures and physical properties were characterized by

H-NMR

Fourier transform infrared (FTIR)

circular dichroism (CD)

etc

. The PALG

-EG

samples with

=3 and 4 displayed lower critical solution temperature (LCST) in water due to the presence of OEG units. The clouding point (CP) of polypeptides can be finely tuned by changing the side chain structures

molecular weights and sample concentrations. In addition

the thioether linkages in the side chains offer additional redox-responsive properties. The influence of both OEG units and thioether linkages on the LCST behavior was systematically investigated. This work provides an efficient way to prepare multi-stimuli responsive materials with highly tunable properties.

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references

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