Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers

Qi Rui-ling; Tian Xue-jiao; Guo Rui; Luo Yu; Shen Ming-wu; Yu Jian-yong; Shi Xiang-yang

doi:10.1007/s10118-016-1827-z

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Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers

PAPERS | Updated：2021-05-12

- Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers
- Chinese Journal of Polymer Science Vol. 34, Issue 9, Pages: 1047-1059(2016)
- Affiliations：
  
  a. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China
  b. Department of Textile Engineering, Henan Institute of Engineering, Zhengzhou 450007, China
  c. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
- Author bio：
  
  Rui Guo(郭睿),E-mail:ruiguo@dhu.edu.cn
  Xiang-yang Shi(史向阳),E-mail:xshi@dhu.edu.cn
- Funds：
- DOI：10.1007/s10118-016-1827-z
  CLC：
- Received：27 February 2016，
  
  Revised：2016-5-10，
  
  Accepted：10 May 2016，
  
  Published：05 October 2016
- Accepted：
Scan QR Code
Qi Rui-ling, Tian Xue-jiao, Guo Rui, et al. Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers[J]. Chinese Journal of Polymer Science, 2016, 34(9): 1047-1059.
DOI：

Qi Rui-ling, Tian Xue-jiao, Guo Rui, et al. Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers[J]. Chinese Journal of Polymer Science, 2016, 34(9): 1047-1059. DOI： 10.1007/s10118-016-1827-z.

摘要

Abstract

In this study

multiwalled carbon nanotubes (MWCNTs) were used to encapsulate a model anticancer drug

doxorubicin (Dox). Then

the drug-loaded MWCNTs (Dox/MWCNTs) with an optimized drug encapsulation percentage were mixed with poly(lactide-

-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The structure

morphology

and mechanical properties of the formed electrospun Dox/PLGA

MWCNTs/PLGA

and Dox/MWCNTs/PLGA composite nanofibrous mats were characterized using scanning electron microscopy (SEM)

Fourier transform infrared spectroscopy

and tensile testing.

In vitro

viability assay and SEM morphology observation of mouse fibroblast cells cultured onto the MWCNTs/PLGA fibrous scaffolds demonstrate that the developed MWCNTs/PLGA composite nanofibers are cytocompatible. The incorporation of Dox-loaded MWCNTs within the PLGA nanofibers is able to improve the mechanical durability and maintain the three-dimensional structure of the nanofibrous mats. More importantly

our results indicate that this double-container drug delivery system (both PLGA polymer and MWCNTs are drug carriers) is beneficial to avoid the burst release of the drug and able to release the antitumor drug Dox in a sustained manner for 42 days. The developed composite electrospun nanofibrous drug delivery system may be used as therapeutic scaffold materials for post-operative local chemotherapy.

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