Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications

Fan Zhang-yu; Zhao Yi-li; Zhu Xiao-yue; Luo Yu; Shen Ming-wu; Shi Xiang-yang

doi:10.1007/s10118-016-1792-6

Your Location：

Home >

Browse articles >

Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications

Papers | Updated：2022-02-21

- Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications
- Vol. 34, Issue 6, Pages: 755-765(2016)
- Affiliations：
  
  a.College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
  b.Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China
- Author bio：
  
  Xiao-yue Zhu (朱晓玥), E-mail: zhu@dhu.edu.cn
  Xiang-yang Shi (史向阳), E-mail: xshi@dhu.edu.cn
- Funds：
  
  the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and the Key Laboratory of Textile Science & Technology, Ministry of Education, “111 Project”;M. Shen and Z. Zhu thank the Fundamental Research Funds for the Central Universities. Y. Zhao thanks the Chinese Universities Scientific Fund;X. Zhu gratefully acknowledges the support from Shanghai Pujiang Program;the National Natural Science Foundation of China;the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University
- DOI：10.1007/s10118-016-1792-6
  CLC：
- Received：22 December 2015，
  
  Revised：2016-1-24，
  
  Published：2016-06
- Accepted：
Scan QR Code
Fan Zhang-yu, Zhao Yi-li, Zhu Xiao-yue, et al. Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications[J]. 2016, 34(6): 755-765.
DOI：

Fan Zhang-yu, Zhao Yi-li, Zhu Xiao-yue, et al. Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications[J]. 2016, 34(6): 755-765. DOI： 10.1007/s10118-016-1792-6.

摘要

Abstract

Capture and detection of metastatic cancer cells are crucial for diagnosis and treatment of malignant neoplasm. Here

we report the use of folic acid (FA) modified electrospun poly(vinyl alcohol) (PVA)/polyethyleneimine (PEI) nanofibers for cancer cell capture applications. Electrospun PVA/PEI nanofibers crosslinked by glutaraldehyde vapor were modified with FA

via

a poly(ethylene glycol) (PEG) spacer

followed by acetylation of the fiber surface PEI amines. The formed FA-modified nanofibers were well characterized. The morphology of the electrospun PVA/PEI nanofibers is smooth and uniform despite the surface modification. In addition

the FA-modified nanofibers display good hemocompatibility as confirmed by hemolysis assay. Importantly

the developed FA-modified nanofibers are able to specifically capture cancer cells overexpressing FA receptors

which were validated by quantitative cell counting assay and qualitative confocal microscopy analysis. The developed FA-modified PVA/PEI nanofibers may be used for capturing circulating tumor cells for cancer diagnosis applications.

关键词

Keywords

references

T.R. Ashworth, . Med. J. Aust. , 1869 . 14 ( 3 ): 146 .

P.S. Steeg, . Nat. Med. , 2006 . 12 ( 8 ): 895 .

S. Riethdorf, , H. Fritsche, , V. Mueller, , T. Rau, , C. Schindibeck, , B. Rack, , W. Janni, , C. Coith, , K. Beck, , F. Jaenicke, , S. Jackson, , T. Gornet, , M Cristofanilli, , K. Pantel, . Clin. Cancer Res. , 2007 . 13 ( 3 ): 920 .

V. Marx, . Nature , 2013 . 494 ( 7435 ): 133 .

B.P Paterlini, , N.L. Benali, . Cancer Lett. , 2007 . 253 ( 2 ): 180 .

M. Hosokawa, , T. Hayata, , Y. Fukuda, , A. Arakaki, , T. Yoshino, , T Tanaka, , T. Matsunaga, . Anal. Chem. , 2010 . 82 ( 15 ): 6629 .

G. Vona, , A. Sabile, , M. Louha, , V. Sitruk, , S. Romana, , K. Schütze, , F. Capron, , D. Franco, , M Pazzagli, , M. Vekemans, . Am. J. Pathol. , 2000 . 156 ( 1 ): 57 .

I. Desitter, , B.S. Guerrouahen, , N. Benali-Furet, , J. Wechsler, , P.A. Jaenne, , Y.N. Kuang, , M. Yanagita, , L.L. Wang, , J.A Berkowitz, , R.J. Distel, . Anticancer Res. , 2011 . 31 ( 2 ): 427 .

S.Y. Zheng, , H. Lin, , J.Q. Liu, , M. Balic, , R. Datar, , R.J Cote, , Y.C. Tai, . J. Chromatogr. A , 2007 . 1162 ( 2 ): 154 .

R. Rosenberg, , R. Gertler, , J. Friederichs, , K. Fuehrer, , M. Dahm, , R. Phelps, , S. Thorban, , H Nekarda, , J.R. Siewert, . Cytometry , 2002 . 49 ( 4 ): 150 .

T. Fehm, , E.F. Solomayer, , S. Meng, , T. Tucker, , N. Lane, , J Wang, , G. Gebauer, . Cytotherapy , 2005 . 7 ( 2 ): 171 .

H.Y. Xu, , Z.P. Aguilar, , L. Yang, , M. Kuang, , H.W. Duan, , Y.H. Xiong, , H Wei, , A. Wang, . Biomaterials , 2011 . 32 ( 36 ): 9758 .

E.Q. Song, , J. Hu, , C.Y. Wen, , Z.Q. Tian, , X. Yu, , Z.L. Zhang, , Y.B Shi, , D.W. Pang, . ACS Nano , 2011 . 5 ( 2 ): 761 .

X.G. Hu, , C.W. Wei, , J.J. Xia, , I. Pelivanov, , M O'Donnell, , X.H. Gao, . Small , 2013 . 9 ( 12 ): 2046 .

S.M. Jo, , J.J. Lee, , W Heu, , H.S. Kim, . Small , 2015 . 11 ( 16 ): 1975 .

J.R. Xiao, , W.Q. He, , Z.T. Zhang, , W.Y. Zhang, , Y.P. Cao, , R.X He, , Y. Chen, . RSC Adv. , 2015 . 5 ( 64 ): 52161 .

S. Nagrath, , L.V. Sequist, , S. Maheswaran, , D.W. Bell, , D. Irimia, , L. Ulkus, , M.R. Smith, , E.L. Kwak, , S Digumarthy, , A. Muzikansky, . Nature , 2007 . 450 ( 7173 ): 1235 .

N.G. Zhang, , Y.L. Deng, , Q.D. Tai, , B. Cheng, , L.B. Zhao, , Q.L. Shen, , R.X. He, , L.Y. Hong, , W. Liu, , S.S. Guo, , K. Liu, , H.R. Tseng, , B Xiong, , X.Z. Zhao, . Adv. Mater. , 2012 . 24 ( 20 ): 2756 .

S. Hou, , L.B. Zhao, , Q.L. Shen, , J.H. Yu, , C. Ng, , X.J. Kong, , D.X. Wu, , M. Song, , X.H. Shi, , X.C. Xu, , W.H. OuYang, , R.X. He, , X.Z. Zhao, , T. Lee, , F.C. Brunicardi, , M.A. Garcia, , A. Ribas, , R.S Lo, , H.R. Tseng, , Chem. Angew. . Int. Ed. , 2013 . 52 ( 12 ): 3379 .

A Greiner, , J.H. Wendorff, , Chem. Angew. . Int. Ed. , 2007 . 46 ( 30 ): 5670 .

Z.M. Huang, , Y.Z. Zhang, , M Kotaki, , S. Ramakrishna, . Compos. Sci. Technol. , 2003 . 63 ( 15 ): 2223 .

D.H Reneker, , I. Chun, . Nanotechnology , 1996 . 7 ( 3 ): 216 .

B. Kim, , H. Park, , S.H Lee, , W.M. Sigmund, . Mater. Lett. , 2005 . 59 ( 7 ): 829 .

M.M. Demir, , I. Yilgor, , E Yilgor, , B. Erman, . Polymer , 2002 . 43 ( 11 ): 3303 .

D.H Reneker, , A.L. Yarin, . Polymer , 2008 . 49 ( 10 ): 2387 .

K. Yoon, , B.S Hsiao, , B. Chu, . J. Mater. Chem. , 2008 . 18 ( 44 ): 5326 .

M. Bazhban, , M Nouri, , J. Mokhtari, . Chinese J. Polym. Sci. , 2013 . 31 ( 10 ): 1343 .

M.Y. Li, , P. Bidez, , E. Guterman-Tretter, , Y. Guo, , A.G. MacDiarmid, , P.I. Lelkes, , X.B. Yuan, , X.Y. Yuan, , J Sheng, , H. Li, . Chinese J. Polym. Sci. , 2007 . 25 ( 4 ): 331 .

T.Y Song, , C. Yao, . Chinese J. Polym. Sci. , 2010 . 28 ( 2 ): 171 .

Z.B. Zha, , C. Cohn, , Z.F. Dai, , W.G. Qiu, , J.H Zhang, , X.Y. Wu, . Adv. Mater. , 2011 . 23 ( 30 ): 3435 .

Y.Y. Wang, , L.X. Lü, , Z.Q. Feng, , Z.D Xiao, , N.P. Huang, . Biomed. Mater. , 2010 . 5 ( 5 ): 054112 .

K. Ma, , C.K. Chan, , S.S. Liao, , W.Y. Hwang, , Q Feng, , S. Ramakrishna, . Biomaterials , 2008 . 29 ( 13 ): 2096 .

Y. Hu, , L. Gan, , Q.X. Li, , H. Tao, , A.Y Zhang, , Z.G. Feng, . Chinese J. Polym. Sci. , 2014 . 32 ( 12 ): 1714 .

Y.L. Zhao, , X.Y. Zhu, , H. Liu, , Y. Luo, , S.G. Wang, , M.W. Shen, , M.F Zhu, , X.Y. Shi, . J. Mater. Chem. B , 2014 . 2 ( 42 ): 7384 .

X. Fang, , H. Ma, , S.L. Xiao, , M.W. Shen, , R. Guo, , X.Y Cao, , X.Y. Shi, . J. Mater. Chem. , 2011 . 21 ( 12 ): 4493 .

Y. Zhang, , J.M Liu, , X.P. Yan, . Anal. Chem. , 2012 . 85 ( 1 ): 228 .

S Patnaik, , K.C. Gupta, . Expert Opin. Drug Delivery , 2013 . 10 ( 2 ): 215 .

K. Park, , M.Y. Lee, , K.S Kim, , S.K. Hahn, . Biomaterials , 2010 . 31 ( 19 ): 5258 .

Y.L. Zhao, , Z.Y. Fan, , M.W Shen, , X.Y. Shi, . Adv. Mater. Interfaces , 2015 . 2 1500256 .

Y.L. Zhao, , Z.Y. Fan, , M.W Shen, , X.Y. Shi, . RSC Adv. , 2015 . 5 ( 86 ): 70439 .

J.C. Li, , L.F. Zheng, , H.D. Cai, , W.J. Sun, , M.W. Shen, , G.X Zhang, , X.Y. Shi, . Biomaterials , 2013 . 34 ( 33 ): 8382 .

X.H. Feng, , S.K. Zhang, , H Wu, , X. Lou, . Colloids Surf., B , 2015 . 125 197 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Biodegradable Alginate-based Fibers with High Mechanical Performance and Aqueous Stability via Stretch-mediated Network Engineering

Stable Integration of Hydrophobic Silica Aerogels into Rubber Latex via Poly(vinyl alcohol)-assisted Aqueous Processing for Thermal Insulating Composites

Sustainable Flame-retardant and Tough Poly(vinyl alcohol) Films with Phytic Acid and Biochar: A Simple and Effective Approach

Improvements of Hydrophobicity and Toughness of Epoxy Coatings Modified with Hydroxyl-terminated Fluororubber

Manipulating Hierarchical Aggregation Structure via Film-forming Kinetics Enables Organic Photovoltaics over 20% Efficiency

Related Author

Han-Xu Zhou

Ling-Chun Liu

De-Shuai Kong

Hua Yuan

Cong Du

Yan-Chun Han

Fang-Shuo Li

Jian-Chao Zhang

Related Institution

Shandong Key Laboratory of Renewable Membrane Materials, College of Materials Science and Engineering, Qingdao University

Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science & Technology

Key Laboratory of Impact and Safety Engineering, Ministry of Education, Ningbo University

School of Materials Science and Chemical Engineering, Ningbo University

Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM)

⁰